TWAS hub - TOP2B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0730	0.0270	0.00036	0.008	0.025	0.036	0.028	0.014	3.5e-02	0.00045	2.7e-05	0.00023	6.7e-03
2	GTEx	Cells EBV-transformed lymphocytes	0.3590	0.0950	0.00044	0.196	NA	0.143	NA	0.192	5.6e-07	NA	2.2e-05	NA	7.4e-07
3	GTEx	Cells Transformed fibroblasts	0.0570	0.0260	0.00920	0.000	NA	0.000	NA	-0.003	3.0e-01	NA	3.3e-01	NA	6.1e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.0649	0.0265	0.00160	0.025	0.016	0.007	0.017	0.018	2.9e-04	0.00320	3.5e-02	0.00260	1.7e-03
5	TCGA	Pheochromocytoma and Paraganglioma	0.4100	0.0970	0.00011	0.074	0.081	0.065	NA	0.089	7.3e-04	0.00041	1.4e-03	NA	2.2e-04
6	TCGA	Thyroid Carcinoma	0.0290	0.0140	0.00150	0.016	0.015	0.011	NA	0.012	9.5e-03	0.01200	2.8e-02	NA	2.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Chronic bronchitis/emphysema (mother)	8.5	9.9	17.2	3.1	0.1	4.2	3.8	2.0	3.8
Past tobacco smoking	6.0	11.1	23.1	-2.5	-0.1	-4.8	-4.6	0.2	-4.0
Ever smoked	5.9	10.3	21.1	2.3	0.4	4.6	4.5	1.3	3.7
Smoking Status	5.7	13.6	31.7	3.2	0.5	5.6	4.7	-1.2	4.0
Smoking status: Previous	5.1	7.7	14.7	2.5	0.5	3.8	3.6	-1.3	3.2
Financial situation satisfaction	5.1	6.3	13.5	1.4	-0.2	3.3	2.7	1.9	3.7
Long-standing illness, disability or infirmity	4.9	7.4	17.7	2.2	1.4	3.4	4.2	0.2	2.9
Lung FEV1/FVC ratio	4.5	22.9	48.6	-2.7	-3.1	-6.3	-7.0	-1.8	-5.5
Chronic bronchitis/emphysema (father)	4.1	4.8	9.4	1.5	-0.6	3.1	2.6	-1.4	2.9
Peak expiratory flow (PEF)	4.1	9.5	19.0	-2.1	0.0	-4.4	-3.7	-1.7	-4.2
Maternal smoking around birth	4.0	5.9	10.4	2.8	0.5	3.2	3.0	0.5	2.7
Fluid intelligence score	4.0	8.3	18.3	-0.8	1.2	-4.2	-4.3	-0.1	-3.5
Mouth/teeth dental problems	3.9	6.0	11.7	-0.6	-0.6	-3.4	-3.4	1.0	-3.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.8	8.0	16.4	-1.9	-0.7	-4.0	-3.6	0.3	-3.8
Noisy workplace	3.5	4.3	10.0	-0.4	-2.1	2.8	1.9	0.5	3.2
Ever had prostate specific antigen (PSA) test	3.5	4.0	6.6	-0.9	-1.2	-2.4	-2.2	-2.1	-2.6
Supplements: Glucosamine	3.4	4.5	10.4	-0.2	0.5	-3.2	-2.4	-0.6	-3.2
Financial difficulties in last 2 years	3.4	4.6	6.9	2.0	0.0	2.6	2.5	2.0	2.6
Pulse wave reflection index	3.4	4.2	6.2	-1.7	-2.2	-2.5	-1.5	-2.5	-1.6
Average weekly beer plus cider intake	3.3	4.8	10.8	1.6	0.9	3.3	3.1	-0.2	2.3
Wheeze or whistling in the chest in last year	3.2	5.7	12.0	1.0	-0.2	3.2	3.3	-0.0	3.5
Pain experienced in last month	3.1	5.2	11.7	-1.2	-0.9	-2.6	-3.4	0.8	-3.1
Overall health rating	3.0	6.5	12.9	-0.0	-0.8	3.6	3.6	-0.7	3.4
Verbal and Numeric Reasoning (VNR)	2.8	6.7	15.9	-1.0	0.6	-3.5	-4.0	0.5	-3.2
Shortness of breath walking on level ground	2.8	3.3	7.9	0.9	-0.3	2.2	2.5	-0.0	2.8
Pulse wave Arterial Stiffness index	2.7	3.2	9.6	-1.5	-2.6	-0.4	-0.2	-3.1	0.4
Pulse wave peak to peak time	2.6	3.0	9.6	1.4	2.5	0.6	0.2	3.1	-0.2
Age started oral contraceptive pill	2.5	3.1	4.3	-1.6	-2.1	-1.8	-1.9	-1.8	-1.4
Average weekly spirits intake	2.4	2.9	5.6	0.7	-1.2	2.0	2.3	-0.9	2.4
Age at first live birth	2.4	4.3	13.3	0.2	0.2	-2.7	-2.2	-0.6	-3.6
Diabetes (father)	2.2	2.7	4.5	-2.1	-1.1	-1.5	-2.0	1.0	-1.8
Birth weight of first child	2.2	3.9	7.6	-2.0	-0.9	-2.8	-2.5	0.1	-2.2
Bilateral oophorectomy (both ovaries removed)	2.1	2.4	7.2	1.3	2.7	-0.5	0.0	1.2	-1.9
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	6.2	1.3	0.5	1.8	1.4	-0.6	2.5
Serious illness, injury or assault to yourself	2.1	2.6	3.7	1.4	1.1	1.9	1.7	1.6	1.8
Heart attack	2.1	2.6	5.7	-2.4	-2.3	-1.2	-1.3	1.1	-0.6
Father’s age at death	2.1	2.8	6.3	-0.6	-0.4	-2.2	-2.5	-1.0	-2.0
Number of children fathered	2.1	2.3	4.5	0.0	-1.7	1.3	1.5	-2.1	1.7
Vitamin and mineral supplements	2.0	2.8	9.3	-0.7	0.7	1.4	1.5	3.1	1.4
Had other major operations	2.0	2.5	6.2	2.5	2.0	0.8	1.9	0.5	0.6
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.5	8.4	-1.8	0.1	-2.7	-2.8	-0.0	-2.9
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	5.4	0.4	0.6	1.7	2.3	0.8	2.3
Friendships satisfaction	2.0	2.5	6.6	-0.0	1.2	1.8	2.6	1.2	1.5
Heart attack/myocardial infarction (self-reported)	2.0	2.5	5.9	-2.4	-2.2	-1.3	-1.3	0.9	-0.7
Fasting Glucose	1.9	2.2	4.0	-0.2	1.4	1.7	2.0	1.5	1.5
LDL Cholesterol	1.9	2.9	4.6	1.9	0.5	2.1	2.0	1.1	2.0
Supplements: Vitamin C	1.9	2.3	6.9	2.6	-0.3	-0.8	-0.6	-1.9	-1.5
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	9.2	0.3	3.0	1.5	1.2	0.0	0.9
Emphysema/chronic bronchitis	1.8	2.1	3.5	-1.5	-0.9	1.8	1.5	-0.5	1.9
Medication: Omeprazole	1.8	2.2	3.5	1.5	1.9	0.9	1.7	-1.8	0.7
Leg pain on walking	1.8	2.2	4.3	1.9	0.2	1.5	1.4	0.8	2.1
Illnesses of siblings: Diabetes	1.8	2.2	6.5	-2.0	-2.5	-0.5	-0.7	-1.4	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	4.6	-1.4	-1.2	-1.5	-1.2	-2.1	-1.0
Schizophrenia (2018)	1.7	3.5	9.9	-3.1	-2.5	-0.7	-1.7	-1.2	-0.3
Frequency of depressed mood in last 2 weeks	1.7	2.4	6.9	1.6	2.6	1.0	1.7	0.8	0.5
Hearing difficulty/problems: Yes	1.7	2.6	5.3	-2.3	-2.3	-0.9	-0.6	-2.0	0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.7	6.9	-1.8	-0.3	-2.5	-2.5	0.2	-2.6
Hearing difficulty/problems with background noise	1.7	2.7	8.1	-1.6	-2.1	-0.3	0.8	-2.8	0.7
Forced expiratory volume in 1-second (FEV1)	1.7	5.7	9.9	-2.3	0.3	-3.1	-3.0	0.4	-3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	3.2	1.1	0.3	1.8	1.5	-1.5	1.7
Supplements: Fish oil (including cod liver oil)	1.7	2.2	6.7	-0.0	-2.2	-0.6	-1.2	-2.6	-0.4
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	3.5	0.9	1.8	1.0	1.9	-1.6	1.2
Blood Platelet Count	1.6	18.7	42.1	2.7	0.5	6.5	4.7	0.9	6.3
Sensitivity / hurt feelings	1.6	2.7	6.5	1.8	0.5	1.9	2.5	0.2	1.6
Medication: Co-codamol	1.6	1.9	5.0	-1.4	-0.7	-1.2	-1.2	-2.2	-0.9
Trunk fat percentage	1.6	6.4	13.2	0.0	1.1	3.5	3.3	0.9	3.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	3.9	1.3	1.5	2.0	1.8	1.0	0.7
Hair/balding pattern: Pattern 2	1.6	2.0	4.6	-1.4	-1.2	0.8	1.4	2.1	1.1
Had menopause	1.6	2.0	4.0	-0.6	-1.7	-2.0	-1.1	-0.8	-1.6
Health satisfaction	1.6	2.1	4.3	0.7	0.1	1.7	2.1	1.4	1.7
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	6.7	1.1	-0.1	2.0	1.8	-0.5	2.6
Number of operations (self-reported)	1.6	2.4	6.2	1.9	2.5	0.9	1.8	0.2	0.6
Ever depressed for a whole week	1.6	1.9	4.0	1.1	0.8	1.2	2.0	1.3	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	4.8	0.3	-0.4	2.0	2.2	0.8	2.1
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.5	1.9	0.9	1.8	1.4	0.1	1.2
Body fat percentage	1.5	6.0	12.9	0.3	1.1	3.3	3.2	0.7	3.6
Medication: Paracetamol	1.5	2.4	5.3	-1.1	-2.3	-1.3	-1.5	-1.6	-1.2
Schizophrenia (2014)	1.4	3.0	11.6	-3.4	-2.3	-0.5	-0.9	-0.1	-0.2
Waist Hip Ratio (WHR)	1.4	6.3	15.2	-0.6	-0.2	3.5	2.8	-1.6	3.9
Supplements: Zinc	1.4	1.5	3.5	0.3	-1.7	-0.9	-1.2	-1.9	-0.6
Current tobacco smoking	1.4	2.2	5.9	0.8	-1.1	2.4	1.7	0.1	1.6
Trunk fat mass	1.4	5.9	12.7	-0.1	0.8	3.5	3.0	0.8	3.6
Arm fat percentage (right)	1.4	5.7	11.1	0.6	1.2	3.2	3.2	0.8	3.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.4	7.2	-2.0	0.3	-2.6	-2.7	1.1	-2.7
Medication: Paracetamol	1.4	2.3	3.5	-1.4	-1.9	-1.2	-1.5	-1.8	-1.0
Knee pain experienced in last month	1.4	2.2	4.5	-1.0	-0.4	2.0	2.1	-0.2	1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.4	5.8	2.4	0.5	1.4	0.6	0.4	0.1
Depression (Nagel 2018)	1.3	1.9	5.7	0.9	2.4	1.0	1.9	0.2	0.3
Ovarian Cancer	1.3	1.7	3.5	-1.7	-1.9	-1.6	-1.2	-0.0	-0.4
Prostate Cancer	1.3	1.8	9.6	-0.3	0.9	-0.2	-0.3	3.1	-0.0
Relative age voice broke	1.3	2.0	3.1	-1.5	-1.4	-1.8	-1.0	-1.5	-1.3
Multivitamins +/- minerals	1.3	1.6	6.1	0.4	-0.8	-1.0	-1.0	-2.5	-0.8
Mouth/teeth dental problems: Dentures	1.3	2.3	4.0	0.5	-2.0	1.6	1.6	-1.4	1.5
Mouth/teeth dental problems: Loose teeth	1.3	1.6	3.6	-1.4	-1.1	0.8	1.9	0.3	1.4
Medication for pain relief, constipation, heartburn	1.3	2.2	12.0	-0.8	0.1	-0.3	0.5	3.5	-0.4
Mineral and other dietary supplements	1.3	1.7	3.0	-0.3	1.5	1.3	1.3	1.7	1.2
Smoking status: Current	1.3	2.0	5.2	0.5	-1.4	2.3	1.6	-0.0	1.4
Myopia	1.3	1.8	3.9	-0.7	-0.4	-1.7	-2.0	-0.8	-1.7
Alzheimer’s Disease (in mother)	1.2	1.4	3.4	-1.8	-1.2	-0.5	0.3	-1.8	0.2
Lung FVC	1.2	6.2	11.9	-1.7	-1.1	-3.4	-3.0	1.3	-3.2
Townsend deprivation index at recruitment	1.2	1.7	3.7	1.0	0.1	1.9	1.0	1.2	1.7
Waist circumference	1.2	4.4	9.1	0.4	0.9	3.0	2.7	0.5	3.0
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	5.3	2.3	1.9	0.1	-0.1	-0.7	-0.2
Prospective memory result	1.2	1.5	3.9	0.0	-0.8	2.0	1.6	0.5	1.3
Breastfed as a baby	1.2	1.5	4.9	2.2	1.8	0.3	0.7	0.0	0.6
Tense / ‘highly strung’	1.2	2.0	4.3	1.3	2.1	-1.4	-0.8	0.8	-1.8
Hair/balding pattern: Pattern 4	1.2	2.9	5.8	-1.0	-2.4	-1.5	-2.4	-1.0	-1.2
Neck or shoulder pain in last month	1.2	1.7	4.6	2.1	1.3	1.2	1.5	-0.0	0.7
Medication: Ibuprofen	1.2	1.4	4.7	2.2	1.8	0.2	-0.0	-0.6	0.1
Whole body fat mass	1.2	5.0	10.6	0.1	1.1	3.1	2.8	0.6	3.2
Heart disease (siblings)	1.2	1.4	2.0	1.4	0.8	1.4	1.4	-1.3	0.5
Intelligence (Savage-Jansen 2018)	1.1	3.3	7.7	-0.2	0.9	-2.8	-2.4	0.7	-2.3
Schizophrenia vs Biploar Disorder	1.1	1.5	4.7	-1.4	-2.2	-0.7	-0.8	-0.5	-0.9
Ever had hysterectomy (womb removed)	1.1	1.2	4.0	2.0	1.7	-0.5	-0.2	0.4	-0.4
Diabetes (mother)	1.1	1.4	3.1	1.0	1.8	1.2	1.5	0.1	0.8
Age when periods started (menarche)	1.1	2.6	4.3	-2.1	-1.5	-1.7	-1.5	-1.1	-1.6
Pain all over the body in last month	1.1	1.1	2.1	1.5	1.0	0.7	1.4	0.7	0.9
Alcohol intake versus 10 years previously	1.1	1.7	4.1	0.3	0.4	2.0	1.5	0.7	1.8
Arm fat mass (right)	1.1	4.7	9.2	0.2	1.1	2.9	2.9	0.9	3.0
Arm fat percentage (left)	1.1	4.5	9.4	0.1	1.0	2.9	2.7	0.8	3.1
Back pain experienced in last month	1.1	1.7	4.1	2.0	0.6	1.1	1.6	0.4	1.3
Osteoarthritis (self-reported)	1.1	1.5	2.7	1.6	1.3	1.4	1.4	0.1	0.9
Medication: Gliclazide	1.1	1.2	2.9	0.3	0.9	1.7	0.1	-1.1	1.5
Ulcerative Colitis (UC)	1.0	2.0	4.3	-1.2	-2.1	-0.4	-1.6	-1.8	0.1
Other serious medical condition/disability diagnosed by doctor	1.0	1.4	4.8	0.3	0.6	0.7	1.3	2.2	0.8
Qualifications: CSEs or equivalent	1.0	1.3	3.1	0.2	0.5	1.7	1.8	-0.2	1.2
Hair/balding pattern: Pattern 3	1.0	1.5	3.6	0.1	1.1	-1.2	-1.5	-0.4	-1.9
Depression (self-reported)	1.0	1.2	3.8	1.9	1.4	0.0	0.3	-0.2	-1.1
Arm fat mass (left)	1.0	4.2	8.8	-0.0	0.9	2.8	2.7	0.6	3.0
Wears glasses or contact lenses	1.0	1.1	3.0	0.7	0.5	-1.7	-1.2	-0.7	-0.9
Ever taken oral contraceptive pill	1.0	1.1	2.4	1.0	0.6	1.2	1.6	0.7	0.9
Alcohol drinker status: Never	1.0	1.2	3.4	-1.6	-1.8	-1.0	-0.3	-0.5	0.1
Leg fat percentage (left)	1.0	3.6	8.5	0.4	0.8	2.4	2.5	0.6	2.9
Leg fat mass (left)	1.0	4.0	8.1	0.5	1.2	2.7	2.5	0.7	2.9
Ulcerative Colitis	0.9	1.4	3.3	-0.8	-1.8	0.3	-0.9	-1.7	0.6
Number of incorrect matches in round	0.9	1.4	4.1	-0.9	-2.0	0.0	-0.5	-1.8	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	3.2	1.8	1.5	1.2	1.3	-0.1	0.6
Gout (self-reported)	0.9	1.2	2.3	1.5	1.5	0.4	1.0	0.9	0.7
High blood pressure (siblings)	0.9	1.3	3.9	0.2	-0.2	-1.6	-0.5	-1.1	-2.0
Eye problems/disorders: None of the above	0.9	1.0	1.7	-1.3	-1.2	-0.9	-1.3	0.6	-0.1
Leg fat mass (right)	0.9	3.3	6.9	0.3	1.2	2.4	2.3	0.5	2.6
Number of full sisters	0.9	1.0	1.4	1.2	0.2	1.2	1.0	-1.1	1.1
Age at last live birth	0.9	1.3	4.5	0.0	0.4	-1.2	-1.3	0.1	-2.1
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	1.8	-0.7	-0.3	-1.2	-1.2	-1.2	-1.3
Qualifications: nursing, teaching	0.9	1.3	3.6	-0.1	-0.9	-1.9	-1.1	-0.0	-1.6
Guilty feelings	0.9	1.4	3.2	1.8	1.1	1.1	1.3	0.3	0.9
Eye problems/disorders: Glaucoma	0.9	1.0	4.2	1.2	2.0	0.2	0.5	0.5	0.2
Irritable Bowel Disease (IBD)	0.8	1.8	5.1	-1.7	-2.3	-0.1	-1.1	-1.3	0.2
Age at First Birth	0.8	1.2	3.3	0.2	0.5	-1.8	-1.0	-0.3	-1.5
BMI	0.8	4.9	8.6	0.3	2.5	2.6	2.9	0.6	2.7
Respiratory disease	0.8	1.9	3.0	1.7	0.2	0.9	1.7	-1.4	1.5
Number of treatments/medications taken	0.8	1.4	6.7	1.1	-0.3	-0.4	-0.3	-2.6	-0.4
Medication: Metformin	0.8	1.1	2.7	-0.2	-0.4	1.6	0.8	0.6	1.6
Alcohol usually taken with meals	0.8	1.2	3.2	1.8	0.9	0.0	1.0	1.5	0.5
Hip circumference	0.8	3.5	6.0	0.8	1.4	2.4	2.3	1.4	2.3
Asthma	0.8	1.6	3.1	1.5	0.5	0.5	1.5	-1.8	1.2
Length of working week for main job	0.8	0.8	2.8	0.1	0.6	0.8	0.7	1.7	0.9
Qualifications: College or University degree	0.8	2.4	5.2	-0.8	-0.4	-2.1	-1.8	0.9	-2.3
Suffer from ‘nerves’	0.8	1.2	4.8	-0.0	0.8	0.9	0.9	-2.2	0.5
Eye problems/disorders: Cataract	0.8	1.0	1.7	1.2	1.1	-0.6	0.3	-1.3	-1.0
Hearing aid user	0.8	0.9	2.1	1.1	0.9	0.8	0.9	-0.2	1.4
Irritability	0.8	1.4	2.7	0.5	1.6	-1.4	-0.9	1.1	-1.2
Bipolar Disorder or Schizophrenia	0.7	1.8	7.4	-2.7	-1.5	-0.0	-0.6	-0.8	0.2
Alzheimer’s Disease (including proxy)	0.7	1.0	3.5	-0.9	-1.1	0.2	0.4	-1.9	0.7
Breast Cancer	0.7	1.8	2.9	-0.7	-1.5	-1.1	-1.0	-1.7	-1.7
HbA1C	0.7	0.8	2.9	0.2	-0.5	1.7	0.6	0.7	0.9
Lupus	0.7	1.1	2.5	0.2	-0.5	1.0	0.8	-1.6	1.5
Relative age of first facial hair	0.7	1.5	4.9	-2.2	0.7	-1.3	-0.5	0.3	-1.3
Medication for hormone replacement therapy	0.7	0.7	3.6	1.9	0.2	0.4	0.6	0.5	0.0
Qualifications: None of the above	0.7	1.5	3.2	0.1	0.1	1.8	1.2	-1.6	1.3
Medication: Ramipril	0.7	0.9	1.6	1.3	0.3	1.1	1.2	-0.0	0.9
Weight	0.7	3.6	7.5	0.2	1.0	2.7	2.4	0.7	2.6
Qualifications: A levels/AS levels or equivalent	0.7	1.7	2.3	-1.2	-0.5	-1.5	-1.5	1.5	-1.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	1.9	0.1	0.2	-1.4	-1.4	1.1	-1.1
Headache pain in last month	0.7	1.1	4.4	0.8	-0.3	0.5	0.3	-2.1	1.2
Medication: Amlodipine	0.7	1.1	3.1	1.8	0.7	0.6	0.8	-1.3	0.0
Leg fat percentage (right)	0.7	2.5	6.4	0.0	0.6	1.9	2.2	0.3	2.5
Medication: Allopurinol	0.7	0.9	3.4	0.8	1.9	0.0	0.9	0.8	0.2
Heart disease (mother)	0.7	0.8	1.9	-0.8	-1.4	-0.8	-0.8	-0.8	-0.7
Family relationship satisfaction	0.7	0.8	3.0	-1.7	-0.5	-0.4	-0.1	1.3	0.2
Average weekly red wine intake	0.7	1.0	2.2	0.2	0.1	-0.9	-1.1	-1.4	-1.5
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.7	-1.3	1.1	-1.0	-0.4	0.9	-0.6
Medication: Aspirin	0.7	0.9	3.1	0.2	0.9	-0.1	-1.2	-1.8	-0.4
High cholesterol (Self-reported)	0.7	1.3	1.8	1.0	-0.5	1.1	1.3	-1.3	1.3
Medication: Atorvastatin	0.7	0.9	2.0	0.2	-0.1	1.2	1.4	0.1	1.4
Alzheimer’s Disease (in father)	0.6	0.7	2.0	-0.1	-0.5	0.7	0.3	-1.4	1.1
Crohns Disease (2017)	0.6	1.4	4.5	-2.1	-1.8	-0.1	-0.4	-0.5	0.3
Major Depression (MDD)	0.6	0.8	3.0	-1.7	-0.8	0.0	0.9	-0.2	0.2
Crohns Disease (2012)	0.6	1.0	1.8	-1.0	-1.2	1.4	0.5	0.1	1.2
Neuroticism (2016)	0.6	0.9	1.7	0.5	0.9	1.3	1.1	-0.3	1.1
Primary Biliary Cirrhosis	0.6	0.9	1.5	1.1	1.2	-0.7	-0.4	0.9	-1.1
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.2	0.1	-0.6	-1.5	-0.4	-1.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.5	1.2	1.2	1.1	0.4	0.2	-0.0
Impedance of arm (right)	0.6	2.8	5.6	-0.3	0.8	2.3	1.9	1.2	2.4
Worrier / anxious feelings	0.6	1.2	2.9	-0.7	-1.7	-1.1	-1.2	-0.7	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.4	0.6	0.8	1.0	1.2	1.0	1.2
Glaucoma (self-reported)	0.6	0.7	2.9	0.7	1.7	0.0	0.3	0.7	-0.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	3.3	0.3	0.7	0.2	0.6	-1.8	0.5
Worry too long after embarrassment	0.6	0.9	2.0	0.4	-0.2	1.4	1.4	0.7	1.0
Medication for cholesterol	0.6	1.0	4.0	-2.0	-0.9	0.4	0.0	-0.8	0.4
Breast cancer (self-reported)	0.6	0.7	4.0	0.4	-0.2	0.0	0.4	2.0	0.2
Asthma (self-reported)	0.6	1.3	2.8	1.2	0.4	0.3	1.4	-1.7	1.1
Osteoporosis (self-reported)	0.6	0.7	2.0	-0.3	-1.1	-0.8	-0.5	-1.4	0.3
Medication: Blood pressure	0.6	1.0	3.0	1.6	1.7	-0.1	0.4	0.7	-0.1
Pack years of smoking	0.6	0.8	1.6	-1.3	-1.2	0.4	-0.0	-0.9	1.0
Neuroticism (Nagel 2018)	0.5	1.2	2.4	1.4	1.6	0.8	1.4	-0.3	0.0
Reaction Time	0.5	0.9	2.7	0.7	0.9	1.6	0.6	0.9	0.6
Coronary Artery Disease (CAD)	0.5	0.6	1.7	0.4	0.4	1.3	0.9	-0.0	0.9
Blood White Count	0.5	3.5	5.7	2.4	1.9	1.9	1.9	-1.9	1.1
Systolic Blood Pressure	0.5	2.5	6.0	1.9	2.4	-1.1	-1.4	0.8	-1.3
Hypothyroidism (self reported)	0.5	1.1	4.8	2.2	0.9	0.9	0.5	0.1	0.0
Chronotype (morning person)	0.5	1.2	3.5	0.9	0.8	-1.1	-0.7	-1.9	-0.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.2	-1.1	-0.1	-0.5	-0.9	-1.0	-0.2
Average weekly fortified wine intake	0.5	0.5	1.2	-0.4	0.4	-0.9	-0.8	-0.4	-1.1
Taking other prescription medications	0.5	0.8	4.0	2.0	0.5	0.1	0.6	-0.5	-0.1
Medication: Atenolol	0.5	0.6	1.3	-0.4	0.5	-1.0	-1.1	-0.0	-1.2
Body mass index (BMI)	0.5	2.2	4.1	0.5	0.9	1.9	2.0	0.7	2.0
Allergy	0.5	1.2	3.8	-0.7	-0.4	-0.6	-1.5	0.5	-1.9
Diabetes (self-reported)	0.5	0.8	2.6	-1.6	-1.4	0.4	-0.5	-0.1	0.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.4	-1.0	1.2	0.3	0.7	0.8	0.9
Illnesses of mother	0.5	0.6	1.0	-0.7	0.4	-0.6	-1.0	-0.8	-1.0
Impedance of arm (left)	0.5	2.2	4.5	-0.6	0.7	2.0	1.7	1.0	2.1
Birth weight	0.5	1.0	3.6	-0.4	-0.4	-0.6	-1.1	-1.9	-0.7
Number of full brothers	0.5	0.6	1.1	0.4	0.5	1.0	1.1	-0.2	1.0
Angina (self-reported)	0.5	0.6	2.4	-0.6	-1.5	-0.0	-0.2	0.4	0.9
Medication: Seretide 50 evohaler	0.5	0.6	1.5	-0.3	1.2	0.1	1.2	-0.5	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.9	0.2	1.7	0.3	0.5	-0.5	-0.1
Loneliness, isolation	0.5	0.6	1.4	0.8	1.1	-0.1	0.1	1.2	-0.7
Ever had bowel cancer screening	0.5	0.6	2.7	0.3	-1.6	-0.4	0.1	-0.0	0.7
Medication: Bendroflumethiazide	0.5	0.8	2.9	1.7	0.6	0.8	0.3	-0.8	0.3
Supplements: Calcium	0.5	0.5	1.7	1.3	-1.0	-0.2	0.2	-0.6	-0.2
Alcohol drinker status: Previous	0.5	0.5	2.9	-0.1	-0.3	-0.2	-0.2	1.7	0.3
Bipolar Disorder (2018)	0.4	0.6	1.1	-0.4	0.9	0.8	1.0	0.2	0.8
Depressed Affect (Nagel 2018)	0.4	0.9	2.6	0.4	1.6	0.6	1.2	-0.4	-0.7
Worry (Nagel 2018)	0.4	0.8	1.2	0.9	1.0	-0.8	-0.6	-1.1	-0.9
Bipolar Disorder (2011)	0.4	0.4	1.6	0.4	0.1	0.4	0.4	1.3	0.6
Body Mass Index (BMI) (2010)	0.4	0.6	1.4	0.6	0.7	0.3	1.2	1.1	-0.1
Mean Putamen Volume	0.4	0.4	1.0	-0.0	0.8	0.9	0.2	0.0	1.0
Rheumatoid Arthritis	0.4	0.6	1.4	0.4	0.7	-0.7	-0.5	-1.2	-0.8
Triglycerides	0.4	0.7	2.0	1.4	1.1	0.2	0.3	0.9	-0.4
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.9	-0.5	-0.5	-0.8	-0.9	-0.4	-0.5
Blood Eosinophil Count	0.4	2.7	10.0	3.2	2.3	-0.8	0.1	-0.6	-0.5
Heel T-Score	0.4	3.3	7.4	-1.2	0.3	-2.5	-2.1	0.8	-2.7
Cardiovascular Disease	0.4	1.2	3.0	0.6	0.9	-1.0	-0.6	-1.3	-1.7
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.8	-0.9	0.2	1.3	0.6	-0.4	1.1
Neuroticism	0.4	1.0	2.4	1.4	1.5	0.7	1.1	0.3	-0.1
Hand grip strength (left)	0.4	1.1	2.4	-1.0	-0.2	-1.4	-0.9	-0.7	-1.5
Angina	0.4	0.5	1.6	-0.5	-1.3	0.0	-0.4	0.6	0.8
Pack years adult smoking proportion	0.4	0.6	1.2	-1.1	-1.0	0.5	0.1	-0.6	1.0
Fed-up feelings	0.4	0.7	1.9	0.7	1.4	0.5	0.6	-0.9	-0.4
Medication: Levothyroxine sodium	0.4	0.7	1.6	1.0	-0.0	0.7	1.1	1.2	0.3
High blood pressure (mother)	0.4	0.6	3.3	0.0	0.5	-0.2	-0.1	1.8	-0.4
Forced vital capacity (FVC)	0.4	1.6	2.6	-1.5	0.4	-1.4	-1.5	0.7	-1.6
Neuroticism score	0.4	0.8	1.7	1.0	1.3	0.9	1.1	0.1	0.4
Time employed in main current job	0.4	0.5	1.0	0.6	-0.5	-0.6	-0.8	-0.7	-1.0
Falls in the last year	0.4	0.5	1.0	-0.6	-0.2	0.9	0.6	0.7	1.0
Medication: Lansoprazole	0.4	0.4	1.3	-0.1	-1.1	0.1	-0.0	-1.2	-0.0
Exposure to tobacco smoke at home	0.4	0.5	1.5	-0.7	-1.2	0.1	-0.7	-0.1	0.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.2	1.5	0.3	0.7	0.7	1.0	-0.3
Forced vital capacity (FVC), Best measure	0.4	1.4	2.5	-0.9	0.8	-1.0	-1.1	1.6	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.9	0.3	1.4	-0.4	0.3	0.2	0.5
Migraine (self-reported)	0.4	0.5	2.5	1.6	-0.1	0.5	0.4	0.2	0.5
Alcohol intake frequency.	0.4	0.9	3.5	-1.0	-1.9	-0.1	-0.2	-0.2	0.7
Chest pain or discomfort	0.4	0.6	2.3	-0.4	-1.5	0.6	-0.3	0.4	0.6
Medication: Aspirin	0.4	0.6	2.4	0.2	0.8	0.3	-0.7	-1.6	0.0
Leg fat-free mass (right)	0.4	2.2	5.6	0.2	1.3	2.4	1.6	1.0	1.5
Mood swings	0.4	0.8	2.4	0.8	1.6	-0.5	0.1	0.3	-1.1
Commuting to job workplace: Walk	0.4	0.4	1.1	-0.4	-0.3	-0.6	-1.0	-0.4	-0.9
Leg predicted mass (right)	0.4	2.2	5.5	0.2	1.3	2.3	1.6	1.1	1.5
Miserableness	0.4	0.7	2.5	0.5	1.6	0.5	0.7	0.5	-0.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.1	1.0	0.7	0.2	0.9	0.6	0.0
Commuting to job workplace: Public transport	0.4	0.5	1.3	-0.3	-0.5	1.1	0.4	-0.6	1.0
Illnesses of father: High blood pressure	0.4	0.5	1.3	0.9	1.1	-0.3	-0.1	0.2	-0.7
Commuting to job workplace: Cycle	0.4	0.5	1.0	-0.6	0.1	0.8	1.0	0.5	0.7
Severe depression (siblings)	0.3	0.3	0.6	-0.0	0.7	0.5	0.8	-0.5	-0.0
Leg fat-free mass (left)	0.3	1.8	4.9	0.0	1.0	2.2	1.5	0.9	1.3
Leg predicted mass (left)	0.3	1.9	5.2	0.0	1.0	2.3	1.5	0.8	1.4
Illnesses of siblings	0.3	0.5	1.4	-0.1	0.6	0.3	-0.1	1.2	1.0
Number of live births	0.3	0.4	0.9	-0.2	0.5	0.5	0.9	0.3	0.9
Pulse rate	0.3	0.5	1.0	0.2	0.3	-0.3	-0.8	-1.0	-1.0
Happiness	0.3	0.4	1.2	-0.1	1.1	-0.1	0.8	0.7	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.0	-1.0	-0.7	0.1	0.2	0.4	0.2
Loud music exposure frequency	0.3	0.3	1.2	0.5	1.1	0.3	-0.4	0.0	0.3
Pulse rate, automated reading	0.3	0.8	2.0	-0.9	-0.3	-0.7	-1.1	-0.7	-1.4
Comparative height size at age 10	0.3	1.8	4.1	0.9	0.6	2.0	1.3	0.3	1.9
Hypertension (Self-reported)	0.3	0.7	1.5	1.2	0.4	-1.0	-0.6	-0.2	-1.1
Diabetes diagnosed by doctor	0.3	0.5	1.5	-1.2	-0.7	0.7	-0.2	-0.5	0.4
Illnesses of father: None of the above (group 1)	0.3	0.4	1.1	-0.9	-0.3	-1.1	-0.2	-0.1	-0.5
Basal metabolic rate	0.3	1.4	3.7	0.3	0.9	1.9	1.3	0.6	1.4
Unable to work because of sickness or disability	0.3	0.4	1.0	-0.2	0.7	0.7	1.0	0.4	0.4
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.7	-0.4	0.9	1.3	0.8	-0.0	0.8
Impedance of whole body	0.3	1.6	4.1	-0.2	0.8	1.7	1.4	0.7	2.0
Hand grip strength (right)	0.2	0.4	0.8	-0.7	-0.0	0.7	0.8	-0.3	0.9
High blood pressure	0.2	0.5	1.1	0.6	-0.1	-1.1	-0.7	-0.2	-0.9
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.3	0.9	0.1	0.0	0.6	0.2	1.1
Stomach or abdominal pain in last month	0.2	0.3	0.8	-0.1	-0.3	0.2	0.8	-0.5	0.9
Impedance of leg (left)	0.2	0.7	2.0	-0.0	1.0	0.6	0.8	0.7	1.4
Nervous feelings	0.2	0.4	1.2	1.1	0.9	-0.4	-0.3	-0.2	-0.2
Lung cancer (father)	0.2	0.2	0.9	0.1	0.1	0.3	-0.2	1.0	0.6
Standing height	0.2	2.1	6.0	-0.5	0.6	2.4	1.4	0.4	2.0
Exposure to tobacco smoke outside home	0.2	0.3	1.5	-0.2	-0.3	-0.2	-0.1	-1.2	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	0.8	-0.1	0.3	0.4	0.5	0.3
Medication: Blood pressure	0.2	0.3	0.7	0.5	-0.1	-0.6	-0.7	-0.3	-0.8
Mean time to correctly identify matches	0.2	0.3	1.3	0.6	-0.3	1.1	-0.0	0.1	0.4
Had major operations	0.2	0.3	1.1	-0.2	1.0	-0.2	-0.3	0.5	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	0.7	-0.2	0.7	0.3	0.3	0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.1	1.0	0.3	-0.1	-0.0	0.3	0.5
Illnesses of father: Heart disease	0.2	0.3	0.8	-0.2	0.4	-0.2	-0.7	0.9	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.9	-0.0	1.0	-0.2	-0.7	-0.3	-0.8
Whole body fat-free mass	0.2	0.9	2.5	0.3	0.7	1.6	0.9	0.5	1.0
Number of self-reported non-cancer illnesses	0.2	0.3	0.7	-0.0	-0.4	-0.8	-0.1	-0.8	-0.4
Average weekly champagne plus white wine intake	0.2	0.2	0.8	0.9	0.7	0.2	0.2	-0.2	-0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.0	-0.5	-1.0	0.1	-0.0	-0.3	0.0
Medication: Lisinopril	0.2	0.2	0.5	-0.6	-0.0	0.4	0.7	0.3	-0.4
Arm fat-free mass (left)	0.2	1.2	2.9	0.6	0.8	1.7	1.4	0.3	1.2
Fractured/broken bones in last 5 years	0.2	0.3	0.7	0.2	0.7	0.4	-0.1	-0.8	-0.5
Diastolic blood pressure, automated reading	0.2	0.5	1.1	-1.0	0.3	-0.9	-0.7	0.3	-0.4
Basal cell carcinoma (self-reported)	0.2	0.3	1.0	-0.6	-1.0	0.2	-0.6	-0.1	0.2
Arm predicted mass (left)	0.2	1.3	2.9	0.7	0.9	1.7	1.4	0.0	1.2
HDL Cholesterol	0.1	0.1	0.5	-0.1	-0.7	-0.1	-0.0	-0.5	-0.0
Allergy or Eczema	0.1	0.3	0.9	0.7	0.2	-1.0	-0.0	0.2	0.4
Systolic blood pressure, automated reading	0.1	0.2	0.6	0.2	0.4	-0.4	-0.7	0.5	-0.2
Sitting height	0.1	0.7	2.1	-0.2	1.5	1.1	0.1	0.6	0.5
Medication: Simvastatin	0.1	0.1	0.2	-0.4	-0.3	-0.0	-0.1	-0.3	-0.3
Medication: Cholesterol lowering	0.1	0.2	0.3	-0.2	-0.2	0.6	0.6	0.2	0.6
Trunk predicted mass	0.1	0.4	1.2	0.4	0.4	1.1	0.6	0.1	0.7
Blood clot in the leg (DVT)	0.1	0.1	0.4	-0.2	-0.3	0.7	0.5	-0.1	0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	-0.1	0.5	0.2	0.3	-0.1	0.3
Comparative body size at age 10	0.1	0.4	1.1	0.3	1.1	0.5	0.4	0.6	-0.4
Arm predicted mass (right)	0.1	0.4	1.0	0.1	0.8	1.0	0.5	0.3	0.5
Whole body water mass	0.1	0.8	2.4	0.3	0.7	1.5	0.9	0.5	0.9
Mother’s age at death	0.1	0.2	0.6	-0.6	-0.0	-0.8	0.1	0.0	0.2
Risk taking	0.1	0.2	0.6	0.6	0.1	-0.4	0.1	-0.8	0.3
Cholesterol lowering medication	0.1	0.2	0.8	0.9	0.3	0.1	0.2	-0.4	0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	-0.1	-0.3	0.6	0.2	-0.2	-0.1
Blood Red Count	0.0	0.4	1.5	0.2	0.2	-0.2	-0.7	1.2	-0.3
Height	0.0	0.8	2.3	-1.5	-0.4	0.6	0.6	-0.6	1.1
Hair Pigment	0.0	0.5	1.5	-0.2	-1.0	-0.6	-0.2	-1.2	0.1
Tanning	0.0	0.5	1.9	0.6	-0.5	-0.2	-0.3	-1.4	0.3
Impedance of leg (right)	0.0	0.1	0.5	-0.5	0.3	-0.0	0.1	0.3	0.7
Trunk fat-free mass	0.0	0.3	0.9	0.4	0.3	1.0	0.4	0.1	0.6
Arm fat-free mass (right)	0.0	0.2	0.7	-0.1	0.5	0.8	0.4	0.3	0.5

Hub : Genes

TOP2B

Models

Trait associations