[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr22:29,015,590-31,171,274

Best TWAS P=1.26e-29 · Best GWAS P=5.52e-29 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	ASCC2	0.04	0.00	blup	48	0.01	1.1e-02	-3.1	-11.3	1.3e-29	-0.50	0.01	0.56	TRUE
18	GTEx	Cells Transformed fibroblasts	NIPSNAP1	0.12	0.17	enet	11	0.13	3.1e-10	-7.7	8.9	6.6e-19	0.54	1.00	0.00	TRUE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NF2	0.02	0.01	blup	72	0.00	8.4e-02	-7.6	-8.7	3.7e-18	-0.54	0.08	0.22	TRUE
19	GTEx	Colon Sigmoid	NIPSNAP1	0.22	0.15	lasso	3	0.12	6.2e-05	-7.4	8.1	3.9e-16	0.41	0.17	0.24	TRUE
40	GTEx	Skin Sun Exposed Lower leg	NIPSNAP1	0.07	0.06	lasso	3	0.03	7.8e-04	6.0	7.0	2.6e-12	0.34	0.42	0.11	TRUE
30	GTEx	Nerve Tibial	ASCC2	0.17	0.07	lasso	6	0.08	2.6e-06	-3.2	-6.4	1.3e-10	-0.36	0.36	0.62	TRUE
62	The Cancer Genome Atlas	Soft Tissue Sarcoma	NIPSNAP1	0.11	0.06	enet	17	0.01	6.0e-02	-7.0	6.0	2.1e-09	0.27	0.01	0.91	TRUE
37	GTEx	Skin Not Sun Exposed Suprapubic	ZMAT5	0.10	0.00	lasso	4	0.00	5.0e-01	5.8	5.2	2.0e-07	0.73	0.07	0.44	TRUE
39	GTEx	Skin Sun Exposed Lower leg	UQCR10	0.07	0.10	lasso	8	0.09	5.5e-08	11.1	11.0	2.5e-28	0.83	0.01	0.99	FALSE
49	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ASCC2	0.07	0.07	enet	5	0.07	2.5e-04	11.1	-11.0	5.8e-28	-0.80	0.01	0.92	FALSE
14	GTEx	Breast Mammary Tissue (Female)	CTA-85E5.10	0.13	-0.01	lasso	4	-0.01	5.7e-01	11.1	-10.7	1.2e-26	-0.77	0.02	0.64	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	UQCR10	0.12	0.03	lasso	4	0.06	6.6e-03	11.1	-10.3	4.6e-25	-0.84	0.05	0.61	FALSE
3	GTEx	Adipose Subcutaneous	CTA-85E5.10	0.10	0.04	lasso	9	0.03	1.9e-03	9.0	-9.8	1.8e-22	-0.27	0.68	0.09	FALSE
17	GTEx	Cells Transformed fibroblasts	ASCC2	0.05	0.05	lasso	4	0.04	6.8e-04	-9.8	-9.4	6.7e-21	-0.79	0.06	0.88	FALSE
45	GTEx	Thyroid	ASCC2	0.11	0.04	lasso	6	0.05	6.4e-05	-6.4	-9.1	7.7e-20	-0.67	0.06	0.90	FALSE
13	GTEx	Breast Mammary Tissue	CTA-85E5.10	0.14	-0.01	enet	13	0.00	6.1e-01	-4.8	-8.2	2.3e-16	-0.50	0.04	0.71	FALSE
46	METSIM	Adipose	NIPSNAP1	0.02	0.01	enet	14	0.02	1.0e-03	-7.8	8.2	3.4e-16	0.47	0.15	0.32	FALSE
38	GTEx	Skin Sun Exposed Lower leg	ZMAT5	0.06	0.03	enet	15	0.02	4.4e-03	8.2	8.1	8.4e-16	0.83	0.03	0.95	FALSE
26	GTEx	Heart Left Ventricle	NIPSNAP1	0.09	0.06	enet	10	0.03	9.7e-03	-7.6	8.0	8.9e-16	0.44	0.60	0.12	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NIPSNAP1	0.16	0.15	enet	19	0.12	8.7e-15	-7.6	8.0	1.8e-15	0.41	1.00	0.00	FALSE
43	GTEx	Testis	MTMR3	0.27	0.17	enet	13	0.26	8.9e-12	-8.7	-7.9	2.7e-15	-0.70	0.97	0.03	FALSE
29	GTEx	Muscle Skeletal	MTMR3	0.07	0.04	lasso	3	0.03	5.5e-04	-4.3	-7.8	4.9e-15	-0.61	0.16	0.78	FALSE
5	GTEx	Artery Coronary	NIPSNAP1	0.26	0.23	lasso	3	0.24	8.7e-09	-7.8	7.8	7.1e-15	0.44	0.98	0.00	FALSE
47	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NIPSNAP1	0.04	0.02	blup	47	0.03	2.7e-03	-7.7	7.7	1.0e-14	0.39	0.01	0.86	FALSE
25	GTEx	Heart Atrial Appendage	NIPSNAP1	0.14	0.15	enet	8	0.10	2.3e-05	-7.8	7.7	1.4e-14	0.43	0.90	0.01	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	NIPSNAP1	0.05	0.05	blup	48	0.05	8.3e-06	-7.4	7.7	1.5e-14	0.41	0.01	0.98	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	NIPSNAP1	0.09	0.05	lasso	3	0.04	2.3e-05	-7.7	7.7	1.6e-14	0.42	0.01	0.99	FALSE
24	GTEx	Esophagus Muscularis	NIPSNAP1	0.15	0.16	enet	6	0.12	1.9e-07	-7.6	7.7	1.8e-14	0.44	1.00	0.00	FALSE
31	GTEx	Nerve Tibial	NIPSNAP1	0.12	0.10	lasso	7	0.07	1.3e-05	-7.6	7.6	2.1e-14	0.42	0.96	0.01	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	NIPSNAP1	0.04	0.06	lasso	4	0.06	8.4e-13	-7.6	7.6	3.7e-14	0.44	0.01	0.99	FALSE
4	GTEx	Artery Aorta	NIPSNAP1	0.16	0.09	enet	14	0.07	8.9e-05	-6.8	7.6	4.1e-14	0.38	0.94	0.00	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	ASCC2	0.04	0.02	enet	6	0.03	6.0e-04	6.6	-7.5	4.9e-14	-0.77	0.04	0.72	FALSE
64	The Cancer Genome Atlas	Testicular Germ Cell Tumors	NIPSNAP1	0.20	0.11	blup	47	0.09	3.2e-04	-7.7	7.5	8.3e-14	0.39	0.01	0.94	FALSE
56	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	NIPSNAP1	0.06	0.05	enet	9	0.06	8.6e-04	-6.8	7.4	9.8e-14	0.42	0.01	0.83	FALSE
63	The Cancer Genome Atlas	Stomach Adenocarcinoma	NIPSNAP1	0.05	0.04	blup	48	0.03	2.0e-03	-7.7	7.4	1.0e-13	0.43	0.01	0.97	FALSE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NIPSNAP1	0.03	0.02	lasso	1	0.02	5.2e-03	-7.4	7.4	1.6e-13	0.39	0.01	0.76	FALSE
34	GTEx	Prostate	MTMR3	0.62	0.29	lasso	14	0.24	9.3e-07	-4.3	-7.3	3.4e-13	-0.56	0.66	0.29	FALSE
44	GTEx	Testis	NIPSNAP1	0.14	0.21	lasso	3	0.19	6.2e-09	-7.0	-7.1	9.8e-13	-0.42	0.99	0.00	FALSE
28	GTEx	Lung	NIPSNAP1	0.23	0.00	enet	24	0.07	2.5e-06	-7.6	7.1	1.3e-12	0.35	0.66	0.03	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	GAS2L1	0.36	-0.01	enet	26	0.10	1.3e-03	0.5	-7.0	2.1e-12	-0.34	0.04	0.53	FALSE
58	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NIPSNAP1	0.05	0.07	blup	48	0.07	5.7e-08	-6.8	7.0	3.5e-12	0.44	0.01	0.99	FALSE
32	GTEx	Pancreas	NIPSNAP1	0.11	0.06	enet	16	0.06	1.2e-03	7.3	6.8	8.2e-12	0.44	0.38	0.11	FALSE
8	GTEx	Brain Cerebellum	CTA-85E5.10	0.13	0.09	lasso	4	0.02	1.1e-01	6.4	-6.8	1.3e-11	-0.82	0.11	0.13	FALSE
27	GTEx	Lung	MTMR3	0.15	0.07	lasso	5	0.11	1.7e-08	-6.4	-6.6	4.0e-11	-0.53	0.68	0.32	FALSE
50	The Cancer Genome Atlas	Esophageal Carcinoma	MTMR3	0.23	0.04	lasso	8	0.08	1.4e-03	-4.0	-6.6	4.3e-11	-0.67	0.03	0.76	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	NIPSNAP1	0.14	0.16	blup	48	0.18	4.6e-17	-7.7	6.5	5.6e-11	0.40	0.01	0.99	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	NIPSNAP1	0.20	0.00	enet	10	-0.01	6.7e-01	-7.6	6.5	5.9e-11	0.58	0.07	0.09	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	NIPSNAP1	0.07	0.07	enet	6	0.07	1.6e-08	-7.4	6.5	8.5e-11	0.42	0.02	0.98	FALSE
23	GTEx	Esophagus Mucosa	NIPSNAP1	0.19	0.04	enet	16	0.10	3.3e-07	2.7	6.4	1.4e-10	0.39	0.99	0.00	FALSE
35	GTEx	Prostate	CTA-85E5.10	0.24	0.00	lasso	4	0.02	1.2e-01	-4.1	-6.4	1.7e-10	-0.53	0.08	0.54	FALSE
2	GTEx	Adipose Subcutaneous	NIPSNAP1	0.07	0.06	enet	10	0.06	2.5e-05	-7.4	6.4	2.0e-10	0.43	0.31	0.24	FALSE
33	GTEx	Pituitary	NF2	0.25	0.01	lasso	7	0.08	4.4e-03	1.5	-6.3	3.3e-10	-0.33	0.08	0.12	FALSE
21	GTEx	Esophagus Mucosa	AP1B1	0.06	0.05	lasso	3	0.05	1.8e-04	-6.0	-6.2	4.1e-10	-0.12	0.54	0.15	FALSE
7	GTEx	Brain Caudate basal ganglia	CTA-85E5.10	0.35	0.06	lasso	9	0.03	6.1e-02	-3.7	-6.2	5.2e-10	-0.49	0.11	0.21	FALSE
41	GTEx	Testis	ZMAT5	0.09	0.08	lasso	2	0.05	2.3e-03	6.6	-6.1	1.4e-09	-0.75	0.05	0.78	FALSE
42	GTEx	Testis	ASCC2	0.28	0.30	lasso	2	0.36	4.0e-17	6.6	5.9	3.1e-09	0.75	1.00	0.00	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	NIPSNAP1	0.38	0.18	enet	30	0.26	4.4e-09	7.3	5.8	5.1e-09	0.32	0.89	0.02	FALSE
53	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NF2	0.05	0.00	blup	72	0.03	5.8e-03	4.9	-5.8	9.1e-09	-0.49	0.08	0.17	FALSE
22	GTEx	Esophagus Mucosa	MTMR3	0.20	0.19	enet	13	0.20	2.5e-13	-4.3	-5.5	3.0e-08	-0.49	1.00	0.00	FALSE
20	GTEx	Colon Transverse	MTMR3	0.33	0.29	enet	24	0.33	3.5e-16	-4.0	-5.5	4.7e-08	-0.51	1.00	0.00	FALSE
12	GTEx	Breast Mammary Tissue	MTMR3	0.33	0.26	lasso	6	0.29	2.0e-15	-4.3	-5.3	1.2e-07	-0.42	1.00	0.00	FALSE
6	GTEx	Artery Tibial	NIPSNAP1	0.20	0.16	enet	33	0.17	1.9e-13	-7.6	5.2	2.2e-07	0.31	1.00	0.00	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	NEFH	0.16	0.04	lasso	5	0.06	3.5e-04	-3.1	-5.2	2.2e-07	-0.28	0.42	0.05	FALSE
9	GTEx	Brain Frontal Cortex BA9	MTMR3	0.22	0.10	lasso	5	0.19	8.0e-06	-2.5	-5.2	2.6e-07	-0.47	0.12	0.28	FALSE
61	The Cancer Genome Atlas	Rectum Adenocarcinoma	MTMR3	0.22	0.11	enet	18	0.15	1.9e-04	-4.0	-5.1	3.0e-07	-0.55	0.04	0.63	FALSE