Hub : Genes

NID2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0950	0.0360	4.0e-03	0.079	NA	0.041	NA	0.074	1.5e-06	NA	4.8e-04	NA	3.5e-06
2	GTEx	Testis	0.2770	0.0770	8.1e-04	0.130	NA	0.074	NA	0.095	2.2e-06	NA	3.3e-04	NA	5.2e-05
3	GTEx	Thyroid	0.1590	0.0490	3.2e-04	0.080	NA	0.046	NA	0.080	9.9e-07	NA	1.9e-04	NA	9.7e-07
4	TCGA	Breast Invasive Carcinoma	0.0286	0.0141	1.8e-03	0.002	0.008	0.009	NA	0.007	1.0e-01	6.7e-03	5.2e-03	NA	1.3e-02
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1360	0.0510	3.6e-07	0.152	0.137	0.124	NA	0.137	4.7e-09	3.2e-08	1.4e-07	NA	2.9e-08
6	TCGA	Brain Lower Grade Glioma	0.0722	0.0363	7.4e-03	0.017	0.014	0.012	NA	0.013	4.4e-03	8.4e-03	1.3e-02	NA	1.1e-02
7	TCGA	Thyroid Carcinoma	0.0560	0.0270	5.1e-04	0.029	0.021	0.016	NA	0.017	6.7e-04	3.5e-03	9.3e-03	NA	8.5e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.6	1.0	2.4	0.6	0.2	-0.9	0.4	-1.6	1.3	-1.3
Bipolar Disorder or Schizophrenia	0.2	0.5	1.6	0.3	0.2	-0.1	-0.0	-1.0	0.9	-1.3
Depressed Affect (Nagel 2018)	0.6	1.2	3.1	-1.5	-1.8	-0.1	-1.4	-0.4	-0.7	-0.6
Depression (Nagel 2018)	0.9	1.4	4.3	-0.3	-0.8	1.2	-0.1	1.2	-2.1	1.5
Intelligence (Savage-Jansen 2018)	0.7	2.1	8.1	1.1	0.3	1.5	-2.8	1.3	0.5	1.2
Neuroticism (Nagel 2018)	1.9	4.5	11.4	-3.1	-3.4	-1.6	-0.5	-2.0	-0.1	-2.1
Schizophrenia (2018)	0.1	0.1	0.4	-0.1	0.0	0.6	-0.0	-0.1	0.1	-0.6
Schizophrenia vs Biploar Disorder	0.4	0.5	1.2	-1.1	-0.8	-0.1	-0.4	-0.5	-0.4	-1.0
Worry (Nagel 2018)	3.5	7.4	17.6	-3.7	-4.2	-2.2	0.9	-2.5	-0.7	-2.9
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	0.2	0.9	-0.4	-0.4	-0.5	0.7	-0.8
Alzheimer’s Disease (in father)	0.9	0.9	2.0	0.2	0.4	-0.8	1.4	-0.7	1.4	-1.2
Alzheimer’s Disease (including proxy)	0.7	1.1	2.6	0.6	0.9	-0.9	0.5	-0.7	1.5	-1.6
Crohns Disease (2017)	0.9	2.0	4.5	-1.0	-1.4	-1.7	0.0	-2.1	0.6	-1.8
Irritable Bowel Disease (IBD)	0.8	2.0	3.2	-0.9	-1.7	-1.5	1.3	-1.4	1.1	-1.8
Ulcerative Colitis (UC)	1.5	2.9	5.1	-0.7	-1.4	-1.6	2.3	-1.3	1.8	-2.2
Major Depression (MDD)	0.2	0.3	0.5	-0.4	-0.6	0.5	0.7	0.6	0.6	-0.0
Reaction Time	0.7	1.3	3.0	-0.6	-0.7	-1.3	1.7	-1.2	0.8	-1.1
Verbal and Numeric Reasoning (VNR)	1.1	2.5	6.2	0.9	0.3	1.8	-2.5	1.8	-0.8	1.9
Breast Cancer	0.5	1.2	2.1	1.2	1.2	1.0	-1.4	1.2	0.0	0.8
Ovarian Cancer	0.2	0.2	0.5	0.4	0.1	-0.7	-0.1	-0.7	0.4	-0.3
Prostate Cancer	0.3	0.4	1.3	-0.6	-0.3	-0.8	1.1	-0.7	0.2	-0.3
Age at First Birth	0.1	0.2	0.5	-0.7	-0.5	-0.5	-0.3	-0.2	-0.4	0.2
Bipolar Disorder (2011)	0.4	0.4	1.1	0.4	0.5	0.8	-0.7	0.2	1.1	-0.0
Body Mass Index (BMI) (2010)	0.3	0.4	2.0	0.4	0.5	-0.3	1.4	-0.1	0.5	-0.6
Coronary Artery Disease (CAD)	0.4	0.5	3.1	0.0	-0.5	-0.1	1.8	-0.2	-0.1	0.0
Crohns Disease (2012)	0.3	0.5	0.8	-0.7	-0.9	-0.7	-0.5	-0.8	-0.4	-0.7
Mean Putamen Volume	1.2	1.4	4.6	-0.9	-1.4	-0.7	2.1	-0.4	-1.3	-0.3
Fasting Glucose	0.6	0.7	1.5	-1.0	-1.2	0.6	-0.8	0.4	-0.8	0.7
HbA1C	1.4	1.6	2.9	1.6	1.2	1.7	0.1	1.5	-0.6	1.2
HDL Cholesterol	0.8	1.3	4.1	1.4	2.0	0.4	-0.9	1.0	0.8	0.5
LDL Cholesterol	1.9	3.0	5.8	-1.1	-0.8	-2.4	1.4	-2.2	1.3	-2.1
Lupus	2.4	3.7	7.8	0.8	0.7	-1.9	2.7	-1.5	2.8	-1.9
Neuroticism (2016)	0.5	0.8	2.5	-0.7	-1.6	0.5	-1.1	-0.4	-1.0	-0.1
Primary Biliary Cirrhosis	0.8	1.2	2.1	-1.5	-1.4	-1.2	0.7	-1.1	0.8	-0.6
Rheumatoid Arthritis	0.9	1.2	2.8	0.2	-0.9	1.7	-1.6	1.2	-0.3	1.0
Schizophrenia (2014)	0.4	0.9	2.4	0.6	0.8	0.1	-0.2	-1.0	1.3	-1.6
Triglycerides	1.3	2.1	5.2	-1.9	-2.3	-1.3	0.3	-1.3	-1.1	-0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.6	-0.3	-1.3	0.2	-0.5	0.5	-0.7	-0.0
Ulcerative Colitis	2.1	3.0	6.5	-0.9	-1.7	-1.7	2.5	-1.5	1.4	-1.9
Blood Eosinophil Count	1.2	8.9	12.4	-2.4	-3.3	-3.5	1.6	-3.0	3.2	-3.5
Blood Platelet Count	0.0	0.3	0.8	0.5	0.0	0.4	-0.3	0.7	0.9	-0.4
Blood Red Count	0.2	2.1	9.2	-1.2	-1.3	-0.5	-1.2	-0.6	-3.0	0.1
Blood White Count	0.6	4.7	9.5	-3.0	-3.1	-1.9	-2.1	-1.4	-0.6	-1.8
Heel T-Score	0.7	6.0	11.2	3.3	3.0	2.9	-0.8	2.4	0.5	2.6
BMI	0.5	2.8	7.2	1.8	2.0	1.0	-2.7	0.2	1.9	-0.1
Height	0.2	3.8	9.0	-1.1	-1.3	1.2	-1.9	0.5	-3.0	3.0
Waist Hip Ratio (WHR)	3.7	16.5	33.4	-5.8	-4.9	-4.5	1.1	-3.8	-2.3	-4.1
Systolic Blood Pressure	0.7	3.7	9.7	0.9	0.7	3.1	-0.4	2.5	-0.7	2.8
Smoking Status	0.2	0.5	1.4	1.2	1.1	0.2	0.6	0.4	0.1	0.2
Allergy or Eczema	0.9	2.5	7.7	-0.6	-0.8	-1.5	0.8	-1.8	2.8	-1.7
Cardiovascular Disease	0.5	1.7	6.8	1.0	0.6	2.6	-0.9	0.9	0.2	1.5
Hypothyroidism (self reported)	0.9	2.0	3.7	0.3	-0.4	1.1	-1.9	1.8	-1.4	1.9
Respiratory disease	2.7	6.1	10.2	-2.6	-2.4	-3.2	2.4	-2.5	0.3	-2.8
Type 2 Diabetes (T2D) (2018)	1.2	2.2	5.1	-2.3	-1.9	-0.2	-1.7	0.3	-1.8	-0.1
Lung FEV1/FVC ratio	2.6	13.3	34.4	5.2	5.9	2.2	2.4	1.1	4.1	1.8
Lung FVC	0.2	1.1	2.9	-0.6	-1.4	-0.9	0.9	-1.7	0.5	-0.8
Neuroticism	1.4	3.4	9.8	-2.7	-3.1	-1.4	-0.6	-1.5	-0.5	-1.5
Chronotype (morning person)	0.2	0.5	1.4	-0.2	-0.3	-1.2	0.8	-0.9	0.7	-0.4
Hair Pigment	0.0	1.4	2.2	-1.3	-1.5	-1.5	0.6	-1.3	-0.7	-0.9
Tanning	0.0	0.2	0.3	0.2	0.3	-0.6	-0.5	-0.5	0.6	-0.6
Hand grip strength (left)	0.1	0.3	1.1	0.2	0.2	0.3	-0.5	-0.5	-0.2	1.1
Number of treatments/medications taken	0.2	0.4	1.2	0.3	0.1	0.3	-0.6	0.9	-1.1	0.5
Average weekly spirits intake	3.2	4.0	9.7	3.1	3.1	1.8	0.3	1.5	0.8	1.7
Sensitivity / hurt feelings	0.3	0.5	2.4	-1.0	-0.6	-0.0	-1.6	-0.1	-0.1	-0.2
Frequency of depressed mood in last 2 weeks	1.2	1.6	2.8	0.4	0.1	1.3	-1.3	1.7	-1.6	1.6
Hearing difficulty/problems: Yes	1.7	2.6	5.4	-2.3	-2.1	-1.3	-0.5	-2.1	0.6	-1.2
Relative age of first facial hair	0.3	0.6	1.4	1.0	0.8	0.6	-0.2	0.8	-0.2	1.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.6	-0.3	0.3	0.5	-0.0	0.4	0.1	0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.8	0.5	0.4	0.0	1.3	-0.3	-0.1	0.2
Ever had hysterectomy (womb removed)	0.7	0.8	1.6	1.1	-0.1	1.2	0.2	1.3	-0.8	0.9
Systolic blood pressure, automated reading	1.3	3.8	7.7	1.9	2.3	2.8	-0.9	2.1	-0.3	2.1
Eye problems/disorders: Diabetes related eye disease	1.3	1.5	3.8	-1.5	-1.1	-1.2	0.5	-1.2	-0.1	-1.9
Angina	0.2	0.3	0.9	-0.1	-0.8	0.7	-0.4	0.9	-0.2	0.4
Medication for hormone replacement therapy	0.5	0.5	1.5	0.7	0.2	0.7	-0.7	1.2	-0.2	0.9
Vitamin and mineral supplements	0.1	0.1	0.3	-0.3	-0.2	0.2	-0.2	-0.6	0.0	-0.1
Supplements: Zinc	0.8	0.9	2.1	-0.2	0.5	-1.4	1.4	-1.0	0.2	-1.0
Medication: Co-codamol	0.3	0.3	0.9	-0.5	0.5	-0.1	0.9	-0.1	0.9	-0.1
Medication: Metformin	0.7	1.0	3.1	-1.8	-1.2	-0.8	0.3	-0.5	-1.1	-0.7
Diabetes (father)	0.9	1.1	2.2	-0.4	1.1	-1.5	1.2	-1.0	-0.3	-1.3
Diabetes (mother)	0.3	0.3	0.8	-0.8	-0.6	-0.7	0.1	-0.9	-0.1	-0.2
Severe depression (siblings)	0.7	0.7	1.4	0.7	1.1	1.1	0.7	0.7	-0.1	1.2
Pack years adult smoking proportion	0.8	1.2	3.2	-1.4	-1.8	-0.4	1.6	-0.3	0.2	-0.5
Impedance of leg (right)	0.0	0.1	0.4	-0.0	0.2	0.0	-0.4	0.3	-0.2	0.6
Leg fat-free mass (left)	0.3	1.5	4.5	0.2	0.1	1.3	-2.1	1.1	-1.1	1.5
Trunk fat percentage	0.6	2.4	4.2	1.2	2.0	1.5	-1.9	1.2	1.5	1.4
Hand grip strength (right)	0.1	0.2	0.3	-0.0	-0.5	0.2	-0.5	-0.4	-0.4	0.6
Townsend deprivation index at recruitment	0.6	0.9	2.8	0.2	0.8	0.8	-0.7	1.7	-0.3	1.3
Current tobacco smoking	0.5	0.9	2.7	1.2	1.2	0.4	1.6	0.0	0.5	0.1
Average weekly fortified wine intake	1.0	1.2	3.9	0.8	0.7	-0.8	-0.9	-0.9	2.0	-1.1
Maternal smoking around birth	0.4	0.6	2.1	0.9	1.4	0.1	0.5	-0.4	0.4	-0.7
Fed-up feelings	0.4	0.7	3.4	-0.5	-0.6	0.3	-1.9	0.3	-0.6	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.4	-0.2	-0.4	0.7	-0.5	1.0	-1.8	1.0
Relative age voice broke	0.4	0.6	2.0	-0.5	-0.9	-0.2	-0.8	0.1	-1.4	0.5
Taking other prescription medications	0.6	1.0	1.7	-0.7	-0.8	-1.2	1.0	-0.9	0.8	-1.3
Age when periods started (menarche)	0.2	0.4	1.9	-0.1	0.5	-0.4	0.6	0.1	1.4	-0.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.9	0.4	0.4	0.7	-0.4	0.6	-0.9	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.5	9.5	1.6	0.9	2.5	-0.5	2.2	-0.5	3.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.0	0.9	0.2	0.7	0.4	1.0	-0.9	0.5
Qualifications: CSEs or equivalent	1.4	1.8	3.2	0.1	1.1	-1.4	1.0	-1.7	1.6	-1.8
Serious illness, injury or assault to yourself	0.5	0.6	2.5	0.0	0.3	-0.6	0.3	-0.4	0.9	-1.6
High blood pressure	1.9	5.4	12.5	2.0	1.4	3.5	-1.5	2.4	-1.4	3.1
Hayfever, allergic rhinitis or eczema	0.8	1.6	3.3	-0.3	-0.4	-1.4	0.6	-1.7	1.8	-1.7
Multivitamins +/- minerals	0.4	0.5	1.3	0.7	0.7	0.1	-0.9	1.1	-0.1	0.4
Stomach or abdominal pain in last month	0.8	1.0	3.7	0.4	1.5	-0.4	-1.9	-0.6	0.7	-0.4
Supplements: Glucosamine	0.5	0.7	1.2	1.1	0.9	0.7	-0.4	1.1	-0.5	0.9
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	4.2	1.8	1.6	2.0	-2.0	1.3	0.1	1.3
Medication: Atenolol	0.8	0.9	3.4	-1.8	-1.7	0.3	-0.2	-0.2	0.3	-0.0
Medication: Levothyroxine sodium	0.3	0.5	1.1	0.7	0.0	0.3	-0.8	0.9	0.2	1.0
Sitting height	1.0	7.3	14.3	0.5	-0.2	2.9	-3.8	2.0	-3.1	3.7
Chronic bronchitis/emphysema (father)	0.5	0.5	1.4	0.6	1.2	0.7	-0.4	0.7	0.1	1.0
High blood pressure (mother)	1.7	2.4	4.0	1.4	1.8	1.5	-0.9	1.6	-1.4	2.0
Body mass index (BMI)	0.3	1.2	2.7	0.9	1.3	0.7	-1.6	0.5	1.6	0.0
Impedance of leg (left)	0.0	0.2	0.6	0.2	0.5	0.2	0.2	0.3	-0.2	0.8
Leg predicted mass (left)	0.3	1.7	5.1	0.2	0.1	1.4	-2.3	1.1	-1.2	1.5
Trunk fat mass	0.6	2.5	6.4	0.9	1.5	1.7	-2.5	1.3	0.7	1.7
Waist circumference	0.3	1.0	5.6	-0.6	-0.4	0.2	-2.4	0.2	-0.6	0.1
Number of incorrect matches in round	0.7	1.1	5.2	-0.9	-0.7	-0.8	0.3	-0.5	-2.3	-0.5
Past tobacco smoking	0.4	0.7	1.9	-1.2	-1.4	-0.4	-1.1	-0.3	-0.6	-0.2
Alcohol usually taken with meals	0.1	0.1	0.3	0.6	-0.2	0.5	-0.3	0.1	-0.3	0.2
Nervous feelings	2.5	4.7	11.4	-3.2	-3.4	-1.6	-0.5	-1.9	-1.1	-1.9
Frequency of tenseness / restlessness in last 2 weeks	2.4	3.7	6.8	0.7	0.2	2.4	-1.5	2.2	-2.6	2.3
Hearing difficulty/problems with background noise	0.7	1.1	2.3	-1.4	-1.5	-0.7	-0.4	-1.4	-0.2	-0.8
Hair/balding pattern: Pattern 2	0.4	0.6	2.1	-0.5	-0.0	0.6	-0.0	0.2	-1.4	1.1
Had menopause	0.5	0.6	1.1	-0.2	-0.1	-1.1	1.0	-0.9	-0.3	-0.9
Had other major operations	0.5	0.6	1.7	0.5	0.7	0.9	0.3	0.9	0.3	1.3
Forced vital capacity (FVC)	0.5	2.1	6.0	-1.6	-2.4	-0.6	0.2	-0.8	-2.2	0.1
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.7	12.2	1.9	1.6	2.7	-0.7	2.3	-1.1	3.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.8	0.4	0.2	-0.3	1.3	-0.0	-0.1	-0.5
Qualifications: None of the above	0.4	0.9	2.4	-1.5	-1.0	-0.8	1.4	-0.3	0.4	-0.5
Financial difficulties in last 2 years	0.2	0.3	0.8	0.3	0.8	0.9	0.1	0.5	-0.4	0.5
Mouth/teeth dental problems	0.6	0.9	2.1	-0.9	-1.4	-0.3	0.7	-1.5	0.3	-0.7
Heart attack	0.3	0.4	1.1	0.4	0.8	-0.2	0.1	-0.0	1.0	-0.9
Allergy	1.0	2.3	5.6	0.6	0.5	2.4	-0.8	2.0	-0.7	2.1
Pain all over the body in last month	1.6	1.8	5.0	1.1	0.8	1.4	-0.0	2.2	-1.3	1.4
Diabetes (self-reported)	1.4	2.1	5.9	-2.4	-2.1	-1.1	-0.7	-0.6	-1.2	-1.1
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	3.8	-1.6	-1.7	-2.0	-0.6	-1.3	0.9	-1.2
Medication: Ramipril	1.6	2.1	4.1	1.9	2.0	1.5	0.5	1.2	0.7	1.5
Medication: Simvastatin	0.5	0.7	1.9	0.3	-0.0	1.4	0.6	1.2	-0.2	1.2
Fluid intelligence score	0.3	0.5	2.0	-0.1	-0.8	0.5	-1.4	0.6	0.5	0.5
Illnesses of siblings	0.9	1.2	4.5	0.8	0.5	-0.5	0.6	-0.6	2.1	-1.5
Neuroticism score	1.1	2.2	6.5	-2.2	-2.5	-0.8	-1.3	-0.9	-0.6	-0.9
Weight	0.4	1.9	6.4	0.5	0.7	1.5	-2.5	1.1	-0.1	1.5
Impedance of arm (right)	0.1	0.6	1.9	0.2	0.9	0.3	0.5	0.9	0.6	1.4
Arm fat percentage (right)	0.5	1.8	3.7	1.1	1.9	0.9	-1.7	0.8	1.9	0.6
Trunk fat-free mass	0.4	2.4	5.8	-0.5	-0.9	1.3	-2.4	0.9	-2.2	1.6
Hip circumference	1.2	5.4	11.0	1.7	1.5	2.8	-3.3	2.5	0.3	2.7
Time employed in main current job	0.6	0.7	2.5	-0.4	0.2	-1.6	0.8	-0.8	-0.4	-0.6
Alcohol intake versus 10 years previously	0.3	0.5	1.1	-0.2	0.3	0.4	-1.0	0.4	-0.8	1.0
Father’s age at death	0.6	0.8	2.5	0.9	0.4	0.7	-1.6	0.7	0.1	0.9
Worrier / anxious feelings	2.8	5.2	9.2	-2.4	-2.9	-2.1	1.2	-3.0	0.7	-2.6
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	4.8	0.1	-0.0	1.7	-2.2	1.3	-1.8	1.7
Falls in the last year	0.5	0.6	1.5	0.3	-0.3	1.2	-0.8	1.2	-0.6	0.8
Hair/balding pattern: Pattern 3	0.1	0.1	0.4	0.2	0.4	0.5	-0.2	0.0	0.7	0.2
Number of live births	0.1	0.2	0.9	-0.2	-0.3	0.3	-0.4	-0.0	-0.9	-0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.0	0.3	-0.3	0.7	0.9	-0.0	-1.0	1.0
Pulse rate	4.9	8.3	16.4	-2.7	-1.6	-3.7	0.8	-3.5	2.4	-4.0
Happiness	0.8	1.0	4.7	0.5	-0.4	0.0	-2.2	-0.2	-1.4	0.1
Noisy workplace	0.4	0.5	2.0	-0.6	-0.3	-0.2	0.9	-1.4	0.5	-0.2
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.5	-0.3	-0.7	0.5	-1.4	1.5	-2.1	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.3	-0.5	-1.1	-1.0	-0.7	-0.7	-0.5	-0.7
Mouth/teeth dental problems: Dentures	0.4	0.7	1.6	-0.8	-0.2	-0.1	-1.1	0.6	-1.3	0.9
Asthma	2.7	5.4	10.8	-2.4	-2.3	-3.3	1.7	-2.3	-0.1	-2.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.2	1.1	1.5	0.6	-0.7	0.9	-0.7	0.7
Medication: Cholesterol lowering	0.4	0.6	2.0	-0.2	-0.3	1.1	1.4	0.9	0.7	0.1
Depression (self-reported)	2.6	3.1	5.3	1.7	1.4	1.9	-1.3	2.3	-1.1	2.3
Medication: Lansoprazole	0.4	0.5	1.5	-0.5	-0.6	-0.6	0.8	-0.3	1.2	-0.5
Prospective memory result	1.3	1.6	2.8	-1.4	-1.7	-1.1	0.9	-1.4	-1.4	-0.9
Lung cancer (father)	0.6	0.7	1.4	-0.5	-1.2	-0.9	0.7	-1.0	-0.7	-0.5
Illnesses of mother	1.3	1.6	4.6	-1.3	-2.1	-1.2	0.5	-1.1	0.3	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.4	1.1	-0.0	1.1	0.3	0.6	-1.5	1.5
Pulse wave Arterial Stiffness index	0.4	0.5	1.8	0.5	0.4	-0.2	-1.1	0.3	1.3	-0.3
Impedance of arm (left)	0.1	0.5	1.2	0.2	0.8	0.1	0.8	0.7	0.7	1.1
Arm fat mass (right)	0.4	1.4	5.1	0.6	1.1	1.0	-2.3	0.6	1.3	0.6
Trunk predicted mass	0.4	2.3	5.6	-0.5	-0.9	1.2	-2.4	0.8	-2.2	1.5
Standing height	0.6	5.7	14.0	-0.8	-1.2	1.9	-2.5	1.5	-3.7	3.4
Length of working week for main job	1.0	1.1	5.4	-0.1	-0.1	0.5	-0.1	0.9	-2.3	1.0
Exposure to tobacco smoke at home	0.2	0.2	0.4	0.1	-0.5	0.4	-0.5	0.6	0.3	-0.6
Breastfed as a baby	0.4	0.4	1.1	0.3	-0.8	-0.2	1.1	-0.5	0.9	0.2
Tense / ‘highly strung’	0.8	1.3	4.1	-0.5	-0.9	0.7	-2.0	0.6	-1.6	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.4	-0.7	-1.1	1.0	0.0	1.2	-0.5	1.2
Hair/balding pattern: Pattern 4	1.0	2.5	6.1	0.8	0.8	1.7	-2.5	1.7	-1.6	1.3
Birth weight of first child	2.6	4.7	7.6	2.1	1.3	2.6	-2.3	2.7	-0.1	2.8
Peak expiratory flow (PEF)	1.0	2.3	5.5	1.3	0.8	1.9	0.8	1.2	-1.4	2.4
Pulse wave reflection index	3.3	4.0	9.0	2.0	0.5	2.4	-1.9	3.0	-0.2	2.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	-0.3	-0.7	0.3	0.6	0.5	0.6	-0.1
Loud music exposure frequency	0.6	0.7	1.7	1.0	0.1	1.3	0.6	0.7	0.2	1.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.5	-0.1	0.1	-0.2	-1.1	0.3	-1.2	0.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.7	0.8	0.3	0.8	-0.7	0.8	-0.7	0.1
Blood clot in the leg (DVT)	0.2	0.3	1.3	-0.3	-0.1	-0.1	-1.1	0.2	-0.8	0.1
Medication: Paracetamol	1.4	2.3	5.8	-2.4	-2.0	-1.2	0.4	-1.2	-1.5	-0.8
Headache pain in last month	0.8	1.3	3.8	0.1	-0.2	1.0	-2.0	1.0	-1.1	1.4
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	5.0	-0.9	-1.0	-2.2	-0.6	-2.0	-0.6	-1.2
Glaucoma (self-reported)	1.8	2.1	4.2	0.2	0.0	2.0	-1.1	1.9	-1.3	1.9
Gout (self-reported)	0.4	0.6	1.1	-0.7	-0.7	-0.5	0.9	-1.0	0.3	-0.9
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.4	0.7	-0.2	0.6	-1.2	0.9	-0.4	1.1
Medication: Amlodipine	0.4	0.5	0.9	1.0	0.7	0.7	-0.2	0.7	0.8	0.8
Medication: Ventolin 100micrograms inhaler	3.4	4.4	9.1	-1.9	-1.4	-3.0	1.4	-2.3	0.2	-3.0
Birth weight	0.6	1.4	2.5	1.6	1.4	1.1	-0.4	1.0	-0.8	1.4
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.7	0.4	0.6	-0.7	0.8	-0.7	-0.4	-0.7
High blood pressure (siblings)	1.6	2.3	8.2	-0.0	-0.3	0.9	-0.8	1.6	-2.9	1.9
Forced vital capacity (FVC), Best measure	0.4	1.6	6.1	-0.7	-1.8	0.1	-0.3	-0.1	-2.5	1.0
Body fat percentage	0.6	2.4	4.4	1.2	2.0	1.3	-2.1	1.1	1.7	1.0
Leg fat percentage (right)	0.8	3.0	8.8	1.3	1.7	1.6	-3.0	1.5	1.3	1.0
Arm fat-free mass (right)	0.4	2.2	6.7	-0.4	-0.9	1.3	-2.6	0.8	-1.9	1.4
Exposure to tobacco smoke outside home	0.2	0.2	0.6	-0.8	-0.4	0.5	-0.3	-0.5	0.1	-0.6
Comparative body size at age 10	0.5	1.3	2.6	1.5	0.8	1.2	-1.6	1.2	-0.8	-0.3
Number of full brothers	1.4	1.8	3.4	1.6	1.2	1.7	0.1	1.8	-0.7	1.4
Worry too long after embarrassment	0.4	0.7	3.2	-1.2	-1.8	-0.4	-0.5	-0.4	-0.1	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	4.4	0.9	0.5	1.9	-1.8	2.1	-1.5	1.6
Wheeze or whistling in the chest in last year	1.9	3.4	6.6	-2.0	-1.7	-2.6	-0.1	-2.2	-0.0	-2.3
Number of children fathered	0.4	0.5	1.7	-0.3	-0.1	-0.3	0.9	-1.3	0.6	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	3.5	1.4	1.9	0.7	0.2	0.6	0.8	0.6
Age at first live birth	0.8	1.4	2.2	-0.7	-1.5	0.8	-0.9	1.1	-1.4	1.5
Pulse wave peak to peak time	0.5	0.6	2.7	-0.5	-0.4	0.3	1.0	-0.2	-1.6	0.5
Health satisfaction	0.5	0.7	2.4	-0.4	-1.6	0.1	-1.1	-0.1	-0.9	0.4
Shortness of breath walking on level ground	0.1	0.2	0.4	-0.6	-0.3	-0.5	0.1	-0.4	-0.1	-0.5
Qualifications: College or University degree	0.2	0.8	2.2	-0.8	-1.4	-1.5	-0.3	-0.6	-0.2	0.3
Eye problems/disorders: None of the above	0.8	0.9	2.7	0.6	0.7	-0.7	1.6	-0.2	1.2	-0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.7	1.3	1.3	0.8	-0.1	0.5	0.3	0.3
Emphysema/chronic bronchitis	1.7	1.9	7.3	-0.9	-0.6	-1.6	2.7	-1.2	-0.2	-0.9
Medication for pain relief, constipation, heartburn	0.0	0.0	0.1	0.1	0.1	0.1	0.2	-0.2	0.3	0.0
Neck or shoulder pain in last month	0.4	0.5	2.1	-0.4	-0.2	0.0	-1.1	0.3	-1.5	0.4
Medication: Blood pressure	2.5	4.5	10.4	2.0	1.7	3.2	0.2	2.9	-0.2	2.4
Angina (self-reported)	0.3	0.4	1.0	-0.2	-0.8	0.6	-0.5	1.0	-0.3	0.3
Migraine (self-reported)	0.3	0.4	0.9	0.7	0.3	1.0	0.1	0.7	-0.6	0.7
Medication: Ibuprofen	0.8	0.9	3.8	1.5	2.0	0.2	0.1	0.7	-0.1	0.1
Medication: Allopurinol	1.3	1.7	4.5	-0.4	-0.5	-0.9	1.5	-1.8	0.9	-2.1
Medication: Omeprazole	0.2	0.2	0.5	-0.1	0.1	0.6	0.5	-0.2	0.7	0.4
Medication: Seretide 50 evohaler	0.4	0.5	1.1	-0.0	0.5	-1.1	0.7	0.1	0.9	-0.8
Mean time to correctly identify matches	0.8	1.5	3.7	-0.6	-0.8	-1.2	1.9	-1.1	1.3	-1.2
Heart disease (mother)	0.5	0.6	1.7	-1.3	-0.6	-0.4	0.2	-0.7	0.2	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.6	-0.2	-0.5	-0.8	0.7	-0.6	0.3	-1.3
Whole body fat mass	0.5	1.9	5.7	0.8	1.3	1.4	-2.4	1.0	1.0	1.2
Leg fat mass (right)	0.6	2.3	8.6	0.9	1.3	1.3	-2.9	1.0	1.2	0.8
Arm predicted mass (right)	0.4	2.1	5.5	-0.5	-1.0	1.3	-2.4	0.7	-2.0	1.3
Pulse rate, automated reading	4.4	14.3	27.5	-3.5	-3.0	-5.1	0.2	-4.6	1.9	-5.2
Alcohol intake frequency.	0.1	0.3	1.1	-0.8	-0.6	0.3	-1.1	-0.1	-0.2	-0.0
Comparative height size at age 10	0.6	3.5	6.9	0.0	0.2	1.7	-2.5	1.5	-2.6	2.3
Number of full sisters	0.7	0.8	1.7	1.1	1.0	1.1	-0.3	1.3	-0.3	0.8
Suffer from ‘nerves’	0.9	1.4	3.5	-1.8	-1.9	-0.8	-1.1	-0.6	-1.1	-0.4
Overall health rating	0.4	1.0	2.7	-1.1	-1.3	0.5	-1.7	0.6	-0.6	0.5
Chest pain or discomfort	0.8	1.2	3.3	-0.2	-0.8	0.4	-1.2	1.4	-1.8	0.5
Had major operations	1.0	1.2	1.9	1.4	1.4	1.3	0.6	1.1	-0.8	1.0
Age at last live birth	1.1	1.6	4.1	-0.6	-1.4	0.8	-2.0	1.0	-1.6	0.9
Family relationship satisfaction	1.0	1.2	2.2	1.1	1.2	0.8	-1.5	1.2	-0.6	1.2
Leg pain on walking	0.3	0.4	1.1	-0.8	-0.5	-0.2	1.0	-0.2	0.3	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.9	1.0	1.4	0.4	-0.3	0.7	-0.5	0.3
Commuting to job workplace: Car/motor vehicle	1.1	1.2	3.2	1.4	0.7	1.1	-0.9	1.8	-0.5	1.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	1.0	-0.9	-1.0	-0.5	0.9	-0.7	0.9	-0.7
Medication: Aspirin	0.5	0.6	1.6	0.9	0.6	0.5	-0.8	1.3	-0.5	0.7
Supplements: Vitamin C	0.1	0.1	0.2	0.2	0.5	-0.3	0.0	-0.0	0.3	0.1
Knee pain experienced in last month	0.3	0.5	2.1	-0.8	-1.5	0.3	-0.0	0.0	0.6	-0.6
Hypertension (Self-reported)	1.7	4.8	12.2	1.8	1.2	3.5	-1.9	2.2	-0.9	2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	5.4	0.3	0.5	0.3	0.1	0.3	2.3	-0.2
Illnesses of father: Heart disease	0.2	0.3	0.7	-0.3	-0.1	-0.0	0.8	0.0	0.8	-0.5
Illnesses of siblings: Diabetes	0.8	0.9	3.8	-1.3	-0.6	-0.6	-0.2	0.3	-1.9	0.5
Smoking status: Previous	0.3	0.4	1.0	0.8	1.0	0.6	0.1	0.8	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.2	9.2	-0.5	-0.7	1.6	-2.7	1.5	-3.0	2.7
Whole body fat-free mass	0.3	1.9	5.1	-0.3	-0.6	1.2	-2.2	0.9	-1.9	1.4
Leg fat-free mass (right)	0.2	1.1	2.4	0.2	0.0	1.1	-1.5	0.9	-1.1	1.3
Arm fat percentage (left)	0.5	1.8	4.5	1.0	1.7	0.8	-1.7	0.7	2.1	0.5
Average weekly red wine intake	1.4	2.1	7.0	2.6	1.7	1.3	-0.3	1.0	-0.9	0.9
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.9	0.3	-0.0	0.3	-1.0	0.5	-0.4	0.8
Mood swings	0.7	1.2	3.3	-1.8	-1.7	-0.7	-0.8	-0.5	0.1	-1.0
Loneliness, isolation	0.6	0.8	4.0	0.1	-0.2	0.7	-2.0	0.5	-1.0	0.5
Long-standing illness, disability or infirmity	0.3	0.5	1.3	0.3	0.6	-0.7	-0.2	0.0	1.0	-1.2
Ever had bowel cancer screening	0.2	0.2	0.6	0.8	0.7	0.1	-0.1	-0.3	0.6	-0.2
Diabetes diagnosed by doctor	0.7	1.1	3.3	-1.8	-1.5	-0.7	-0.6	-0.3	-0.8	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.2	1.1	1.0	1.0	0.3	0.8	-0.7	0.5
Friendships satisfaction	1.1	1.3	3.0	0.6	-0.5	1.1	-1.7	1.2	-1.1	1.2
Qualifications: nursing, teaching	0.3	0.4	0.9	0.9	0.4	0.9	0.0	0.5	0.4	0.9
Commuting to job workplace: Walk	0.9	1.0	2.2	-0.2	-0.4	1.2	-1.5	0.8	-0.7	1.4
Eye problems/disorders: Cataract	0.4	0.5	1.1	-1.0	-0.6	-0.5	-1.1	-0.3	-0.3	0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.9	0.9	1.0	0.0	-0.6	0.4	0.4	0.1
Medication for cholesterol	1.8	2.8	5.0	-0.0	0.4	-1.9	2.2	-1.7	1.8	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	3.1	-0.3	-0.7	-0.9	1.8	-1.1	0.3	-1.2
Back pain experienced in last month	0.8	1.1	2.4	0.6	0.6	1.2	-1.2	1.5	-0.8	1.0
Mineral and other dietary supplements	0.8	1.1	2.6	-1.6	-1.5	-0.3	0.5	-0.9	1.0	-0.9
Breast cancer (self-reported)	0.7	0.9	2.7	1.5	1.6	0.4	-1.0	0.2	0.3	-0.1
Asthma (self-reported)	2.7	5.3	10.6	-2.3	-2.3	-3.3	1.7	-2.3	-0.1	-2.8
Osteoporosis (self-reported)	0.3	0.4	1.4	-0.1	0.7	-0.2	0.7	0.5	1.2	-0.0
Osteoarthritis (self-reported)	0.8	1.0	2.5	-0.1	-0.2	1.1	-1.1	1.6	-0.6	1.4
Medication: Aspirin	0.2	0.2	0.4	0.6	0.5	0.1	-0.7	0.6	-0.2	0.3
Medication: Gliclazide	0.2	0.2	0.6	-0.3	-0.2	-0.7	0.5	-0.3	0.5	-0.8
Illnesses of father: None of the above (group 1)	1.2	1.5	2.7	-0.8	-0.7	0.7	-1.6	1.1	-1.5	1.6
Smoking status: Current	0.5	0.9	2.2	1.3	1.3	0.3	1.5	0.0	0.7	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	4.8	1.3	0.5	-0.1	2.2	-0.8	1.1	-0.8
Whole body water mass	0.3	2.0	5.0	-0.3	-0.6	1.2	-2.2	0.9	-2.0	1.5
Leg predicted mass (right)	0.2	1.1	2.5	0.2	-0.0	1.1	-1.6	0.9	-1.1	1.4
Arm fat mass (left)	0.4	1.8	5.1	1.0	1.4	1.2	-2.3	0.9	1.4	0.9
Number of self-reported non-cancer illnesses	1.3	2.2	4.3	0.2	-0.7	1.8	-1.5	2.1	-1.0	2.1
Average weekly champagne plus white wine intake	0.8	1.1	3.9	-0.3	-0.0	0.2	-2.0	0.6	-1.8	0.5
Miserableness	1.2	2.1	5.2	-2.0	-2.3	-1.4	-0.1	-1.3	-0.1	-1.2
Guilty feelings	0.6	0.9	2.4	-1.2	-1.2	-0.2	-1.5	-0.8	0.8	-0.2
Wears glasses or contact lenses	0.4	0.5	1.2	0.9	0.8	0.8	-0.2	0.4	0.5	1.1
Ever taken oral contraceptive pill	1.1	1.2	3.0	1.2	1.7	0.1	0.5	1.2	-0.8	1.3
Hearing aid user	2.4	2.7	6.7	-2.6	-1.8	-1.5	-0.4	-1.9	0.8	-1.4
Mother’s age at death	1.8	2.2	4.5	1.0	0.6	1.8	-2.1	1.0	-1.1	2.0
Financial situation satisfaction	0.1	0.2	0.5	-0.2	-0.6	-0.2	0.5	0.1	-0.7	-0.2
Tinnitus: Yes, now most or all of the time	1.0	1.1	4.5	-2.1	-1.7	-0.2	-0.4	-0.6	-0.2	0.2
Commuting to job workplace: Public transport	0.2	0.3	0.6	-0.7	-0.8	-0.5	0.3	-0.7	-0.1	0.1
Eye problems/disorders: Glaucoma	0.8	0.9	2.1	0.3	0.0	1.4	-0.5	1.5	-0.7	1.2
Medication: Blood pressure	2.4	4.6	15.1	0.1	-0.0	2.2	-3.9	1.1	-2.4	2.2
Pain type(s) experienced in last month: Hip pain	1.0	1.2	4.1	0.1	-0.1	-0.5	1.8	-0.5	2.0	-0.8
Supplements: Fish oil (including cod liver oil)	0.7	1.0	2.9	1.2	1.7	0.1	-0.5	0.4	-1.1	0.9
High cholesterol (Self-reported)	0.5	0.9	2.7	0.3	0.0	1.5	0.2	1.2	-0.3	1.6
Medication: Bendroflumethiazide	1.9	2.9	7.1	1.3	1.8	1.8	-2.7	1.5	-0.3	1.7
Medication: Paracetamol	1.9	2.9	7.2	-2.7	-2.3	-1.4	0.8	-1.3	-1.2	-1.4
Medication: Lisinopril	0.9	1.1	4.4	-0.7	-0.2	0.2	-1.6	0.5	-2.1	0.3
Medication: Atorvastatin	0.2	0.3	0.8	-0.8	-0.1	0.2	0.7	-0.2	0.9	-0.3
Illnesses of father: High blood pressure	2.4	3.0	6.7	2.5	2.6	1.4	-1.0	1.3	-1.5	1.0
Alcohol drinker status: Never	0.2	0.2	0.5	0.5	0.7	0.6	-0.1	0.5	-0.5	0.1
Ever smoked	0.6	1.0	3.0	1.1	1.3	-0.2	1.7	-0.1	1.0	-0.4
Basal metabolic rate	0.4	2.0	5.9	0.0	-0.2	1.4	-2.4	1.0	-1.5	1.6
Leg fat percentage (left)	0.7	2.7	6.2	1.3	1.7	1.7	-2.5	1.4	1.3	1.1
Arm fat-free mass (left)	0.4	1.9	5.8	0.0	-0.3	1.3	-2.4	1.0	-1.8	1.3
Number of operations (self-reported)	1.0	1.5	4.5	1.0	0.5	2.1	-0.9	0.6	-0.7	1.6
Average weekly beer plus cider intake	0.2	0.4	1.3	-0.4	-0.3	-0.5	-0.3	-0.7	0.3	-1.1
Irritability	0.4	0.7	3.1	-1.1	-1.8	0.2	-0.7	-0.3	0.1	-0.2
Risk taking	1.3	1.9	5.1	2.1	1.7	0.4	2.3	0.6	-0.2	0.4
Ever had prostate specific antigen (PSA) test	3.6	4.1	9.5	1.0	0.3	2.3	-1.1	2.7	-2.2	3.1
Fractured/broken bones in last 5 years	1.7	2.2	7.2	2.1	2.7	0.3	1.1	-0.1	1.6	-0.2
Age started oral contraceptive pill	1.5	1.9	3.0	-1.7	-1.7	-1.6	0.8	-1.4	0.4	-1.5
Diastolic blood pressure, automated reading	0.9	2.8	4.9	1.8	1.8	2.2	-2.1	1.2	0.4	1.6
Ever depressed for a whole week	0.2	0.2	1.1	0.6	0.3	-0.3	1.0	-0.1	-0.1	-0.4
Unable to work because of sickness or disability	0.3	0.4	1.5	0.9	0.7	0.1	1.2	0.1	0.1	-0.3
Commuting to job workplace: Cycle	0.7	0.8	1.5	-0.9	-1.2	-0.1	-1.2	0.4	-1.1	1.0
Myopia	0.1	0.2	0.4	-0.5	-0.0	-0.4	0.4	0.7	-0.6	0.2
Vascular/heart problems diagnosed by doctor	1.2	3.4	7.9	-1.2	-0.8	-2.8	1.1	-2.0	1.3	-2.5
Cholesterol lowering medication	0.7	1.0	2.6	-0.3	-0.7	1.0	0.1	1.3	-1.0	1.6
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.5	0.9	0.6	1.9	-0.3	0.7	0.7	1.1
Pain experienced in last month	0.2	0.3	1.2	0.4	0.0	-0.1	1.1	-0.3	0.8	-0.3
Supplements: Calcium	0.7	0.8	3.1	1.1	1.8	-0.2	0.1	0.6	0.9	0.1
Basal cell carcinoma (self-reported)	0.8	0.9	1.6	0.8	1.0	-0.6	1.1	-0.7	1.3	-1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.1	0.2	0.7	-0.2	0.1	-0.0	1.0	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	1.2	-0.3	-0.2	-0.2	-1.1	0.1	-0.5	-0.1
Heart disease (siblings)	1.2	1.4	4.8	-1.8	-2.2	0.1	-0.7	-0.4	-0.9	0.8
Alcohol drinker status: Previous	0.3	0.3	1.5	-0.2	0.3	0.2	-0.5	-0.5	1.2	-0.3
Pack years of smoking	0.9	1.3	3.5	-1.8	-1.9	-0.4	1.5	-0.2	-0.1	-0.4
Impedance of whole body	0.1	0.4	1.1	0.1	0.8	0.3	0.7	0.5	0.3	1.0
Leg fat mass (left)	0.5	2.1	7.3	0.9	1.3	1.4	-2.7	1.0	1.1	0.9
Arm predicted mass (left)	0.5	2.3	6.2	0.2	-0.1	1.7	-2.5	1.1	-1.9	1.5