Best TWAS P=5.08e-17 · Best GWAS P=3.27e-15 conditioned to 2.65e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CABLES2 | 0.17 | 0.11 | enet | 11 | 0.14 | 2.3e-11 | -3.07 | 5.2 | 2.6e-07 | -0.27 | 0.95 | 0.05 | FALSE |
| 2 | GTEx | Artery Aorta | CABLES2 | 0.26 | 0.09 | enet | 28 | 0.16 | 3.6e-09 | -2.88 | 5.7 | 9.0e-09 | -0.20 | 0.99 | 0.00 | FALSE |
| 3 | GTEx | Artery Tibial | MTG2 | 0.37 | 0.12 | enet | 45 | 0.12 | 1.9e-09 | -4.37 | 5.2 | 1.9e-07 | -0.20 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | RP11-157P1.5 | 0.15 | 0.12 | enet | 15 | 0.10 | 7.3e-08 | 3.37 | -5.4 | 7.8e-08 | 0.17 | 0.99 | 0.00 | TRUE |
| 5 | GTEx | Colon Sigmoid | CABLES2 | 0.29 | 0.08 | lasso | 11 | 0.08 | 6.3e-04 | -5.93 | 5.2 | 2.2e-07 | -0.19 | 0.46 | 0.06 | FALSE |
| 6 | GTEx | Heart Left Ventricle | CABLES2 | 0.19 | 0.20 | lasso | 5 | 0.18 | 3.8e-10 | -5.93 | 5.8 | 7.3e-09 | -0.28 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Nerve Tibial | CABLES2 | 0.30 | 0.15 | enet | 52 | 0.22 | 2.4e-15 | -5.93 | 5.4 | 6.2e-08 | -0.23 | 0.99 | 0.01 | FALSE |
| 8 | GTEx | Prostate | CABLES2 | 0.31 | 0.10 | lasso | 8 | 0.14 | 2.1e-04 | -5.93 | 6.2 | 5.8e-10 | -0.22 | 0.12 | 0.06 | FALSE |
| 9 | GTEx | Thyroid | CABLES2 | 0.38 | 0.08 | enet | 34 | 0.19 | 3.0e-14 | 4.16 | 5.6 | 2.5e-08 | -0.28 | 1.00 | 0.00 | FALSE |
| 10 | METSIM | Adipose | CABLES2 | 0.16 | 0.14 | lasso | 8 | 0.15 | 8.6e-22 | -5.93 | 6.5 | 1.0e-10 | -0.28 | 0.97 | 0.03 | FALSE |
| 11 | YFS | Blood | CABLES2 | 0.03 | 0.03 | lasso | 6 | 0.02 | 2.0e-08 | 6.74 | 6.0 | 1.9e-09 | -0.36 | 0.26 | 0.74 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CABLES2 | 0.06 | 0.00 | blup | 79 | 0.02 | 3.7e-03 | -0.71 | 6.8 | 1.2e-11 | -0.21 | 0.03 | 0.13 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CABLES2 | 0.12 | 0.03 | enet | 19 | 0.07 | 2.3e-08 | 4.16 | 8.3 | 1.1e-16 | -0.24 | 0.83 | 0.12 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GATA5 | 0.04 | 0.01 | blup | 33 | 0.02 | 3.1e-03 | -0.52 | 5.6 | 2.4e-08 | -0.48 | 0.03 | 0.17 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CABLES2 | 0.09 | 0.04 | enet | 10 | 0.07 | 4.5e-08 | -5.93 | 7.3 | 2.3e-13 | -0.41 | 0.81 | 0.18 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | CABLES2 | 0.10 | 0.07 | enet | 16 | 0.08 | 2.8e-09 | 4.16 | 8.4 | 5.1e-17 | -0.25 | 0.99 | 0.01 | TRUE |