TWAS hub - ADAMTS5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.3280	0.1050	0.0041	0.192	NA	0.071	NA	0.140	2.4e-06	NA	0.0039	NA	6.3e-05
2	GTEx	Cells Transformed fibroblasts	0.1180	0.0410	0.0029	-0.003	NA	-0.004	NA	-0.002	5.8e-01	NA	0.8600	NA	5.6e-01
3	GTEx	Lung	0.1317	0.0462	0.0022	0.003	NA	0.010	NA	0.022	1.7e-01	NA	0.0500	NA	7.2e-03
4	METSIM	Adipose	0.0532	0.0222	0.0057	0.004	0.015	0.005	0.017	0.001	8.0e-02	0.0023	0.0520	0.0011	2.5e-01
5	YFS	Blood	0.0230	0.0092	0.0048	-0.001	0.003	0.004	NA	-0.001	8.2e-01	0.0260	0.0160	NA	5.5e-01
6	TCGA	Testicular Germ Cell Tumors	0.1070	0.0590	0.0052	0.050	0.039	0.000	NA	0.024	7.4e-03	0.0160	0.3100	NA	4.9e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Major Depression (MDD)	3.2	3.8	10.8	2.6	3.3	0.5	0.9	-2.0	-0.7
Hair/balding pattern: Pattern 3	2.9	4.4	11.8	-0.4	-0.7	3.1	-2.0	0.6	3.4
Medication: Simvastatin	2.8	4.2	16.8	-4.1	-2.2	-0.8	-1.4	-0.6	0.6
Lung FEV1/FVC ratio	2.7	13.8	33.8	-1.6	-3.7	-5.2	2.3	-0.4	-5.8
Basal cell carcinoma (self-reported)	2.3	2.8	6.7	1.4	2.6	-1.0	1.8	-1.1	-1.7
Chronic bronchitis/emphysema (father)	2.2	2.5	5.3	1.6	2.3	2.0	-0.5	-0.1	1.8
Prospective memory result	2.2	2.7	5.7	-0.9	1.7	1.3	-2.3	0.0	2.4
Supplements: Glucosamine	2.0	2.6	6.6	-1.6	0.5	1.5	-2.6	-1.6	1.0
Multivitamins +/- minerals	1.9	2.4	4.4	0.5	1.8	2.1	-1.0	-1.5	1.7
Commuting to job workplace: Walk	1.9	2.1	8.6	1.1	1.0	-1.0	0.6	-0.5	-2.9
Townsend deprivation index at recruitment	1.8	2.5	10.0	-0.1	0.5	1.6	-1.3	0.3	3.2
Peak expiratory flow (PEF)	1.8	4.2	21.1	0.3	-1.8	-4.6	0.4	0.1	-0.7
Glaucoma (self-reported)	1.8	2.2	5.7	0.0	0.5	2.4	-1.0	2.3	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.2	9.5	0.2	0.4	3.1	-0.3	1.8	-0.3
Miserableness	1.8	3.1	9.8	-0.1	-0.3	3.1	1.6	2.5	0.6
Supplements: Calcium	1.8	2.0	4.0	0.8	2.0	0.4	-1.8	-1.6	1.3
Relative age of first facial hair	1.7	3.5	14.4	3.8	1.7	-1.6	1.1	-0.1	-0.2
Hair/balding pattern: Pattern 2	1.7	2.1	7.7	-0.6	0.8	-1.9	0.7	0.1	-2.8
Exposure to tobacco smoke at home	1.7	2.0	6.4	1.0	1.8	2.5	0.6	-0.7	0.8
Qualifications: O levels/GCSEs or equivalent	1.7	2.8	5.3	-1.4	-1.4	-2.2	0.6	-1.5	-2.3
Illnesses of father: None of the above (group 1)	1.7	2.1	6.6	0.5	-1.9	-2.6	-0.6	-0.5	-1.3
Medication: Blood pressure	1.7	3.2	4.8	-2.1	-1.9	-1.7	-0.6	-1.9	-2.2
Bipolar Disorder (2011)	1.6	1.5	3.5	0.8	1.3	0.9	-1.9	-1.2	0.8
Hand grip strength (right)	1.6	4.2	12.4	-1.5	-3.5	-1.5	-2.8	0.6	0.1
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.6	6.1	2.1	-0.0	-0.6	2.5	0.1	-2.1
Number of full brothers	1.6	2.1	5.0	-1.2	-2.2	-2.2	0.0	1.2	-0.3
Pulse wave peak to peak time	1.6	1.9	6.3	1.4	0.2	-0.5	1.2	2.5	-1.2
Friendships satisfaction	1.6	2.0	4.5	-0.9	-0.2	1.9	-2.1	-0.1	1.7
Average weekly beer plus cider intake	1.6	2.4	5.4	-0.9	-1.1	2.3	-0.7	1.1	2.3
Alzheimer’s Disease (in father)	1.5	1.6	3.8	0.2	1.6	1.9	-1.5	-1.0	0.7
Current tobacco smoking	1.5	2.4	5.3	0.9	0.5	1.5	-2.1	1.2	2.3
Qualifications: None of the above	1.5	3.2	5.4	0.4	1.5	2.3	-2.1	1.2	2.3
Heart attack	1.5	1.9	6.4	0.4	0.7	1.5	-1.2	0.8	2.5
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	4.0	1.7	1.8	2.0	0.8	-0.2	0.9
Medication: Lansoprazole	1.5	1.7	3.8	-0.2	-1.1	-1.9	-1.4	-1.4	1.3
Vitamin and mineral supplements	1.4	1.9	3.1	-0.8	-1.5	-1.8	1.2	1.4	-1.4
Average weekly fortified wine intake	1.4	1.7	5.4	-0.5	-0.3	2.0	0.1	2.3	0.4
Impedance of leg (left)	1.4	7.0	17.5	0.2	-2.3	-2.9	2.8	1.7	-4.2
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.1	-1.8	-1.3	0.0	1.1	1.7	0.4
Smoking status: Current	1.4	2.3	5.6	0.8	0.6	1.4	-1.9	1.3	2.4
Medication: Paracetamol	1.4	2.2	7.8	-1.4	-2.8	0.2	0.2	1.7	-0.7
Heel T-Score	1.3	10.0	27.6	-2.5	-3.8	2.9	-5.3	0.3	1.8
Sensitivity / hurt feelings	1.3	2.1	3.5	-1.8	-1.8	1.9	0.0	1.6	-0.4
Supplements: Zinc	1.3	1.4	2.4	-0.2	1.2	1.0	-1.5	-1.1	1.5
Impedance of leg (right)	1.3	6.5	16.0	0.5	-1.8	-2.7	3.1	1.5	-4.0
Forced expiratory volume in 1-second (FEV1)	1.3	4.2	20.3	-0.5	-2.1	-4.5	0.4	0.3	-0.4
Depression (self-reported)	1.3	1.5	5.5	-0.4	0.6	1.3	2.3	1.2	0.1
Medication: Omeprazole	1.3	1.5	4.3	-2.1	-1.4	-0.5	-0.8	-1.1	-0.9
Diabetes diagnosed by doctor	1.3	2.1	7.9	-2.8	-0.5	-0.6	-1.5	-0.4	1.1
Medication for cholesterol	1.3	1.9	6.5	2.5	1.5	1.0	0.5	0.6	1.0
Cholesterol lowering medication	1.3	2.0	3.8	-1.7	-1.4	-1.9	-0.8	-0.2	-1.6
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.5	-0.9	-1.6	1.4	1.9	0.1	-1.1
Eye problems/disorders: Diabetes related eye disease	1.2	1.4	3.7	-1.6	-1.9	0.1	-1.3	0.0	0.5
Pulse wave Arterial Stiffness index	1.2	1.4	5.4	-1.2	-0.2	0.2	-0.8	-2.3	0.9
Medication: Paracetamol	1.2	2.0	5.4	-1.5	-2.3	1.2	-0.2	1.8	-0.3
Headache pain in last month	1.2	2.1	8.7	-0.3	-1.6	0.6	0.3	3.0	-1.0
Loneliness, isolation	1.2	1.7	4.5	-1.7	-2.1	-0.2	0.8	1.3	-0.2
Osteoarthritis (self-reported)	1.2	1.6	2.3	-1.1	-0.8	1.1	-1.4	-1.5	-1.5
Heart attack/myocardial infarction (self-reported)	1.2	1.6	6.1	0.3	0.5	1.3	-1.1	0.6	2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	2.6	0.2	-1.0	1.6	1.6	1.2	-1.1
Relative age voice broke	1.1	1.7	4.2	2.0	0.5	-2.1	0.7	-0.6	-0.7
Medication: Atenolol	1.1	1.4	3.5	-0.8	-1.9	-1.0	-1.4	-0.9	0.5
Pulse rate	1.1	1.9	6.4	-0.5	0.2	2.5	-0.8	-0.7	2.0
Length of working week for main job	1.1	1.3	3.1	1.7	1.2	0.2	1.8	0.4	-0.1
Birth weight of first child	1.1	2.1	5.9	-0.3	-1.6	-1.9	-0.3	-0.3	-2.4
Medication: Amlodipine	1.1	1.6	2.7	-1.1	-1.0	-1.6	0.6	-1.2	-1.6
Health satisfaction	1.1	1.4	3.2	-1.6	-1.8	-0.8	0.7	-0.6	-1.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	5.6	-0.5	-0.4	0.7	2.4	0.5	-2.0
Guilty feelings	1.1	1.6	6.9	-0.7	-0.1	0.4	1.4	2.6	0.3
Depression (Nagel 2018)	1.0	1.5	3.1	-0.4	-1.4	0.7	1.5	1.0	-1.8
Lupus	1.0	1.4	3.3	-1.0	1.1	1.8	-0.6	0.7	1.5
Rheumatoid Arthritis	1.0	1.3	3.2	-0.2	1.0	1.8	0.9	1.6	0.6
Fed-up feelings	1.0	1.8	5.2	-0.7	-0.4	2.3	-0.3	1.5	1.6
Father’s age at death	1.0	1.4	2.5	-0.2	1.6	0.8	1.4	-0.9	-1.5
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.8	-0.2	0.5	1.0	-1.7	-1.7	0.6
Leg fat percentage (right)	1.0	3.5	6.9	0.6	1.5	-1.6	2.6	-1.6	-2.5
Age at first live birth	1.0	1.7	3.3	-1.3	-1.3	-1.8	-1.2	0.0	-1.5
Migraine (self-reported)	1.0	1.3	3.0	0.2	-0.2	0.3	1.4	1.6	-1.7
Leg pain on walking	1.0	1.2	3.2	1.8	0.9	1.2	0.7	1.0	-0.8
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.0	-1.7	-1.6	-0.0	1.1	-0.1	-0.6
Mood swings	1.0	1.7	3.7	0.1	-0.3	1.6	1.9	1.7	-1.0
Ever had bowel cancer screening	1.0	1.2	2.6	-0.8	-1.6	-0.8	-0.8	-1.3	-1.0
Mineral and other dietary supplements	1.0	1.3	3.0	1.1	-0.3	-0.9	1.2	1.7	-1.1
Tinnitus: Yes, now most or all of the time	1.0	1.2	4.4	0.9	2.1	0.9	0.7	-0.7	0.4
Eye problems/disorders: Glaucoma	1.0	1.1	2.1	0.7	0.9	1.4	-1.4	1.2	0.2
Ever depressed for a whole week	1.0	1.2	4.4	1.5	2.1	0.3	0.5	-0.1	-0.6
Impedance of whole body	1.0	5.1	12.5	0.5	-1.7	-1.8	2.9	1.8	-3.5
Schizophrenia (2018)	0.9	1.9	5.4	0.6	2.0	2.3	0.7	0.4	1.1
Body Mass Index (BMI) (2010)	0.9	1.2	4.4	0.7	-0.6	0.7	-1.3	0.1	2.1
High blood pressure (mother)	0.9	1.2	3.1	-0.5	-0.1	-0.4	1.7	-0.8	-1.8
Alcohol usually taken with meals	0.9	1.5	3.7	0.2	-0.1	-1.8	-0.0	-1.9	-1.5
Neuroticism score	0.9	1.8	3.3	-1.3	-1.2	1.7	1.2	1.8	-0.4
Happiness	0.9	1.1	2.1	-1.1	-0.9	0.5	-0.3	-1.4	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.7	0.6	1.5	-0.3	-1.6	-0.9	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	11.8	0.2	-1.5	-3.4	1.0	1.2	-0.5
Breastfed as a baby	0.9	1.1	3.0	-0.4	-1.3	-1.7	-1.2	0.1	0.7
Medication: Ventolin 100micrograms inhaler	0.9	1.2	4.9	1.1	0.3	0.5	-0.8	-0.1	2.2
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	3.2	0.4	-0.4	-1.8	1.1	0.3	-1.2
Heart disease (mother)	0.9	1.0	5.1	-0.0	0.1	-0.6	-2.2	-0.8	-0.4
Pulse rate, automated reading	0.9	2.8	12.2	-0.7	0.7	3.5	-1.3	0.3	1.3
Osteoporosis (self-reported)	0.9	1.1	3.7	1.2	0.9	1.9	0.7	0.6	0.1
Medication: Aspirin	0.9	1.2	2.1	-1.2	-0.9	-1.4	-1.1	-0.4	-1.4
Illnesses of father: High blood pressure	0.9	1.2	2.6	-1.3	-0.9	1.6	1.1	0.8	0.1
Age started oral contraceptive pill	0.9	1.1	4.4	-1.2	-0.7	-2.1	-0.3	-0.5	0.3
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	2.0	-1.4	-0.8	-0.1	-0.9	-1.1	-1.3
Age at First Birth	0.8	1.1	2.6	-1.1	1.2	1.6	-0.8	0.7	0.7
Crohns Disease (2012)	0.8	1.3	4.0	2.0	0.4	1.7	0.0	-0.6	-0.1
HDL Cholesterol	0.8	1.3	2.9	-1.3	-1.7	-0.5	-1.5	-0.5	0.5
Neuroticism (2016)	0.8	1.2	3.0	0.7	1.4	1.2	1.7	0.3	0.2
Waist Hip Ratio (WHR)	0.8	3.7	10.2	-0.4	-3.2	-1.0	0.4	0.9	-3.2
Hand grip strength (left)	0.8	2.2	6.2	-0.5	-2.5	-2.0	-1.5	-0.3	-0.6
Number of treatments/medications taken	0.8	1.5	3.0	-1.7	-0.7	1.5	-1.6	-0.2	0.7
Maternal smoking around birth	0.8	1.1	2.1	1.3	0.8	0.7	-1.5	0.2	1.2
Taking other prescription medications	0.8	1.2	2.4	-1.1	0.3	1.5	-1.4	0.8	1.2
Pain all over the body in last month	0.8	0.9	3.8	0.1	0.6	-0.8	0.5	-2.0	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	4.3	-0.1	-1.2	0.8	2.1	0.7	-1.1
Number of live births	0.8	1.2	3.9	-0.5	-1.2	0.5	2.0	-0.2	-1.0
Noisy workplace	0.8	1.0	3.8	0.0	0.9	0.8	1.9	0.2	-0.7
Tense / ‘highly strung’	0.8	1.3	2.0	1.3	-0.5	1.2	1.1	1.4	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	5.3	-0.1	0.5	2.3	1.1	0.0	-0.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	2.7	-1.5	0.9	1.7	-1.6	-1.1	0.4
Exposure to tobacco smoke outside home	0.8	1.0	2.6	1.1	0.5	1.3	1.6	-0.5	0.2
Number of full sisters	0.8	1.0	1.9	-1.4	-1.3	-0.9	0.8	0.8	-0.3
Age at last live birth	0.8	1.2	4.4	-1.1	-0.7	-0.9	0.2	-0.2	-2.1
Illnesses of father: Heart disease	0.8	1.1	2.8	-0.1	1.7	1.3	-0.3	-0.4	1.3
Mother’s age at death	0.8	1.0	3.1	1.0	1.8	0.3	1.1	0.6	0.0
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.5	-1.1	-1.0	0.0	-0.8	-1.6	0.9
High cholesterol (Self-reported)	0.8	1.4	3.5	-0.6	-1.8	-0.3	-0.6	1.9	-1.0
Leg fat percentage (left)	0.8	3.0	5.8	0.4	1.4	-1.5	2.2	-1.7	-2.4
Heart disease (siblings)	0.8	1.0	3.2	-0.1	-1.0	0.9	-1.8	1.0	-0.0
Bipolar Disorder or Schizophrenia	0.7	1.7	4.9	0.4	2.0	2.2	1.0	0.3	0.5
Schizophrenia vs Biploar Disorder	0.7	0.9	4.2	-0.6	-2.1	-0.9	0.1	0.5	0.3
Crohns Disease (2017)	0.7	1.5	4.3	2.1	0.9	1.8	0.7	-0.1	-0.5
Coronary Artery Disease (CAD)	0.7	0.9	2.8	0.5	-1.3	-1.7	-0.1	0.5	0.6
Lung FVC	0.7	3.7	8.2	-0.1	1.4	-2.9	-2.2	-2.3	1.4
Chronotype (morning person)	0.7	1.7	5.4	-2.0	-0.7	0.1	0.5	0.3	-2.3
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	1.5	0.5	1.1	1.2	0.8	0.8	1.2
Medication for hormone replacement therapy	0.7	0.8	1.4	-1.1	0.3	1.1	0.3	0.8	1.2
Medication: Levothyroxine sodium	0.7	1.2	3.6	-0.5	0.8	1.9	-1.0	-1.4	-0.3
Had other major operations	0.7	0.8	1.7	-1.3	-1.0	0.3	-0.6	-1.0	0.8
Diabetes (self-reported)	0.7	1.1	3.8	-2.0	-0.6	-0.8	-1.2	-0.8	0.3
Fluid intelligence score	0.7	1.4	5.5	1.2	-0.5	-2.4	-0.5	-0.6	-0.7
Illnesses of siblings	0.7	1.0	2.6	0.2	0.9	-0.6	1.6	-0.7	-1.3
Alcohol intake versus 10 years previously	0.7	1.0	3.7	0.2	1.9	-0.8	0.5	0.3	1.1
Medication: Allopurinol	0.7	1.0	1.8	0.6	1.2	-0.3	-1.1	-0.9	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.5	-1.2	-0.9	-0.6	-1.1	-1.0	-0.1
Medication: Aspirin	0.7	1.0	2.3	-1.2	-0.6	-0.9	-1.5	-0.5	-0.9
Ever taken oral contraceptive pill	0.7	0.8	2.4	-1.1	-1.6	-0.7	-0.1	0.5	0.7
Medication: Bendroflumethiazide	0.7	1.1	2.2	-0.2	1.2	0.9	0.7	-1.2	-1.5
Medication: Lisinopril	0.7	0.9	2.0	-1.4	-0.6	-0.8	-1.1	-0.9	-0.8
Alcohol drinker status: Never	0.7	0.8	2.1	0.8	-0.4	0.4	-1.5	0.5	1.3
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.4	-0.6	-1.1	-0.5	-1.2	-1.1	-0.5
Diastolic blood pressure, automated reading	0.7	2.2	8.8	3.0	2.0	0.4	-0.7	-0.2	0.0
Unable to work because of sickness or disability	0.7	0.9	2.0	-1.3	-1.0	0.3	0.5	1.4	-0.7
Irritable Bowel Disease (IBD)	0.6	1.5	5.6	2.4	0.6	0.5	1.3	0.9	-0.5
Verbal and Numeric Reasoning (VNR)	0.6	1.5	4.6	1.1	-0.2	-2.1	-0.5	-1.7	-0.4
Triglycerides	0.6	1.0	2.6	1.6	1.4	-0.6	0.8	0.0	-0.6
Allergy or Eczema	0.6	1.6	6.0	-0.1	-0.3	-1.6	-0.8	-2.4	0.3
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.1	-1.3	-1.3	-1.4	-1.0	0.0	0.4
Neuroticism	0.6	1.5	2.8	-1.2	-1.0	1.7	1.2	1.4	-0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.5	-0.8	1.2	-0.8	-0.2	-0.9	0.9
Diabetes (mother)	0.6	0.7	1.8	-0.6	0.6	-0.0	1.0	0.9	-1.4
Pack years adult smoking proportion	0.6	0.9	1.6	0.7	0.8	1.0	-0.8	1.3	0.8
Trunk fat percentage	0.6	2.5	6.1	0.3	0.6	-1.5	2.3	-0.8	-2.5
Forced vital capacity (FVC)	0.6	2.4	10.3	-0.4	-1.6	-3.2	-0.3	0.7	0.8
Financial difficulties in last 2 years	0.6	0.8	1.7	0.3	0.0	1.3	-1.1	0.9	1.2
Impedance of arm (right)	0.6	2.7	6.8	0.7	-0.6	-0.7	2.6	1.9	-2.1
Falls in the last year	0.6	0.8	2.8	-1.0	0.8	1.7	-0.2	0.5	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.9	-0.0	-0.2	0.2	0.8	1.7	-1.1
Pulse wave reflection index	0.6	0.8	2.4	-0.5	1.2	-0.5	0.5	-1.6	0.3
Body fat percentage	0.6	2.6	5.9	0.5	1.1	-1.4	2.4	-1.0	-2.2
Wheeze or whistling in the chest in last year	0.6	1.1	2.8	1.7	1.0	1.5	-0.4	-0.0	0.3
Emphysema/chronic bronchitis	0.6	0.7	1.8	0.8	1.1	0.7	1.3	-0.2	0.2
Medication for pain relief, constipation, heartburn	0.6	1.0	3.2	1.0	0.9	-0.7	0.6	-0.5	1.8
Suffer from ‘nerves’	0.6	1.0	4.0	0.3	0.1	2.0	0.6	0.9	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.6	-0.4	-0.9	-0.8	-1.6	0.1	0.5
Illnesses of siblings: Diabetes	0.6	0.7	1.4	0.1	0.6	1.2	-0.9	-0.8	1.0
Average weekly red wine intake	0.6	0.9	4.0	0.4	0.0	-2.0	0.7	-0.5	-0.8
Back pain experienced in last month	0.6	0.9	3.2	0.0	-0.4	1.2	-0.5	1.8	-0.2
Medication: Gliclazide	0.6	0.7	2.7	-0.4	0.8	-1.7	-0.6	0.5	-0.5
Pack years of smoking	0.6	0.9	1.7	0.8	1.3	1.1	-0.9	0.7	0.8
Depressed Affect (Nagel 2018)	0.5	1.1	3.0	-0.9	-0.7	1.4	0.4	1.7	0.5
Alzheimer’s Disease (in mother)	0.5	0.6	1.9	0.9	0.5	0.5	1.4	0.7	0.1
Ulcerative Colitis (UC)	0.5	1.0	2.5	1.4	-0.4	-0.8	0.7	1.6	-0.5
Mean Putamen Volume	0.5	0.6	1.0	0.8	0.7	0.9	1.0	0.3	-0.8
Primary Biliary Cirrhosis	0.5	0.7	2.7	-0.7	-0.6	-1.7	0.3	-0.6	0.1
Schizophrenia (2014)	0.5	1.2	3.2	-0.5	0.5	1.7	-0.1	0.5	1.8
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.4	0.1	-0.9	0.2	-1.6	0.0	0.4
Hypothyroidism (self reported)	0.5	1.2	2.6	-1.6	1.5	0.9	-0.3	-1.1	-0.1
Respiratory disease	0.5	1.1	2.8	1.2	0.5	0.9	-1.1	0.1	1.7
Hearing difficulty/problems: Yes	0.5	0.8	3.1	-0.0	0.1	1.1	-0.7	0.4	1.7
Severe depression (siblings)	0.5	0.5	1.8	0.5	-0.2	1.3	0.2	0.9	0.4
Serious illness, injury or assault to yourself	0.5	0.6	1.3	-0.2	0.8	0.9	-1.0	0.2	1.1
Hayfever, allergic rhinitis or eczema	0.5	1.0	3.0	0.5	0.0	-1.1	-0.9	-1.7	0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.5	1.1	1.2	0.4	0.4	-0.2	0.7
Trunk fat mass	0.5	2.1	4.5	0.2	0.6	-1.7	2.0	-0.9	-2.1
Number of incorrect matches in round	0.5	0.9	1.7	-1.3	0.3	0.9	-1.0	-0.4	1.2
Mouth/teeth dental problems: Dentures	0.5	0.9	2.3	-0.5	-0.4	0.3	-0.8	1.5	1.3
Impedance of arm (left)	0.5	2.4	6.1	0.4	-1.1	-0.5	2.5	1.7	-2.1
Standing height	0.5	4.8	13.7	0.1	-2.2	-3.7	0.6	1.9	-2.4
Hair/balding pattern: Pattern 4	0.5	1.3	4.1	-0.7	-0.7	0.3	2.0	-0.2	-1.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.3	-0.2	1.1	1.5	-0.1	0.3	0.0
Worry too long after embarrassment	0.5	0.9	2.1	-1.4	-0.8	0.9	0.8	0.3	-1.0
Medication: Ibuprofen	0.5	0.6	2.7	-0.3	-0.1	0.6	0.7	1.7	-0.3
Overall health rating	0.5	1.1	3.8	-0.5	-0.7	2.0	-0.7	1.2	-0.0
Chest pain or discomfort	0.5	0.7	2.1	-1.4	-1.2	-0.5	-0.3	0.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.8	0.7	-1.1	-1.7	1.1	0.9	-0.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.6	-0.6	0.3	1.3	-0.8	0.4	-0.8
Qualifications: nursing, teaching	0.5	0.8	2.2	0.3	-1.5	-1.2	0.3	0.1	-0.9
Breast cancer (self-reported)	0.5	0.6	2.7	-0.2	0.1	0.0	0.6	-1.6	0.8
Asthma (self-reported)	0.5	0.9	2.2	0.3	0.6	1.3	-1.1	0.2	1.5
Average weekly champagne plus white wine intake	0.5	0.7	1.6	0.9	0.3	0.0	1.3	-1.0	-0.9
Wears glasses or contact lenses	0.5	0.5	1.8	-0.6	0.2	-0.4	-0.9	-1.3	-0.1
Commuting to job workplace: Public transport	0.5	0.6	3.1	0.5	-0.3	0.1	1.8	0.2	-0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.4	1.2	0.6	1.2	-0.3	0.5	-0.2
Irritability	0.5	0.8	2.3	-0.7	0.6	1.5	0.7	-0.6	-0.9
Myopia	0.5	0.7	1.6	-1.1	-0.6	1.3	-0.4	-0.6	-0.4
Intelligence (Savage-Jansen 2018)	0.4	1.4	4.4	0.4	-0.0	-0.9	-1.6	-2.1	0.6
HbA1C	0.4	0.5	1.8	-0.4	0.0	0.7	-0.4	0.6	1.4
LDL Cholesterol	0.4	0.6	1.8	0.2	-0.6	-0.7	1.4	-0.8	-0.4
Height	0.4	6.9	20.1	-1.4	-3.2	-4.5	-0.5	-0.3	-3.0
Angina	0.4	0.5	2.6	-0.0	0.3	0.5	-0.6	-0.1	1.6
Medication: Co-codamol	0.4	0.5	2.1	-0.1	0.3	-0.2	-0.6	-1.5	0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.4	0.6	0.8	0.4	-0.5	1.2	-0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.2	-0.8	0.2	0.8	-0.3	1.1	0.3
Nervous feelings	0.4	0.8	2.5	-0.8	-0.7	1.6	0.6	0.7	-0.4
Hearing difficulty/problems with background noise	0.4	0.6	2.0	-0.7	-0.7	0.3	0.6	1.4	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.6	-0.9	-1.4	0.8	-1.6	-0.3	0.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.2	0.4	0.5	-0.3	0.1	-1.0	-1.1
Allergy	0.4	1.0	3.1	-0.6	-0.3	0.4	0.8	1.3	-1.8
Arm fat percentage (right)	0.4	1.6	4.2	0.5	1.7	-0.1	2.1	-1.2	-0.8
Asthma	0.4	0.9	1.9	0.3	0.5	1.2	-1.2	-0.1	1.4
Lung cancer (father)	0.4	0.4	0.8	-0.3	-0.7	0.7	0.5	0.9	-0.6
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	2.5	0.0	-0.1	0.2	0.3	-0.9	-1.6
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	3.2	0.1	-0.3	-0.5	1.8	0.8	-0.5
Birth weight	0.4	0.9	2.6	1.1	0.9	-1.6	-0.2	-0.3	-1.0
Forced vital capacity (FVC), Best measure	0.4	1.6	7.1	0.6	-0.6	-2.7	0.0	0.7	1.1
Comparative body size at age 10	0.4	1.2	3.0	1.7	1.2	-0.8	0.4	-1.2	-0.4
Shortness of breath walking on level ground	0.4	0.5	1.4	-0.6	0.7	-0.3	0.7	-1.2	-0.1
Angina (self-reported)	0.4	0.5	2.5	0.0	0.1	0.4	-0.6	-0.3	1.6
Medication: Seretide 50 evohaler	0.4	0.5	1.6	0.2	1.3	0.7	-0.2	-0.9	0.5
Whole body fat mass	0.4	1.9	3.6	0.5	0.8	-1.5	1.9	-0.9	-1.9
Leg fat mass (right)	0.4	1.5	2.3	0.5	1.0	-1.4	1.5	-1.3	-1.4
Had major operations	0.4	0.5	1.3	1.1	0.6	-0.6	0.1	0.5	-0.6
Family relationship satisfaction	0.4	0.4	1.1	0.4	-1.0	0.6	-0.7	0.6	0.4
Supplements: Vitamin C	0.4	0.4	0.8	0.6	0.1	-0.1	-0.8	-0.8	0.9
Arm fat percentage (left)	0.4	1.5	4.5	0.5	1.5	-0.1	2.1	-1.2	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.6	0.8	0.7	0.8	-0.7	-0.5	-0.1
Fractured/broken bones in last 5 years	0.4	0.5	1.4	0.6	0.4	1.2	-0.3	0.3	0.9
Alcohol drinker status: Previous	0.4	0.4	1.5	0.8	-0.0	-0.1	0.4	1.2	0.2
Neuroticism (Nagel 2018)	0.3	0.8	1.7	-0.5	-0.7	1.3	1.1	1.1	-0.2
Alzheimer’s Disease (including proxy)	0.3	0.4	1.4	1.2	0.7	0.5	0.1	-0.7	-0.0
Reaction Time	0.3	0.5	1.3	-0.1	-0.2	-0.4	1.1	0.7	1.0
Fasting Glucose	0.3	0.3	0.6	0.2	0.7	0.5	0.6	0.8	-0.4
Ulcerative Colitis	0.3	0.4	1.5	1.2	-0.6	0.4	0.1	0.4	-0.6
Blood Platelet Count	0.3	3.4	6.6	-0.7	-0.4	2.6	-0.7	2.6	2.4
Average weekly spirits intake	0.3	0.4	1.2	-0.3	0.3	0.6	-1.1	-0.8	-0.1
Diabetes (father)	0.3	0.4	1.4	-0.1	0.4	0.6	0.6	1.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.0	-0.1	-1.2	0.8	-1.4	-0.3	0.1
Qualifications: CSEs or equivalent	0.3	0.4	1.3	0.3	-0.1	0.5	0.9	1.1	-0.4
High blood pressure	0.3	1.0	4.8	0.1	-0.0	-0.2	-1.0	-0.2	-2.2
Stomach or abdominal pain in last month	0.3	0.4	1.0	-0.7	-1.0	-0.4	-0.3	0.6	-0.4
Sitting height	0.3	2.2	5.1	2.3	1.9	0.8	-1.1	1.4	0.6
Body mass index (BMI)	0.3	1.2	3.7	0.6	1.9	0.1	0.9	-1.6	0.1
Mouth/teeth dental problems	0.3	0.5	1.0	1.0	0.6	-0.7	0.8	0.7	0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.9	0.2	0.0	0.8	-0.7	-1.7	-0.6
Medication: Cholesterol lowering	0.3	0.5	1.3	-1.1	-0.4	0.6	-0.9	0.4	-0.1
Illnesses of mother	0.3	0.4	0.8	-0.3	-0.1	-0.8	0.0	0.8	0.9
Arm fat mass (right)	0.3	1.1	2.5	0.6	1.2	-0.9	1.6	-1.0	-0.8
Blood clot in the leg (DVT)	0.3	0.3	0.7	0.2	0.8	0.8	0.8	0.2	0.2
Gout (self-reported)	0.3	0.4	1.2	-0.0	1.1	-0.3	-1.1	-0.1	0.3
High blood pressure (siblings)	0.3	0.4	1.8	-0.3	0.2	0.1	-1.3	-0.4	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	0.3	0.0	1.0	-0.8	0.3	0.6
Number of children fathered	0.3	0.4	1.0	-0.5	-0.4	0.6	-1.0	0.0	0.8
Qualifications: College or University degree	0.3	0.9	2.8	0.5	0.2	-0.8	1.7	-0.9	-1.0
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.1	0.6	0.3	0.4	0.6	1.0	-0.1
Neck or shoulder pain in last month	0.3	0.5	0.9	-0.5	-0.4	0.7	-0.5	1.0	-0.8
Mean time to correctly identify matches	0.3	0.5	1.8	-0.7	-0.1	-1.3	0.6	-0.2	0.5
Comparative height size at age 10	0.3	1.8	7.1	0.2	-0.4	-1.9	0.2	2.7	-0.3
Knee pain experienced in last month	0.3	0.5	1.6	0.4	0.2	0.6	-0.8	-0.1	-1.3
Long-standing illness, disability or infirmity	0.3	0.5	1.5	0.2	0.1	1.2	-0.1	0.8	1.0
Eye problems/disorders: Cataract	0.3	0.3	0.9	0.0	0.4	0.2	0.9	-0.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.8	-0.2	-1.1	-1.4	-0.5	-0.6	0.4
Medication: Atorvastatin	0.3	0.4	1.3	0.5	0.2	0.5	0.2	0.7	-1.1
Commuting to job workplace: Cycle	0.3	0.3	0.9	-0.0	0.7	-0.1	-0.1	-0.8	-0.9
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.6	0.2	0.1	0.4	1.4	0.3	1.6
Pain experienced in last month	0.3	0.5	1.8	-0.5	0.0	-0.9	0.5	-1.3	0.3
Leg fat mass (left)	0.3	1.3	2.2	0.4	0.8	-1.5	1.2	-1.3	-1.3
Bipolar Disorder (2018)	0.2	0.3	0.5	-0.1	0.7	0.7	0.7	0.2	-0.5
Prostate Cancer	0.2	0.2	0.3	-0.5	-0.4	0.6	-0.3	-0.6	-0.4
Blood Red Count	0.2	1.5	3.4	0.1	0.2	-1.8	1.0	-1.2	-1.7
Blood White Count	0.2	1.3	2.9	-1.7	-1.4	1.4	0.4	0.9	0.1
BMI	0.2	1.2	4.3	0.6	2.1	0.7	0.5	-0.5	1.1
Smoking Status	0.2	0.5	0.8	0.4	0.9	0.8	-0.4	0.6	0.8
Cardiovascular Disease	0.2	0.5	1.9	0.3	0.7	-0.3	-0.7	0.4	-1.4
Hair Pigment	0.2	6.9	20.4	0.1	2.4	3.3	-2.1	-0.1	4.5
Ever had hysterectomy (womb removed)	0.2	0.3	0.8	-0.4	0.1	0.4	-0.4	-0.9	-0.6
Systolic blood pressure, automated reading	0.2	0.7	2.0	0.2	0.5	-0.7	-0.7	0.9	-1.4
Medication: Metformin	0.2	0.3	0.9	-0.9	-0.5	-0.2	-0.4	0.5	0.1
Had menopause	0.2	0.3	0.7	-0.7	0.1	-0.8	-0.4	0.5	-0.1
Weight	0.2	0.9	2.2	0.5	0.7	-1.5	1.0	-0.6	-1.0
Hip circumference	0.2	1.0	1.9	0.5	1.1	-1.4	0.9	-1.3	0.2
Worrier / anxious feelings	0.2	0.4	0.9	0.1	-0.5	0.7	0.5	-1.0	-0.8
Eye problems/disorders: None of the above	0.2	0.2	1.2	-0.4	0.1	1.1	-0.2	-0.0	0.3
Medication: Blood pressure	0.2	0.4	1.2	0.5	0.7	-0.5	-1.1	-0.6	0.1
Alcohol intake frequency.	0.2	0.4	0.8	-0.5	0.7	0.8	-0.3	0.3	0.9
Hypertension (Self-reported)	0.2	0.6	2.2	-0.5	-0.1	-0.2	-1.1	-0.4	-1.5
Smoking status: Previous	0.2	0.3	0.6	-0.4	-0.3	-0.4	-0.1	-0.8	-0.8
Arm fat mass (left)	0.2	1.0	2.2	0.6	1.1	-0.9	1.5	-1.0	-0.4
Number of self-reported non-cancer illnesses	0.2	0.4	0.9	-0.3	-0.8	0.3	-1.0	-0.4	-0.8
Risk taking	0.2	0.3	1.5	0.2	1.2	0.1	-0.0	0.2	0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.2	0.2	0.6	0.5	1.1	0.1	0.0
Worry (Nagel 2018)	0.1	0.3	0.6	-0.4	-0.6	0.6	0.6	-0.0	-0.8
Breast Cancer	0.1	0.2	0.3	0.3	0.5	-0.5	0.5	-0.4	0.6
Ovarian Cancer	0.1	0.2	0.5	0.2	-0.6	0.3	-0.1	0.3	-0.7
Systolic Blood Pressure	0.1	0.5	0.9	0.1	-0.8	-0.6	-0.9	0.8	-0.9
Tanning	0.1	0.7	2.0	-0.2	0.6	1.2	-1.4	0.1	0.5
Leg fat-free mass (left)	0.1	0.5	1.4	0.6	0.7	0.2	-0.7	-0.1	1.2
Age when periods started (menarche)	0.1	0.3	1.2	0.2	0.0	-0.1	-1.1	-0.7	0.5
Leg predicted mass (left)	0.1	0.4	1.3	0.6	0.7	0.3	-0.7	0.0	1.1
Waist circumference	0.1	0.5	1.1	-0.1	0.4	-0.8	0.4	-0.8	-1.0
Past tobacco smoking	0.1	0.1	0.3	0.5	0.1	0.2	0.4	0.4	-0.3
Medication: Ramipril	0.1	0.1	0.5	0.3	-0.1	-0.5	0.1	0.1	0.7
Time employed in main current job	0.1	0.1	0.3	-0.1	0.5	-0.1	0.2	-0.4	-0.5
Loud music exposure frequency	0.1	0.2	0.4	-0.1	0.1	-0.6	0.6	-0.4	-0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	-0.2	-0.2	-0.6	0.2	-0.4	0.4
Leg fat-free mass (right)	0.1	0.5	1.5	0.6	0.6	0.3	-0.8	0.3	1.2
Leg predicted mass (right)	0.1	0.5	1.4	0.6	0.6	0.3	-0.8	0.3	1.2
Hearing aid user	0.1	0.1	0.4	0.6	-0.3	0.2	-0.1	0.3	0.0
Financial situation satisfaction	0.1	0.2	0.6	0.1	-0.8	-0.4	0.3	-0.2	0.1
Ever smoked	0.1	0.2	0.7	-0.8	-0.3	0.1	-0.3	0.2	0.3
Arm fat-free mass (left)	0.1	0.4	2.0	0.3	0.3	-1.4	-0.3	-0.3	-0.1
Number of operations (self-reported)	0.1	0.1	0.6	-0.2	0.2	-0.2	-0.8	-0.0	0.2
Blood Eosinophil Count	0.0	0.2	0.5	0.4	0.2	-0.2	0.7	0.1	0.4
Trunk fat-free mass	0.0	0.2	0.5	0.1	0.2	-0.7	-0.5	-0.1	0.5
Trunk predicted mass	0.0	0.1	0.4	0.2	0.2	-0.6	-0.4	0.0	0.4
Arm fat-free mass (right)	0.0	0.3	1.0	0.1	0.1	-1.0	-0.5	-0.0	0.4
Arm predicted mass (right)	0.0	0.2	0.9	0.1	0.1	-0.9	-0.2	0.2	0.4
Whole body fat-free mass	0.0	0.2	0.5	0.2	0.3	-0.5	-0.6	-0.0	0.7
Whole body water mass	0.0	0.2	0.7	0.2	0.4	-0.3	-0.7	-0.0	0.8
Basal metabolic rate	0.0	0.1	0.3	0.3	0.4	-0.6	-0.2	-0.1	0.4
Arm predicted mass (left)	0.0	0.2	0.9	0.1	0.3	-0.9	-0.4	0.0	-0.0

Hub : Genes

ADAMTS5

Models

Trait associations