TWAS
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Traits
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Lung FEV1/FVC ratio
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chr21:27,593,540-29,033,093
Best TWAS P=6.2e-09 · Best GWAS P=2.3e-10 conditioned to 0.157
27.6M
27.8M
28M
28.2M
28.4M
28.6M
28.8M
29M
0
2
4
6
8
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Testicular Germ Cell Tumors
ADAMTS5
0.11
0.05
blup
95
0.04
0.0156
6.1
-5.8
6.2e-09
-0.92
0.02
0.82
TRUE
1
GTEx
Lung
ADAMTS5
0.13
0.00
lasso
7
0.02
0.0072
-2.8
-5.2
1.7e-07
-0.33
0.20
0.28
TRUE