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Lung FEV1/FVC ratio
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chr21:34,589,270-36,786,042
Best TWAS P=1.58e-21 · Best GWAS P=7.58e-37 conditioned to 1.88e-34
34.5M
35M
35.5M
36M
36.5M
0
10
20
30
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Artery Tibial
MRPS6
0.10
0.04
enet
4
0.00
1.2e-01
-9.7
-9.5
1.6e-21
-0.02
0.11
0.08
TRUE
4
METSIM
Adipose
LINC00310
0.05
0.01
enet
19
0.03
8.4e-06
1.6
5.7
1.5e-08
-0.03
0.26
0.02
TRUE
2
GTEx
Esophagus Gastroesophageal Junction
CLIC6
0.24
0.25
lasso
3
0.24
3.4e-09
5.2
5.4
6.0e-08
-0.03
0.98
0.00
TRUE
3
GTEx
Skin Not Sun Exposed Suprapubic
LINC00649
0.14
0.01
enet
14
0.03
5.5e-03
-2.1
-5.3
9.0e-08
-0.34
0.13
0.36
TRUE