TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Lung FEV1/FVC ratio
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chr22:20,732,809-21,465,050
Best TWAS P=8.58e-23 · Best GWAS P=7.27e-28 conditioned to 1.05e-06
20.7M
20.8M
20.9M
21M
21.1M
21.2M
21.3M
21.4M
21.5M
0
5
10
15
20
25
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Breast Invasive Carcinoma
SCARF2
0.06
0.03
enet
11
0.03
7.6e-07
-10.94
9.8
8.6e-23
-0.86
0.00
1.00
TRUE
5
The Cancer Genome Atlas
Head and Neck Squamous Cell Carcinoma
ZNF74
0.03
0.02
lasso
2
0.01
2.3e-02
-6.86
-6.6
3.4e-11
0.60
0.05
0.17
FALSE
2
METSIM
Adipose
ZNF74
0.08
0.03
enet
20
0.06
4.9e-09
-0.82
-6.2
6.9e-10
0.31
0.70
0.12
FALSE
1
GTEx
Esophagus Mucosa
ZNF74
0.18
0.09
lasso
4
0.11
1.2e-07
-3.76
-5.5
4.2e-08
0.50
0.71
0.28
FALSE
3
YFS
Blood
MED15
0.14
0.09
lasso
10
0.14
2.5e-43
-5.78
5.4
7.1e-08
-0.47
1.00
0.00
FALSE