TWAS
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Models
Genes
Traits
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Traits
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Lung FEV1/FVC ratio
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chr22:19,262,852-20,330,744
Best TWAS P=1.63e-16 · Best GWAS P=2.69e-15 conditioned to 0.00319
19.2M
19.4M
19.6M
19.8M
20M
20.2M
0
5
10
15
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Brain Cortex
ZDHHC8
0.30
0.04
lasso
4
0.03
6.1e-02
6.1
8.2
1.6e-16
0.61
0.05
0.34
TRUE
3
GTEx
Cells Transformed fibroblasts
ARVCF
0.25
0.10
enet
23
0.16
4.3e-12
-4.7
-5.3
1.2e-07
-0.11
1.00
0.00
TRUE
1
GTEx
Brain Cerebellar Hemisphere
ZDHHC8
0.27
0.14
lasso
10
0.07
8.1e-03
7.3
7.5
4.7e-14
0.84
0.02
0.79
FALSE