[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr3:40,594,264-42,967,174

Best TWAS P=1.85e-12 · Best GWAS P=5.66e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	ULK4	0.18	0.26	enet	22	0.27	2.5e-28	6.5	7.0	1.8e-12	0.98	0.03	0.97	TRUE
46	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ULK4	0.28	0.31	lasso	13	0.33	5.8e-14	6.5	6.8	8.2e-12	0.97	0.04	0.96	FALSE
48	The Cancer Genome Atlas	Rectum Adenocarcinoma	ULK4	0.29	0.23	blup	258	0.22	6.7e-06	6.4	6.8	1.2e-11	0.92	0.04	0.94	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	ULK4	0.30	0.46	enet	23	0.47	2.9e-51	6.5	6.8	1.2e-11	0.99	0.03	0.97	FALSE
6	GTEx	Artery Tibial	ULK4	0.26	0.20	enet	34	0.23	5.5e-18	6.3	6.7	2.1e-11	0.96	0.07	0.93	FALSE
27	GTEx	Whole Blood	ULK4	0.23	0.12	enet	35	0.18	5.1e-16	6.5	6.7	2.1e-11	0.91	0.04	0.96	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ULK4	0.15	0.22	enet	35	0.24	5.6e-27	6.5	6.7	2.2e-11	0.99	0.03	0.97	FALSE
9	GTEx	Brain Cortex	ULK4	0.53	0.41	lasso	14	0.42	7.7e-13	6.4	6.7	2.4e-11	0.95	0.06	0.93	FALSE
39	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ULK4	0.32	0.36	lasso	17	0.36	3.5e-21	6.5	6.7	2.4e-11	0.98	0.03	0.97	FALSE
41	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ULK4	0.12	0.03	blup	256	0.05	1.9e-03	6.3	6.7	2.7e-11	0.81	0.05	0.82	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	ULK4	0.54	0.34	enet	49	0.39	7.3e-14	6.5	6.6	4.2e-11	0.96	0.03	0.97	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	ULK4	0.14	0.19	enet	17	0.20	5.4e-25	6.2	6.6	4.5e-11	0.93	0.08	0.92	FALSE
11	GTEx	Brain Putamen basal ganglia	ULK4	0.53	0.39	lasso	10	0.34	7.3e-09	6.5	6.6	4.8e-11	0.98	0.06	0.93	FALSE
20	GTEx	Nerve Tibial	ULK4	0.31	0.27	lasso	10	0.31	1.9e-22	6.5	6.6	4.9e-11	0.98	0.04	0.96	FALSE
31	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ULK4	0.16	0.18	lasso	12	0.20	7.9e-17	6.5	6.6	4.9e-11	0.98	0.03	0.97	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	ULK4	0.20	0.30	lasso	9	0.32	1.1e-66	6.5	6.6	5.2e-11	0.99	0.03	0.97	FALSE
2	GTEx	Adipose Subcutaneous	ULK4	0.16	0.09	lasso	7	0.07	1.9e-06	6.3	6.6	5.3e-11	0.97	0.07	0.93	FALSE
5	GTEx	Artery Coronary	ULK4	0.23	0.18	lasso	12	0.15	8.0e-06	6.3	6.6	5.5e-11	0.89	0.06	0.91	FALSE
44	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ULK4	0.16	0.14	lasso	4	0.14	7.8e-10	6.5	6.5	5.8e-11	0.99	0.03	0.97	FALSE
45	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ULK4	0.29	0.35	lasso	6	0.32	7.4e-14	6.3	6.5	5.9e-11	0.97	0.04	0.96	FALSE
3	GTEx	Adipose Visceral Omentum	ULK4	0.15	0.15	lasso	4	0.14	6.2e-08	6.4	6.5	6.2e-11	0.95	0.07	0.93	FALSE
19	GTEx	Muscle Skeletal	ULK4	0.17	0.16	lasso	8	0.20	6.1e-19	6.2	6.5	6.8e-11	0.97	0.07	0.93	FALSE
14	GTEx	Colon Transverse	ULK4	0.24	0.05	lasso	8	0.03	9.1e-03	6.5	6.5	7.3e-11	0.98	0.04	0.93	FALSE
16	GTEx	Esophagus Mucosa	ULK4	0.34	0.24	lasso	9	0.26	3.0e-17	6.5	6.5	7.5e-11	0.98	0.03	0.97	FALSE
18	GTEx	Lung	TRAK1	0.07	0.01	enet	4	0.00	2.1e-01	6.5	6.5	7.6e-11	0.93	0.06	0.68	FALSE
17	GTEx	Esophagus Muscularis	ULK4	0.20	0.18	enet	16	0.18	4.1e-11	6.5	6.5	7.7e-11	0.99	0.04	0.96	FALSE
26	GTEx	Thyroid	ULK4	0.38	0.25	lasso	7	0.30	2.4e-23	6.3	6.5	7.8e-11	0.97	0.09	0.91	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ULK4	0.14	0.16	lasso	4	0.20	9.6e-22	6.5	6.5	7.9e-11	0.98	0.04	0.96	FALSE
4	GTEx	Artery Aorta	ULK4	0.45	0.45	enet	35	0.48	9.1e-30	6.3	6.5	8.1e-11	0.97	0.08	0.92	FALSE
28	METSIM	Adipose	ULK4	0.07	0.10	enet	32	0.10	1.1e-14	6.3	6.5	8.6e-11	0.96	0.05	0.95	FALSE
49	The Cancer Genome Atlas	Soft Tissue Sarcoma	ULK4	0.15	0.12	lasso	7	0.13	6.5e-08	6.5	6.5	9.0e-11	0.99	0.04	0.96	FALSE
50	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ULK4	0.32	0.16	lasso	13	0.22	1.9e-06	6.4	6.5	1.1e-10	0.98	0.04	0.96	FALSE
30	YFS	Blood	ULK4	0.04	0.07	lasso	5	0.07	5.7e-21	6.5	6.4	1.2e-10	1.00	0.03	0.97	FALSE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	ULK4	0.34	0.35	lasso	13	0.37	3.6e-22	6.5	6.4	1.2e-10	1.00	0.03	0.97	FALSE
43	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ULK4	0.14	0.17	enet	15	0.18	1.7e-19	6.5	6.4	1.2e-10	0.97	0.03	0.97	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	ULK4	0.21	0.25	lasso	10	0.26	1.5e-29	6.5	6.4	1.3e-10	1.00	0.03	0.97	FALSE
8	GTEx	Brain Cerebellum	ULK4	0.23	0.13	lasso	9	0.08	2.3e-03	6.3	6.4	1.4e-10	0.94	0.06	0.89	FALSE
54	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ULK4	0.23	0.15	enet	14	0.18	9.9e-06	6.4	6.4	1.4e-10	0.89	0.04	0.95	FALSE
7	GTEx	Brain Caudate basal ganglia	ULK4	0.26	0.09	lasso	4	0.01	1.6e-01	6.3	6.4	1.6e-10	0.88	0.07	0.62	FALSE
36	The Cancer Genome Atlas	Glioblastoma Multiforme	ULK4	0.37	0.31	lasso	9	0.31	3.1e-10	6.4	6.4	1.7e-10	0.98	0.04	0.96	FALSE
35	The Cancer Genome Atlas	Esophageal Carcinoma	ULK4	0.30	0.18	blup	256	0.21	3.3e-07	6.5	6.4	1.9e-10	0.93	0.04	0.96	FALSE
13	GTEx	Cells Transformed fibroblasts	ULK4	0.54	0.38	enet	79	0.58	3.7e-53	6.5	6.3	2.2e-10	0.94	0.04	0.96	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	ULK4	0.22	0.36	lasso	10	0.35	1.5e-41	6.3	6.3	2.8e-10	0.99	0.03	0.97	FALSE
51	The Cancer Genome Atlas	Stomach Adenocarcinoma	ULK4	0.18	0.23	enet	13	0.24	5.3e-17	6.5	6.3	3.0e-10	0.98	0.03	0.97	FALSE
24	GTEx	Spleen	ULK4	0.78	0.51	enet	39	0.50	5.4e-15	6.3	6.3	4.0e-10	0.92	0.09	0.91	FALSE
10	GTEx	Brain Frontal Cortex BA9	ULK4	0.51	0.30	enet	34	0.37	1.1e-10	6.4	6.2	5.1e-10	0.88	0.08	0.92	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	ULK4	0.22	0.10	lasso	5	0.09	3.0e-04	6.5	6.2	6.2e-10	0.98	0.04	0.93	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ULK4	0.49	0.63	enet	43	0.66	4.3e-109	6.5	6.2	7.0e-10	0.98	0.03	0.97	FALSE
25	GTEx	Stomach	ULK4	0.33	0.22	enet	21	0.27	3.0e-13	6.5	6.2	7.4e-10	0.95	0.05	0.95	FALSE
21	GTEx	Pancreas	ULK4	0.47	0.10	lasso	8	0.17	1.4e-07	6.3	6.1	8.8e-10	0.95	0.04	0.96	FALSE
23	GTEx	Skin Sun Exposed Lower leg	ULK4	0.20	0.16	enet	29	0.15	1.2e-12	6.5	5.8	5.6e-09	0.92	0.05	0.95	FALSE
33	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ULK4	0.16	0.16	enet	14	0.15	8.0e-08	6.4	5.4	5.5e-08	0.81	0.04	0.96	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	ULK4	0.12	0.00	lasso	5	0.00	2.3e-01	6.3	5.4	8.4e-08	0.80	0.06	0.68	FALSE
52	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ULK4	0.14	0.06	enet	24	0.10	1.6e-04	6.5	5.3	1.3e-07	0.89	0.04	0.92	FALSE