TWAS
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Usage
Models
Genes
Traits
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Traits
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Lung FEV1/FVC ratio
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chr3:24,520,283-26,396,178
Best TWAS P=2.67e-26 · Best GWAS P=6.44e-67 conditioned to 3.89e-48
24.5M
25M
25.5M
26M
26.5M
0
20
40
60
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
RARB
0.06
0.05
enet
14
0.04
1.7e-06
6.7
-10.6
2.7e-26
-0.24
0.94
0.03
TRUE
4
The Cancer Genome Atlas
Thyroid Carcinoma
TOP2B
0.03
0.02
blup
73
0.01
1.2e-02
5.1
-5.5
4.3e-08
0.02
0.06
0.82
TRUE
3
ROSMAP
Brain Pre-frontal Cortex
TOP2B
0.06
0.03
lasso
2
0.02
1.7e-03
6.7
-7.0
3.2e-12
-0.05
0.49
0.02
FALSE
1
GTEx
Cells Transformed fibroblasts
TOP2B
0.06
0.00
enet
11
0.00
3.3e-01
6.5
-6.3
3.8e-10
-0.03
0.33
0.04
FALSE