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Lung FEV1/FVC ratio
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chr14:51,775,331-53,232,305
Best TWAS P=4.59e-09 · Best GWAS P=4.89e-11 conditioned to 0.000793
51.8M
52M
52.2M
52.4M
52.6M
52.8M
53M
53.2M
0
2
4
6
8
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Testis
NID2
0.28
0.13
lasso
5
0.10
5.2e-05
5.6
5.9
4.6e-09
-0.73
0.05
0.91
TRUE
4
The Cancer Genome Atlas
Ovarian Serous Cystadenocarcinoma
C14orf166
0.08
0.04
lasso
2
0.05
3.4e-04
-5.6
5.4
5.7e-08
-0.78
0.05
0.61
FALSE
1
GTEx
Cells Transformed fibroblasts
NID2
0.10
0.08
lasso
5
0.07
3.5e-06
-5.9
5.2
1.7e-07
-0.74
0.11
0.85
FALSE
3
The Cancer Genome Atlas
Head and Neck Squamous Cell Carcinoma
C14orf166
0.06
0.04
lasso
4
0.04
2.3e-05
-5.5
5.2
2.3e-07
-0.73
0.07
0.86
FALSE