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Traits
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Lung FEV1/FVC ratio
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chr17:72,829,885-74,267,010
Best TWAS P=1.05e-11 · Best GWAS P=1.09e-09 conditioned to 0.567
72.8M
73M
73.2M
73.4M
73.6M
73.8M
74M
74.2M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Heart Left Ventricle
LLGL2
0.23
0.09
lasso
5
0.11
2.5e-06
6.1
6.8
1.0e-11
0.93
0.00
1.00
TRUE
3
GTEx
Muscle Skeletal
LLGL2
0.22
0.08
lasso
8
0.08
4.3e-08
6.1
6.4
1.6e-10
0.97
0.00
1.00
FALSE
1
GTEx
Esophagus Muscularis
LLGL2
0.23
0.17
lasso
4
0.17
2.0e-10
6.1
6.3
2.4e-10
0.97
0.00
1.00
FALSE
4
GTEx
Thyroid
LLGL2
0.08
0.04
lasso
3
0.04
4.7e-04
5.8
5.2
1.9e-07
0.85
0.01
0.89
FALSE