Best TWAS P=2.67e-26 · Best GWAS P=6.44e-67 conditioned to 3.89e-48
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | TOP2B | 0.06 | 0.00 | enet | 11 | 0.00 | 3.3e-01 | 6.5 | -6.3 | 3.8e-10 | -0.03 | 0.33 | 0.04 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | RARB | 0.06 | 0.05 | enet | 14 | 0.04 | 1.7e-06 | 6.7 | -10.6 | 2.7e-26 | -0.24 | 0.94 | 0.03 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | TOP2B | 0.06 | 0.03 | lasso | 2 | 0.02 | 1.7e-03 | 6.7 | -7.0 | 3.2e-12 | -0.05 | 0.49 | 0.02 | FALSE |
| 4 | The Cancer Genome Atlas | Thyroid Carcinoma | TOP2B | 0.03 | 0.02 | blup | 73 | 0.01 | 1.2e-02 | 5.1 | -5.5 | 4.3e-08 | 0.02 | 0.06 | 0.82 | TRUE |