Best TWAS P=8.58e-23 · Best GWAS P=7.27e-28 conditioned to 1.05e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | ZNF74 | 0.18 | 0.09 | lasso | 4 | 0.11 | 1.2e-07 | -3.76 | -5.5 | 4.2e-08 | 0.50 | 0.71 | 0.28 | FALSE |
| 2 | METSIM | Adipose | ZNF74 | 0.08 | 0.03 | enet | 20 | 0.06 | 4.9e-09 | -0.82 | -6.2 | 6.9e-10 | 0.31 | 0.70 | 0.12 | FALSE |
| 3 | YFS | Blood | MED15 | 0.14 | 0.09 | lasso | 10 | 0.14 | 2.5e-43 | -5.78 | 5.4 | 7.1e-08 | -0.47 | 1.00 | 0.00 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SCARF2 | 0.06 | 0.03 | enet | 11 | 0.03 | 7.6e-07 | -10.94 | 9.8 | 8.6e-23 | -0.86 | 0.00 | 1.00 | TRUE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZNF74 | 0.03 | 0.02 | lasso | 2 | 0.01 | 2.3e-02 | -6.86 | -6.6 | 3.4e-11 | 0.60 | 0.05 | 0.17 | FALSE |