[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr21:39,849,553-41,512,399

Best TWAS P=1.54e-11 · Best GWAS P=3.64e-09 conditioned to 0.659

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
23	The Cancer Genome Atlas	Glioblastoma Multiforme	HMGN1	0.19	0.04	blup	43	0.08	2.1e-03	5.4	-6.7	1.5e-11	-0.84	0.01	0.86	TRUE
7	GTEx	Muscle Skeletal	BRWD1-IT2	0.06	0.02	lasso	4	0.01	1.7e-02	5.6	5.9	4.5e-09	0.61	0.03	0.94	FALSE
19	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HMGN1	0.07	0.12	lasso	5	0.09	6.2e-08	5.6	-5.8	6.0e-09	-0.60	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	WRB	0.08	0.08	lasso	4	0.08	6.1e-09	5.1	5.8	7.0e-09	0.85	0.03	0.97	FALSE
35	The Cancer Genome Atlas	Soft Tissue Sarcoma	WRB	0.10	0.13	blup	48	0.13	4.9e-08	4.9	5.8	7.0e-09	0.75	0.07	0.93	FALSE
12	GTEx	Whole Blood	WRB	0.22	0.12	lasso	7	0.11	3.0e-10	4.8	5.8	8.4e-09	0.86	0.07	0.93	FALSE
17	NTR	Blood	WRB	0.07	0.07	enet	13	0.08	5.9e-24	5.2	5.7	1.5e-08	0.77	0.07	0.93	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HMGN1	0.08	0.10	lasso	2	0.09	8.7e-11	5.6	-5.6	1.8e-08	-0.55	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HMGN1	0.06	0.05	blup	43	0.02	1.6e-02	5.6	-5.6	1.8e-08	-0.62	0.01	0.87	FALSE
37	The Cancer Genome Atlas	Stomach Adenocarcinoma	HMGN1	0.07	0.08	lasso	2	0.06	2.9e-05	5.6	-5.6	1.8e-08	-0.55	0.01	0.99	FALSE
14	METSIM	Adipose	HMGN1	0.11	0.13	lasso	5	0.11	9.7e-17	5.6	-5.6	2.6e-08	-0.54	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Skin Cutaneous Melanoma	WRB	0.12	0.06	blup	48	0.10	1.2e-03	2.5	5.6	2.8e-08	0.78	0.01	0.56	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	WRB	0.05	0.05	enet	12	0.05	9.1e-07	5.0	5.5	3.2e-08	0.72	0.15	0.85	FALSE
3	GTEx	Cells Transformed fibroblasts	WRB	0.43	0.46	enet	23	0.48	4.0e-40	5.0	5.5	4.7e-08	0.72	0.17	0.83	FALSE
11	GTEx	Testis	HMGN1	0.21	0.22	lasso	3	0.21	9.7e-10	5.6	-5.4	5.1e-08	-0.53	0.01	0.99	FALSE
18	YFS	Blood	WRB	0.20	0.29	enet	18	0.29	8.4e-95	5.1	5.4	5.1e-08	0.74	0.16	0.84	FALSE
24	The Cancer Genome Atlas	Glioblastoma Multiforme	WRB	0.15	0.10	blup	48	0.14	4.8e-05	5.0	5.4	5.9e-08	0.76	0.02	0.90	FALSE
29	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	WRB	0.11	0.12	enet	6	0.12	2.5e-07	5.1	5.4	6.7e-08	0.76	0.07	0.92	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	WRB	0.35	0.31	lasso	3	0.31	1.4e-17	5.0	5.4	6.9e-08	0.82	0.14	0.85	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	WRB	0.13	0.25	lasso	8	0.26	4.2e-25	5.1	5.4	7.6e-08	0.76	0.15	0.85	FALSE
13	GTEx	Whole Blood	PSMG1	0.12	0.00	lasso	1	0.00	3.9e-01	5.4	5.4	8.2e-08	0.83	0.01	0.97	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HMGN1	0.17	0.14	lasso	4	0.14	2.4e-15	5.6	-5.4	8.7e-08	-0.52	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	HMGN1	0.23	0.09	enet	8	0.18	9.6e-06	-4.0	-5.4	8.7e-08	-0.52	0.03	0.96	FALSE
4	GTEx	Cells Transformed fibroblasts	HMGN1	0.07	0.03	lasso	4	0.03	2.1e-03	5.6	-5.3	9.0e-08	-0.63	0.03	0.95	FALSE
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LCA5L	0.04	0.03	blup	53	0.04	2.0e-05	5.9	5.3	9.7e-08	0.76	0.00	1.00	FALSE
10	GTEx	Stomach	BRWD1-IT2	0.16	0.10	enet	13	0.07	3.4e-04	2.2	5.3	1.0e-07	0.54	0.05	0.77	FALSE
5	GTEx	Esophagus Muscularis	WRB	0.34	0.38	lasso	5	0.39	7.1e-25	5.0	5.3	1.1e-07	0.72	0.17	0.83	FALSE
6	GTEx	Heart Left Ventricle	LCA5L	0.27	0.22	lasso	6	0.24	3.4e-13	5.0	5.3	1.2e-07	0.72	0.12	0.88	FALSE
15	METSIM	Adipose	WRB	0.18	0.27	lasso	7	0.27	5.7e-40	5.2	5.3	1.2e-07	0.77	0.14	0.86	FALSE
32	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HMGN1	0.05	0.03	lasso	3	0.03	1.6e-04	4.7	-5.3	1.4e-07	-0.67	0.02	0.94	FALSE
2	GTEx	Brain Cerebellar Hemisphere	LCA5L	0.65	0.53	lasso	7	0.49	1.8e-14	5.0	5.2	1.6e-07	0.70	0.17	0.83	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	WRB	0.04	0.06	blup	48	0.06	7.3e-12	4.9	5.2	1.8e-07	0.73	0.20	0.80	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	HMGN1	0.15	0.21	lasso	4	0.20	9.9e-19	5.6	-5.2	1.8e-07	-0.51	0.01	0.99	FALSE
8	GTEx	Nerve Tibial	WRB	0.47	0.43	lasso	4	0.43	3.5e-33	5.0	5.2	2.1e-07	0.74	0.18	0.82	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	HMGN1	0.04	0.05	lasso	4	0.05	5.9e-10	5.6	-5.2	2.1e-07	-0.51	0.01	0.99	FALSE
1	GTEx	Artery Tibial	WRB	0.57	0.58	enet	19	0.59	4.8e-56	5.0	5.2	2.3e-07	0.69	0.18	0.82	FALSE
16	NTR	Blood	LCA5L	0.04	0.04	bslmm	718	0.03	4.5e-11	5.1	5.2	2.3e-07	0.72	0.15	0.85	FALSE
22	The Cancer Genome Atlas	Colon Adenocarcinoma	HMGN1	0.06	0.03	blup	43	0.05	1.3e-03	5.6	-5.2	2.3e-07	-0.61	0.01	0.87	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	WRB	0.17	0.32	enet	11	0.31	4.6e-36	5.0	5.1	2.8e-07	0.70	0.16	0.84	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	HMGN1	0.14	0.08	blup	43	0.08	3.9e-09	5.6	-5.1	3.0e-07	-0.48	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LCA5L	0.09	0.01	blup	53	0.02	6.1e-02	5.2	5.1	3.1e-07	0.64	0.02	0.36	FALSE