[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr17:65,123,352-66,885,526

Best TWAS P=1.4e-17 · Best GWAS P=9.8e-16 conditioned to 0.61

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	LINC00674	0.12	0.13	enet	6	0.14	9.9e-12	8.0	8.5	1.4e-17	0.92	0.01	0.99	TRUE
25	YFS	Blood	KPNA2	0.01	0.01	blup	312	0.01	2.8e-04	6.6	-8.4	5.4e-17	-0.79	0.05	0.93	FALSE
10	GTEx	Cells Transformed fibroblasts	SH3GL1P3	0.26	0.31	lasso	7	0.31	1.5e-23	8.0	8.2	2.3e-16	0.98	0.01	0.99	FALSE
21	GTEx	Spleen	C17orf58	0.30	-0.01	lasso	8	-0.01	4.6e-01	6.1	8.1	5.5e-16	0.68	0.03	0.32	FALSE
9	GTEx	Cells Transformed fibroblasts	LRRC37A16P	0.50	0.46	lasso	8	0.47	1.1e-38	8.0	7.9	2.1e-15	0.99	0.01	0.99	FALSE
19	GTEx	Nerve Tibial	LRRC37A16P	0.09	0.08	lasso	4	0.06	2.7e-05	8.0	7.9	2.6e-15	1.00	0.01	0.97	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	C17orf58	0.02	0.02	lasso	2	0.01	1.8e-02	7.8	7.8	4.3e-15	0.82	0.00	0.76	FALSE
8	GTEx	Cells Transformed fibroblasts	LINC00674	0.30	0.31	enet	10	0.32	1.5e-24	8.0	7.7	1.9e-14	0.97	0.01	0.99	FALSE
7	GTEx	Brain Cortex	C17orf58	0.34	0.09	lasso	6	0.13	2.4e-04	7.9	7.5	5.6e-14	0.88	0.03	0.95	FALSE
11	GTEx	Colon Sigmoid	LINC00674	0.42	0.09	lasso	8	0.12	5.5e-05	6.6	7.2	4.5e-13	0.82	0.03	0.93	FALSE
15	GTEx	Heart Atrial Appendage	LINC00674	0.14	0.08	lasso	17	0.09	1.1e-04	5.2	7.0	2.8e-12	0.63	0.08	0.79	FALSE
16	GTEx	Lung	LINC00674	0.14	0.03	enet	22	0.08	2.1e-06	7.5	6.9	4.7e-12	0.76	0.06	0.94	FALSE
3	GTEx	Adipose Subcutaneous	SH3GL1P3	0.08	0.06	lasso	5	0.04	2.5e-04	8.0	6.8	1.2e-11	0.95	0.02	0.97	FALSE
14	GTEx	Esophagus Muscularis	LINC00674	0.11	0.04	lasso	6	0.07	7.9e-05	5.2	6.7	1.7e-11	0.74	0.11	0.88	FALSE
5	GTEx	Artery Aorta	LINC00674	0.12	0.00	lasso	5	0.01	1.5e-01	5.2	6.6	3.5e-11	0.57	0.05	0.54	FALSE
6	GTEx	Brain Cerebellum	BPTF	0.22	-0.01	lasso	10	-0.01	6.9e-01	5.5	-6.5	6.3e-11	-0.74	0.04	0.43	FALSE
18	GTEx	Nerve Tibial	LINC00674	0.09	0.01	enet	13	0.03	2.2e-03	5.2	6.1	1.0e-09	0.67	0.06	0.75	FALSE
13	GTEx	Esophagus Mucosa	LRRC37A16P	0.11	0.06	enet	13	0.08	7.5e-06	5.3	-6.0	2.0e-09	-0.63	0.16	0.77	FALSE
22	GTEx	Stomach	RP11-147L13.8	0.23	-0.01	enet	9	0.01	8.1e-02	3.2	5.8	6.4e-09	0.58	0.03	0.34	FALSE
4	GTEx	Adipose Visceral Omentum	LINC00674	0.29	0.03	enet	40	0.03	6.9e-03	6.6	5.8	6.9e-09	0.69	0.07	0.55	FALSE
23	GTEx	Thyroid	SH3GL1P3	0.08	0.00	lasso	3	0.00	2.8e-01	5.2	5.8	7.1e-09	0.48	0.06	0.38	FALSE
17	GTEx	Muscle Skeletal	LRRC37A16P	0.14	0.04	lasso	5	0.08	3.3e-08	5.2	-5.8	7.6e-09	-0.50	0.99	0.00	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LOC651250	0.02	0.02	blup	2	0.03	1.9e-03	5.1	-5.7	1.1e-08	-0.57	0.00	0.34	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC651250	0.03	0.02	enet	2	0.02	2.0e-03	5.1	-5.7	1.2e-08	-0.61	0.00	0.49	FALSE
2	GTEx	Adipose Subcutaneous	LRRC37A16P	0.10	0.10	enet	10	0.14	2.9e-11	8.0	5.5	3.5e-08	0.81	0.01	0.99	FALSE
20	GTEx	Skin Sun Exposed Lower leg	BPTF	0.10	0.01	enet	14	0.03	2.7e-03	6.7	-5.5	3.7e-08	-0.71	0.03	0.87	FALSE
12	GTEx	Colon Sigmoid	RP11-147L13.8	0.12	0.20	lasso	3	0.15	4.4e-06	5.2	5.5	4.0e-08	0.45	0.35	0.46	FALSE
24	GTEx	Thyroid	RP11-147L13.8	0.23	0.17	lasso	3	0.16	3.5e-12	5.2	5.3	1.2e-07	0.43	1.00	0.00	FALSE