Hub : Genes

TRAK1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1010	0.0310	6.6e-06	0.046	0.050	0.072	0.057	0.078	2.3e-06	8.7e-07	4.1e-09	1.7e-07	9.5e-10
2	GTEx	Artery Coronary	0.3760	0.0990	2.8e-04	0.009	NA	0.051	NA	0.041	1.6e-01	NA	8.4e-03	NA	1.6e-02
3	GTEx	Artery Tibial	0.3317	0.0789	6.9e-05	0.068	NA	0.118	NA	0.101	5.0e-06	NA	1.7e-09	NA	2.6e-08
4	GTEx	Cells Transformed fibroblasts	0.1690	0.0540	1.2e-03	0.008	NA	0.021	NA	-0.001	7.8e-02	NA	9.8e-03	NA	3.8e-01
5	GTEx	Esophagus Mucosa	0.1070	0.0400	3.1e-03	0.014	NA	0.005	NA	0.009	4.0e-02	NA	1.4e-01	NA	7.9e-02
6	GTEx	Lung	0.0653	0.0273	3.6e-03	0.009	NA	0.002	NA	0.001	6.5e-02	NA	2.1e-01	NA	2.6e-01
7	METSIM	Adipose	0.0690	0.0186	1.3e-07	0.002	0.056	0.052	0.055	0.045	1.4e-01	8.9e-09	2.5e-08	1.2e-08	2.6e-07
8	NTR	Blood	0.0293	0.0126	4.9e-03	0.020	0.005	0.014	0.009	0.017	2.7e-07	7.2e-03	1.4e-05	5.5e-04	3.1e-06
9	YFS	Blood	0.1035	0.0219	3.9e-16	0.053	0.062	0.066	0.066	0.061	8.8e-17	1.2e-19	1.1e-20	1.1e-20	4.2e-19
10	TCGA	Prostate Adenocarcinoma	0.0371	0.0203	3.3e-03	0.021	0.022	0.004	NA	0.016	2.7e-03	2.1e-03	1.0e-01	NA	7.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.1	1.7	7.5	0.1	1.4	-0.5	0.8	2.1	0.8	1.2	-0.1	2.7	-0.2
Bipolar Disorder or Schizophrenia	0.2	0.5	3.4	0.1	-0.8	-1.8	-0.4	-0.2	0.4	0.2	-0.1	-0.5	0.2
Depressed Affect (Nagel 2018)	0.6	1.2	3.7	1.1	0.2	0.9	-0.8	-0.7	0.9	-1.4	0.5	-1.4	1.9
Depression (Nagel 2018)	1.0	1.5	4.9	1.4	-0.3	1.8	1.0	-1.3	0.4	-1.1	0.3	-0.5	2.2
Intelligence (Savage-Jansen 2018)	0.1	0.4	2.4	0.4	0.2	0.4	0.1	1.0	1.5	-0.5	-0.2	-0.4	-0.3
Neuroticism (Nagel 2018)	0.4	0.9	3.8	1.4	-0.1	0.0	-2.0	-0.3	0.2	-1.0	0.6	-0.9	1.1
Schizophrenia (2018)	1.0	2.1	7.7	0.1	-2.1	-1.8	-1.0	-2.0	-0.2	-0.7	-0.0	-2.8	0.4
Schizophrenia vs Biploar Disorder	3.8	5.0	20.4	-0.7	-2.3	-0.2	-0.7	-4.5	-2.4	-1.3	1.0	-3.5	1.4
Worry (Nagel 2018)	0.3	0.6	1.6	0.8	-0.9	0.3	-0.7	-0.8	-0.5	-0.2	-0.8	-1.1	1.3
Alzheimer’s Disease (in mother)	2.6	3.0	7.2	2.5	-1.6	-2.7	-1.3	-0.3	0.8	-1.4	-0.6	-2.7	1.6
Alzheimer’s Disease (in father)	0.5	0.5	1.9	0.6	1.4	-0.8	0.1	0.6	0.8	0.1	-1.0	0.3	0.4
Alzheimer’s Disease (including proxy)	1.2	1.7	4.5	1.7	-0.5	-2.1	-2.0	-0.3	0.4	-0.8	-0.4	-2.0	0.9
Crohns Disease (2017)	0.7	1.5	4.3	-0.9	1.3	0.9	0.1	0.9	-2.1	1.4	1.4	1.3	-0.5
Irritable Bowel Disease (IBD)	0.5	1.2	5.3	-0.6	0.3	1.5	0.0	0.3	-2.3	0.6	1.9	0.6	-0.2
Ulcerative Colitis (UC)	0.3	0.6	3.2	0.6	-0.7	0.7	0.2	-0.1	-1.8	-0.3	0.5	-0.6	0.6
Major Depression (MDD)	0.3	0.4	1.5	-0.2	0.4	1.0	0.2	0.0	1.2	-0.3	1.0	-0.4	0.3
Reaction Time	0.6	1.1	5.7	-1.0	0.6	1.4	0.4	0.1	2.4	-0.9	-0.0	-0.8	-0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.2	0.2	0.4	-0.6	-1.0	0.7	1.5	-0.8	0.2	-0.1	-0.4
Breast Cancer	0.6	1.4	3.0	-1.2	1.7	0.7	-0.4	0.6	1.5	-0.3	1.2	1.6	-1.5
Ovarian Cancer	0.8	1.0	2.7	-1.7	-0.8	1.1	0.5	-0.2	-0.2	0.9	1.3	0.9	-1.4
Prostate Cancer	0.6	0.9	3.2	0.6	1.0	-1.5	-1.8	0.8	0.3	0.2	-0.6	-0.1	-1.0
Age at First Birth	0.8	1.2	6.2	0.2	2.5	0.9	1.2	0.4	0.2	-0.1	-0.7	-0.5	1.6
Bipolar Disorder (2011)	0.9	0.9	4.7	-0.2	-0.7	0.5	0.5	0.6	0.5	1.4	0.2	2.2	-0.8
Body Mass Index (BMI) (2010)	1.4	1.9	3.7	-0.7	-0.7	-1.7	-1.5	-1.9	0.9	-1.4	1.8	-1.8	-0.1
Coronary Artery Disease (CAD)	1.0	1.1	2.8	-1.6	-0.3	1.5	-1.0	0.0	-0.5	1.0	1.1	0.4	-1.7
Crohns Disease (2012)	0.4	0.7	2.0	-0.1	1.4	1.3	0.3	0.7	-0.3	0.6	0.8	0.7	-0.9
Mean Putamen Volume	0.8	0.9	2.5	1.4	-0.4	0.4	-1.6	-0.4	1.0	-1.5	0.4	0.2	0.5
Fasting Glucose	0.6	0.8	3.7	1.5	-1.9	-0.1	-0.7	-0.5	-0.7	-0.2	-0.1	-0.2	0.6
HbA1C	1.1	1.3	4.5	-0.3	0.9	2.1	1.8	-0.5	-0.9	0.7	1.5	-0.2	0.5
HDL Cholesterol	0.6	1.0	3.2	-0.9	1.5	0.2	0.3	0.6	0.2	0.7	0.6	1.8	-1.6
LDL Cholesterol	0.8	1.3	5.9	-1.1	0.4	-0.1	-2.4	0.2	1.7	0.2	1.3	0.4	-1.0
Lupus	0.5	0.7	1.9	0.1	-0.6	1.4	0.7	-1.2	-0.5	-0.1	1.0	0.9	0.5
Neuroticism (2016)	0.8	1.2	4.4	0.6	-1.5	-0.6	-0.3	-1.3	1.1	-2.1	1.2	-0.1	0.1
Primary Biliary Cirrhosis	0.2	0.3	1.9	-0.2	0.1	-0.3	0.4	0.3	0.3	0.0	0.6	1.4	-0.8
Rheumatoid Arthritis	0.4	0.6	2.4	-0.9	-1.3	-0.2	-0.4	-0.1	-0.2	0.5	0.5	1.5	-0.7
Schizophrenia (2014)	0.8	1.7	5.7	-0.3	-1.6	-1.2	-1.4	-2.4	-0.1	-0.4	0.7	-2.1	-0.2
Triglycerides	0.1	0.2	1.1	-0.2	0.3	1.0	0.0	-0.2	-0.1	0.3	-0.1	-0.1	-0.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.3	-0.3	-0.8	0.3	-0.0	-1.5	1.0	-1.4	0.7	-0.9	0.0
Ulcerative Colitis	0.5	0.7	2.3	1.5	-0.9	1.2	0.4	-0.1	-0.3	-1.3	0.3	-0.7	0.7
Blood Eosinophil Count	0.1	0.7	2.2	-1.1	0.3	0.6	1.5	-0.6	0.1	0.5	0.7	-1.3	-0.2
Blood Platelet Count	0.2	1.8	8.3	0.4	-2.9	0.2	-1.4	-0.8	-1.9	1.2	0.4	0.5	-1.1
Blood Red Count	1.0	9.5	65.8	0.5	1.2	-1.0	-2.4	1.2	8.1	-3.9	0.5	0.1	-2.0
Blood White Count	0.1	1.1	2.7	-0.2	1.4	0.3	0.7	0.9	1.4	0.4	-1.3	1.6	-1.1
Heel T-Score	0.4	3.0	10.2	-0.8	-0.6	1.1	-0.9	-0.1	-3.2	2.3	2.6	0.7	-1.9
BMI	0.3	1.6	6.5	-0.0	-0.5	-1.8	0.3	-1.3	1.3	-2.5	-1.4	-0.6	0.5
Height	0.0	0.5	2.8	-1.7	0.3	-0.2	0.7	-0.2	-0.1	0.7	0.3	-0.5	1.0
Waist Hip Ratio (WHR)	0.5	2.1	4.7	-1.1	-1.6	2.0	1.8	-0.6	-1.4	2.2	0.9	1.0	-1.3
Systolic Blood Pressure	1.1	5.3	29.5	-0.4	-1.9	1.6	0.7	-0.8	-5.4	3.9	0.3	-0.3	0.7
Smoking Status	0.8	1.9	4.7	-2.2	-0.4	1.8	0.5	-1.3	-2.0	1.6	0.7	1.1	-1.0
Allergy or Eczema	0.5	1.2	3.8	0.1	-0.9	0.9	-0.4	-0.9	1.2	-1.7	0.6	-1.9	1.0
Cardiovascular Disease	0.4	1.3	3.6	0.6	-1.4	1.9	-1.0	-1.5	1.0	-1.3	0.5	-0.2	-0.8
Hypothyroidism (self reported)	0.2	0.4	1.3	-0.5	-0.6	-0.3	-0.5	0.2	0.3	0.2	0.9	1.0	-1.2
Respiratory disease	0.5	1.0	3.2	-0.1	1.2	-0.4	-0.5	0.7	-1.6	1.8	-1.5	-0.1	0.4
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.4	-0.1	-1.5	-0.9	-0.3	-0.6	-1.0	-0.0	-1.6	-0.9	0.2
Lung FEV1/FVC ratio	1.3	6.6	42.4	-0.6	0.3	0.3	0.1	-0.2	6.5	-4.0	2.3	-0.9	-0.9
Lung FVC	0.4	1.8	6.1	-0.1	1.5	0.1	-0.0	-0.4	2.5	-2.2	-1.8	-1.0	0.7
Neuroticism	0.2	0.5	1.6	1.3	-1.0	0.2	-0.5	-0.7	-0.1	-0.3	0.4	-0.3	0.9
Chronotype (morning person)	0.5	1.3	4.6	1.2	0.8	0.3	0.5	1.9	1.0	0.7	0.4	2.1	-0.4
Hair Pigment	0.1	2.0	6.1	-1.0	2.5	1.6	2.0	-0.5	0.8	-0.2	2.0	1.1	0.8
Tanning	0.1	0.6	1.9	-0.1	1.2	-0.6	0.2	-0.3	-0.6	1.1	-0.3	1.4	-1.0
Hand grip strength (left)	0.4	1.0	4.0	1.3	0.3	-1.4	0.4	0.4	-0.8	-0.2	-0.5	-2.0	1.2
Number of treatments/medications taken	0.2	0.4	1.0	-0.1	1.0	-0.6	-0.7	0.5	0.9	0.3	-0.1	0.9	-0.7
Average weekly spirits intake	0.5	0.6	2.2	1.5	-0.2	0.0	-0.4	0.6	1.0	-1.2	-0.5	0.2	0.6
Sensitivity / hurt feelings	0.3	0.6	2.0	-0.3	1.2	0.2	-0.8	0.7	-0.7	0.5	1.4	0.4	-0.7
Frequency of depressed mood in last 2 weeks	1.5	2.1	7.3	1.8	-0.8	0.5	0.8	-1.6	1.0	-1.9	-0.5	-1.1	2.7
Hearing difficulty/problems: Yes	1.9	2.9	6.1	-1.9	1.4	-1.9	-1.9	1.3	2.2	0.8	1.5	0.7	-2.5
Relative age of first facial hair	1.5	3.0	8.9	2.4	0.7	-1.9	-1.9	1.2	1.8	-1.1	-3.0	-0.8	1.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	3.7	1.5	-1.1	-0.3	-0.0	-1.1	1.3	-1.9	-0.3	-0.2	0.6
Ever used hormone-replacement therapy (HRT)	1.2	1.5	4.4	-1.5	-0.2	0.3	-0.8	-0.3	0.2	1.2	2.0	2.1	-1.5
Ever had hysterectomy (womb removed)	0.9	1.0	2.9	0.4	-1.0	0.4	-1.4	-1.6	-1.7	-0.2	-0.2	-1.0	0.6
Systolic blood pressure, automated reading	1.9	5.5	29.4	-1.7	-0.2	0.9	0.7	1.0	-5.4	4.4	-0.6	0.8	-0.4
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	5.8	0.2	-0.4	-0.7	2.4	-0.8	-2.1	1.3	-0.8	0.5	1.4
Angina	0.7	1.0	4.7	-0.1	-0.9	2.2	1.0	-0.7	-0.5	0.3	0.6	1.1	-0.9
Medication for hormone replacement therapy	0.5	0.5	1.7	0.3	-1.2	0.2	-0.8	-0.2	-0.8	0.8	1.3	0.3	-0.1
Vitamin and mineral supplements	1.0	1.3	7.7	0.7	-2.8	0.8	-0.6	-1.1	-1.0	-0.3	-0.3	0.1	1.1
Supplements: Zinc	0.6	0.6	1.7	0.4	-1.2	0.4	-1.3	-0.4	-1.1	-0.1	0.1	-1.1	0.6
Medication: Co-codamol	0.9	1.1	5.4	-0.6	1.1	2.3	-0.5	0.8	0.7	0.6	0.4	1.0	-0.9
Medication: Metformin	0.5	0.7	2.7	0.4	-1.6	0.1	-0.2	0.2	-1.2	0.2	-1.2	-0.7	0.7
Diabetes (father)	2.1	2.6	8.0	-0.8	-2.8	-1.0	-0.9	-2.5	-0.1	-2.3	0.0	-2.1	-0.3
Diabetes (mother)	2.2	2.8	5.7	2.0	-1.9	0.1	0.8	-0.8	-0.3	-1.5	-2.4	-2.3	2.4
Severe depression (siblings)	1.2	1.3	3.4	1.8	-0.1	-0.9	-1.3	-0.2	0.4	-0.7	-1.5	-1.1	1.7
Pack years adult smoking proportion	0.5	0.7	1.9	1.0	0.0	0.2	1.2	0.4	-0.4	1.2	-1.4	0.7	0.7
Impedance of leg (right)	1.2	5.7	19.3	-1.6	0.5	4.4	2.6	-0.6	-3.1	1.9	3.6	1.2	-0.5
Leg fat-free mass (left)	0.6	3.4	11.5	1.1	-0.1	-3.4	-0.9	-0.4	2.1	-2.3	-2.6	-1.1	1.7
Trunk fat percentage	0.4	1.5	5.9	-1.7	0.4	1.0	2.4	-1.3	-1.1	-0.5	-0.8	0.8	0.7
Hand grip strength (right)	0.4	1.1	3.6	1.8	-0.5	-0.8	0.1	-0.4	-1.0	-0.2	-0.5	-1.9	1.3
Townsend deprivation index at recruitment	0.4	0.6	2.0	0.4	0.0	-0.5	-0.5	-0.6	1.4	-1.0	0.8	0.7	-0.6
Current tobacco smoking	0.6	1.0	5.5	-2.3	-0.2	0.3	1.1	-0.8	0.3	0.6	0.8	0.9	-0.9
Average weekly fortified wine intake	0.5	0.6	1.5	-0.0	0.7	-0.3	-1.2	1.2	-0.3	0.6	-0.3	0.8	-0.8
Maternal smoking around birth	0.9	1.3	3.8	-0.8	0.7	1.0	-0.4	1.9	-0.3	1.0	0.1	1.6	-1.8
Fed-up feelings	0.7	1.3	5.0	1.7	-0.5	0.2	-1.4	-0.4	-0.5	-0.9	-0.7	-1.1	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	7.7	1.2	0.5	0.5	0.8	-1.2	-1.0	-0.0	-1.1	-1.0	2.8
Relative age voice broke	2.1	3.2	7.2	2.4	2.7	-0.6	-1.9	2.2	2.2	-1.3	-1.8	0.3	0.3
Taking other prescription medications	0.8	1.2	4.0	1.9	-0.8	-0.4	-0.9	0.8	0.0	-0.3	-2.0	-0.2	1.3
Age when periods started (menarche)	0.4	0.9	2.4	-0.3	1.5	-0.0	1.2	0.5	1.1	0.0	1.4	1.2	-0.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.7	-0.4	-1.3	1.3	-1.3	-0.3	-0.8	0.9	0.3	0.4	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	3.0	-0.0	0.1	-0.3	-0.2	-0.5	0.1	-0.4	1.7	-1.1	-0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.7	0.4	-0.4	-1.3	0.8	-0.5	0.6	-0.6	0.5	0.1	0.2
Qualifications: CSEs or equivalent	0.3	0.4	2.2	-0.0	0.0	0.4	-0.2	-0.1	-1.5	0.4	0.6	0.5	0.6
Serious illness, injury or assault to yourself	0.9	1.1	3.6	1.1	-0.3	-1.0	-1.9	-1.0	0.4	0.4	-1.4	-0.9	0.8
High blood pressure	0.3	0.9	1.9	-0.5	-1.4	1.4	-0.9	-1.2	0.7	-0.6	0.1	0.8	-1.1
Hayfever, allergic rhinitis or eczema	0.9	1.9	4.6	-0.3	-0.9	1.0	-0.8	-1.8	1.0	-2.1	1.7	-2.0	0.5
Multivitamins +/- minerals	1.5	1.9	11.2	-0.2	3.4	0.5	1.0	1.9	1.6	0.1	0.1	0.0	-0.3
Stomach or abdominal pain in last month	0.8	1.0	5.0	1.6	-1.0	-0.3	-0.1	-0.0	0.3	-0.9	-2.2	-0.7	0.5
Supplements: Glucosamine	1.2	1.5	5.2	-1.0	2.3	-0.3	0.9	1.8	0.3	1.1	0.4	1.1	-1.4
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	9.9	-1.6	-1.6	2.0	-1.8	-1.9	-0.5	0.7	3.1	-0.3	-2.0
Medication: Atenolol	0.7	0.9	3.2	-0.0	-0.9	-0.7	-1.8	-0.9	-0.3	-1.1	0.8	-0.7	-1.1
Medication: Levothyroxine sodium	0.7	1.2	3.9	0.2	0.3	-0.9	-1.0	2.0	0.3	1.0	-0.3	1.9	-1.4
Sitting height	0.1	0.6	2.2	-0.5	0.0	-1.5	-1.3	0.4	-0.4	0.9	-0.4	0.9	-0.1
Chronic bronchitis/emphysema (father)	0.9	1.0	5.3	-1.0	-0.0	-0.5	0.2	-0.5	-2.3	1.4	-1.0	0.1	-0.3
High blood pressure (mother)	0.8	1.1	5.5	0.3	-0.7	0.3	0.5	-0.9	-0.2	-0.2	-1.2	-2.3	1.4
Body mass index (BMI)	0.2	0.9	5.1	0.4	1.2	-0.7	0.4	0.2	0.2	-0.9	-2.2	0.0	0.8
Impedance of leg (left)	1.1	5.5	17.2	-1.6	0.2	4.2	2.1	-0.7	-3.6	2.2	3.3	1.1	-0.7
Leg predicted mass (left)	0.7	3.6	10.7	1.1	-0.1	-3.3	-0.7	-0.4	2.2	-2.4	-2.7	-1.2	1.8
Trunk fat mass	0.2	1.0	3.3	-1.1	0.5	-0.3	1.8	-1.1	-0.7	-0.7	-1.4	0.2	1.1
Waist circumference	0.1	0.5	1.6	-0.6	0.8	0.0	1.1	-0.4	0.6	-0.6	-1.3	0.2	0.2
Number of incorrect matches in round	2.5	4.2	18.6	-4.3	0.2	-0.2	-0.6	-0.5	0.6	1.4	3.1	1.1	-3.1
Past tobacco smoking	0.6	1.2	3.0	1.7	-0.7	-0.8	0.7	0.5	1.0	-1.1	-1.0	-1.0	1.7
Alcohol usually taken with meals	0.5	0.8	2.5	-0.7	-0.4	0.3	1.6	-1.4	-0.8	0.3	-0.5	-0.5	1.1
Nervous feelings	0.7	1.3	4.3	1.2	0.0	-1.5	-1.4	-0.4	-1.4	-0.0	-0.6	-1.0	2.1
Frequency of tenseness / restlessness in last 2 weeks	2.4	3.8	9.2	2.1	-2.0	-1.5	-1.0	-2.1	1.6	-3.0	-1.4	-0.8	2.8
Hearing difficulty/problems with background noise	0.8	1.2	8.4	-0.5	0.4	-0.4	-2.9	-0.4	0.3	0.4	1.5	-0.3	-0.6
Hair/balding pattern: Pattern 2	0.9	1.1	4.0	1.2	-0.8	0.9	-0.5	-0.4	1.4	-2.0	-0.4	-1.2	0.7
Had menopause	0.5	0.7	2.3	-0.9	-0.8	-0.2	-1.2	0.1	-0.1	0.9	0.2	0.6	-1.5
Had other major operations	1.0	1.2	3.7	-0.5	0.4	-1.2	-0.4	1.9	-0.2	1.6	0.1	1.1	-1.6
Forced vital capacity (FVC)	0.4	1.5	8.2	-0.6	1.2	-0.4	-0.2	-0.5	2.9	-2.0	0.1	-0.7	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	6.1	0.8	-0.9	0.3	-1.0	-0.7	-0.0	-0.8	2.5	-1.1	-0.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	2.1	-1.5	0.2	-0.3	-0.4	-0.8	-0.6	0.8	0.7	0.7	-0.4
Qualifications: None of the above	1.1	2.3	6.9	-0.3	1.6	-1.1	-0.9	2.2	-1.7	2.6	-0.6	1.5	-1.1
Financial difficulties in last 2 years	0.2	0.3	1.5	-0.4	0.3	1.2	0.1	-0.4	0.7	0.4	-0.2	0.0	0.0
Mouth/teeth dental problems	0.4	0.6	1.8	0.3	-0.4	0.8	-1.1	0.5	0.4	-0.3	1.3	-0.1	-1.3
Heart attack	0.5	0.6	1.9	-0.3	0.2	-0.9	-0.3	-1.4	-1.0	0.2	0.6	1.2	-0.4
Allergy	0.2	0.5	1.3	0.1	0.3	-0.3	1.1	0.9	-0.2	1.0	-1.0	0.7	0.4
Pain all over the body in last month	1.3	1.3	5.0	1.1	0.2	-2.2	-1.3	0.5	-0.3	-0.2	-2.1	-0.5	0.7
Diabetes (self-reported)	0.7	1.1	3.7	-0.8	-0.5	-0.1	0.3	-0.6	-1.9	0.6	-1.6	-1.4	1.0
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	4.6	0.1	-2.1	2.0	0.9	-1.3	1.6	-1.8	1.1	-0.7	0.4
Medication: Ramipril	0.4	0.5	2.3	0.1	0.1	0.5	-1.0	-0.1	1.5	-0.8	-0.8	-0.1	0.0
Medication: Simvastatin	0.2	0.3	0.8	-0.0	0.5	-0.2	-0.7	0.7	-0.1	0.0	0.2	0.7	-0.9
Fluid intelligence score	0.1	0.3	1.3	0.0	0.3	0.1	0.6	-0.2	1.1	-0.8	0.8	0.1	-0.2
Illnesses of siblings	0.6	0.8	3.4	-0.8	0.4	-1.8	0.1	0.2	0.6	0.0	-0.2	1.5	-1.3
Neuroticism score	0.2	0.3	0.7	0.8	-0.6	0.3	-0.3	-0.9	0.4	-0.5	0.7	-0.1	0.8
Weight	0.2	1.1	4.6	0.4	0.9	-1.4	0.5	-0.1	0.5	-1.2	-2.1	-0.4	1.4
Impedance of arm (right)	0.8	3.6	11.2	-2.7	-0.8	3.3	2.5	-1.6	-0.7	0.1	2.6	0.8	-0.3
Arm fat percentage (right)	0.2	0.9	2.9	-1.3	0.7	0.8	1.7	-0.9	-0.4	-0.8	-1.3	0.1	0.7
Trunk fat-free mass	0.8	4.4	16.2	1.9	0.4	-4.0	-2.2	0.7	2.3	-1.7	-2.2	-1.8	1.3
Hip circumference	0.3	1.3	3.9	-0.2	0.8	-0.1	0.8	-0.6	1.8	-2.0	-1.6	0.1	1.0
Time employed in main current job	0.5	0.6	2.3	-1.1	0.6	1.5	0.1	-0.5	-0.3	0.3	1.2	0.2	-0.1
Alcohol intake versus 10 years previously	0.4	0.7	1.6	-0.3	0.1	-1.2	-0.7	-0.5	-1.3	0.5	0.8	1.2	-0.6
Father’s age at death	0.7	1.0	2.8	1.7	-1.0	-0.9	-0.9	-0.5	0.3	-1.0	0.4	-0.2	1.6
Worrier / anxious feelings	0.2	0.4	0.9	-0.3	0.8	0.5	-0.9	-0.7	-0.5	0.6	0.6	0.0	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	4.6	1.1	1.7	0.6	0.3	0.4	1.2	-0.6	-1.4	-1.1	2.1
Falls in the last year	1.5	2.0	8.4	-0.3	-1.6	-0.0	0.9	-2.9	0.4	-1.4	0.5	-1.7	1.8
Hair/balding pattern: Pattern 3	0.6	0.8	2.2	-0.9	0.9	-0.4	-0.4	0.4	-0.7	1.5	1.2	1.1	-0.8
Number of live births	0.7	1.1	2.3	-1.0	1.5	1.2	-0.9	-0.0	1.2	-0.2	0.5	1.4	-1.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	13.4	-0.6	1.6	-0.3	-0.2	-0.4	3.7	-2.3	0.6	-0.6	0.2
Pulse rate	0.4	0.7	2.4	1.1	-1.4	-0.6	-0.2	-0.5	-1.6	0.6	-0.1	0.3	0.5
Happiness	0.8	1.0	1.8	-1.4	0.5	0.4	-1.1	-0.4	1.4	0.1	1.3	1.2	-1.2
Noisy workplace	1.3	1.6	6.2	0.4	2.5	-1.2	-0.9	2.1	0.4	0.9	-1.0	1.1	-0.2
Qualifications: A levels/AS levels or equivalent	0.8	1.8	7.1	1.2	0.0	-0.4	0.6	-0.3	2.7	-1.8	-0.8	-1.3	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.3	1.5	1.2	-0.3	-0.1	1.0	0.6	-0.3	-0.8	0.5	1.0
Mouth/teeth dental problems: Dentures	0.8	1.4	5.8	0.4	0.5	0.6	2.4	-0.2	-0.8	0.5	-1.1	-0.9	2.2
Asthma	0.4	0.9	2.8	-0.1	1.7	-0.3	-0.9	0.2	-1.6	1.4	-0.3	0.6	-0.0
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	5.6	1.5	-1.3	-0.8	-1.8	-0.2	2.4	-2.3	0.5	-0.9	-0.8
Medication: Cholesterol lowering	1.3	2.0	8.2	-1.4	-0.2	1.8	0.4	-0.7	-2.9	1.6	0.5	1.3	-0.9
Depression (self-reported)	1.1	1.3	6.2	1.0	-0.2	2.5	0.8	-0.2	1.3	-1.0	-1.2	-0.2	1.0
Medication: Lansoprazole	0.5	0.6	1.5	-0.2	0.5	0.5	1.2	-1.0	0.8	-0.8	0.4	-0.5	0.9
Prospective memory result	1.2	1.5	4.0	-0.3	0.5	-0.8	-0.3	1.7	-2.0	2.0	-1.4	0.7	-0.7
Lung cancer (father)	0.9	1.1	5.4	0.3	-0.3	0.8	-0.3	-0.1	1.8	-2.3	-0.2	-1.1	-0.1
Illnesses of mother	1.5	1.9	6.5	-0.6	1.4	-0.2	0.2	1.2	0.7	-0.1	2.4	2.6	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	6.7	0.2	1.4	-1.2	-0.3	-0.3	2.6	-2.2	-0.2	-0.8	0.7
Pulse wave Arterial Stiffness index	0.7	0.8	2.1	-0.3	1.1	-0.2	0.2	1.3	0.5	0.6	-1.0	1.1	-1.4
Impedance of arm (left)	1.0	4.6	12.0	-2.7	-1.2	3.5	3.3	-2.2	-1.3	0.4	2.6	1.2	-0.0
Arm fat mass (right)	0.2	0.7	2.4	-0.6	0.9	-0.1	1.1	-0.6	0.1	-1.1	-1.6	-0.1	1.1
Trunk predicted mass	0.8	4.6	17.1	2.0	0.5	-4.1	-2.3	0.8	2.3	-1.8	-2.2	-1.9	1.3
Standing height	0.1	0.8	3.1	0.2	-0.2	-1.6	0.4	-0.6	0.8	-0.8	0.1	-1.0	1.8
Length of working week for main job	0.3	0.3	0.9	-0.1	0.1	-0.0	0.4	0.3	0.7	-0.2	0.8	0.7	-0.9
Exposure to tobacco smoke at home	2.2	2.5	9.9	-2.1	0.5	0.2	0.3	1.7	0.0	1.6	1.0	1.9	-3.1
Breastfed as a baby	0.8	1.0	2.1	0.9	-1.1	0.7	-1.0	-1.3	-0.1	-0.7	1.5	-1.3	0.5
Tense / ‘highly strung’	0.5	0.8	3.2	-0.1	-0.6	-1.0	-1.8	0.9	0.1	0.8	-0.5	1.0	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.6	-0.3	-1.2	1.0	-1.1	-1.1	0.4	-0.4	0.6	0.6	-0.7
Hair/balding pattern: Pattern 4	0.4	1.1	2.7	1.2	-1.6	-1.1	-1.2	-0.1	0.2	-1.6	-0.6	-0.9	0.3
Birth weight of first child	0.3	0.6	1.8	-0.1	0.2	-0.6	-0.7	-0.3	1.3	-1.1	-0.8	-1.0	-0.2
Peak expiratory flow (PEF)	0.2	0.4	1.3	-0.4	0.5	-0.5	-0.4	-0.9	1.1	-0.9	0.2	-0.3	-0.3
Pulse wave reflection index	1.2	1.4	4.3	0.1	1.8	-0.5	-0.9	2.1	1.4	0.2	-0.5	1.3	-1.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.9	-1.4	0.6	0.4	-0.5	-0.6	-0.9	1.2	-0.1	0.4	-0.7
Loud music exposure frequency	0.6	0.7	2.0	1.3	0.7	-1.4	0.1	0.6	-0.0	0.9	-0.3	0.4	0.9
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	8.3	0.1	-0.1	0.6	0.5	-0.2	2.9	-2.1	-0.9	-0.4	1.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.8	-0.3	1.4	-1.2	-0.5	0.1	-0.4	0.9	-1.1	0.7	0.2
Blood clot in the leg (DVT)	0.8	1.1	5.2	0.8	-2.3	-0.6	-0.1	-1.7	-0.9	-0.4	-0.0	0.6	-0.2
Medication: Paracetamol	0.6	0.9	2.3	0.9	0.3	-1.2	-1.5	0.5	1.5	-1.3	-0.1	0.2	0.8
Headache pain in last month	1.1	1.8	9.7	-0.2	1.3	-0.3	-0.9	1.0	3.1	-0.8	1.1	1.4	-0.9
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.8	0.3	0.4	-1.7	-0.1	0.9	2.0	-0.8	0.2	-1.2	0.3
Glaucoma (self-reported)	0.8	1.0	3.1	-1.0	1.8	-0.3	-0.9	1.2	1.0	0.7	0.4	0.7	-1.2
Gout (self-reported)	0.2	0.3	1.3	-1.1	0.3	-0.5	-0.1	-1.0	-0.2	-0.0	0.0	-0.3	0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.1	-0.3	-0.1	-1.1	-0.4	0.9	-0.7	0.9	0.8	1.4	-1.2
Medication: Amlodipine	0.9	1.2	6.2	-0.1	0.0	2.5	0.1	-1.5	0.9	-1.3	0.5	-0.9	0.3
Medication: Ventolin 100micrograms inhaler	1.8	2.4	7.1	0.3	-2.3	-1.0	-0.8	-2.2	-0.1	-1.7	0.5	-2.7	1.3
Birth weight	0.2	0.4	1.7	1.3	-0.1	-0.1	-0.6	0.4	0.6	-0.6	0.1	0.6	-0.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	5.8	-2.4	0.7	1.0	-0.1	-0.4	-1.7	1.1	0.9	-0.1	-1.4
High blood pressure (siblings)	0.5	0.7	4.8	-0.2	0.8	2.2	0.2	-0.2	0.2	0.5	0.1	-0.8	0.8
Forced vital capacity (FVC), Best measure	0.3	1.3	3.4	-0.0	1.1	-1.3	-0.5	-0.5	1.8	-1.8	-0.7	-1.0	1.1
Body fat percentage	0.4	1.4	5.0	-1.5	0.8	1.1	2.2	-1.1	-1.4	-0.3	-0.9	0.7	0.7
Leg fat percentage (right)	0.4	1.5	4.6	-0.8	1.6	1.4	1.8	0.1	-2.1	0.6	-1.0	0.7	0.5
Arm fat-free mass (right)	0.6	3.0	13.3	1.9	0.3	-3.6	-1.6	0.3	1.1	-1.3	-2.1	-1.1	1.2
Exposure to tobacco smoke outside home	1.4	1.8	4.3	-1.2	-2.1	-1.2	0.3	-2.0	-1.7	0.0	2.1	-0.2	0.2
Comparative body size at age 10	0.5	1.2	3.3	-1.4	1.4	-1.1	-0.5	0.7	1.7	0.2	-0.1	0.6	-1.8
Number of full brothers	0.9	1.1	4.4	1.6	-2.1	0.7	0.4	1.0	0.5	-0.4	-1.1	0.8	0.0
Worry too long after embarrassment	0.3	0.5	1.6	1.1	0.3	0.7	-0.3	-0.2	0.7	-1.2	0.4	-0.7	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	2.9	0.9	-1.7	-1.4	-1.7	-1.1	-1.0	-0.5	-0.2	-0.6	0.9
Wheeze or whistling in the chest in last year	0.1	0.2	1.0	0.1	0.7	-0.1	-0.3	-0.0	-0.1	-0.4	-1.0	-0.5	0.6
Number of children fathered	0.6	0.7	1.8	-1.0	1.0	-0.5	0.1	0.7	-0.7	0.9	-0.3	1.1	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	3.8	1.9	-0.8	0.6	-0.7	0.3	0.1	-0.6	-1.8	-0.3	1.0
Age at first live birth	0.4	0.7	2.9	-0.3	1.7	-1.4	-0.1	0.2	0.4	-0.3	0.1	-1.1	0.4
Pulse wave peak to peak time	0.8	1.0	2.7	0.3	-1.1	0.2	-0.0	-1.4	-0.4	-0.7	1.2	-1.4	1.6
Health satisfaction	1.3	1.7	4.7	-1.8	1.1	1.5	-0.4	0.5	1.4	0.1	1.2	1.3	-2.2
Shortness of breath walking on level ground	0.2	0.3	1.0	-0.6	-0.1	1.0	0.3	-0.3	0.7	-0.4	-0.7	0.1	0.2
Qualifications: College or University degree	0.5	1.6	3.5	0.4	-1.5	-1.8	0.0	-1.1	1.9	-1.8	0.7	-1.4	-0.3
Eye problems/disorders: None of the above	1.3	1.5	6.0	-2.4	0.5	0.4	-0.8	-1.1	1.4	-0.2	1.2	-1.4	-1.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.4	-0.2	-0.2	-0.0	1.4	0.4	-0.9	1.1	-1.6	0.9	-0.9
Emphysema/chronic bronchitis	0.9	1.0	4.6	-1.0	0.2	-0.9	-0.4	0.7	-0.8	2.1	0.2	1.0	-1.1
Medication for pain relief, constipation, heartburn	0.7	1.3	3.5	-1.0	0.7	-0.1	0.8	0.8	-1.4	1.9	0.5	1.8	-1.0
Neck or shoulder pain in last month	0.8	1.1	3.1	-0.4	0.0	0.1	-1.4	0.3	1.4	-1.0	1.8	0.5	-1.7
Medication: Blood pressure	0.4	0.7	2.4	0.1	-1.1	1.4	-0.4	-1.5	-0.5	-0.2	-0.5	1.0	0.2
Angina (self-reported)	0.9	1.2	5.9	-0.3	-0.9	2.4	0.6	-0.5	-0.3	0.2	1.1	1.4	-1.3
Migraine (self-reported)	1.8	2.2	8.2	2.9	0.1	-0.1	-1.0	1.0	2.4	-1.9	-1.4	-0.2	0.4
Medication: Ibuprofen	2.7	3.2	8.2	2.1	-2.2	-1.3	-2.2	-0.4	2.3	-2.9	1.0	-1.1	-0.5
Medication: Allopurinol	0.4	0.5	1.2	-1.1	0.5	-1.0	-0.0	0.0	-0.4	1.1	-0.6	0.5	-0.6
Medication: Omeprazole	0.2	0.2	0.7	-0.3	-0.3	-0.2	0.3	-0.1	-0.4	0.1	-0.7	-0.3	0.8
Medication: Seretide 50 evohaler	0.8	0.9	3.1	-1.3	-0.0	0.1	-1.4	0.8	-1.8	1.2	0.3	0.4	-0.6
Mean time to correctly identify matches	0.3	0.5	2.0	-0.6	0.8	1.0	0.3	0.1	1.4	-0.5	0.2	-1.0	0.0
Heart disease (mother)	0.5	0.6	2.6	0.7	0.4	0.7	-1.1	0.3	-0.0	0.6	-1.6	-0.5	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	2.1	-0.7	0.6	-0.4	0.9	-1.4	-1.3	0.9	0.9	0.3	1.2
Whole body fat mass	0.2	0.9	2.3	-0.7	0.7	-0.2	1.5	-0.9	-0.8	-0.8	-1.4	0.0	1.2
Leg fat mass (right)	0.3	1.1	3.1	-0.4	1.6	-0.2	1.6	-0.1	-1.1	-0.3	-1.8	0.3	1.3
Arm predicted mass (right)	0.6	3.3	13.5	2.1	0.3	-3.7	-1.4	0.6	1.4	-1.2	-2.4	-0.8	1.4
Pulse rate, automated reading	0.4	1.4	7.1	1.2	-1.5	-0.0	-0.6	0.1	-2.7	1.6	-0.7	0.2	0.2
Alcohol intake frequency.	0.6	1.3	6.3	1.0	0.5	-1.9	-0.3	0.1	2.5	-0.5	-0.7	0.6	0.8
Comparative height size at age 10	0.1	0.6	1.5	-1.2	0.6	-0.9	-0.9	0.0	-0.4	0.9	-0.5	-0.8	0.8
Number of full sisters	1.1	1.4	4.5	1.8	-0.9	0.2	-0.2	-1.2	-0.7	-1.4	0.6	-2.1	1.0
Suffer from ‘nerves’	0.5	0.7	1.9	1.0	-0.7	-0.2	-1.1	-0.6	-1.4	-0.1	-0.6	-0.7	1.2
Overall health rating	0.3	0.7	2.2	-1.5	0.8	0.5	0.2	-0.1	-1.1	1.3	-0.7	0.3	-0.1
Chest pain or discomfort	0.2	0.4	1.3	-0.9	-0.3	-0.6	0.1	-0.6	0.5	-0.6	0.1	-1.1	0.1
Had major operations	0.5	0.5	2.3	-0.5	-0.2	-0.5	-0.6	0.2	1.5	-0.9	0.8	0.3	-0.7
Age at last live birth	0.5	0.7	3.5	-0.1	1.9	-0.7	-0.5	0.4	1.4	-0.2	0.1	0.8	-0.4
Family relationship satisfaction	0.3	0.4	2.0	-0.2	0.5	-0.7	-0.7	0.1	0.0	0.5	1.4	0.3	-0.6
Leg pain on walking	0.6	0.8	1.8	1.3	-0.0	-0.3	-0.3	-0.2	1.2	-1.3	-0.7	-0.9	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	11.7	0.0	1.3	3.4	2.2	0.1	-1.1	0.8	-0.3	0.3	-0.0
Commuting to job workplace: Car/motor vehicle	1.9	2.2	6.5	-1.6	2.5	0.8	1.2	-0.4	-2.5	1.8	0.2	1.0	-0.6
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	6.9	-1.1	0.5	2.6	0.8	0.8	-1.1	1.2	0.9	0.9	-1.3
Medication: Aspirin	1.5	1.9	5.7	-1.9	0.7	2.4	0.9	-0.8	-2.2	1.4	0.9	-0.2	-0.4
Supplements: Vitamin C	0.7	0.8	3.9	-0.9	-1.0	-2.0	-0.1	-1.1	-0.5	-0.2	0.7	-0.7	-0.1
Knee pain experienced in last month	0.8	1.3	4.1	1.3	-0.3	-0.7	-0.9	-0.3	1.4	-2.0	0.6	-1.4	1.2
Hypertension (Self-reported)	0.3	0.7	1.7	-0.2	-1.2	1.1	-0.7	-1.3	0.7	-1.0	-0.2	0.5	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.2	0.1	0.7	-0.4	1.3	-0.3	1.5	-1.2	-1.0	-1.2	1.8
Illnesses of father: Heart disease	0.9	1.2	3.2	0.1	0.3	-0.7	-1.8	-0.7	-1.4	0.5	-1.7	-1.6	0.3
Illnesses of siblings: Diabetes	2.6	3.2	11.7	1.4	-0.8	1.3	3.0	-0.8	-1.8	-0.3	-0.7	-1.6	3.4
Smoking status: Previous	0.5	0.8	1.6	-0.7	0.6	1.2	-0.2	-0.1	-1.1	1.1	0.6	1.0	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.7	0.2	0.8	-0.3	0.8	-0.2	0.7	-0.3	0.5	0.6	0.7
Whole body fat-free mass	0.7	4.2	15.5	1.8	0.1	-3.9	-1.8	0.3	2.2	-2.0	-2.4	-1.6	1.5
Leg fat-free mass (right)	0.7	3.7	12.8	1.2	-0.3	-3.6	-1.2	-0.3	2.2	-2.2	-2.8	-1.2	1.5
Arm fat percentage (left)	0.3	1.2	4.1	-1.1	0.5	0.6	2.0	-1.2	-0.7	-0.9	-1.4	0.2	1.0
Average weekly red wine intake	0.5	0.7	3.6	-1.9	0.7	-0.4	0.4	-0.1	-0.6	0.9	1.0	-0.2	-0.6
Handedness (chirality/laterality): Left-handed	1.3	1.6	5.8	0.0	1.3	-1.9	-1.1	0.9	2.4	-1.6	0.5	0.2	-0.2
Mood swings	0.6	1.1	3.7	1.3	0.3	0.1	-0.7	-0.5	1.5	-1.9	0.9	0.0	1.3
Loneliness, isolation	0.8	1.1	4.4	0.6	0.3	0.2	0.6	-1.0	1.1	-0.7	-1.6	-0.7	2.1
Long-standing illness, disability or infirmity	0.5	0.8	2.1	0.6	-0.6	0.3	-0.0	0.0	1.2	-1.2	-1.5	-1.2	0.9
Ever had bowel cancer screening	0.7	0.8	2.7	0.4	0.2	-1.6	-0.3	-0.8	0.7	-1.5	-0.8	-0.9	0.7
Diabetes diagnosed by doctor	0.7	1.2	4.2	-0.3	-0.4	-0.8	0.3	-0.6	-2.1	0.4	-1.8	-1.4	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	2.7	-0.7	1.3	1.4	-1.4	0.3	-0.7	1.3	0.6	0.8	-1.6
Friendships satisfaction	0.5	0.6	3.8	-0.9	0.6	-0.5	-0.7	-0.6	0.2	0.2	2.0	-0.2	0.1
Qualifications: nursing, teaching	1.7	2.6	8.4	0.6	0.9	-0.8	0.4	-1.0	1.5	-2.4	-0.6	-2.5	2.9
Commuting to job workplace: Walk	0.8	0.8	3.0	-0.1	-1.7	-0.4	0.1	-0.5	1.1	-0.4	1.4	0.7	-0.9
Eye problems/disorders: Cataract	1.8	2.1	12.6	3.5	-1.4	-0.2	-0.5	0.5	-0.9	-1.5	-1.1	0.0	1.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.1	0.4	-1.1	-0.8	-0.9	0.6	0.1	-0.6	-0.1	0.3	0.5
Medication for cholesterol	0.4	0.6	2.0	0.3	-0.2	-1.0	0.4	-0.5	-1.0	0.2	-1.4	0.9	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.0	-0.1	-0.7	0.0	-0.1	-0.5	0.3	0.4	0.1	0.5	-1.0
Back pain experienced in last month	0.1	0.1	0.5	0.2	0.4	0.7	-0.2	0.2	0.3	-0.2	0.1	0.3	-0.6
Mineral and other dietary supplements	0.7	1.0	5.6	0.5	-2.4	0.9	0.5	-1.3	-0.5	-0.2	-0.4	0.2	1.0
Breast cancer (self-reported)	0.6	0.7	3.1	0.6	-0.8	-1.8	-0.3	-0.2	-1.1	0.8	1.0	-0.3	0.1
Asthma (self-reported)	0.4	0.8	2.8	0.2	1.6	-0.3	-0.8	0.0	-1.7	1.3	-0.6	0.3	0.2
Osteoporosis (self-reported)	0.3	0.4	1.6	0.4	-0.3	-0.6	0.5	-0.1	1.1	-0.5	-0.1	-0.6	1.3
Osteoarthritis (self-reported)	1.1	1.4	4.9	0.4	-0.9	0.9	-1.0	-0.2	2.2	-2.2	-0.3	-1.0	-0.5
Medication: Aspirin	1.4	1.9	5.1	-1.8	0.7	2.2	0.9	-0.3	-2.2	1.6	1.2	0.1	-0.5
Medication: Gliclazide	0.9	1.0	2.9	0.7	-1.1	0.2	0.7	-1.3	0.2	-0.8	-1.2	-1.2	1.7
Illnesses of father: None of the above (group 1)	1.6	1.9	9.4	1.2	0.9	0.4	1.0	0.7	3.1	-1.7	0.5	1.7	0.4
Smoking status: Current	0.5	0.9	5.1	-2.2	-0.3	0.1	0.7	-0.9	0.1	0.6	0.6	0.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	10.2	-0.4	0.7	-0.5	-1.4	0.6	3.2	-1.7	0.3	-0.3	-0.7
Whole body water mass	0.7	4.2	15.5	1.6	0.1	-3.9	-1.9	0.2	2.3	-2.0	-2.5	-1.6	1.5
Leg predicted mass (right)	0.7	3.6	12.8	1.1	-0.3	-3.6	-1.2	-0.3	2.2	-2.2	-2.7	-1.2	1.5
Arm fat mass (left)	0.2	1.0	4.2	-0.3	0.7	-0.2	1.3	-0.6	-0.2	-1.0	-2.0	-0.0	1.3
Number of self-reported non-cancer illnesses	1.0	1.8	9.6	1.2	-3.1	-0.4	-0.9	-1.9	-0.0	-0.6	-0.2	-0.9	1.1
Average weekly champagne plus white wine intake	0.5	0.6	3.2	0.6	-1.0	-0.3	0.8	-0.6	0.4	-1.8	0.5	0.3	-0.2
Miserableness	0.3	0.5	1.4	-1.0	1.2	1.0	0.6	-0.4	-0.1	0.8	0.1	0.0	0.7
Guilty feelings	0.5	0.7	2.8	1.3	0.1	-1.7	-1.0	-0.1	-1.0	0.3	-0.2	0.4	0.9
Wears glasses or contact lenses	0.8	0.9	2.8	-0.7	-0.6	-0.1	-1.0	0.3	-0.5	1.0	0.7	1.5	-1.7
Ever taken oral contraceptive pill	0.3	0.4	1.6	1.3	-0.4	0.2	0.5	0.3	-0.8	-0.1	-0.7	0.2	0.4
Hearing aid user	0.4	0.5	1.3	0.1	0.8	-1.1	-0.1	1.1	0.2	0.8	-0.5	0.7	-0.1
Mother’s age at death	0.6	0.8	2.5	-1.0	-0.5	0.5	-0.5	-0.9	-1.3	0.8	1.6	-0.2	-0.7
Financial situation satisfaction	0.9	1.2	3.8	-2.0	-0.3	1.6	-0.4	-0.7	0.1	1.2	0.9	1.3	-0.7
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.2	-1.0	-0.7	-1.5	-0.1	-1.3	0.7	-0.6	1.0	-1.3	0.4
Commuting to job workplace: Public transport	0.9	1.1	3.8	1.3	-2.0	-0.7	0.1	0.5	1.4	-1.4	0.2	-0.8	0.7
Eye problems/disorders: Glaucoma	1.3	1.6	3.9	-1.2	1.2	0.4	0.2	1.4	1.1	1.1	0.8	2.0	-2.0
Medication: Blood pressure	0.3	0.6	1.9	-0.5	0.3	1.0	-0.6	0.4	1.4	-0.6	0.5	-0.8	-1.2
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.6	1.0	-0.7	-0.5	-0.7	-0.3	0.1	-1.1	-1.2	-0.5	0.9
Supplements: Fish oil (including cod liver oil)	0.7	0.9	5.9	-0.1	2.4	-1.0	-0.3	0.8	0.0	0.1	-0.1	-0.9	-0.3
High cholesterol (Self-reported)	0.2	0.4	1.0	0.4	-0.4	1.0	-0.4	0.7	-0.5	0.7	-0.1	0.7	-0.9
Medication: Bendroflumethiazide	1.3	1.9	4.0	-1.9	0.0	1.7	-1.9	-0.9	1.0	-0.1	1.5	0.9	-2.0
Medication: Paracetamol	0.9	1.3	3.7	1.1	-0.4	-1.3	-1.5	-0.1	1.8	-1.9	0.4	-0.1	0.9
Medication: Lisinopril	0.3	0.4	2.1	-0.6	-0.1	-0.6	-1.4	-0.3	-0.4	-0.1	0.6	0.5	-0.9
Medication: Atorvastatin	2.2	2.8	8.1	-1.8	0.6	2.8	1.6	-0.3	-2.2	2.0	0.5	1.5	-1.3
Illnesses of father: High blood pressure	0.8	1.0	3.5	-1.6	-0.4	0.9	0.1	-1.0	0.4	0.2	1.4	-1.9	-0.3
Alcohol drinker status: Never	0.6	0.8	3.1	0.7	-0.5	-0.2	0.7	-0.1	1.3	-0.6	-1.8	-0.4	0.9
Ever smoked	0.5	0.8	2.6	-1.6	-0.3	0.2	-0.6	-1.3	-0.9	0.5	1.0	0.5	-0.9
Basal metabolic rate	0.6	3.1	10.7	1.3	0.3	-3.3	-1.3	0.1	1.9	-1.9	-2.4	-1.3	1.5
Leg fat percentage (left)	0.4	1.5	5.3	-1.0	1.4	1.4	1.6	-0.2	-2.3	0.8	-1.0	0.6	0.4
Arm fat-free mass (left)	0.6	3.1	11.0	1.8	0.4	-3.3	-2.1	0.4	1.5	-1.4	-2.4	-1.1	1.1
Number of operations (self-reported)	0.5	0.7	2.1	-0.2	-0.4	-1.5	-1.0	0.5	0.6	-0.2	1.0	0.9	-1.3
Average weekly beer plus cider intake	0.5	0.8	4.1	-2.0	0.9	-0.4	-0.4	0.2	0.9	0.4	-0.5	-0.3	-1.1
Irritability	0.4	0.7	2.4	1.2	-1.1	-0.7	-1.6	0.0	0.5	-0.7	0.6	0.8	-0.6
Risk taking	1.3	2.0	7.5	0.2	-2.7	-1.3	1.0	-2.1	1.1	-1.0	0.8	0.0	1.4
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.0	-0.8	-0.4	-0.4	-0.5	0.1	-0.8	1.0	0.7	0.2	-1.0
Fractured/broken bones in last 5 years	0.9	1.1	3.2	0.5	1.7	-0.3	0.7	-0.4	0.1	-0.3	-1.7	-1.0	1.8
Age started oral contraceptive pill	0.3	0.3	1.0	-0.2	-1.0	-0.3	0.2	-1.0	-0.2	0.1	-1.0	-0.6	0.1
Diastolic blood pressure, automated reading	3.5	10.9	78.1	-2.2	0.7	0.2	-1.1	-0.1	8.8	-4.3	0.8	0.2	-2.2
Ever depressed for a whole week	0.2	0.3	0.7	0.3	-0.7	-0.9	-0.6	-0.3	0.7	-0.3	0.1	-0.1	-0.5
Unable to work because of sickness or disability	0.8	1.0	3.2	0.6	-1.0	-0.1	-1.6	-1.0	1.8	-1.3	-0.0	-0.1	-0.3
Commuting to job workplace: Cycle	2.1	2.6	7.0	0.8	-1.4	-2.7	-1.7	-2.1	0.6	-2.3	-0.1	-1.5	0.8
Myopia	1.2	1.7	4.1	-0.6	-1.0	-1.5	-1.3	-2.0	0.3	-1.4	1.3	-1.9	-0.2
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.5	0.2	1.5	-1.9	0.6	1.2	-0.1	0.4	-0.2	-0.7	0.9
Cholesterol lowering medication	0.7	1.1	4.9	-0.6	0.5	0.5	-0.0	1.5	-0.1	1.0	0.3	1.2	-2.2
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.7	0.2	-0.7	-0.7	0.3	-1.0	-0.3	-0.8	-0.8	-1.3	1.6
Pain experienced in last month	1.5	2.5	6.8	0.6	-0.5	1.0	2.6	-0.7	-2.6	1.2	-0.8	-1.0	2.5
Supplements: Calcium	0.6	0.7	2.1	-0.8	1.1	-0.4	-0.5	1.5	1.1	0.7	-0.4	0.1	-0.7
Basal cell carcinoma (self-reported)	1.0	1.1	3.5	-1.0	-1.0	-0.1	-0.1	-1.7	1.6	-0.3	1.9	0.1	0.4
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.9	-0.6	0.5	-0.8	-0.1	-1.4	-0.8	0.3	0.7	1.2	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	6.7	0.5	-2.6	-0.3	-0.2	-1.8	-0.9	-0.4	0.3	1.0	-0.6
Heart disease (siblings)	0.5	0.7	2.0	0.6	-1.1	1.4	0.2	-0.4	-0.2	-0.4	0.7	-1.4	-0.3
Alcohol drinker status: Previous	0.9	1.0	4.6	-0.1	-1.6	-2.1	0.2	-0.7	-0.8	0.8	-0.5	0.4	0.8
Pack years of smoking	0.6	0.9	1.9	0.9	-0.3	0.3	1.4	0.5	-0.7	1.4	-1.4	0.9	0.5
Impedance of whole body	1.1	5.7	16.9	-2.5	-0.7	4.1	2.9	-1.6	-2.6	1.4	3.3	1.5	-0.6
Leg fat mass (left)	0.3	1.1	3.1	-0.4	1.4	-0.0	1.4	-0.4	-1.3	-0.2	-1.8	0.2	1.4
Arm predicted mass (left)	0.6	3.1	9.4	1.8	0.6	-3.1	-2.0	0.5	1.7	-1.5	-2.5	-1.1	1.1