TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Lung FEV1/FVC ratio
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chr22:17,581,838-19,203,078
Best TWAS P=1.17e-26 · Best GWAS P=3.66e-27 conditioned to 0.000918
17.6M
17.8M
18M
18.2M
18.4M
18.6M
18.8M
19M
19.2M
0
5
10
15
20
25
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Thyroid
MICAL3
0.18
0.13
enet
18
0.13
6.5e-10
-10.7
-10.7
1.2e-26
0.84
0.00
1.00
TRUE
1
GTEx
Cells EBV-transformed lymphocytes
MICAL3
0.23
0.06
lasso
4
0.03
2.7e-02
9.3
-10.0
1.7e-23
0.63
0.05
0.66
FALSE
4
The Cancer Genome Atlas
Thyroid Carcinoma
MICAL3
0.10
0.09
enet
14
0.10
1.4e-09
-10.7
-9.9
2.8e-23
0.85
0.00
1.00
FALSE
3
The Cancer Genome Atlas
Kidney Renal Papillary Cell Carcinoma
MICAL3
0.10
0.06
enet
14
0.04
1.5e-03
9.5
-7.8
5.1e-15
0.48
0.35
0.15
FALSE