Best TWAS P=8.12e-56 · Best GWAS P=6.96e-58 conditioned to 1.5e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CCDC113 | 0.15 | 0.15 | lasso | 2 | 0.15 | 7.9e-18 | -5.1 | 5.1 | 3.1e-07 | -0.26 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Lung | MMP15 | 0.10 | 0.02 | enet | 13 | 0.07 | 4.4e-06 | -4.7 | -9.1 | 6.0e-20 | 0.58 | 0.05 | 0.87 | FALSE |
| 3 | GTEx | Muscle Skeletal | SETD6 | 0.09 | 0.07 | enet | 23 | 0.06 | 3.3e-06 | -1.1 | -7.3 | 3.1e-13 | 0.32 | 0.94 | 0.01 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | AC009107.1 | 0.18 | 0.07 | lasso | 6 | 0.08 | 2.4e-05 | -5.1 | 5.5 | 3.2e-08 | -0.28 | 0.17 | 0.42 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | CSNK2A2 | 0.09 | 0.04 | enet | 7 | 0.03 | 1.0e-03 | -8.0 | -7.6 | 2.4e-14 | 0.48 | 0.86 | 0.02 | FALSE |
| 6 | GTEx | Testis | AC009107.1 | 0.20 | 0.12 | lasso | 8 | 0.09 | 5.7e-05 | -3.6 | 6.5 | 1.0e-10 | -0.34 | 0.56 | 0.12 | FALSE |
| 7 | GTEx | Thyroid | MMP15 | 0.11 | 0.05 | lasso | 5 | 0.06 | 1.5e-05 | -14.6 | -15.7 | 8.1e-56 | 0.83 | 0.04 | 0.96 | TRUE |
| 8 | GTEx | Thyroid | ZNF319 | 0.13 | 0.03 | enet | 16 | 0.04 | 3.6e-04 | -9.8 | 10.9 | 8.6e-28 | -0.74 | 0.04 | 0.93 | FALSE |
| 9 | METSIM | Adipose | CSNK2A2 | 0.13 | 0.10 | bslmm | 522 | 0.10 | 5.1e-15 | -8.0 | -9.6 | 1.0e-21 | 0.52 | 1.00 | 0.00 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | TEPP | 0.08 | 0.04 | bslmm | 484 | 0.04 | 2.1e-05 | -5.9 | 6.9 | 6.2e-12 | -0.58 | 0.39 | 0.56 | FALSE |
| 11 | YFS | Blood | CSNK2A2 | 0.02 | 0.01 | enet | 26 | 0.01 | 5.3e-05 | -6.8 | -6.0 | 1.9e-09 | 0.35 | 1.00 | 0.00 | FALSE |
| 12 | YFS | Blood | ZNF319 | 0.10 | 0.13 | lasso | 3 | 0.12 | 1.6e-38 | -9.8 | 10.1 | 5.7e-24 | -0.68 | 1.00 | 0.00 | FALSE |
| 13 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TEPP | 0.06 | 0.02 | blup | 55 | 0.06 | 8.3e-06 | -9.9 | 13.2 | 5.3e-40 | -0.65 | 0.12 | 0.71 | TRUE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCDC113 | 0.05 | 0.04 | lasso | 4 | 0.04 | 3.4e-08 | -5.1 | 5.3 | 9.7e-08 | -0.27 | 0.03 | 0.97 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TEPP | 0.03 | 0.01 | enet | 6 | 0.02 | 9.7e-05 | -6.4 | 6.7 | 2.0e-11 | -0.63 | 0.11 | 0.81 | FALSE |
| 16 | The Cancer Genome Atlas | Colon Adenocarcinoma | MMP15 | 0.04 | 0.05 | lasso | 2 | 0.04 | 2.9e-03 | -14.5 | -15.4 | 1.3e-53 | 0.82 | 0.03 | 0.45 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | TEPP | 0.07 | 0.05 | lasso | 5 | 0.05 | 1.8e-06 | -6.4 | 10.5 | 1.0e-25 | -0.79 | 0.03 | 0.97 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TEPP | 0.03 | 0.02 | blup | 55 | 0.02 | 1.0e-03 | -6.4 | 10.8 | 4.0e-27 | -0.73 | 0.02 | 0.73 | FALSE |
| 19 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TEPP | 0.08 | 0.00 | blup | 55 | 0.02 | 5.6e-02 | -9.9 | 8.0 | 1.2e-15 | -0.71 | 0.01 | 0.56 | TRUE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CSNK2A2 | 0.05 | 0.03 | blup | 72 | 0.03 | 3.9e-04 | -8.0 | -9.2 | 5.0e-20 | 0.46 | 0.00 | 0.99 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TEPP | 0.09 | 0.09 | lasso | 4 | 0.08 | 4.8e-09 | -6.4 | 9.7 | 3.6e-22 | -0.73 | 0.92 | 0.08 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZNF319 | 0.03 | 0.04 | blup | 54 | 0.04 | 1.3e-04 | -9.2 | -9.1 | 6.0e-20 | 0.65 | 0.24 | 0.19 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | C16orf57 | 0.13 | 0.14 | enet | 2 | 0.14 | 1.1e-13 | -9.8 | 10.0 | 2.1e-23 | -0.67 | 1.00 | 0.00 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | CSNK2A2 | 0.09 | 0.03 | blup | 72 | 0.03 | 3.4e-04 | -8.0 | -6.7 | 2.6e-11 | 0.45 | 0.01 | 0.98 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | MMP15 | 0.05 | 0.02 | lasso | 3 | 0.02 | 1.6e-03 | -14.9 | -14.8 | 7.2e-50 | 0.74 | 0.13 | 0.08 | FALSE |
| 26 | The Cancer Genome Atlas | Thyroid Carcinoma | TEPP | 0.13 | 0.21 | lasso | 3 | 0.22 | 7.5e-21 | -9.8 | 9.8 | 1.6e-22 | -0.68 | 1.00 | 0.00 | FALSE |
| 27 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF319 | 0.13 | 0.20 | lasso | 2 | 0.20 | 5.7e-19 | -9.8 | 9.8 | 1.2e-22 | -0.67 | 1.00 | 0.00 | FALSE |