TWAS hub - RARB

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.3230	0.0970	0.00045	-0.005	NA	0.089	NA	0.036	6.8e-01	NA	8.1e-05	NA	9.5e-03
2	ROSMAP	Brain Pre-frontal Cortex	0.0629	0.0234	0.00270	0.046	0.012	0.045	0.036	0.045	1.4e-06	0.00980	1.7e-06	1.8e-05	1.8e-06
3	TCGA	Prostate Adenocarcinoma	0.0659	0.0303	0.00500	0.030	0.036	0.046	NA	0.042	3.8e-04	0.00011	1.4e-05	NA	3.1e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Chronic bronchitis/emphysema (mother)	11.3	13.1	20.3	1.7	4.5	4.0
Lung FEV1/FVC ratio	9.2	46.4	112.4	-2.8	-10.6	-4.4
Pulse wave reflection index	6.3	7.8	10.8	-2.8	-2.2	-3.3
Fluid intelligence score	5.5	11.5	26.5	-2.2	-5.1	-1.8
Peak expiratory flow (PEF)	5.1	11.7	25.6	-2.5	-5.1	-1.9
Past tobacco smoking	4.8	8.9	15.5	-2.1	-3.9	-2.6
Ever smoked	4.8	8.5	13.0	1.7	3.6	3.1
Fasting Glucose	4.5	5.4	8.0	0.8	2.7	2.8
Supplements: Glucosamine	4.5	5.8	7.4	-1.6	-2.7	-2.7
Prospective memory result	4.5	5.5	8.0	-1.7	2.8	2.4
Smoking Status	4.1	9.7	19.5	1.6	4.4	2.7
Chronic bronchitis/emphysema (father)	4.1	4.8	6.5	1.3	2.5	2.5
Long-standing illness, disability or infirmity	4.0	6.2	15.8	0.3	4.0	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.0	8.5	19.5	-1.1	-4.4	-2.1
Smoking status: Previous	3.9	5.9	10.0	2.0	3.2	1.9
Shortness of breath walking on level ground	3.8	4.5	8.0	2.3	2.8	0.6
Health satisfaction	3.7	4.8	7.0	1.5	2.6	2.3
Financial situation satisfaction	3.5	4.3	7.5	1.4	2.7	1.8
Ever unenthusiastic/disinterested for a whole week	3.4	4.2	6.3	0.8	2.4	2.5
Mouth/teeth dental problems	3.4	5.3	8.8	1.2	-3.0	-2.3
Financial difficulties in last 2 years	3.2	4.3	5.8	1.6	2.1	2.4
Maternal smoking around birth	3.1	4.4	8.6	0.1	2.9	2.2
Birth weight of first child	3.1	5.7	6.2	-2.4	-2.5	-2.3
Overall health rating	3.1	6.6	17.1	0.8	4.1	1.4
Pain experienced in last month	3.1	5.1	8.9	-1.5	-3.0	-2.0
Wheeze or whistling in the chest in last year	3.0	5.4	12.7	0.7	3.6	1.7
Verbal and Numeric Reasoning (VNR)	2.8	6.8	18.5	-0.7	-4.3	-1.1
Trunk fat percentage	2.8	11.2	26.6	0.5	5.2	2.6
Average weekly beer plus cider intake	2.8	4.0	10.8	0.2	3.3	1.1
Arm fat percentage (right)	2.7	10.6	20.5	1.1	4.5	3.2
Age at first live birth	2.6	4.6	8.2	-0.2	-2.9	-2.3
Body fat percentage	2.5	9.9	23.0	0.8	4.8	2.5
Medication: Atorvastatin	2.5	3.0	5.1	1.1	1.7	2.3
Father’s age at death	2.4	3.2	3.5	-1.9	-1.8	-1.7
Forced expiratory volume in 1-second (FEV1)	2.4	8.2	15.2	-2.0	-3.9	-2.3
Ever depressed for a whole week	2.4	2.9	4.8	-0.6	2.2	1.9
HbA1C	2.3	2.6	7.3	-0.0	0.6	2.7
Blood Platelet Count	2.3	26.5	39.7	3.9	4.9	6.3
Average weekly fortified wine intake	2.3	2.7	6.5	-2.6	-1.3	0.1
Leg pain on walking	2.3	2.9	6.3	1.5	2.5	0.4
Average weekly spirits intake	2.2	2.8	5.2	-0.8	2.3	1.6
Friendships satisfaction	2.2	2.7	5.6	0.3	2.4	1.6
Supplements: Fish oil (including cod liver oil)	2.2	2.9	6.0	0.1	-1.7	-2.5
Vitamin and mineral supplements	2.1	2.9	7.3	-0.6	2.7	0.9
Arm fat percentage (left)	2.1	8.4	16.2	1.0	4.0	2.8
Diabetes (father)	2.0	2.4	5.6	-2.4	-1.3	-0.3
Qualifications: CSEs or equivalent	2.0	2.7	6.1	1.1	2.5	0.8
Trunk fat mass	2.0	8.4	20.5	0.4	4.5	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	3.0	-1.4	-1.7	-1.4
Medication: Gliclazide	2.0	2.2	6.6	-0.1	2.6	0.1
Ever taken oral contraceptive pill	2.0	2.2	4.7	1.1	2.2	0.9
Medication: Paracetamol	2.0	3.1	5.5	-0.6	-1.9	-2.3
Primary Biliary Cirrhosis	1.9	2.7	4.2	-2.0	0.2	-2.0
Noisy workplace	1.9	2.3	5.5	0.7	2.4	0.9
Length of working week for main job	1.9	2.1	5.4	0.4	0.8	2.3
Commuting to job workplace: Public transport	1.9	2.2	4.8	-0.9	1.0	2.2
Ever had prostate specific antigen (PSA) test	1.9	2.1	3.5	-0.8	-1.9	-1.5
Unable to work because of sickness or disability	1.9	2.5	3.8	-1.7	2.0	0.8
Waist circumference	1.8	6.4	11.4	1.6	3.4	2.3
Mother’s age at death	1.8	2.2	3.2	-1.8	-0.6	-1.8
Supplements: Calcium	1.8	2.0	5.3	2.3	-0.2	0.8
Body Mass Index (BMI) (2010)	1.7	2.3	6.4	-0.2	0.6	2.5
Neuroticism (2016)	1.7	2.5	3.8	1.9	2.0	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.5	12.1	-1.2	-3.5	-1.6
Arm fat mass (right)	1.7	6.8	13.1	0.9	3.6	2.5
Whole body fat mass	1.6	6.8	15.4	0.7	3.9	2.1
Leg fat percentage (left)	1.6	5.9	13.0	1.6	3.6	1.5
Myopia	1.6	2.3	5.8	0.1	-2.4	-1.1
LDL Cholesterol	1.5	2.4	4.1	1.3	2.0	1.2
Multivitamins +/- minerals	1.5	2.0	4.0	0.5	-2.0	-1.3
Emphysema/chronic bronchitis	1.5	1.7	3.7	-0.2	1.9	1.1
Chest pain or discomfort	1.5	2.1	5.5	2.4	0.6	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	4.7	-0.2	0.8	-2.2
Arm fat mass (left)	1.5	6.1	11.4	1.1	3.4	2.4
Townsend deprivation index at recruitment	1.4	2.0	5.7	0.2	2.4	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	3.1	0.7	1.8	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	6.6	-2.6	-1.8	-0.0
Had menopause	1.4	1.7	2.6	-1.6	-0.9	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	4.8	-2.1	-2.2	-0.5
Impedance of arm (right)	1.4	6.3	14.7	-0.1	3.8	2.0
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	3.9	1.6	2.0	0.6
Medication: Paracetamol	1.4	2.3	4.7	0.1	-2.2	-1.4
Leg fat percentage (right)	1.4	4.9	10.6	1.3	3.3	1.5
Number of children fathered	1.4	1.6	2.7	1.7	1.1	0.9
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	2.8	-1.4	-0.6	-1.7
Alzheimer’s Disease (in mother)	1.3	1.6	2.8	-0.5	1.3	-1.7
Waist Hip Ratio (WHR)	1.3	6.0	10.8	1.4	3.3	2.2
Alcohol intake versus 10 years previously	1.3	1.9	4.3	1.2	2.1	-0.3
Falls in the last year	1.3	1.7	3.9	-0.8	2.0	0.9
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.5	0.5	1.2	1.9
Supplements: Vitamin C	1.3	1.5	2.4	1.1	-1.6	-1.0
Qualifications: nursing, teaching	1.3	2.0	5.9	-0.4	-2.4	-0.0
Commuting to job workplace: Cycle	1.3	1.6	4.0	2.0	0.8	0.5
Major Depression (MDD)	1.2	1.5	3.4	1.0	-0.3	1.9
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	1.3	1.2	1.1	-1.1
Hair/balding pattern: Pattern 2	1.2	1.6	2.0	1.4	0.8	1.4
Loud music exposure frequency	1.2	1.4	4.0	2.0	-0.1	-0.2
Mouth/teeth dental problems: Loose teeth	1.2	1.4	3.7	-0.6	1.9	0.4
Mineral and other dietary supplements	1.2	1.6	3.3	0.1	1.3	1.8
Leg fat mass (left)	1.2	4.6	9.4	1.2	3.1	1.7
Ovarian Cancer	1.1	1.4	2.6	-0.1	-1.3	-1.6
Age at First Birth	1.1	1.7	3.6	1.2	-1.9	-0.1
Mean Putamen Volume	1.1	1.3	1.9	1.4	1.0	0.9
Respiratory disease	1.1	2.5	5.6	0.0	2.4	1.4
Serious illness, injury or assault to yourself	1.1	1.3	3.4	0.2	1.8	0.8
Had other major operations	1.1	1.4	2.2	-1.2	0.7	1.5
Headache pain in last month	1.1	1.9	5.3	2.3	-0.2	0.5
Heart disease (mother)	1.1	1.4	2.0	-0.9	-1.4	1.2
Leg fat mass (right)	1.1	4.2	8.2	1.1	2.9	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	1.5	0.9	1.2	1.2
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	2.1	-1.4	1.5	1.2
Risk taking	1.1	1.7	3.7	1.9	-1.1	-0.4
Intelligence (Savage-Jansen 2018)	1.0	3.1	7.7	0.4	-2.8	-1.3
Alzheimer’s Disease (including proxy)	1.0	1.4	2.3	-0.6	1.3	-1.5
Diabetes (mother)	1.0	1.2	2.6	0.5	1.6	0.9
Stomach or abdominal pain in last month	1.0	1.2	1.9	1.2	0.6	1.4
Medication: Levothyroxine sodium	1.0	1.8	2.9	-1.3	0.9	1.7
Qualifications: A levels/AS levels or equivalent	1.0	2.3	5.5	-0.3	-2.4	-1.1
Pulse wave Arterial Stiffness index	1.0	1.2	3.2	-0.6	-0.1	-1.8
Impedance of arm (left)	1.0	4.7	10.8	-0.2	3.3	1.8
Eye problems/disorders: None of the above	1.0	1.1	1.3	-0.9	-1.1	-1.1
Illnesses of siblings: Diabetes	1.0	1.2	1.8	-1.4	0.5	-1.3
Osteoarthritis (self-reported)	1.0	1.3	2.4	1.1	1.6	0.4
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.2	-1.3	0.2	-1.5
Depressed Affect (Nagel 2018)	0.9	1.8	2.9	1.7	1.6	-0.0
Coronary Artery Disease (CAD)	0.9	1.1	1.7	1.0	1.3	0.8
BMI	0.9	5.3	10.0	1.3	3.2	2.0
Sensitivity / hurt feelings	0.9	1.5	3.9	0.6	2.0	-0.5
Medication for hormone replacement therapy	0.9	1.0	1.9	0.9	0.5	1.4
Body mass index (BMI)	0.9	3.8	5.3	1.4	2.3	2.0
Alcohol usually taken with meals	0.9	1.5	3.4	0.7	0.7	1.9
Qualifications: None of the above	0.9	2.0	4.9	-0.2	2.2	1.0
Allergy	0.9	2.1	3.4	-1.4	-1.8	-1.0
Pulse rate	0.9	1.5	2.9	1.7	-0.3	1.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.0	0.5	1.4	0.9
Birth weight	0.9	1.9	5.3	0.6	-2.3	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	3.0	-1.7	-0.1	0.3
Pulse wave peak to peak time	0.9	1.1	3.0	0.5	0.1	1.7
Number of full sisters	0.9	1.0	1.7	-0.6	1.3	1.0
Knee pain experienced in last month	0.9	1.4	2.8	0.5	1.7	1.0
Bipolar Disorder (2018)	0.8	1.3	2.5	-1.6	0.8	0.9
Schizophrenia vs Biploar Disorder	0.8	1.0	3.0	0.0	0.0	-1.7
Worry (Nagel 2018)	0.8	1.8	2.6	1.3	-1.0	-1.6
Lung FVC	0.8	4.1	6.4	-0.7	-2.5	-2.4
Medication: Metformin	0.8	1.1	2.6	0.4	1.6	0.8
Current tobacco smoking	0.8	1.3	2.0	-0.4	1.4	1.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.4	1.2	0.8	1.1
Hip circumference	0.8	3.5	8.0	0.6	2.8	1.4
Asthma	0.8	1.7	2.9	0.4	1.7	1.4
Lung cancer (father)	0.8	0.9	2.6	-0.4	0.2	1.6
Hair/balding pattern: Pattern 4	0.8	1.8	3.6	-0.4	-1.3	-1.9
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.9	-1.0	0.0	2.0
Number of full brothers	0.8	0.9	2.6	0.3	1.6	-0.3
Medication: Seretide 50 evohaler	0.8	0.9	2.6	-0.1	1.6	0.3
Average weekly red wine intake	0.8	1.2	2.8	-0.5	-1.7	0.7
Smoking status: Current	0.8	1.2	1.9	-0.4	1.4	1.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.8	0.2	-0.1	1.7
Medication: Bendroflumethiazide	0.8	1.2	3.6	1.9	0.3	0.2
Basal cell carcinoma (self-reported)	0.8	0.9	1.8	1.3	0.1	1.0
Neuroticism (Nagel 2018)	0.7	1.6	3.0	1.7	1.2	-0.6
Breast Cancer	0.7	1.6	3.3	-1.8	-1.2	0.4
Hand grip strength (left)	0.7	1.8	2.3	-1.1	-1.4	-1.5
Supplements: Zinc	0.7	0.8	1.8	0.4	-1.3	-0.6
Taking other prescription medications	0.7	1.1	1.5	-1.2	0.5	1.2
Hearing difficulty/problems with background noise	0.7	1.1	3.0	1.7	0.4	-0.3
Weight	0.7	3.4	6.9	0.6	2.6	1.7
Worrier / anxious feelings	0.7	1.2	3.3	-0.4	-0.5	-1.8
Tense / ‘highly strung’	0.7	1.2	2.3	0.6	-1.5	-0.9
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.5	-0.5	-1.6	-0.8
Worry too long after embarrassment	0.7	1.2	3.2	0.6	1.8	-0.1
Back pain experienced in last month	0.7	1.0	1.5	1.2	1.1	0.3
Asthma (self-reported)	0.7	1.3	2.4	0.4	1.6	1.2
Wears glasses or contact lenses	0.7	0.8	1.7	-0.8	-1.3	-0.0
Eye problems/disorders: Glaucoma	0.7	0.8	1.4	1.2	-0.1	1.0
Medication: Lisinopril	0.7	0.9	1.5	1.2	0.6	1.0
Heart disease (siblings)	0.7	0.9	1.1	1.0	0.8	1.1
Depression (Nagel 2018)	0.6	1.0	2.0	0.6	0.8	1.4
Bipolar Disorder (2011)	0.6	0.6	1.4	-0.5	-0.2	1.2
Rheumatoid Arthritis	0.6	0.9	0.9	1.0	-0.8	1.0
Hypothyroidism (self reported)	0.6	1.3	3.8	-0.4	0.2	2.0
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.0	0.5	1.4	1.1
Neuroticism	0.6	1.3	2.9	1.7	1.0	-0.4
Relative age voice broke	0.6	0.9	1.7	-0.6	-1.3	-0.8
Age when periods started (menarche)	0.6	1.5	2.3	1.5	-1.4	-0.5
High blood pressure (mother)	0.6	0.8	2.3	0.4	-1.5	0.3
Medication: Ramipril	0.6	0.7	1.7	0.6	1.3	-0.1
Time employed in main current job	0.6	0.7	1.6	-0.7	-0.2	-1.2
Happiness	0.6	0.8	1.8	0.5	0.5	1.4
Mouth/teeth dental problems: Dentures	0.6	1.0	1.6	-1.2	1.3	0.3
Neck or shoulder pain in last month	0.6	0.9	1.3	-0.4	1.1	1.1
Medication: Allopurinol	0.6	0.8	2.0	-1.4	0.5	-0.4
Age at last live birth	0.6	0.8	1.5	0.5	-1.2	-0.8
Loneliness, isolation	0.6	0.9	1.2	1.1	0.9	0.8
Medication: Aspirin	0.6	0.8	1.9	0.6	-1.4	-0.3
Miserableness	0.6	1.0	1.3	0.8	1.1	1.1
Number of operations (self-reported)	0.6	0.9	1.4	0.4	1.1	1.2
Impedance of whole body	0.6	3.2	8.8	-0.1	3.0	0.8
Lupus	0.5	0.8	2.2	1.5	0.4	0.0
Height	0.5	8.7	19.5	-4.4	0.2	-2.6
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.1	0.4	1.1	1.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.6	-1.3	0.2	0.6
Ever used hormone-replacement therapy (HRT)	0.5	0.6	0.9	-0.7	-0.9	-0.6
Medication: Atenolol	0.5	0.6	0.9	0.8	-1.0	-0.3
Hair/balding pattern: Pattern 3	0.5	0.8	1.3	-1.2	-0.9	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.0	1.0	0.3	0.8
Depression (self-reported)	0.5	0.6	1.2	-0.6	0.5	1.1
Illnesses of mother	0.5	0.7	1.3	0.6	-0.5	-1.2
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.7	-0.1	1.3	-0.6
High blood pressure (siblings)	0.5	0.7	1.2	-1.1	-0.9	-0.4
Qualifications: College or University degree	0.5	1.5	4.5	0.2	-2.1	0.1
Comparative height size at age 10	0.5	2.9	7.5	-2.7	0.8	-0.7
Illnesses of father: Heart disease	0.5	0.6	1.3	-1.1	-0.8	-0.1
Osteoporosis (self-reported)	0.5	0.6	1.4	0.6	-1.2	-0.1
Age started oral contraceptive pill	0.5	0.6	1.4	-0.5	-1.2	-0.4
Cholesterol lowering medication	0.5	0.7	1.4	-1.2	-0.7	0.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.9	-0.1	1.4	0.1
Crohns Disease (2012)	0.4	0.6	1.6	0.1	0.4	1.3
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.3	-1.2	-0.3	-0.2
Ulcerative Colitis	0.4	0.6	0.9	-0.5	0.9	-0.7
Blood Eosinophil Count	0.4	2.8	5.7	-2.4	-1.2	-1.1
Medication: Co-codamol	0.4	0.5	0.9	0.3	-1.0	0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.2	0.2	-0.4	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.8	0.3	0.4	1.3
Forced vital capacity (FVC)	0.4	1.5	2.1	-1.1	-1.4	-1.1
Pain all over the body in last month	0.4	0.4	1.1	-0.1	1.0	-0.4
Neuroticism score	0.4	0.7	1.5	0.9	1.2	0.0
Number of live births	0.4	0.5	0.8	-0.4	0.8	-0.9
Breastfed as a baby	0.4	0.5	1.4	0.2	-0.1	1.2
Exposure to tobacco smoke outside home	0.4	0.5	0.9	-1.0	-0.6	0.5
Medication for pain relief, constipation, heartburn	0.4	0.7	1.0	-1.0	0.8	0.8
Medication: Omeprazole	0.4	0.5	1.0	0.6	1.0	-0.0
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.7	0.3	-0.8	-0.8
Medication: Aspirin	0.4	0.5	0.8	0.9	-0.8	-0.0
Ever had bowel cancer screening	0.4	0.4	1.2	-0.0	-0.2	-1.1
Diabetes diagnosed by doctor	0.4	0.6	1.1	-1.0	0.8	0.3
Schizophrenia (2018)	0.3	0.6	1.5	0.0	-0.5	-1.2
Ulcerative Colitis (UC)	0.3	0.6	1.2	-0.8	0.0	-1.1
Reaction Time	0.3	0.6	0.9	-1.0	0.7	0.5
Blood White Count	0.3	2.6	6.1	-0.9	2.5	0.9
Heel T-Score	0.3	2.7	3.2	-1.8	-1.6	1.5
Hearing difficulty/problems: Yes	0.3	0.5	1.1	0.3	-0.5	-1.0
Ever had hysterectomy (womb removed)	0.3	0.4	1.1	1.1	0.1	-0.0
Angina	0.3	0.4	0.9	0.5	0.9	0.5
Severe depression (siblings)	0.3	0.3	0.7	0.5	0.8	0.1
Pack years adult smoking proportion	0.3	0.4	1.1	1.1	0.3	0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.5	0.6	-0.5	0.7
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.0	1.4	0.3	0.0
Impedance of leg (left)	0.3	1.2	3.4	0.2	1.9	-0.4
Nervous feelings	0.3	0.6	1.1	0.8	-0.0	-1.1
Heart attack	0.3	0.4	0.9	-0.5	-0.4	-0.9
Medication: Simvastatin	0.3	0.5	0.9	-1.0	0.1	-0.7
Medication: Cholesterol lowering	0.3	0.5	0.7	0.8	0.7	0.6
Glaucoma (self-reported)	0.3	0.4	0.8	0.6	0.1	0.9
Gout (self-reported)	0.3	0.5	1.1	-0.5	1.0	-0.2
Medication: Blood pressure	0.3	0.5	1.2	1.1	-0.4	-0.4
Angina (self-reported)	0.3	0.4	0.9	0.3	1.0	0.3
Migraine (self-reported)	0.3	0.3	0.6	-0.5	0.2	0.8
Mean time to correctly identify matches	0.3	0.6	1.6	-1.3	0.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.6	-0.2	-1.2	-0.5
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.3	-0.5	-0.6	0.6
Commuting to job workplace: Walk	0.3	0.4	0.7	-0.8	-0.6	0.0
Guilty feelings	0.3	0.4	0.6	-0.3	0.8	0.7
Hearing aid user	0.3	0.3	0.5	-0.2	0.7	0.6
Irritability	0.3	0.5	0.9	-0.8	-1.0	0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.8	-0.3	-0.4	-0.9
Alcohol drinker status: Previous	0.3	0.3	1.0	1.0	0.0	-0.1
Bipolar Disorder or Schizophrenia	0.2	0.4	1.1	-1.0	0.1	-0.5
Prostate Cancer	0.2	0.3	0.4	-0.4	0.5	0.6
Allergy or Eczema	0.2	0.4	0.7	0.8	-0.6	-0.5
Chronotype (morning person)	0.2	0.5	0.8	0.0	-0.9	-0.9
Systolic blood pressure, automated reading	0.2	0.5	1.2	-0.5	-0.2	-1.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.3	-0.2	0.6
Leg fat-free mass (left)	0.2	1.3	2.5	0.0	1.2	1.6
Fed-up feelings	0.2	0.3	0.9	0.3	1.0	-0.2
Leg predicted mass (left)	0.2	1.3	2.3	0.1	1.2	1.5
Number of incorrect matches in round	0.2	0.4	0.9	-1.0	-0.4	-0.2
Diabetes (self-reported)	0.2	0.4	0.5	-0.6	0.7	0.4
Illnesses of siblings	0.2	0.3	0.7	0.5	0.1	0.9
Medication: Lansoprazole	0.2	0.3	0.6	0.4	0.0	-0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	-0.9	0.2	0.0
Forced vital capacity (FVC), Best measure	0.2	0.7	0.7	-0.8	-0.8	-0.8
Comparative body size at age 10	0.2	0.4	1.2	-0.2	0.0	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	-0.0	-0.4	0.6
Alcohol intake frequency.	0.2	0.5	1.2	1.1	0.6	0.1
Had major operations	0.2	0.2	0.4	0.2	-0.7	-0.3
Hypertension (Self-reported)	0.2	0.5	0.8	0.9	-0.9	-0.3
Leg fat-free mass (right)	0.2	1.3	2.2	0.3	1.2	1.5
Eye problems/disorders: Cataract	0.2	0.2	0.5	-0.3	-0.1	0.7
Medication for cholesterol	0.2	0.3	0.7	0.3	0.8	-0.1
Breast cancer (self-reported)	0.2	0.3	0.6	-0.8	0.4	0.3
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	0.7	-0.2	-0.4
Leg predicted mass (right)	0.2	1.2	2.2	0.2	1.2	1.5
Illnesses of father: High blood pressure	0.2	0.3	0.7	-0.1	-0.9	0.3
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.6	-0.7	0.7	0.5
Pack years of smoking	0.2	0.3	0.9	0.9	0.3	-0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.0	-0.1	0.4
Crohns Disease (2017)	0.1	0.1	0.3	-0.2	-0.2	-0.6
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	-0.5	-0.0	-0.9
HDL Cholesterol	0.1	0.2	0.6	0.8	-0.0	-0.1
Schizophrenia (2014)	0.1	0.3	0.8	0.2	-0.3	-0.9
Triglycerides	0.1	0.1	0.2	-0.4	-0.1	-0.3
Blood Red Count	0.1	1.4	3.3	1.8	0.9	0.2
Systolic Blood Pressure	0.1	0.6	1.3	-1.1	-0.6	-0.2
Cardiovascular Disease	0.1	0.2	0.6	-0.2	-0.8	-0.2
Number of treatments/medications taken	0.1	0.3	0.6	0.4	-0.8	-0.2
Relative age of first facial hair	0.1	0.1	0.3	0.3	0.1	0.5
Impedance of leg (right)	0.1	0.6	1.5	-0.4	1.2	-0.4
Hand grip strength (right)	0.1	0.2	0.5	-0.1	0.7	0.1
High blood pressure	0.1	0.3	0.7	0.6	-0.8	-0.2
Standing height	0.1	1.3	2.0	-1.4	1.3	-0.5
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.5	-0.0	0.2
Blood clot in the leg (DVT)	0.1	0.1	0.4	-0.6	0.3	0.0
Medication: Ibuprofen	0.1	0.1	0.2	0.3	-0.1	-0.4
Pulse rate, automated reading	0.1	0.2	0.2	0.4	0.5	0.4
Suffer from ‘nerves’	0.1	0.2	0.3	0.5	0.6	0.1
Family relationship satisfaction	0.1	0.1	0.3	0.2	0.5	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.2	0.5	-0.0
Average weekly champagne plus white wine intake	0.1	0.1	0.3	-0.0	-0.5	-0.2
High cholesterol (Self-reported)	0.1	0.2	0.4	0.0	0.4	0.6
Alcohol drinker status: Never	0.1	0.1	0.1	0.4	-0.4	0.3
Basal metabolic rate	0.1	0.6	1.0	0.1	1.0	0.8
Fractured/broken bones in last 5 years	0.1	0.2	0.3	0.5	-0.3	0.2
Arm predicted mass (left)	0.1	0.3	0.7	0.1	0.9	0.3
Hair Pigment	0.0	0.3	0.4	-0.6	-0.5	-0.5
Tanning	0.0	0.5	1.3	-1.1	-0.5	-0.3
Sitting height	0.0	0.2	0.3	-0.6	-0.3	-0.5
Trunk fat-free mass	0.0	0.2	0.3	-0.3	-0.3	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	-0.2	-0.3	-0.1
Trunk predicted mass	0.0	0.1	0.2	-0.2	-0.1	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.2	-0.0	0.4	0.2
Medication: Amlodipine	0.0	0.0	0.0	-0.1	0.1	0.0
Arm fat-free mass (right)	0.0	0.2	0.2	-0.4	-0.2	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.0	-0.0	-0.3
Arm predicted mass (right)	0.0	0.1	0.1	-0.2	-0.2	-0.3
Whole body fat-free mass	0.0	0.1	0.2	-0.1	0.4	0.4
Mood swings	0.0	0.1	0.3	-0.1	0.5	0.0
Whole body water mass	0.0	0.1	0.2	-0.2	0.4	0.4
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	-0.3	-0.1	0.2
Medication: Blood pressure	0.0	0.1	0.1	-0.2	-0.3	0.1
Arm fat-free mass (left)	0.0	0.2	0.6	-0.1	0.8	0.3
Diastolic blood pressure, automated reading	0.0	0.1	0.3	0.1	-0.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.0	0.1	0.2	-0.4	-0.1	0.1

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