[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr16:57,311,211-59,241,430

Best TWAS P=8.12e-56 · Best GWAS P=6.96e-58 conditioned to 1.5e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Thyroid	MMP15	0.11	0.05	lasso	5	0.06	1.5e-05	-14.6	-15.7	8.1e-56	0.83	0.04	0.96	TRUE
13	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TEPP	0.06	0.02	blup	55	0.06	8.3e-06	-9.9	13.2	5.3e-40	-0.65	0.12	0.71	TRUE
19	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TEPP	0.08	0.00	blup	55	0.02	5.6e-02	-9.9	8.0	1.2e-15	-0.71	0.01	0.56	TRUE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	MMP15	0.04	0.05	lasso	2	0.04	2.9e-03	-14.5	-15.4	1.3e-53	0.82	0.03	0.45	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	MMP15	0.05	0.02	lasso	3	0.02	1.6e-03	-14.9	-14.8	7.2e-50	0.74	0.13	0.08	FALSE
8	GTEx	Thyroid	ZNF319	0.13	0.03	enet	16	0.04	3.6e-04	-9.8	10.9	8.6e-28	-0.74	0.04	0.93	FALSE
18	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TEPP	0.03	0.02	blup	55	0.02	1.0e-03	-6.4	10.8	4.0e-27	-0.73	0.02	0.73	FALSE
17	The Cancer Genome Atlas	Lung Adenocarcinoma	TEPP	0.07	0.05	lasso	5	0.05	1.8e-06	-6.4	10.5	1.0e-25	-0.79	0.03	0.97	FALSE
12	YFS	Blood	ZNF319	0.10	0.13	lasso	3	0.12	1.6e-38	-9.8	10.1	5.7e-24	-0.68	1.00	0.00	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	C16orf57	0.13	0.14	enet	2	0.14	1.1e-13	-9.8	10.0	2.1e-23	-0.67	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF319	0.13	0.20	lasso	2	0.20	5.7e-19	-9.8	9.8	1.2e-22	-0.67	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	TEPP	0.13	0.21	lasso	3	0.22	7.5e-21	-9.8	9.8	1.6e-22	-0.68	1.00	0.00	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	TEPP	0.09	0.09	lasso	4	0.08	4.8e-09	-6.4	9.7	3.6e-22	-0.73	0.92	0.08	FALSE
9	METSIM	Adipose	CSNK2A2	0.13	0.10	bslmm	522	0.10	5.1e-15	-8.0	-9.6	1.0e-21	0.52	1.00	0.00	FALSE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	CSNK2A2	0.05	0.03	blup	72	0.03	3.9e-04	-8.0	-9.2	5.0e-20	0.46	0.00	0.99	FALSE
2	GTEx	Lung	MMP15	0.10	0.02	enet	13	0.07	4.4e-06	-4.7	-9.1	6.0e-20	0.58	0.05	0.87	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF319	0.03	0.04	blup	54	0.04	1.3e-04	-9.2	-9.1	6.0e-20	0.65	0.24	0.19	FALSE
5	GTEx	Skin Sun Exposed Lower leg	CSNK2A2	0.09	0.04	enet	7	0.03	1.0e-03	-8.0	-7.6	2.4e-14	0.48	0.86	0.02	FALSE
3	GTEx	Muscle Skeletal	SETD6	0.09	0.07	enet	23	0.06	3.3e-06	-1.1	-7.3	3.1e-13	0.32	0.94	0.01	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	TEPP	0.08	0.04	bslmm	484	0.04	2.1e-05	-5.9	6.9	6.2e-12	-0.58	0.39	0.56	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	TEPP	0.03	0.01	enet	6	0.02	9.7e-05	-6.4	6.7	2.0e-11	-0.63	0.11	0.81	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	CSNK2A2	0.09	0.03	blup	72	0.03	3.4e-04	-8.0	-6.7	2.6e-11	0.45	0.01	0.98	FALSE
6	GTEx	Testis	AC009107.1	0.20	0.12	lasso	8	0.09	5.7e-05	-3.6	6.5	1.0e-10	-0.34	0.56	0.12	FALSE
11	YFS	Blood	CSNK2A2	0.02	0.01	enet	26	0.01	5.3e-05	-6.8	-6.0	1.9e-09	0.35	1.00	0.00	FALSE
4	GTEx	Skin Not Sun Exposed Suprapubic	AC009107.1	0.18	0.07	lasso	6	0.08	2.4e-05	-5.1	5.5	3.2e-08	-0.28	0.17	0.42	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCDC113	0.05	0.04	lasso	4	0.04	3.4e-08	-5.1	5.3	9.7e-08	-0.27	0.03	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CCDC113	0.15	0.15	lasso	2	0.15	7.9e-18	-5.1	5.1	3.1e-07	-0.26	1.00	0.00	FALSE