Best TWAS P=1.4e-28 · Best GWAS P=1.05e-60 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AMDHD1 | 0.13 | 0.06 | bslmm | 546 | 0.09 | 8.9e-11 | -3.4 | 6.5 | 6.1e-11 | 0.36 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Aorta | FGD6 | 0.19 | 0.19 | lasso | 6 | 0.19 | 6.2e-11 | 8.0 | -10.0 | 1.6e-23 | -0.05 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Artery Tibial | AMDHD1 | 0.31 | 0.15 | enet | 10 | 0.26 | 4.3e-20 | 5.0 | 6.4 | 2.0e-10 | 0.27 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Tibial | FGD6 | 0.17 | 0.09 | lasso | 9 | 0.09 | 7.1e-08 | 8.0 | -8.6 | 7.8e-18 | -0.03 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | FGD6 | 0.19 | 0.22 | lasso | 5 | 0.20 | 2.4e-15 | 7.1 | -7.3 | 2.6e-13 | -0.01 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Esophagus Muscularis | AMDHD1 | 0.33 | 0.23 | enet | 25 | 0.25 | 2.5e-15 | -3.2 | 5.2 | 2.0e-07 | 0.26 | 1.00 | 0.00 | FALSE |
| 7 | YFS | Blood | METAP2 | 0.07 | 0.05 | enet | 33 | 0.06 | 5.5e-18 | -1.3 | -5.6 | 2.3e-08 | -0.12 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Glioblastoma Multiforme | LTA4H | 0.21 | 0.00 | enet | 11 | 0.00 | 3.0e-01 | 1.4 | 5.6 | 1.8e-08 | 0.02 | 0.03 | 0.26 | TRUE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NTN4 | 0.07 | 0.05 | enet | 10 | 0.05 | 2.5e-06 | -5.8 | 5.6 | 2.3e-08 | 0.02 | 0.97 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | AMDHD1 | 0.10 | 0.12 | blup | 93 | 0.06 | 1.5e-04 | -3.4 | 5.7 | 1.1e-08 | 0.13 | 0.03 | 0.96 | TRUE |
| 11 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SNRPF | 0.24 | 0.05 | enet | 10 | 0.08 | 3.6e-05 | 2.0 | 8.9 | 4.5e-19 | 0.17 | 0.09 | 0.05 | FALSE |
| 12 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | AMDHD1 | 0.08 | 0.04 | blup | 93 | 0.02 | 4.4e-02 | 5.5 | 5.7 | 1.3e-08 | 0.41 | 0.05 | 0.03 | TRUE |
| 13 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | CCDC38 | 0.13 | 0.02 | blup | 123 | 0.05 | 2.1e-03 | 5.5 | 11.1 | 1.4e-28 | 0.64 | 0.06 | 0.16 | TRUE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | NTN4 | 0.04 | 0.02 | blup | 135 | 0.00 | 9.0e-02 | 6.6 | -7.1 | 1.1e-12 | -0.08 | 0.39 | 0.03 | TRUE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | SNRPF | 0.09 | 0.02 | lasso | 2 | 0.01 | 8.4e-02 | 2.0 | 5.6 | 1.9e-08 | 0.11 | 0.01 | 0.04 | TRUE |