Hub : Genes

MTG2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.122	0.0470	8.2e-03	0.023	NA	-0.003	NA	0.006	4.9e-03	NA	7.9e-01	NA	9.1e-02
2	GTEx	Artery Aorta	0.238	0.0720	1.2e-03	0.024	NA	0.062	NA	0.057	1.8e-02	NA	2.7e-04	NA	4.4e-04
3	GTEx	Artery Tibial	0.369	0.0606	5.7e-09	0.120	NA	0.117	NA	0.113	1.2e-09	NA	1.9e-09	NA	3.6e-09
4	GTEx	Brain Cerebellar Hemisphere	0.394	0.1160	2.1e-03	0.172	NA	0.237	NA	0.211	3.6e-05	NA	8.9e-07	NA	4.0e-06
5	GTEx	Esophagus Muscularis	0.183	0.0640	3.3e-03	0.219	NA	0.195	NA	0.214	2.1e-13	NA	5.4e-12	NA	3.8e-13
6	GTEx	Heart Atrial Appendage	0.284	0.0920	4.7e-03	-0.006	NA	0.034	NA	-0.005	8.8e-01	NA	1.1e-02	NA	6.3e-01
7	GTEx	Muscle Skeletal	0.269	0.0441	5.7e-10	0.170	NA	0.202	NA	0.193	2.0e-16	NA	1.6e-19	NA	1.2e-18
8	GTEx	Nerve Tibial	0.216	0.0506	6.6e-06	0.213	NA	0.172	NA	0.203	4.8e-15	NA	3.1e-12	NA	2.3e-14
9	GTEx	Skin Sun Exposed Lower leg	0.204	0.0510	3.5e-05	0.167	NA	0.150	NA	0.163	8.4e-14	NA	2.0e-12	NA	1.7e-13
10	GTEx	Thyroid	0.322	0.0590	8.9e-09	0.124	NA	0.197	NA	0.176	9.5e-10	NA	4.8e-15	NA	2.0e-13
11	METSIM	Adipose	0.174	0.0329	2.5e-11	0.119	0.098	0.128	0.132	0.141	2.0e-17	1.9e-14	1.1e-18	3.2e-19	2.0e-20

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.3	0.5	2.1	-0.9	0.3	-0.4	-0.5	1.5	-0.4	0.6	0.0	-0.8	-0.9	0.6
Bipolar Disorder or Schizophrenia	0.5	1.2	4.2	-1.3	1.2	-1.3	-0.2	2.1	-0.6	1.3	0.0	-1.1	-0.5	0.5
Depressed Affect (Nagel 2018)	0.8	1.6	3.5	1.3	1.9	0.6	0.5	0.9	1.0	-1.1	1.4	1.3	1.7	-1.5
Depression (Nagel 2018)	0.1	0.1	0.4	0.4	-0.2	0.6	-0.3	-0.0	0.4	-0.1	0.5	0.5	-0.1	0.0
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.9	0.3	-0.4	-1.0	0.4	-0.9	-0.6	0.1	0.2	0.1	-0.3	0.3
Neuroticism (Nagel 2018)	1.0	2.4	6.4	0.7	2.0	-0.4	0.8	1.7	1.6	-1.5	0.9	0.9	2.5	-2.4
Schizophrenia (2018)	0.4	0.8	2.4	-0.9	1.1	-1.5	-0.2	1.5	-0.6	1.2	0.0	-0.8	0.0	0.2
Schizophrenia vs Biploar Disorder	0.4	0.6	2.4	-0.3	0.0	-1.6	-0.6	0.0	0.9	0.0	0.0	-0.2	1.5	-0.6
Worry (Nagel 2018)	0.9	1.9	7.3	0.1	1.3	-1.2	1.1	1.6	1.0	-1.4	0.4	0.4	1.8	-2.7
Alzheimer’s Disease (in mother)	1.0	1.2	6.6	0.6	-1.5	0.2	-0.8	-2.6	-0.5	-0.1	0.7	0.9	-1.2	0.4
Alzheimer’s Disease (in father)	0.6	0.7	3.2	-0.3	0.3	-0.7	0.2	0.5	1.5	0.3	-0.5	-0.6	1.8	-0.4
Alzheimer’s Disease (including proxy)	0.6	0.9	2.0	1.3	-0.7	0.2	0.2	-1.3	0.2	-0.7	1.3	1.4	1.1	-0.7
Crohns Disease (2017)	1.1	2.3	4.8	-1.7	-2.2	-1.7	-0.1	-2.1	-1.2	1.1	-1.6	-1.6	-1.5	0.7
Irritable Bowel Disease (IBD)	1.2	2.8	6.5	-1.8	-2.5	-1.6	-0.7	-2.5	-1.1	0.9	-1.8	-1.6	-2.0	0.6
Ulcerative Colitis (UC)	0.4	0.7	1.8	-0.7	-1.1	-1.0	-0.6	-1.2	-0.2	0.1	-0.8	-0.5	-1.4	0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.9	1.7	4.2	0.7	1.7	-1.3	0.2	1.7	-1.2	-1.5	0.9	0.8	1.3	-2.0
Verbal and Numeric Reasoning (VNR)	0.1	0.2	1.0	-0.1	0.1	-0.3	0.1	-1.0	-0.1	-0.0	-0.1	-0.3	-0.9	0.3
Breast Cancer	0.8	1.8	9.1	0.3	1.0	1.6	-0.3	3.0	0.1	-0.6	0.3	0.2	2.3	-1.4
Ovarian Cancer	0.7	0.9	3.7	0.3	1.9	1.6	-0.6	1.3	0.9	-0.3	0.4	0.3	-0.1	0.5
Prostate Cancer	0.5	0.7	2.9	-0.8	-0.1	0.2	-0.2	-0.8	0.7	1.3	-0.7	-0.6	-1.7	0.8
Age at First Birth	0.4	0.6	2.9	-0.8	-0.2	0.4	-0.5	-0.7	-0.2	0.2	-0.8	-1.0	-1.7	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	1.8	0.4	-0.9	-0.2	1.3	-0.7	-1.0	-0.7	0.4	0.4	0.8	-1.1
Coronary Artery Disease (CAD)	0.3	0.4	2.3	0.5	-0.1	1.5	0.7	0.0	0.4	0.1	0.6	0.6	0.4	0.5
Crohns Disease (2012)	1.2	2.0	5.7	-2.4	-1.5	-2.0	-1.1	0.0	-1.1	1.1	0.0	-2.2	-1.0	0.1
Mean Putamen Volume	0.3	0.4	1.4	-0.3	-0.4	-1.0	-0.0	-0.8	0.1	1.2	-0.3	-0.2	-0.7	0.7
Fasting Glucose	0.7	0.9	2.7	-0.6	0.9	-0.8	-1.1	0.9	0.9	1.6	-0.7	-0.8	-0.1	1.2
HbA1C	1.3	1.4	5.4	1.1	-1.2	-0.5	2.3	-1.1	-0.4	-0.9	1.0	1.2	-0.0	-1.6
HDL Cholesterol	1.1	1.8	5.1	1.6	-0.4	-0.1	0.9	-0.5	-1.6	-2.3	1.6	1.6	0.5	-1.8
LDL Cholesterol	0.1	0.2	1.1	0.6	-0.2	0.4	-0.0	-1.1	0.0	-0.1	0.4	0.5	-0.6	0.1
Lupus	0.4	0.7	2.3	-0.6	-1.5	-0.5	-0.4	0.2	-0.4	1.4	-0.8	-0.8	0.3	0.9
Neuroticism (2016)	0.5	0.7	1.9	1.0	0.2	0.5	1.3	-0.5	-0.6	-0.8	1.3	1.4	0.4	-0.6
Primary Biliary Cirrhosis	2.5	3.6	10.8	-1.8	-2.4	-3.3	-0.8	-1.4	-2.4	0.8	-1.9	-1.7	-2.0	0.1
Rheumatoid Arthritis	0.3	0.4	0.9	-0.9	-0.8	-0.6	-0.4	-0.7	-0.4	0.1	-0.8	-1.0	-0.4	0.4
Schizophrenia (2014)	0.5	1.2	4.6	-1.0	1.4	-2.1	-0.1	1.7	-0.1	1.1	0.0	-1.0	0.5	-0.0
Triglycerides	1.0	1.7	5.7	-1.1	-0.3	-0.3	-0.9	-0.8	1.2	2.2	-1.0	-1.0	-1.0	2.4
Type 2 Diabetes (T2D) (2012)	0.6	0.6	2.4	-1.2	-0.6	-1.5	-0.2	0.5	-0.3	0.8	0.0	-1.3	0.4	-0.2
Ulcerative Colitis	0.2	0.3	1.0	-0.1	-0.9	-0.5	-0.4	-0.8	-0.2	-0.8	0.0	-0.0	0.2	-1.0
Blood Eosinophil Count	0.1	1.0	2.2	1.5	0.4	0.9	1.2	-0.0	0.2	-1.0	1.5	1.5	1.2	-0.2
Blood Platelet Count	0.1	1.5	5.1	1.1	-2.2	1.0	0.4	-1.1	-2.0	-0.9	0.8	0.8	-1.5	-0.0
Blood Red Count	0.2	1.5	3.8	-1.3	0.4	-1.9	-1.8	-1.3	0.9	1.1	-1.0	-1.2	-0.4	1.1
Blood White Count	0.2	1.2	4.3	1.0	-1.5	2.1	0.8	-1.1	0.3	-0.8	1.0	1.2	-0.2	-0.5
Heel T-Score	0.1	0.8	2.5	0.9	1.6	1.1	-0.1	1.4	0.3	0.1	0.7	0.8	0.9	0.2
BMI	0.8	4.9	10.6	3.1	1.5	3.3	2.0	0.9	-1.6	-2.3	2.9	2.9	1.3	-0.8
Height	0.3	5.7	35.3	-2.8	0.1	-5.9	-0.8	0.1	-1.0	0.5	-2.7	-2.9	0.8	-1.2
Waist Hip Ratio (WHR)	0.3	1.4	3.6	-1.7	0.3	-1.2	-1.1	-0.6	0.7	0.8	-1.7	-1.9	-1.2	1.0
Systolic Blood Pressure	0.5	2.3	6.5	2.5	1.9	1.3	2.1	0.6	0.3	-0.7	2.0	1.8	0.4	0.2
Smoking Status	0.7	1.7	5.5	-1.5	-1.2	-0.8	-0.9	-0.7	-1.7	0.0	-1.6	-1.4	-2.3	0.2
Allergy or Eczema	0.3	0.7	1.9	0.9	0.3	-1.1	0.1	-1.3	-1.4	-0.5	0.7	0.7	-0.5	0.4
Cardiovascular Disease	0.4	1.5	2.8	1.7	1.7	1.5	0.7	0.9	-1.7	-0.8	1.3	1.2	0.3	0.1
Hypothyroidism (self reported)	0.3	0.8	2.7	-0.7	0.7	-0.1	-1.6	1.3	0.9	0.6	-0.8	-0.8	-0.5	0.5
Respiratory disease	0.4	1.0	2.0	1.0	-0.1	-0.2	1.1	-0.8	-1.1	-1.2	0.8	0.9	1.4	-1.3
Type 2 Diabetes (T2D) (2018)	0.4	0.8	3.0	0.5	-1.7	0.6	-0.1	-1.7	-1.2	0.2	0.3	0.2	-0.2	0.9
Lung FEV1/FVC ratio	1.8	9.4	27.1	3.3	3.5	5.2	-0.6	3.3	3.3	-2.7	3.2	3.2	0.8	-1.5
Lung FVC	0.5	2.5	9.5	-1.8	-0.8	-2.6	-3.1	-0.5	-0.5	0.9	-1.6	-1.5	-0.8	1.0
Neuroticism	0.6	1.5	5.6	0.4	0.7	-1.0	1.7	0.8	0.4	-1.6	0.8	0.8	1.5	-2.4
Chronotype (morning person)	1.4	3.3	6.4	1.6	-2.0	2.5	2.2	0.8	-0.4	-1.8	1.8	1.9	2.0	-1.8
Hair Pigment	0.1	2.0	5.2	-0.7	-1.7	-1.9	1.1	-2.3	-1.8	0.4	-1.0	-1.0	-1.8	0.1
Tanning	0.0	0.5	1.2	-0.6	-1.0	-1.1	-0.1	-0.9	-0.9	0.5	-0.6	-0.6	-0.3	0.4
Hand grip strength (left)	0.2	0.5	2.4	0.1	0.5	-1.6	0.5	0.7	-0.2	-0.3	0.1	0.2	1.1	-0.8
Number of treatments/medications taken	0.3	0.5	1.2	-0.9	-0.8	-0.3	0.6	-0.6	-0.2	0.7	-1.1	-1.1	-0.2	0.6
Average weekly spirits intake	0.3	0.4	1.4	-0.6	-1.2	0.0	-0.9	0.4	0.3	0.8	-0.8	-0.7	-0.0	0.5
Sensitivity / hurt feelings	0.2	0.4	0.8	-0.8	-0.6	-0.1	-0.5	0.9	0.8	0.6	-0.5	-0.6	0.9	-0.2
Frequency of depressed mood in last 2 weeks	0.9	1.2	6.8	-1.3	-2.6	-0.2	-0.6	-1.0	0.1	0.8	-1.1	-1.2	-0.2	0.6
Hearing difficulty/problems: Yes	0.4	0.6	3.8	-0.3	2.0	0.6	-1.2	0.7	0.5	0.1	-0.3	-0.3	-0.4	0.4
Relative age of first facial hair	0.2	0.5	1.4	-0.7	-1.1	-0.6	-0.2	-1.2	-0.4	-0.0	-0.7	-0.9	0.6	-0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.1	-0.7	-0.0	-0.3	-0.8	-0.7	-0.3	1.0	-0.9	-0.9	-1.3	1.5
Ever used hormone-replacement therapy (HRT)	0.2	0.3	2.2	0.3	-0.7	-0.6	0.2	-1.5	-0.1	0.0	-0.0	0.1	0.1	-0.0
Ever had hysterectomy (womb removed)	0.8	0.9	1.7	1.3	0.1	-0.2	0.8	-0.9	-1.1	-1.3	1.2	1.1	0.4	-0.6
Systolic blood pressure, automated reading	0.2	0.6	1.6	1.2	1.3	-0.1	1.2	0.2	0.0	0.5	0.7	0.6	-0.6	0.8
Eye problems/disorders: Diabetes related eye disease	2.7	3.0	11.8	-1.2	-0.6	-0.5	-1.0	-0.8	0.9	3.0	-1.4	-1.4	-2.0	3.4
Angina	0.6	0.8	2.6	0.9	-0.4	0.1	1.3	0.1	-1.6	-0.5	0.9	1.0	1.2	-0.5
Medication for hormone replacement therapy	0.3	0.3	1.1	1.1	0.6	0.7	-0.1	-0.2	0.2	0.1	0.8	0.9	-0.2	0.1
Vitamin and mineral supplements	0.9	1.3	6.8	0.9	2.6	1.4	-0.7	1.2	0.9	0.1	1.0	0.8	0.1	0.2
Supplements: Zinc	0.4	0.5	2.4	0.1	-0.1	1.5	0.2	1.1	0.6	0.3	-0.0	-0.0	0.8	0.7
Medication: Co-codamol	0.8	0.9	4.0	0.4	2.0	1.0	-0.6	0.6	1.4	0.3	0.2	0.2	-0.9	0.9
Medication: Metformin	0.7	1.0	4.0	0.2	-1.6	0.0	-0.4	-2.0	-0.8	1.1	-0.0	-0.0	-0.8	1.4
Diabetes (father)	0.5	0.7	1.5	1.1	0.8	-0.4	0.6	-0.4	0.7	-1.2	0.9	1.1	0.7	-0.8
Diabetes (mother)	0.6	0.7	1.5	1.0	0.6	1.1	0.3	0.1	-0.6	-1.2	1.1	1.1	0.9	-0.6
Severe depression (siblings)	2.9	3.2	7.4	2.7	1.5	1.8	2.0	0.5	-0.5	-1.4	2.7	2.7	0.8	-1.2
Pack years adult smoking proportion	0.5	0.7	1.6	1.0	0.5	1.3	-0.1	0.1	-0.8	-1.1	1.1	1.2	0.1	-0.8
Impedance of leg (right)	0.6	3.1	5.5	-2.3	-1.1	-1.8	-2.0	-0.9	0.6	2.3	-2.2	-2.2	-1.3	1.7
Leg fat-free mass (left)	0.2	1.2	2.6	1.2	1.6	0.8	0.3	1.4	-0.9	-1.4	1.1	1.2	0.8	-0.6
Trunk fat percentage	0.1	0.5	2.7	0.2	-0.2	0.2	-0.4	-0.6	-1.6	0.5	0.0	-0.0	-1.0	1.2
Hand grip strength (right)	0.4	1.0	5.0	-1.1	-0.3	-2.2	-0.4	-0.1	0.1	1.0	-1.1	-1.1	0.6	0.3
Townsend deprivation index at recruitment	0.9	1.3	4.0	-0.9	-0.8	-0.2	-1.2	-1.3	0.0	1.6	-1.0	-1.0	-1.0	2.0
Current tobacco smoking	0.1	0.2	0.8	-0.5	-0.2	-0.1	-0.0	0.9	-0.1	-0.4	-0.6	-0.4	0.0	-0.2
Average weekly fortified wine intake	0.5	0.5	3.0	-0.4	-0.8	0.1	-0.7	-0.7	-1.7	-0.1	-0.4	-0.4	-0.7	-0.6
Maternal smoking around birth	0.4	0.6	2.9	-0.3	-0.7	-0.5	-1.7	-0.7	-0.3	0.8	-0.4	-0.4	-1.1	0.5
Fed-up feelings	0.2	0.3	1.2	0.4	0.6	0.7	-0.2	0.2	1.1	0.5	0.3	0.4	0.4	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	0.0	0.2	0.4	-0.8	-0.1	0.6	0.7	0.1	0.1	-0.0	0.8
Relative age voice broke	0.3	0.5	1.4	-0.3	-0.1	-1.0	0.9	-0.5	-1.0	-0.6	-0.1	-0.2	-0.4	-1.2
Taking other prescription medications	1.9	3.0	5.7	-1.9	-2.3	-2.4	0.7	-2.0	-1.5	0.8	-2.2	-2.1	-1.2	0.4
Age when periods started (menarche)	1.5	3.6	8.4	-2.9	-1.1	-1.6	-0.8	-0.5	0.7	2.3	-2.8	-2.9	-1.3	1.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	0.8	0.4	0.0	-0.2	-0.5	-0.6	-0.7	0.5	0.4	0.1	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.6	-0.6	-0.7	0.7	-1.6	0.2	0.3	1.5	-0.7	-0.6	-0.0	1.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	2.8	0.6	0.7	0.6	0.6	1.3	-1.7	-1.2	0.5	0.6	0.7	-0.5
Qualifications: CSEs or equivalent	0.3	0.4	1.3	0.2	0.7	1.1	-1.0	0.9	-0.1	0.5	0.1	0.1	-0.5	0.6
Serious illness, injury or assault to yourself	1.0	1.3	2.6	-0.9	-1.3	-0.9	-1.4	-1.1	-1.6	0.7	-1.0	-1.0	-1.0	1.1
High blood pressure	0.4	1.0	4.2	1.2	0.7	0.9	2.0	0.2	-1.3	-0.6	1.0	0.9	0.5	-0.0
Hayfever, allergic rhinitis or eczema	0.2	0.5	2.1	0.6	-0.0	-1.2	0.1	-0.8	-1.5	-0.3	0.5	0.4	-0.0	0.1
Multivitamins +/- minerals	1.7	2.2	8.7	-1.1	-2.9	-1.2	0.4	-2.4	-1.2	0.9	-1.2	-1.0	-1.3	0.8
Stomach or abdominal pain in last month	0.9	1.1	3.2	-0.4	-1.8	-1.4	1.4	0.0	-1.1	-1.0	-0.3	-0.4	0.5	-1.6
Supplements: Glucosamine	0.5	0.7	2.2	-0.3	-0.3	0.2	-0.9	-0.6	1.5	1.3	-0.2	-0.3	-0.4	1.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	3.3	-0.5	-0.0	-0.3	-0.5	-0.3	1.8	1.3	-0.4	-0.6	-0.5	1.2
Medication: Atenolol	0.2	0.2	1.0	0.1	0.3	-1.0	0.8	0.4	-0.8	-0.2	0.0	-0.1	0.3	0.0
Medication: Levothyroxine sodium	0.4	0.6	1.1	-0.7	0.6	0.1	-0.3	0.5	0.6	1.0	-1.0	-1.0	-1.0	1.0
Sitting height	0.2	1.4	4.8	0.5	2.2	-0.5	-0.3	1.8	0.4	-1.1	0.5	0.5	2.0	-1.2
Chronic bronchitis/emphysema (father)	0.9	1.1	3.3	0.5	-1.0	0.1	1.8	0.1	-1.0	-1.6	0.5	0.5	-0.1	-1.7
High blood pressure (mother)	0.4	0.5	1.8	-0.2	0.0	-0.8	-1.3	0.4	-0.1	1.2	-0.2	-0.4	-0.3	1.2
Body mass index (BMI)	0.8	3.4	7.5	2.7	1.1	2.5	1.5	0.4	-1.6	-2.0	2.5	2.6	0.6	-0.6
Impedance of leg (left)	0.6	3.0	4.7	-2.2	-1.4	-2.2	-2.0	-1.2	0.4	2.2	-2.0	-2.0	-1.2	1.4
Leg predicted mass (left)	0.2	1.2	2.5	1.2	1.6	0.7	0.3	1.4	-1.0	-1.4	1.1	1.1	0.8	-0.6
Trunk fat mass	0.1	0.3	2.0	0.5	0.4	0.5	-0.3	-0.0	-1.4	0.1	0.3	0.3	-0.5	0.8
Waist circumference	0.3	0.9	2.3	1.3	1.4	1.5	0.4	0.0	-1.0	-0.8	1.1	1.0	-0.4	0.4
Number of incorrect matches in round	0.2	0.4	3.1	-0.5	-0.2	-1.8	-0.2	-0.0	0.6	0.4	-0.5	-0.5	0.0	0.4
Past tobacco smoking	2.2	4.0	7.9	2.6	2.1	2.6	0.2	1.7	1.2	-0.2	2.8	2.7	2.5	0.4
Alcohol usually taken with meals	0.7	1.1	7.1	0.5	0.2	1.6	-0.0	-0.8	-0.7	-0.4	0.6	0.6	-2.7	0.7
Nervous feelings	0.9	1.6	5.9	-0.8	1.6	-0.4	0.4	2.4	1.5	-0.3	-0.5	-0.6	1.5	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.6	1.1	-0.5	0.4	0.3	1.1	-0.4	-1.6	1.3	1.2	1.5	-1.6
Hearing difficulty/problems with background noise	0.8	1.2	4.5	-0.6	2.1	-0.9	-1.9	0.8	1.1	0.8	-0.6	-0.7	0.8	0.5
Hair/balding pattern: Pattern 2	1.2	1.6	8.5	-0.4	-0.3	0.7	-2.9	-0.0	-0.7	1.0	-0.4	-0.4	-1.4	2.0
Had menopause	0.7	0.9	2.3	-0.7	0.9	-1.5	-1.0	-0.9	0.5	0.7	-0.8	-0.9	-1.4	0.7
Had other major operations	1.2	1.4	3.1	1.1	0.5	1.1	1.0	1.2	0.5	-1.8	1.1	1.1	1.3	-1.7
Forced vital capacity (FVC)	0.6	2.1	9.2	-1.4	1.0	-1.2	-3.0	0.0	1.4	1.7	-1.2	-1.2	-0.0	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.6	-0.1	-0.4	0.5	-0.2	0.7	1.3	1.1	-0.1	-0.0	0.8	0.5
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.0	0.8	0.6	0.8	-0.8	0.9	-0.4	-1.0	0.9	0.8	0.9	-0.7
Qualifications: None of the above	0.5	1.1	2.4	1.3	1.1	-0.5	1.5	0.2	-0.8	-1.2	1.2	1.2	0.8	-1.0
Financial difficulties in last 2 years	1.0	1.3	3.2	-0.9	-1.2	0.6	-1.6	-0.6	1.2	1.7	-0.9	-0.8	-0.3	1.8
Mouth/teeth dental problems	0.9	1.3	3.8	-0.8	1.7	0.8	-1.3	0.4	1.9	1.1	-0.5	-0.7	-1.2	1.2
Heart attack	0.7	0.8	2.2	1.1	-0.3	1.5	0.9	-0.4	-1.2	-0.9	1.1	1.1	-0.4	0.2
Allergy	0.2	0.5	4.2	-0.3	0.1	1.2	-0.0	0.4	2.1	-0.2	-0.0	0.0	0.0	-0.2
Pain all over the body in last month	0.5	0.5	1.8	0.4	0.8	0.8	-1.3	1.1	0.1	-0.5	0.3	0.3	0.9	0.1
Diabetes (self-reported)	0.4	0.6	2.4	0.5	-1.2	0.2	0.0	-1.6	-0.4	0.7	0.2	0.2	-0.4	1.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.3	-0.2	-0.8	-0.2	0.3	0.0	-1.1	0.8	-0.2	-0.2	-0.0	0.5
Medication: Ramipril	0.3	0.4	1.2	-0.4	0.3	-1.1	0.8	0.9	0.3	0.4	-0.7	-0.6	-0.4	-0.0
Medication: Simvastatin	0.2	0.2	1.1	0.1	0.4	0.3	-0.3	-0.9	-0.4	0.1	0.0	0.0	-1.0	0.3
Fluid intelligence score	0.6	1.2	2.4	1.3	1.4	1.2	0.7	0.0	0.3	-1.5	1.5	1.4	0.6	-0.8
Illnesses of siblings	0.7	1.0	2.5	0.7	0.1	1.5	0.9	-0.0	0.9	-1.6	1.0	0.9	0.9	-1.1
Neuroticism score	0.2	0.4	1.0	-0.5	0.7	-0.8	0.3	0.8	0.8	-0.1	-0.2	-0.2	1.0	-0.9
Weight	0.2	1.2	2.2	1.5	1.4	1.1	0.4	0.7	-1.4	-1.2	1.3	1.3	0.4	-0.2
Impedance of arm (right)	1.4	6.7	11.2	-3.3	-2.4	-3.2	-1.9	-1.6	-1.0	3.1	-3.3	-3.3	-2.1	1.9
Arm fat percentage (right)	0.3	1.3	3.0	1.7	0.5	1.4	1.0	0.1	-1.6	-0.7	1.5	1.5	-0.0	0.2
Trunk fat-free mass	0.3	2.0	5.3	1.3	2.3	0.6	0.5	1.9	-0.0	-1.7	1.3	1.3	1.4	-1.4
Hip circumference	0.3	1.2	2.5	1.5	1.1	1.6	0.5	0.1	-1.5	-0.8	1.3	1.3	-0.1	0.3
Time employed in main current job	0.9	1.1	3.0	-1.3	-0.3	-1.7	-0.6	-1.2	0.6	0.9	-1.0	-1.2	-1.2	0.4
Alcohol intake versus 10 years previously	0.8	1.2	4.4	-0.8	-0.7	-2.1	0.3	-0.9	-1.6	0.8	-1.1	-0.9	-1.2	0.6
Father’s age at death	0.1	0.2	0.7	-0.2	-0.4	0.1	0.8	0.6	0.3	0.2	-0.2	-0.1	0.3	-0.8
Worrier / anxious feelings	0.4	0.7	2.3	0.4	1.3	-1.4	0.4	0.2	-0.1	-0.9	0.6	0.5	0.7	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.6	-0.3	-0.7	-0.5	-0.9	0.8	-0.6	-0.8	-0.3	-0.2	0.8	-1.3
Falls in the last year	0.2	0.2	0.6	0.4	-0.8	-0.8	-0.2	-0.5	-0.5	0.3	0.3	0.3	0.2	0.2
Hair/balding pattern: Pattern 3	0.5	0.8	1.8	0.8	1.0	1.2	1.4	-0.1	1.1	-0.6	0.8	1.0	0.9	0.2
Number of live births	1.1	1.6	3.6	1.2	0.9	1.4	1.8	0.2	0.9	-1.9	1.3	1.2	1.4	-1.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	10.1	-0.6	1.8	0.2	-3.2	1.3	2.4	0.8	-0.4	-0.3	0.5	1.0
Pulse rate	1.1	1.9	3.8	-1.7	-1.0	1.4	-1.9	0.2	0.8	1.5	-1.4	-1.1	-1.0	1.9
Happiness	3.5	4.2	7.0	-2.6	-0.9	-1.6	-2.2	-1.1	1.0	2.6	-2.4	-2.4	-2.6	1.9
Noisy workplace	1.5	1.8	8.4	-0.8	-1.7	-1.4	-0.9	-1.6	-2.9	0.0	-0.9	-0.9	-1.0	0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.9	0.2	0.2	0.6	-1.0	-0.2	0.1	-0.2	0.3	0.2	0.1	0.5
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	6.2	0.7	0.1	-0.5	0.4	1.9	-0.8	-2.1	0.7	0.9	1.2	-2.5
Mouth/teeth dental problems: Dentures	1.2	2.0	4.1	1.2	-1.4	0.4	2.0	0.2	-1.4	-1.7	1.0	1.0	2.0	-1.8
Asthma	0.6	1.2	2.5	1.5	0.8	1.0	0.9	0.1	-1.0	-1.0	1.2	1.2	1.6	-0.7
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	4.7	1.6	1.5	1.0	1.1	1.6	-1.3	-2.2	1.6	1.6	1.9	-2.1
Medication: Cholesterol lowering	0.5	0.8	1.7	-1.2	-1.3	-0.8	-0.6	-0.2	-1.3	0.9	-1.1	-1.1	-0.1	-0.0
Depression (self-reported)	0.3	0.3	2.2	-0.1	0.2	-0.8	0.1	-0.3	-1.5	-0.1	-0.3	-0.2	-0.7	0.0
Medication: Lansoprazole	0.3	0.4	1.1	0.5	-0.1	0.5	0.2	-0.9	-0.5	-0.9	0.3	0.2	-0.3	-1.1
Prospective memory result	0.5	0.6	1.7	-0.5	-1.3	-1.2	0.4	-1.2	-0.9	0.4	-0.5	-0.6	-0.8	0.1
Lung cancer (father)	0.4	0.4	1.4	0.4	-0.3	0.6	0.4	0.3	-0.7	-1.2	0.3	0.5	0.9	-0.8
Illnesses of mother	1.9	2.4	5.5	1.7	1.4	1.5	2.3	0.4	0.8	-1.8	1.7	1.8	1.2	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	10.2	-1.1	1.3	-0.4	-3.2	0.9	2.0	0.9	-0.8	-0.8	0.3	0.9
Pulse wave Arterial Stiffness index	1.3	1.5	2.9	-1.5	-0.8	-0.6	-0.7	-0.8	-0.4	1.7	-1.7	-1.7	-0.9	1.5
Impedance of arm (left)	1.6	7.5	13.1	-3.5	-2.1	-3.4	-2.4	-1.1	-0.1	3.6	-3.5	-3.6	-2.1	2.1
Arm fat mass (right)	0.5	1.9	4.5	2.1	1.3	1.8	1.0	0.6	-1.2	-1.3	1.9	1.9	0.5	-0.1
Trunk predicted mass	0.4	2.2	5.8	1.4	2.4	0.6	0.6	2.0	0.1	-1.8	1.4	1.4	1.5	-1.5
Standing height	0.3	3.1	8.2	-2.5	0.6	-2.9	-2.1	0.9	0.5	1.4	-2.4	-2.5	-0.2	0.6
Length of working week for main job	0.9	1.0	3.1	-1.1	-1.8	-0.4	-1.2	-0.4	-0.7	0.6	-0.9	-0.7	-1.6	0.3
Exposure to tobacco smoke at home	1.8	2.0	4.0	1.9	0.7	0.8	1.2	0.5	-0.1	-1.6	1.8	2.0	1.6	-1.7
Breastfed as a baby	1.0	1.3	4.4	-0.5	-1.9	-0.4	-0.4	-2.1	-1.5	-0.0	-0.6	-0.4	-1.6	0.3
Tense / ‘highly strung’	1.4	2.4	7.3	0.8	-1.0	-0.6	2.7	1.0	0.6	-1.0	1.1	1.2	2.2	-2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	2.3	-0.0	-0.0	-0.6	0.5	0.3	-1.5	-0.2	0.1	0.1	1.0	-0.7
Hair/balding pattern: Pattern 4	0.5	1.2	5.0	-0.5	-2.1	-0.9	0.9	-0.9	-2.2	0.3	-0.5	-0.4	-0.2	-0.7
Birth weight of first child	1.1	2.0	6.6	-1.9	-0.4	-2.6	-2.0	-0.3	0.3	1.2	-1.7	-1.6	-0.7	0.5
Peak expiratory flow (PEF)	0.4	1.0	2.4	1.3	0.8	1.6	-0.7	0.6	0.9	-0.8	1.2	1.3	0.8	-0.1
Pulse wave reflection index	0.1	0.2	0.5	0.5	0.7	0.3	-0.2	-0.6	-0.1	0.4	0.3	0.1	-0.2	0.7
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.9	-0.1	-0.8	-0.3	0.9	-0.7	-0.3	-0.2	-0.0	0.0	0.3	0.0
Loud music exposure frequency	2.0	2.2	5.8	-1.8	-1.2	-2.4	0.0	-1.0	-2.4	0.7	-1.5	-1.5	-1.4	-0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	3.0	0.3	1.7	0.8	-0.5	0.8	1.2	0.5	0.3	0.3	0.7	0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.2	-0.1	-0.5	-0.1	0.0	-1.1	-0.5	0.5	-0.3	-0.2	0.9	0.4
Blood clot in the leg (DVT)	0.4	0.5	1.4	-1.0	-0.8	0.6	0.2	-0.0	0.4	0.3	-1.0	-0.9	-1.2	0.3
Medication: Paracetamol	0.7	1.2	2.7	0.7	-0.7	1.3	0.5	1.0	-1.3	-1.3	0.8	0.9	1.7	-1.4
Headache pain in last month	0.5	0.8	2.7	-0.3	-1.6	-0.9	0.6	-1.0	-1.3	-1.0	-0.3	-0.3	0.4	-1.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.9	0.6	1.4	0.4	-0.4	0.3	0.7	-0.6	0.6	0.7	0.2	0.3
Glaucoma (self-reported)	0.6	0.8	3.1	-0.9	-0.9	-0.4	-0.2	-1.7	-0.4	0.4	-0.8	-0.9	-1.3	0.2
Gout (self-reported)	1.6	2.2	5.1	-1.4	-1.7	-1.9	-2.3	-1.6	-1.6	0.4	-1.5	-1.4	-1.1	-0.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.7	-0.5	0.2	-0.5	-0.8	0.1	0.4	1.1	-0.7	-0.7	-1.3	1.3
Medication: Amlodipine	0.9	1.2	3.2	1.2	-0.0	1.1	0.8	-0.9	-1.0	-1.8	1.2	1.2	1.1	-1.0
Medication: Ventolin 100micrograms inhaler	1.7	2.2	4.8	1.9	0.8	0.7	2.2	0.4	0.3	-1.5	1.8	1.8	1.8	-1.5
Birth weight	0.5	1.2	2.6	0.3	1.5	-1.3	-1.3	1.6	-0.2	-0.9	0.4	0.3	1.5	-1.1
Chronic bronchitis/emphysema (mother)	2.2	2.5	6.1	-1.9	-0.8	-1.4	-1.7	-0.8	-1.9	0.8	-2.5	-2.2	-1.5	0.9
High blood pressure (siblings)	0.2	0.2	0.4	0.6	0.6	-0.6	0.6	0.5	-0.5	0.2	0.2	0.3	0.6	-0.2
Forced vital capacity (FVC), Best measure	0.6	2.3	9.3	-1.8	0.7	-1.6	-3.0	0.2	1.0	1.4	-1.5	-1.5	-0.1	1.3
Body fat percentage	0.2	0.6	3.3	0.8	-0.0	0.7	0.2	-0.6	-1.8	-0.0	0.6	0.6	-0.7	0.9
Leg fat percentage (right)	0.4	1.3	3.1	1.6	0.6	1.8	0.6	-0.5	-1.5	-0.6	1.4	1.5	-0.4	0.7
Arm fat-free mass (right)	0.3	1.5	5.2	1.2	2.3	0.8	0.3	1.6	-0.0	-1.5	1.1	1.1	0.8	-0.8
Exposure to tobacco smoke outside home	1.7	2.3	4.7	2.0	0.3	0.8	0.1	1.3	-1.0	-2.2	1.9	2.0	2.0	-1.3
Comparative body size at age 10	0.1	0.2	1.3	-0.0	0.1	0.7	-1.2	0.1	-0.4	-0.3	-0.1	-0.1	-0.3	0.2
Number of full brothers	1.4	1.8	6.9	1.3	0.4	2.6	0.9	-0.1	-1.5	-1.7	1.4	1.4	0.4	-0.9
Worry too long after embarrassment	0.4	0.7	1.9	-1.4	-0.5	-0.8	-0.6	0.7	0.9	0.6	-1.1	-1.1	0.3	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.9	-0.5	0.3	-1.4	-0.2	-0.1	-1.0	0.7	-0.4	-0.4	-0.4	0.2
Wheeze or whistling in the chest in last year	0.9	1.5	10.8	0.2	-1.0	-1.5	0.8	-1.2	-3.3	0.3	0.0	0.0	-0.7	0.1
Number of children fathered	0.1	0.1	0.4	-0.2	0.3	-0.3	-0.6	-0.3	0.5	0.1	-0.2	-0.3	0.1	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.5	-0.1	0.1	1.2	-0.4	-1.6	0.2	0.2	-0.0	-0.1	-0.5	1.5
Age at first live birth	1.1	2.0	3.6	-1.7	-1.5	-1.1	-1.9	-0.2	0.3	1.8	-1.5	-1.8	-1.0	1.4
Pulse wave peak to peak time	1.2	1.4	2.7	1.4	0.8	0.5	0.7	0.9	0.6	-1.7	1.5	1.6	1.0	-1.5
Health satisfaction	0.3	0.4	2.0	-0.4	-0.4	-1.3	0.1	-0.4	-1.4	-0.4	-0.2	-0.3	-0.4	-0.5
Shortness of breath walking on level ground	0.5	0.6	1.7	-0.6	1.1	-0.1	-1.0	0.8	-0.4	0.5	-0.6	-0.6	-1.3	0.9
Qualifications: College or University degree	0.5	1.4	4.0	-2.0	-0.1	-1.2	-0.8	-0.1	0.6	1.5	-1.8	-1.9	-0.5	0.2
Eye problems/disorders: None of the above	0.5	0.6	3.5	-0.2	-0.0	-0.5	-0.1	1.9	-0.3	-0.6	-0.1	-0.1	0.9	-1.1
Mouth/teeth dental problems: Loose teeth	2.6	3.1	6.5	-2.4	-1.3	-2.5	-0.8	-1.2	-2.5	0.8	-2.3	-2.1	-1.1	0.2
Emphysema/chronic bronchitis	0.4	0.5	1.8	-0.2	0.4	-0.7	0.1	0.8	-1.4	-0.5	-0.2	-0.2	1.2	-0.6
Medication for pain relief, constipation, heartburn	0.6	1.0	2.4	-1.1	0.1	-1.3	-1.0	-0.1	1.5	1.1	-1.0	-1.1	-0.2	0.8
Neck or shoulder pain in last month	0.5	0.7	3.5	0.0	-0.2	-1.1	0.9	-0.2	-1.9	-0.7	-0.2	-0.1	0.9	-0.8
Medication: Blood pressure	0.2	0.3	2.3	0.5	-0.4	0.4	1.5	0.2	-0.2	-0.1	0.3	0.2	0.4	-0.5
Angina (self-reported)	0.5	0.7	2.2	0.7	-0.5	0.0	1.2	0.1	-1.5	-0.3	0.8	0.8	1.1	-0.4
Migraine (self-reported)	0.6	0.7	1.6	-1.2	-0.2	-0.5	-0.4	1.2	-0.9	0.5	-1.2	-1.3	-0.2	-0.1
Medication: Ibuprofen	2.0	2.4	3.8	1.6	1.4	0.8	1.4	1.6	-0.9	-2.0	1.6	1.5	1.7	-1.9
Medication: Allopurinol	1.5	2.0	4.4	-1.0	-1.9	-1.6	-2.1	-1.7	-2.1	0.4	-1.1	-1.0	-1.2	-0.1
Medication: Omeprazole	2.2	2.6	5.2	-2.3	-1.6	-1.5	-0.3	-0.7	-0.9	1.7	-2.3	-2.2	-1.7	1.1
Medication: Seretide 50 evohaler	0.2	0.3	2.7	0.1	-0.1	-0.2	0.0	0.5	-1.6	-0.0	-0.1	0.0	-0.1	-0.2
Mean time to correctly identify matches	0.8	1.5	4.7	0.1	1.8	-2.2	0.3	1.6	-1.4	-0.7	0.1	0.1	0.8	-1.6
Heart disease (mother)	0.7	0.8	2.8	-0.7	-0.5	-0.1	-0.5	0.9	1.7	0.3	-0.7	-0.8	1.7	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.7	-0.6	-1.1	-1.3	0.1	-1.2	-0.8	0.1	-0.7	-0.7	-0.6	-0.2
Whole body fat mass	0.2	0.7	2.7	1.2	0.8	0.8	0.3	0.1	-1.6	-0.6	1.0	1.0	0.0	0.3
Leg fat mass (right)	0.5	1.8	3.7	1.9	1.1	1.8	0.9	0.3	-1.6	-1.3	1.7	1.8	0.4	-0.0
Arm predicted mass (right)	0.3	1.6	4.2	1.3	2.1	0.9	0.3	1.8	-0.1	-1.6	1.2	1.3	1.2	-1.0
Pulse rate, automated reading	0.7	2.3	5.5	-1.5	-2.4	-0.2	-2.3	-2.1	-0.7	0.7	-1.2	-0.9	-1.7	1.3
Alcohol intake frequency.	0.1	0.3	1.2	0.1	0.0	-0.3	1.1	0.6	-0.8	0.5	0.1	0.2	0.1	0.4
Comparative height size at age 10	0.6	3.4	9.1	-2.7	-0.1	-3.0	-1.2	-0.1	-1.0	1.1	-2.9	-2.9	-0.1	0.1
Number of full sisters	0.9	1.0	4.6	-0.7	-0.8	-1.5	-1.0	0.4	-2.2	0.6	-1.0	-0.8	-0.5	-0.2
Suffer from ‘nerves’	0.7	1.1	2.7	-0.8	1.0	-1.3	1.0	1.6	-0.4	-0.2	-0.6	-0.6	1.3	-1.5
Overall health rating	0.1	0.2	0.8	-0.2	-0.2	0.0	0.3	0.9	-0.6	-0.8	-0.3	-0.3	0.5	-0.4
Chest pain or discomfort	0.8	1.1	4.3	-0.8	-1.0	-2.1	0.8	-0.5	-1.7	0.9	-1.0	-0.9	-0.1	-0.1
Had major operations	1.1	1.3	2.5	1.4	0.3	1.0	1.6	0.5	-1.4	-1.2	1.3	1.2	0.7	-1.2
Age at last live birth	0.7	1.0	2.2	-1.5	0.2	-0.1	-1.3	1.0	0.9	0.9	-1.3	-1.5	-0.2	0.9
Family relationship satisfaction	0.6	0.7	2.6	-0.0	0.3	0.8	-0.8	-0.9	-0.0	1.0	0.3	0.3	-1.5	1.6
Leg pain on walking	0.4	0.5	3.2	-0.3	0.4	-0.4	-0.4	0.9	-1.8	-0.8	-0.2	-0.3	0.1	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.1	0.8	0.9	1.1	-0.7	0.8	0.1	0.0	0.7	0.7	0.6	0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.2	0.4	-0.4	1.5	0.2	-0.6	0.7	0.3	0.5	0.4	-0.8	0.9
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	5.0	1.6	1.4	1.9	2.2	0.3	0.4	-1.1	1.6	1.4	0.9	-0.6
Medication: Aspirin	0.2	0.3	0.7	0.5	-0.0	0.5	-0.1	-0.0	-0.8	0.0	0.4	0.5	-0.9	0.6
Supplements: Vitamin C	0.6	0.7	3.2	0.1	-1.3	-1.8	-0.3	0.2	-0.8	-0.5	0.1	0.1	0.5	-1.0
Knee pain experienced in last month	0.4	0.6	3.0	-0.2	-0.6	-1.2	-0.5	-1.1	-1.7	-0.1	-0.3	-0.2	-0.3	-0.4
Hypertension (Self-reported)	0.4	1.2	5.8	1.3	0.6	0.9	2.4	0.2	-1.5	-0.6	1.0	1.0	0.3	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.5	0.2	0.5	0.1	0.7	-0.1	-0.1	-0.5	0.1	-0.0	-0.1	-0.3
Illnesses of father: Heart disease	0.2	0.3	0.9	0.5	-0.3	-0.3	0.9	-0.6	0.3	-0.3	0.5	0.5	0.8	-0.4
Illnesses of siblings: Diabetes	0.8	1.0	5.7	0.5	-1.1	-0.5	0.8	-2.4	-1.3	0.2	0.5	0.5	-0.5	0.3
Smoking status: Previous	3.8	5.7	10.3	-3.1	-2.7	-2.4	-1.1	-2.6	-1.3	0.9	-3.2	-3.1	-3.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	5.0	0.6	2.2	0.3	-0.0	2.2	1.2	0.3	0.6	0.6	1.1	0.3
Whole body fat-free mass	0.3	1.7	4.4	1.3	2.1	0.6	0.5	1.7	-0.4	-1.6	1.3	1.3	1.2	-1.1
Leg fat-free mass (right)	0.2	0.9	1.8	1.0	1.4	0.5	0.2	1.3	-0.9	-1.3	0.9	0.9	0.7	-0.6
Arm fat percentage (left)	0.2	1.0	2.5	1.6	0.6	1.2	0.8	0.1	-1.4	-0.5	1.3	1.3	-0.1	0.4
Average weekly red wine intake	0.9	1.3	3.6	-1.1	-0.6	-1.9	-0.8	-1.1	-1.3	0.7	-1.2	-1.3	-1.5	0.2
Handedness (chirality/laterality): Left-handed	1.6	2.0	4.0	1.5	-0.9	0.4	1.7	0.8	0.2	-1.6	1.5	1.5	2.0	-1.9
Mood swings	0.1	0.2	0.5	0.4	0.3	0.5	0.6	0.0	-0.3	-0.7	0.4	0.4	0.5	-0.6
Loneliness, isolation	0.3	0.4	1.3	-0.8	-0.1	-0.6	-1.2	0.1	0.1	1.0	-0.7	-0.7	0.3	0.8
Long-standing illness, disability or infirmity	1.2	1.8	4.2	-1.5	-0.4	-0.5	-1.1	-0.5	-1.3	1.5	-1.7	-1.7	-1.2	2.0
Ever had bowel cancer screening	2.5	2.9	12.4	-2.0	-1.5	-3.5	0.7	-0.7	-1.1	0.5	-2.2	-2.3	-0.1	-0.4
Diabetes diagnosed by doctor	0.3	0.4	1.2	0.3	-0.9	-0.3	0.1	-1.0	-0.7	0.8	-0.0	0.0	-0.4	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.7	0.4	-0.2	0.9	0.9	1.0	1.3	0.2	0.3	0.4	-0.1	0.1
Friendships satisfaction	0.3	0.4	1.4	0.4	0.9	0.5	-1.2	0.2	1.0	-0.1	0.5	0.6	0.5	-0.3
Qualifications: nursing, teaching	0.6	0.9	3.9	0.4	0.8	1.2	-0.8	0.1	2.0	0.9	0.4	0.3	-0.5	1.3
Commuting to job workplace: Walk	0.2	0.2	0.7	0.3	-0.2	0.6	0.6	0.4	0.2	-0.5	0.2	0.3	0.8	-0.0
Eye problems/disorders: Cataract	0.3	0.3	1.4	-0.4	-0.1	-0.0	0.7	-0.6	-0.6	0.5	-0.5	-0.5	-1.2	0.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	7.8	0.6	-1.3	-1.7	0.4	-0.5	-2.8	-1.1	0.6	0.6	0.5	-1.4
Medication for cholesterol	1.0	1.6	5.9	-1.8	-2.4	-1.2	-1.2	0.1	0.5	0.7	-1.4	-1.5	0.3	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.8	3.2	6.7	1.8	-1.0	0.6	2.1	-0.2	-2.2	-2.6	1.9	2.0	1.0	-2.5
Back pain experienced in last month	0.7	1.1	7.2	-0.3	-0.9	-2.7	0.3	0.8	-0.9	0.1	-0.5	-0.4	0.5	-1.3
Mineral and other dietary supplements	1.3	1.7	4.0	1.1	0.9	-0.1	1.6	1.5	-0.8	-1.3	1.0	1.1	1.9	-2.0
Breast cancer (self-reported)	1.1	1.3	4.9	0.3	-0.3	0.2	2.2	0.5	-0.3	-1.9	0.2	0.3	0.9	-2.1
Asthma (self-reported)	0.7	1.4	2.8	1.6	0.8	0.9	1.2	0.2	-1.0	-1.1	1.4	1.3	1.7	-0.9
Osteoporosis (self-reported)	2.9	3.6	8.8	-2.9	-0.9	-1.6	-1.3	-1.4	0.9	1.4	-3.0	-2.9	-1.8	1.3
Osteoarthritis (self-reported)	0.2	0.3	1.2	-0.3	0.0	0.7	-1.1	0.5	-0.3	-0.8	-0.4	-0.2	0.7	-0.4
Medication: Aspirin	0.2	0.3	0.9	0.6	-0.0	0.7	-0.2	-0.1	-0.8	0.0	0.6	0.6	-1.0	0.6
Medication: Gliclazide	0.5	0.6	3.0	-0.3	-1.3	-0.5	0.5	-1.7	-0.7	0.3	-0.5	-0.4	0.2	0.4
Illnesses of father: None of the above (group 1)	0.7	0.9	3.2	-0.5	0.6	0.3	-1.8	1.1	0.6	1.4	-0.4	-0.4	-0.7	1.3
Smoking status: Current	0.1	0.2	1.1	-0.2	-0.2	-0.0	0.1	1.1	-0.2	-0.5	-0.3	-0.1	0.2	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	7.4	0.3	1.7	0.9	-1.3	0.7	2.7	-0.3	0.4	0.4	1.0	-0.2
Whole body water mass	0.3	1.8	4.8	1.4	2.2	0.7	0.5	1.7	-0.3	-1.7	1.4	1.4	1.1	-1.1
Leg predicted mass (right)	0.2	0.8	1.8	1.0	1.3	0.4	0.1	1.3	-1.0	-1.2	0.9	0.9	0.7	-0.6
Arm fat mass (left)	0.5	1.9	4.7	2.2	1.4	1.7	0.8	0.6	-1.0	-1.1	1.9	1.9	0.4	0.0
Number of self-reported non-cancer illnesses	0.7	1.3	9.2	-0.7	0.4	-1.1	0.0	1.0	-3.0	0.1	-1.0	-1.0	-0.2	0.2
Average weekly champagne plus white wine intake	0.2	0.3	1.0	-0.4	-0.9	0.0	0.7	-1.0	-0.4	0.0	-0.3	-0.1	-0.6	-0.2
Miserableness	0.5	0.8	2.9	0.3	1.7	0.9	0.4	1.2	0.7	-0.5	0.5	0.5	1.4	-0.7
Guilty feelings	0.7	1.1	2.7	-1.5	-0.1	-0.5	-1.1	0.6	1.6	0.9	-1.3	-1.4	0.1	0.9
Wears glasses or contact lenses	0.7	0.9	2.4	-0.9	-0.7	0.2	-0.9	-1.4	-0.3	0.3	-1.1	-1.1	-1.6	0.2
Ever taken oral contraceptive pill	0.5	0.6	2.3	0.7	0.7	0.6	0.5	-0.2	1.5	-0.6	0.6	0.6	0.9	-0.8
Hearing aid user	0.1	0.2	0.4	0.6	0.4	-0.2	0.3	0.6	-0.0	0.0	0.4	0.3	0.5	-0.5
Mother’s age at death	0.6	0.7	3.5	0.4	0.5	1.4	0.2	0.9	1.9	0.2	0.7	0.6	-0.5	0.0
Financial situation satisfaction	0.4	0.5	1.4	-0.1	0.5	-0.2	-0.9	-0.9	0.9	0.9	-0.1	-0.1	-0.2	1.2
Tinnitus: Yes, now most or all of the time	1.6	1.9	8.4	-1.1	1.2	-0.3	-0.3	2.9	2.6	0.4	-1.0	-1.1	0.8	0.0
Commuting to job workplace: Public transport	0.7	0.8	3.3	-0.5	1.5	-0.3	-1.5	1.8	0.0	0.5	-0.4	-0.3	-0.1	0.5
Eye problems/disorders: Glaucoma	0.2	0.2	1.1	-0.0	-0.2	1.0	0.1	-0.8	0.8	-0.2	0.1	0.0	-0.0	-0.2
Medication: Blood pressure	1.2	2.2	6.3	1.9	1.6	0.5	2.5	-0.4	-1.6	-1.2	1.8	1.8	0.8	-0.3
Pain type(s) experienced in last month: Hip pain	1.0	1.3	6.9	-1.2	0.1	-2.6	-0.7	0.7	-0.1	1.2	-1.1	-1.1	-0.6	0.6
Supplements: Fish oil (including cod liver oil)	0.8	1.1	4.9	0.2	-0.4	1.0	-0.6	-2.2	1.3	0.2	0.3	0.3	-1.0	1.5
High cholesterol (Self-reported)	0.4	0.6	2.0	-0.5	0.9	-0.5	-1.1	1.4	-1.2	-0.2	-0.6	-0.6	-0.4	0.1
Medication: Bendroflumethiazide	0.7	1.1	2.7	1.5	1.1	0.4	1.6	0.9	0.7	0.6	1.3	1.2	1.1	0.2
Medication: Paracetamol	0.7	1.1	2.5	1.1	-0.6	1.3	0.7	0.2	-1.0	-1.2	1.1	1.2	1.6	-0.9
Medication: Lisinopril	0.9	1.2	3.3	1.8	0.5	1.5	1.8	0.2	0.3	0.1	1.5	1.4	0.8	0.0
Medication: Atorvastatin	0.9	1.1	2.3	-1.4	-0.1	-1.2	-0.6	1.2	-0.3	1.3	-1.5	-1.5	-0.2	0.4
Illnesses of father: High blood pressure	0.8	1.0	2.8	1.2	1.7	1.1	0.6	0.7	-0.6	-1.4	1.1	1.0	-0.0	-0.8
Alcohol drinker status: Never	0.6	0.7	1.9	1.4	1.2	0.2	0.6	0.5	-0.7	-0.5	1.2	1.3	0.3	0.1
Ever smoked	1.4	2.5	6.0	-2.2	-1.4	-2.4	-0.1	-0.7	-0.7	-0.1	-2.4	-2.3	-1.5	-0.8
Basal metabolic rate	0.3	1.8	4.1	1.5	2.0	0.8	0.4	1.6	-0.6	-1.7	1.5	1.5	1.1	-1.0
Leg fat percentage (left)	0.4	1.3	3.1	1.7	0.2	1.3	0.7	-0.7	-1.8	-0.8	1.6	1.6	-0.3	0.5
Arm fat-free mass (left)	0.4	2.2	5.5	1.7	2.3	1.2	0.5	1.7	-0.1	-1.8	1.6	1.7	1.1	-1.0
Number of operations (self-reported)	0.2	0.3	1.0	0.1	-0.6	-0.4	0.6	-0.7	-1.0	-0.1	-0.3	-0.3	-0.7	-0.1
Average weekly beer plus cider intake	0.5	0.8	1.7	-1.3	1.2	0.3	-0.5	1.0	0.0	0.5	-1.3	-1.3	-0.2	0.6
Irritability	0.3	0.5	2.1	0.5	0.7	0.2	0.8	0.4	0.5	-0.7	0.8	0.8	1.4	-0.3
Risk taking	0.4	0.6	2.8	-0.1	0.4	-0.3	-0.7	-0.2	0.7	1.1	-0.1	-0.1	-1.1	1.7
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.8	-0.9	-1.9	-0.6	1.5	-0.6	-1.6	-1.1	-0.9	-0.8	0.3	-1.5
Fractured/broken bones in last 5 years	0.2	0.3	1.3	0.0	-0.3	-0.7	0.5	-0.2	-1.1	-0.1	-0.1	-0.0	0.4	-0.6
Age started oral contraceptive pill	0.4	0.5	1.9	-0.1	0.5	-1.4	0.6	0.9	-0.5	-0.0	-0.3	-0.4	-0.8	-0.9
Diastolic blood pressure, automated reading	0.3	0.8	3.0	1.7	1.2	-0.5	0.5	-0.1	-0.7	-0.3	1.4	1.2	0.0	0.3
Ever depressed for a whole week	1.9	2.3	7.9	1.4	2.8	1.6	-0.1	1.0	1.7	-1.2	1.4	1.3	1.7	-1.1
Unable to work because of sickness or disability	0.6	0.7	3.8	0.2	-1.2	-0.4	0.5	0.4	-1.9	-0.7	0.2	0.4	0.0	-1.2
Commuting to job workplace: Cycle	0.3	0.3	2.2	0.1	0.9	-0.6	0.1	1.5	0.5	0.2	0.1	0.2	0.2	-0.4
Myopia	0.7	1.0	3.7	-0.8	-0.7	0.1	-1.9	-1.2	-0.4	0.2	-0.9	-0.7	-1.5	0.7
Vascular/heart problems diagnosed by doctor	0.2	0.7	2.5	-0.8	-0.5	-0.6	-1.6	0.5	1.6	0.4	-0.6	-0.5	0.1	-0.4
Cholesterol lowering medication	1.0	1.4	3.1	1.7	1.5	0.1	0.7	-0.0	-1.1	-1.8	1.6	1.6	-0.3	-0.8
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.7	-1.7	-1.1	-1.3	0.3	-0.7	-0.6	1.3	-1.6	-1.5	-1.0	0.8
Pain experienced in last month	0.6	1.1	6.7	0.3	-0.3	2.6	0.0	-1.1	0.4	0.8	0.4	0.4	-0.8	1.3
Supplements: Calcium	1.5	1.6	3.6	-1.7	-1.2	-0.9	-1.2	-0.5	0.3	1.2	-1.8	-1.9	-1.2	1.0
Basal cell carcinoma (self-reported)	0.8	0.9	2.4	-0.5	-1.5	-1.4	-0.2	-0.5	-1.6	-0.8	-0.4	-0.5	-0.1	-1.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.6	0.4	-0.9	1.1	0.4	-1.0	-1.3	-0.3	0.5	0.4	-0.9	0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.9	-1.2	-0.9	0.5	-0.2	-0.0	0.4	0.4	-1.2	-1.1	-1.4	0.5
Heart disease (siblings)	1.1	1.3	2.7	-1.6	-1.1	-0.9	-0.6	0.8	-0.4	1.4	-1.6	-1.6	-0.7	0.9
Alcohol drinker status: Previous	0.3	0.3	1.1	-0.5	0.2	0.4	-0.2	1.1	0.2	1.0	-0.6	-0.6	-0.3	0.7
Pack years of smoking	0.5	0.7	1.4	1.0	0.3	0.7	0.1	-0.2	-1.2	-1.1	1.1	1.1	-0.0	-0.9
Impedance of whole body	1.4	6.9	11.8	-3.4	-2.2	-3.0	-2.5	-1.3	0.3	3.4	-3.3	-3.4	-1.8	2.1
Leg fat mass (left)	0.5	1.9	4.1	2.0	0.9	1.5	1.0	0.0	-1.8	-1.4	1.8	1.9	0.5	-0.2
Arm predicted mass (left)	0.4	2.3	5.3	1.8	2.3	1.3	0.6	1.6	-0.3	-1.9	1.8	1.8	1.0	-1.0