[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr16:29,214,126-31,695,263

Best TWAS P=4.8e-13 · Best GWAS P=2.19e-11 conditioned to 0.788

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
40	GTEx	Uterus	C16orf93	0.23	0.00	lasso	5	0.06	2.5e-02	-5.3	7.2	4.8e-13	0.53	0.02	0.60	TRUE
42	METSIM	Adipose	TBX6	0.16	0.02	bslmm	221	0.07	4.6e-11	4.3	-5.4	5.3e-08	-0.56	0.51	0.48	TRUE
48	YFS	Blood	SEPHS2	0.08	0.05	enet	24	0.07	9.6e-22	-4.0	6.5	6.6e-11	0.55	1.00	0.00	FALSE
28	GTEx	Pituitary	C16orf93	0.10	0.00	enet	14	0.00	2.4e-01	-5.1	6.3	2.6e-10	0.23	0.06	0.09	FALSE
21	GTEx	Muscle Skeletal	RP11-347C12.1	0.04	0.02	enet	7	0.04	1.8e-04	6.5	-6.3	3.0e-10	-0.85	0.02	0.98	FALSE
26	GTEx	Ovary	RP11-347C12.1	0.22	0.10	lasso	5	0.13	4.8e-04	-4.8	-6.3	3.3e-10	-0.90	0.01	0.94	FALSE
35	GTEx	Testis	RP11-347C12.1	0.13	0.13	enet	11	0.13	1.5e-06	6.5	-6.3	4.0e-10	-0.86	0.00	0.99	FALSE
49	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TBX6	0.04	0.03	lasso	3	0.02	1.2e-02	6.2	-6.2	4.4e-10	-0.78	0.00	0.80	FALSE
51	The Cancer Genome Atlas	Colon Adenocarcinoma	YPEL3	0.08	0.03	lasso	2	0.02	1.7e-02	6.2	-6.2	4.4e-10	-0.77	0.00	0.88	FALSE
37	GTEx	Thyroid	RP11-347C12.2	0.18	0.14	enet	23	0.16	2.8e-12	-4.7	-6.2	5.1e-10	-0.82	0.04	0.96	FALSE
39	GTEx	Thyroid	RP11-347C12.1	0.18	0.13	enet	26	0.18	6.8e-14	-4.3	-6.2	7.2e-10	-0.81	0.06	0.94	FALSE
13	GTEx	Colon Transverse	RP11-347C12.1	0.15	0.06	enet	11	0.11	9.4e-06	6.5	-6.1	1.1e-09	-0.82	0.00	0.99	FALSE
47	YFS	Blood	PRR14	0.02	0.01	blup	184	0.01	2.0e-05	-5.3	6.1	1.4e-09	0.31	0.67	0.10	FALSE
17	GTEx	Esophagus Muscularis	RP11-347C12.1	0.07	0.05	lasso	4	0.07	2.8e-05	6.5	-6.0	1.6e-09	-0.84	0.01	0.98	FALSE
22	GTEx	Nerve Tibial	MAPK3	0.15	0.02	enet	12	0.09	1.2e-06	6.2	6.0	2.5e-09	0.71	0.02	0.97	FALSE
32	GTEx	Spleen	RP11-347C12.1	0.12	-0.01	lasso	6	0.02	1.3e-01	6.2	-5.9	3.2e-09	-0.79	0.03	0.67	FALSE
12	GTEx	Cells Transformed fibroblasts	RP11-347C12.1	0.14	0.13	lasso	5	0.15	1.7e-11	-4.7	-5.9	3.4e-09	-0.82	0.10	0.90	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	TBX6	0.04	0.01	blup	18	0.04	5.9e-08	6.2	-5.9	3.8e-09	-0.70	0.00	1.00	FALSE
31	GTEx	Skin Sun Exposed Lower leg	RP11-347C12.1	0.15	0.08	lasso	6	0.14	4.9e-12	6.5	-5.9	4.0e-09	-0.86	0.00	1.00	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	RP11-347C12.1	0.18	0.12	lasso	9	0.16	1.8e-20	-4.3	-5.9	4.5e-09	-0.77	0.17	0.83	FALSE
8	GTEx	Artery Tibial	RP11-347C12.1	0.15	0.09	lasso	7	0.12	7.9e-10	-4.3	-5.8	5.2e-09	-0.81	0.08	0.92	FALSE
27	GTEx	Pancreas	RP11-347C12.1	0.16	0.08	lasso	8	0.17	1.5e-07	-4.6	-5.8	6.1e-09	-0.84	0.01	0.99	FALSE
5	GTEx	Artery Aorta	RP11-347C12.1	0.09	0.07	lasso	4	0.08	2.2e-05	-4.8	-5.8	6.9e-09	-0.81	0.06	0.92	FALSE
57	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MAPK3	0.04	0.02	blup	19	0.04	2.0e-03	6.2	5.7	9.7e-09	0.82	0.01	0.51	FALSE
4	GTEx	Artery Aorta	RNF40	0.12	0.02	lasso	4	0.03	1.2e-02	-5.3	-5.7	1.0e-08	-0.23	0.08	0.10	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	RP11-347C12.1	0.29	0.21	enet	13	0.27	4.1e-15	-4.7	-5.7	1.1e-08	-0.79	0.11	0.89	FALSE
25	GTEx	Nerve Tibial	RP11-347C12.1	0.22	0.08	enet	9	0.13	1.0e-09	-4.3	-5.7	1.4e-08	-0.77	0.28	0.72	FALSE
2	GTEx	Adipose Subcutaneous	RP11-347C12.1	0.14	0.08	lasso	11	0.15	4.5e-12	-4.3	-5.7	1.5e-08	-0.79	0.11	0.89	FALSE
9	GTEx	Brain Frontal Cortex BA9	MAPK3	0.24	0.09	enet	29	0.12	3.5e-04	4.3	5.6	1.9e-08	0.74	0.02	0.86	FALSE
62	The Cancer Genome Atlas	Soft Tissue Sarcoma	TBX6	0.06	0.01	blup	18	0.02	1.3e-02	-4.0	-5.6	2.0e-08	-0.67	0.00	0.52	FALSE
10	GTEx	Brain Frontal Cortex BA9	C16orf93	0.25	0.13	enet	16	0.23	8.3e-07	2.9	5.6	2.2e-08	0.17	0.17	0.15	FALSE
34	GTEx	Stomach	RP11-347C12.1	0.10	0.07	enet	14	0.05	1.4e-03	-4.7	-5.6	2.2e-08	-0.72	0.03	0.90	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	C16orf93	0.19	0.26	lasso	10	0.28	5.1e-36	-5.3	5.6	2.4e-08	0.10	0.72	0.28	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TBX6	0.13	0.04	enet	10	0.09	1.9e-10	-4.0	-5.5	3.4e-08	-0.57	0.19	0.80	FALSE
52	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HSD3B7	0.06	0.01	blup	31	0.02	7.4e-04	-4.7	-5.5	3.9e-08	-0.08	0.03	0.82	FALSE
7	GTEx	Artery Tibial	TBX6	0.21	0.13	lasso	4	0.18	3.5e-14	-4.0	-5.5	4.1e-08	-0.69	0.98	0.02	FALSE
11	GTEx	Cells Transformed fibroblasts	RNF40	0.08	0.04	lasso	8	0.04	5.6e-04	-5.2	-5.5	4.2e-08	-0.10	0.45	0.21	FALSE
56	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C16orf93	0.14	0.11	blup	10	0.11	4.5e-07	-5.1	5.5	4.2e-08	0.10	0.00	0.99	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC100271831	0.02	0.03	lasso	1	0.02	4.5e-03	5.5	5.5	4.7e-08	0.72	0.00	0.90	FALSE
20	GTEx	Lung	RP11-347C12.1	0.05	0.04	enet	6	0.05	5.2e-05	4.0	-5.5	4.9e-08	-0.82	0.01	0.98	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	SETD1A	0.02	0.01	blup	232	0.02	4.3e-04	-3.6	-5.5	4.9e-08	-0.13	0.10	0.72	FALSE
53	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LOC595101	0.11	0.02	enet	8	0.05	9.1e-07	6.5	5.4	7.0e-08	0.66	0.00	0.99	FALSE
63	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PRR14	0.08	0.05	blup	10	0.02	5.6e-02	-5.0	5.4	7.4e-08	0.12	0.00	0.45	FALSE
18	GTEx	Heart Left Ventricle	TBX6	0.16	0.14	enet	10	0.12	7.8e-07	5.5	-5.4	7.7e-08	-0.74	0.31	0.64	FALSE
1	CommonMind	Brain Pre-frontal Cortex	LOC595101	0.28	0.33	enet	18	0.36	9.8e-46	-4.3	-5.4	7.8e-08	-0.72	1.00	0.00	FALSE
15	GTEx	Esophagus Muscularis	CDIPT	0.06	0.04	lasso	4	0.05	8.8e-04	5.5	-5.4	7.8e-08	-0.67	0.26	0.18	FALSE
36	GTEx	Thyroid	RNF40	0.07	0.03	lasso	3	0.03	1.5e-03	-5.1	-5.4	8.0e-08	-0.10	0.38	0.18	FALSE
14	GTEx	Esophagus Mucosa	RP11-347C12.1	0.15	0.02	enet	15	0.07	1.1e-05	-4.3	-5.4	8.5e-08	-0.76	0.01	0.98	FALSE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	TBX6	0.09	0.07	enet	8	0.08	1.8e-09	-4.0	-5.4	8.5e-08	-0.64	0.02	0.98	FALSE
29	GTEx	Prostate	YPEL3	0.23	0.06	enet	15	0.05	2.1e-02	-4.0	-5.3	9.6e-08	-0.62	0.12	0.19	FALSE
41	GTEx	Whole Blood	RP11-347C12.1	0.04	0.01	enet	9	0.03	8.8e-04	-4.3	-5.3	1.0e-07	-0.79	0.02	0.92	FALSE
33	GTEx	Stomach	RP11-347C12.2	0.13	0.03	enet	15	0.07	4.5e-04	2.2	-5.3	1.1e-07	-0.68	0.01	0.87	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	C16orf93	0.09	0.09	blup	11	0.09	1.0e-10	-5.1	5.3	1.1e-07	0.10	0.01	0.99	FALSE
24	GTEx	Nerve Tibial	RP11-347C12.2	0.13	0.07	enet	8	0.03	1.7e-03	6.5	-5.3	1.3e-07	-0.85	0.00	0.98	FALSE
38	GTEx	Thyroid	C16orf93	0.17	0.18	lasso	4	0.18	1.6e-13	-5.2	5.3	1.4e-07	0.09	0.70	0.30	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	C16orf93	0.15	0.19	lasso	4	0.19	1.8e-18	-5.1	5.2	1.6e-07	0.08	0.00	0.99	FALSE
3	GTEx	Adipose Visceral Omentum	RP11-347C12.1	0.12	0.08	enet	7	0.09	2.1e-05	-3.5	-5.2	1.7e-07	-0.71	0.14	0.86	FALSE
19	GTEx	Lung	RP11-347C12.2	0.04	0.03	enet	11	0.04	8.8e-04	4.0	-5.2	1.7e-07	-0.82	0.01	0.97	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C16orf93	0.02	0.02	blup	11	0.02	1.5e-03	-5.1	5.2	1.7e-07	0.10	0.00	0.66	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	RP11-347C12.2	0.17	0.15	bslmm	207	0.14	2.2e-17	-4.7	-5.2	2.0e-07	-0.68	0.99	0.01	FALSE
6	GTEx	Artery Coronary	TBX6	0.22	0.00	enet	17	0.02	6.7e-02	3.6	-5.2	2.2e-07	-0.57	0.08	0.16	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	RNF40	0.07	0.11	lasso	5	0.10	7.5e-11	-5.1	-5.1	2.7e-07	-0.08	0.00	0.99	FALSE
16	GTEx	Esophagus Muscularis	RNF40	0.16	0.10	lasso	1	0.08	1.3e-05	-5.1	-5.1	2.8e-07	-0.08	0.45	0.22	FALSE
23	GTEx	Nerve Tibial	RNF40	0.13	0.08	lasso	5	0.09	8.1e-07	-5.3	-5.1	2.9e-07	-0.09	0.66	0.33	FALSE