Hub : Genes

TRAK1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1010 0.0310 6.6e-06 0.046 0.050 0.072 0.057 0.078 2.3e-06 8.7e-07 4.1e-09 1.7e-07 9.5e-10
2 GTEx Artery Coronary 0.3760 0.0990 2.8e-04 0.009 NA 0.051 NA 0.041 1.6e-01 NA 8.4e-03 NA 1.6e-02
3 GTEx Artery Tibial 0.3317 0.0789 6.9e-05 0.068 NA 0.118 NA 0.101 5.0e-06 NA 1.7e-09 NA 2.6e-08
4 GTEx Cells Transformed fibroblasts 0.1690 0.0540 1.2e-03 0.008 NA 0.021 NA -0.001 7.8e-02 NA 9.8e-03 NA 3.8e-01
5 GTEx Esophagus Mucosa 0.1070 0.0400 3.1e-03 0.014 NA 0.005 NA 0.009 4.0e-02 NA 1.4e-01 NA 7.9e-02
6 GTEx Lung 0.0653 0.0273 3.6e-03 0.009 NA 0.002 NA 0.001 6.5e-02 NA 2.1e-01 NA 2.6e-01
7 METSIM Adipose 0.0690 0.0186 1.3e-07 0.002 0.056 0.052 0.055 0.045 1.4e-01 8.9e-09 2.5e-08 1.2e-08 2.6e-07
8 NTR Blood 0.0293 0.0126 4.9e-03 0.020 0.005 0.014 0.009 0.017 2.7e-07 7.2e-03 1.4e-05 5.5e-04 3.1e-06
9 YFS Blood 0.1035 0.0219 3.9e-16 0.053 0.062 0.066 0.066 0.061 8.8e-17 1.2e-19 1.1e-20 1.1e-20 4.2e-19
10 TCGA Prostate Adenocarcinoma 0.0371 0.0203 3.3e-03 0.021 0.022 0.004 NA 0.016 2.7e-03 2.1e-03 1.0e-01 NA 7.9e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 1.1 1.7 7.5 0.1 1.4 -0.5 0.8 2.1 0.8 1.2 -0.1 2.7 -0.2
Bipolar Disorder or Schizophrenia 0.2 0.5 3.4 0.1 -0.8 -1.8 -0.4 -0.2 0.4 0.2 -0.1 -0.5 0.2
Depressed Affect (Nagel 2018) 0.6 1.2 3.7 1.1 0.2 0.9 -0.8 -0.7 0.9 -1.4 0.5 -1.4 1.9
Depression (Nagel 2018) 1.0 1.5 4.9 1.4 -0.3 1.8 1.0 -1.3 0.4 -1.1 0.3 -0.5 2.2
Intelligence (Savage-Jansen 2018) 0.1 0.4 2.4 0.4 0.2 0.4 0.1 1.0 1.5 -0.5 -0.2 -0.4 -0.3
Neuroticism (Nagel 2018) 0.4 0.9 3.8 1.4 -0.1 0.0 -2.0 -0.3 0.2 -1.0 0.6 -0.9 1.1
Schizophrenia (2018) 1.0 2.1 7.7 0.1 -2.1 -1.8 -1.0 -2.0 -0.2 -0.7 -0.0 -2.8 0.4
Schizophrenia vs Biploar Disorder 3.8 5.0 20.4 -0.7 -2.3 -0.2 -0.7 -4.5 -2.4 -1.3 1.0 -3.5 1.4
Worry (Nagel 2018) 0.3 0.6 1.6 0.8 -0.9 0.3 -0.7 -0.8 -0.5 -0.2 -0.8 -1.1 1.3
Alzheimer’s Disease (in mother) 2.6 3.0 7.2 2.5 -1.6 -2.7 -1.3 -0.3 0.8 -1.4 -0.6 -2.7 1.6
Alzheimer’s Disease (in father) 0.5 0.5 1.9 0.6 1.4 -0.8 0.1 0.6 0.8 0.1 -1.0 0.3 0.4
Alzheimer’s Disease (including proxy) 1.2 1.7 4.5 1.7 -0.5 -2.1 -2.0 -0.3 0.4 -0.8 -0.4 -2.0 0.9
Crohns Disease (2017) 0.7 1.5 4.3 -0.9 1.3 0.9 0.1 0.9 -2.1 1.4 1.4 1.3 -0.5
Irritable Bowel Disease (IBD) 0.5 1.2 5.3 -0.6 0.3 1.5 0.0 0.3 -2.3 0.6 1.9 0.6 -0.2
Ulcerative Colitis (UC) 0.3 0.6 3.2 0.6 -0.7 0.7 0.2 -0.1 -1.8 -0.3 0.5 -0.6 0.6
Major Depression (MDD) 0.3 0.4 1.5 -0.2 0.4 1.0 0.2 0.0 1.2 -0.3 1.0 -0.4 0.3
Reaction Time 0.6 1.1 5.7 -1.0 0.6 1.4 0.4 0.1 2.4 -0.9 -0.0 -0.8 -0.6
Verbal and Numeric Reasoning (VNR) 0.2 0.5 2.2 0.2 0.4 -0.6 -1.0 0.7 1.5 -0.8 0.2 -0.1 -0.4
Breast Cancer 0.6 1.4 3.0 -1.2 1.7 0.7 -0.4 0.6 1.5 -0.3 1.2 1.6 -1.5
Ovarian Cancer 0.8 1.0 2.7 -1.7 -0.8 1.1 0.5 -0.2 -0.2 0.9 1.3 0.9 -1.4
Prostate Cancer 0.6 0.9 3.2 0.6 1.0 -1.5 -1.8 0.8 0.3 0.2 -0.6 -0.1 -1.0
Age at First Birth 0.8 1.2 6.2 0.2 2.5 0.9 1.2 0.4 0.2 -0.1 -0.7 -0.5 1.6
Bipolar Disorder (2011) 0.9 0.9 4.7 -0.2 -0.7 0.5 0.5 0.6 0.5 1.4 0.2 2.2 -0.8
Body Mass Index (BMI) (2010) 1.4 1.9 3.7 -0.7 -0.7 -1.7 -1.5 -1.9 0.9 -1.4 1.8 -1.8 -0.1
Coronary Artery Disease (CAD) 1.0 1.1 2.8 -1.6 -0.3 1.5 -1.0 0.0 -0.5 1.0 1.1 0.4 -1.7
Crohns Disease (2012) 0.4 0.7 2.0 -0.1 1.4 1.3 0.3 0.7 -0.3 0.6 0.8 0.7 -0.9
Mean Putamen Volume 0.8 0.9 2.5 1.4 -0.4 0.4 -1.6 -0.4 1.0 -1.5 0.4 0.2 0.5
Fasting Glucose 0.6 0.8 3.7 1.5 -1.9 -0.1 -0.7 -0.5 -0.7 -0.2 -0.1 -0.2 0.6
HbA1C 1.1 1.3 4.5 -0.3 0.9 2.1 1.8 -0.5 -0.9 0.7 1.5 -0.2 0.5
HDL Cholesterol 0.6 1.0 3.2 -0.9 1.5 0.2 0.3 0.6 0.2 0.7 0.6 1.8 -1.6
LDL Cholesterol 0.8 1.3 5.9 -1.1 0.4 -0.1 -2.4 0.2 1.7 0.2 1.3 0.4 -1.0
Lupus 0.5 0.7 1.9 0.1 -0.6 1.4 0.7 -1.2 -0.5 -0.1 1.0 0.9 0.5
Neuroticism (2016) 0.8 1.2 4.4 0.6 -1.5 -0.6 -0.3 -1.3 1.1 -2.1 1.2 -0.1 0.1
Primary Biliary Cirrhosis 0.2 0.3 1.9 -0.2 0.1 -0.3 0.4 0.3 0.3 0.0 0.6 1.4 -0.8
Rheumatoid Arthritis 0.4 0.6 2.4 -0.9 -1.3 -0.2 -0.4 -0.1 -0.2 0.5 0.5 1.5 -0.7
Schizophrenia (2014) 0.8 1.7 5.7 -0.3 -1.6 -1.2 -1.4 -2.4 -0.1 -0.4 0.7 -2.1 -0.2
Triglycerides 0.1 0.2 1.1 -0.2 0.3 1.0 0.0 -0.2 -0.1 0.3 -0.1 -0.1 -0.4
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.3 -0.3 -0.8 0.3 -0.0 -1.5 1.0 -1.4 0.7 -0.9 0.0
Ulcerative Colitis 0.5 0.7 2.3 1.5 -0.9 1.2 0.4 -0.1 -0.3 -1.3 0.3 -0.7 0.7
Blood Eosinophil Count 0.1 0.7 2.2 -1.1 0.3 0.6 1.5 -0.6 0.1 0.5 0.7 -1.3 -0.2
Blood Platelet Count 0.2 1.8 8.3 0.4 -2.9 0.2 -1.4 -0.8 -1.9 1.2 0.4 0.5 -1.1
Blood Red Count 1.0 9.5 65.8 0.5 1.2 -1.0 -2.4 1.2 8.1 -3.9 0.5 0.1 -2.0
Blood White Count 0.1 1.1 2.7 -0.2 1.4 0.3 0.7 0.9 1.4 0.4 -1.3 1.6 -1.1
Heel T-Score 0.4 3.0 10.2 -0.8 -0.6 1.1 -0.9 -0.1 -3.2 2.3 2.6 0.7 -1.9
BMI 0.3 1.6 6.5 -0.0 -0.5 -1.8 0.3 -1.3 1.3 -2.5 -1.4 -0.6 0.5
Height 0.0 0.5 2.8 -1.7 0.3 -0.2 0.7 -0.2 -0.1 0.7 0.3 -0.5 1.0
Waist Hip Ratio (WHR) 0.5 2.1 4.7 -1.1 -1.6 2.0 1.8 -0.6 -1.4 2.2 0.9 1.0 -1.3
Systolic Blood Pressure 1.1 5.3 29.5 -0.4 -1.9 1.6 0.7 -0.8 -5.4 3.9 0.3 -0.3 0.7
Smoking Status 0.8 1.9 4.7 -2.2 -0.4 1.8 0.5 -1.3 -2.0 1.6 0.7 1.1 -1.0
Allergy or Eczema 0.5 1.2 3.8 0.1 -0.9 0.9 -0.4 -0.9 1.2 -1.7 0.6 -1.9 1.0
Cardiovascular Disease 0.4 1.3 3.6 0.6 -1.4 1.9 -1.0 -1.5 1.0 -1.3 0.5 -0.2 -0.8
Hypothyroidism (self reported) 0.2 0.4 1.3 -0.5 -0.6 -0.3 -0.5 0.2 0.3 0.2 0.9 1.0 -1.2
Respiratory disease 0.5 1.0 3.2 -0.1 1.2 -0.4 -0.5 0.7 -1.6 1.8 -1.5 -0.1 0.4
Type 2 Diabetes (T2D) (2018) 0.4 0.8 2.4 -0.1 -1.5 -0.9 -0.3 -0.6 -1.0 -0.0 -1.6 -0.9 0.2
Lung FEV1/FVC ratio 1.3 6.6 42.4 -0.6 0.3 0.3 0.1 -0.2 6.5 -4.0 2.3 -0.9 -0.9
Lung FVC 0.4 1.8 6.1 -0.1 1.5 0.1 -0.0 -0.4 2.5 -2.2 -1.8 -1.0 0.7
Neuroticism 0.2 0.5 1.6 1.3 -1.0 0.2 -0.5 -0.7 -0.1 -0.3 0.4 -0.3 0.9
Chronotype (morning person) 0.5 1.3 4.6 1.2 0.8 0.3 0.5 1.9 1.0 0.7 0.4 2.1 -0.4
Hair Pigment 0.1 2.0 6.1 -1.0 2.5 1.6 2.0 -0.5 0.8 -0.2 2.0 1.1 0.8
Tanning 0.1 0.6 1.9 -0.1 1.2 -0.6 0.2 -0.3 -0.6 1.1 -0.3 1.4 -1.0
Hand grip strength (left) 0.4 1.0 4.0 1.3 0.3 -1.4 0.4 0.4 -0.8 -0.2 -0.5 -2.0 1.2
Number of treatments/medications taken 0.2 0.4 1.0 -0.1 1.0 -0.6 -0.7 0.5 0.9 0.3 -0.1 0.9 -0.7
Average weekly spirits intake 0.5 0.6 2.2 1.5 -0.2 0.0 -0.4 0.6 1.0 -1.2 -0.5 0.2 0.6
Sensitivity / hurt feelings 0.3 0.6 2.0 -0.3 1.2 0.2 -0.8 0.7 -0.7 0.5 1.4 0.4 -0.7
Frequency of depressed mood in last 2 weeks 1.5 2.1 7.3 1.8 -0.8 0.5 0.8 -1.6 1.0 -1.9 -0.5 -1.1 2.7
Hearing difficulty/problems: Yes 1.9 2.9 6.1 -1.9 1.4 -1.9 -1.9 1.3 2.2 0.8 1.5 0.7 -2.5
Relative age of first facial hair 1.5 3.0 8.9 2.4 0.7 -1.9 -1.9 1.2 1.8 -1.1 -3.0 -0.8 1.2
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 3.7 1.5 -1.1 -0.3 -0.0 -1.1 1.3 -1.9 -0.3 -0.2 0.6
Ever used hormone-replacement therapy (HRT) 1.2 1.5 4.4 -1.5 -0.2 0.3 -0.8 -0.3 0.2 1.2 2.0 2.1 -1.5
Ever had hysterectomy (womb removed) 0.9 1.0 2.9 0.4 -1.0 0.4 -1.4 -1.6 -1.7 -0.2 -0.2 -1.0 0.6
Systolic blood pressure, automated reading 1.9 5.5 29.4 -1.7 -0.2 0.9 0.7 1.0 -5.4 4.4 -0.6 0.8 -0.4
Eye problems/disorders: Diabetes related eye disease 1.4 1.6 5.8 0.2 -0.4 -0.7 2.4 -0.8 -2.1 1.3 -0.8 0.5 1.4
Angina 0.7 1.0 4.7 -0.1 -0.9 2.2 1.0 -0.7 -0.5 0.3 0.6 1.1 -0.9
Medication for hormone replacement therapy 0.5 0.5 1.7 0.3 -1.2 0.2 -0.8 -0.2 -0.8 0.8 1.3 0.3 -0.1
Vitamin and mineral supplements 1.0 1.3 7.7 0.7 -2.8 0.8 -0.6 -1.1 -1.0 -0.3 -0.3 0.1 1.1
Supplements: Zinc 0.6 0.6 1.7 0.4 -1.2 0.4 -1.3 -0.4 -1.1 -0.1 0.1 -1.1 0.6
Medication: Co-codamol 0.9 1.1 5.4 -0.6 1.1 2.3 -0.5 0.8 0.7 0.6 0.4 1.0 -0.9
Medication: Metformin 0.5 0.7 2.7 0.4 -1.6 0.1 -0.2 0.2 -1.2 0.2 -1.2 -0.7 0.7
Diabetes (father) 2.1 2.6 8.0 -0.8 -2.8 -1.0 -0.9 -2.5 -0.1 -2.3 0.0 -2.1 -0.3
Diabetes (mother) 2.2 2.8 5.7 2.0 -1.9 0.1 0.8 -0.8 -0.3 -1.5 -2.4 -2.3 2.4
Severe depression (siblings) 1.2 1.3 3.4 1.8 -0.1 -0.9 -1.3 -0.2 0.4 -0.7 -1.5 -1.1 1.7
Pack years adult smoking proportion 0.5 0.7 1.9 1.0 0.0 0.2 1.2 0.4 -0.4 1.2 -1.4 0.7 0.7
Impedance of leg (right) 1.2 5.7 19.3 -1.6 0.5 4.4 2.6 -0.6 -3.1 1.9 3.6 1.2 -0.5
Leg fat-free mass (left) 0.6 3.4 11.5 1.1 -0.1 -3.4 -0.9 -0.4 2.1 -2.3 -2.6 -1.1 1.7
Trunk fat percentage 0.4 1.5 5.9 -1.7 0.4 1.0 2.4 -1.3 -1.1 -0.5 -0.8 0.8 0.7
Hand grip strength (right) 0.4 1.1 3.6 1.8 -0.5 -0.8 0.1 -0.4 -1.0 -0.2 -0.5 -1.9 1.3
Townsend deprivation index at recruitment 0.4 0.6 2.0 0.4 0.0 -0.5 -0.5 -0.6 1.4 -1.0 0.8 0.7 -0.6
Current tobacco smoking 0.6 1.0 5.5 -2.3 -0.2 0.3 1.1 -0.8 0.3 0.6 0.8 0.9 -0.9
Average weekly fortified wine intake 0.5 0.6 1.5 -0.0 0.7 -0.3 -1.2 1.2 -0.3 0.6 -0.3 0.8 -0.8
Maternal smoking around birth 0.9 1.3 3.8 -0.8 0.7 1.0 -0.4 1.9 -0.3 1.0 0.1 1.6 -1.8
Fed-up feelings 0.7 1.3 5.0 1.7 -0.5 0.2 -1.4 -0.4 -0.5 -0.9 -0.7 -1.1 2.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 7.7 1.2 0.5 0.5 0.8 -1.2 -1.0 -0.0 -1.1 -1.0 2.8
Relative age voice broke 2.1 3.2 7.2 2.4 2.7 -0.6 -1.9 2.2 2.2 -1.3 -1.8 0.3 0.3
Taking other prescription medications 0.8 1.2 4.0 1.9 -0.8 -0.4 -0.9 0.8 0.0 -0.3 -2.0 -0.2 1.3
Age when periods started (menarche) 0.4 0.9 2.4 -0.3 1.5 -0.0 1.2 0.5 1.1 0.0 1.4 1.2 -0.7
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.7 -0.4 -1.3 1.3 -1.3 -0.3 -0.8 0.9 0.3 0.4 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 3.0 -0.0 0.1 -0.3 -0.2 -0.5 0.1 -0.4 1.7 -1.1 -0.1
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.7 0.4 -0.4 -1.3 0.8 -0.5 0.6 -0.6 0.5 0.1 0.2
Qualifications: CSEs or equivalent 0.3 0.4 2.2 -0.0 0.0 0.4 -0.2 -0.1 -1.5 0.4 0.6 0.5 0.6
Serious illness, injury or assault to yourself 0.9 1.1 3.6 1.1 -0.3 -1.0 -1.9 -1.0 0.4 0.4 -1.4 -0.9 0.8
High blood pressure 0.3 0.9 1.9 -0.5 -1.4 1.4 -0.9 -1.2 0.7 -0.6 0.1 0.8 -1.1
Hayfever, allergic rhinitis or eczema 0.9 1.9 4.6 -0.3 -0.9 1.0 -0.8 -1.8 1.0 -2.1 1.7 -2.0 0.5
Multivitamins +/- minerals 1.5 1.9 11.2 -0.2 3.4 0.5 1.0 1.9 1.6 0.1 0.1 0.0 -0.3
Stomach or abdominal pain in last month 0.8 1.0 5.0 1.6 -1.0 -0.3 -0.1 -0.0 0.3 -0.9 -2.2 -0.7 0.5
Supplements: Glucosamine 1.2 1.5 5.2 -1.0 2.3 -0.3 0.9 1.8 0.3 1.1 0.4 1.1 -1.4
Diverticular disease/diverticulitis (self-reported) 2.6 3.1 9.9 -1.6 -1.6 2.0 -1.8 -1.9 -0.5 0.7 3.1 -0.3 -2.0
Medication: Atenolol 0.7 0.9 3.2 -0.0 -0.9 -0.7 -1.8 -0.9 -0.3 -1.1 0.8 -0.7 -1.1
Medication: Levothyroxine sodium 0.7 1.2 3.9 0.2 0.3 -0.9 -1.0 2.0 0.3 1.0 -0.3 1.9 -1.4
Sitting height 0.1 0.6 2.2 -0.5 0.0 -1.5 -1.3 0.4 -0.4 0.9 -0.4 0.9 -0.1
Chronic bronchitis/emphysema (father) 0.9 1.0 5.3 -1.0 -0.0 -0.5 0.2 -0.5 -2.3 1.4 -1.0 0.1 -0.3
High blood pressure (mother) 0.8 1.1 5.5 0.3 -0.7 0.3 0.5 -0.9 -0.2 -0.2 -1.2 -2.3 1.4
Body mass index (BMI) 0.2 0.9 5.1 0.4 1.2 -0.7 0.4 0.2 0.2 -0.9 -2.2 0.0 0.8
Impedance of leg (left) 1.1 5.5 17.2 -1.6 0.2 4.2 2.1 -0.7 -3.6 2.2 3.3 1.1 -0.7
Leg predicted mass (left) 0.7 3.6 10.7 1.1 -0.1 -3.3 -0.7 -0.4 2.2 -2.4 -2.7 -1.2 1.8
Trunk fat mass 0.2 1.0 3.3 -1.1 0.5 -0.3 1.8 -1.1 -0.7 -0.7 -1.4 0.2 1.1
Waist circumference 0.1 0.5 1.6 -0.6 0.8 0.0 1.1 -0.4 0.6 -0.6 -1.3 0.2 0.2
Number of incorrect matches in round 2.5 4.2 18.6 -4.3 0.2 -0.2 -0.6 -0.5 0.6 1.4 3.1 1.1 -3.1
Past tobacco smoking 0.6 1.2 3.0 1.7 -0.7 -0.8 0.7 0.5 1.0 -1.1 -1.0 -1.0 1.7
Alcohol usually taken with meals 0.5 0.8 2.5 -0.7 -0.4 0.3 1.6 -1.4 -0.8 0.3 -0.5 -0.5 1.1
Nervous feelings 0.7 1.3 4.3 1.2 0.0 -1.5 -1.4 -0.4 -1.4 -0.0 -0.6 -1.0 2.1
Frequency of tenseness / restlessness in last 2 weeks 2.4 3.8 9.2 2.1 -2.0 -1.5 -1.0 -2.1 1.6 -3.0 -1.4 -0.8 2.8
Hearing difficulty/problems with background noise 0.8 1.2 8.4 -0.5 0.4 -0.4 -2.9 -0.4 0.3 0.4 1.5 -0.3 -0.6
Hair/balding pattern: Pattern 2 0.9 1.1 4.0 1.2 -0.8 0.9 -0.5 -0.4 1.4 -2.0 -0.4 -1.2 0.7
Had menopause 0.5 0.7 2.3 -0.9 -0.8 -0.2 -1.2 0.1 -0.1 0.9 0.2 0.6 -1.5
Had other major operations 1.0 1.2 3.7 -0.5 0.4 -1.2 -0.4 1.9 -0.2 1.6 0.1 1.1 -1.6
Forced vital capacity (FVC) 0.4 1.5 8.2 -0.6 1.2 -0.4 -0.2 -0.5 2.9 -2.0 0.1 -0.7 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 6.1 0.8 -0.9 0.3 -1.0 -0.7 -0.0 -0.8 2.5 -1.1 -0.2
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 2.1 -1.5 0.2 -0.3 -0.4 -0.8 -0.6 0.8 0.7 0.7 -0.4
Qualifications: None of the above 1.1 2.3 6.9 -0.3 1.6 -1.1 -0.9 2.2 -1.7 2.6 -0.6 1.5 -1.1
Financial difficulties in last 2 years 0.2 0.3 1.5 -0.4 0.3 1.2 0.1 -0.4 0.7 0.4 -0.2 0.0 0.0
Mouth/teeth dental problems 0.4 0.6 1.8 0.3 -0.4 0.8 -1.1 0.5 0.4 -0.3 1.3 -0.1 -1.3
Heart attack 0.5 0.6 1.9 -0.3 0.2 -0.9 -0.3 -1.4 -1.0 0.2 0.6 1.2 -0.4
Allergy 0.2 0.5 1.3 0.1 0.3 -0.3 1.1 0.9 -0.2 1.0 -1.0 0.7 0.4
Pain all over the body in last month 1.3 1.3 5.0 1.1 0.2 -2.2 -1.3 0.5 -0.3 -0.2 -2.1 -0.5 0.7
Diabetes (self-reported) 0.7 1.1 3.7 -0.8 -0.5 -0.1 0.3 -0.6 -1.9 0.6 -1.6 -1.4 1.0
Hayfever/allergic rhinitis (self-reported) 1.4 1.8 4.6 0.1 -2.1 2.0 0.9 -1.3 1.6 -1.8 1.1 -0.7 0.4
Medication: Ramipril 0.4 0.5 2.3 0.1 0.1 0.5 -1.0 -0.1 1.5 -0.8 -0.8 -0.1 0.0
Medication: Simvastatin 0.2 0.3 0.8 -0.0 0.5 -0.2 -0.7 0.7 -0.1 0.0 0.2 0.7 -0.9
Fluid intelligence score 0.1 0.3 1.3 0.0 0.3 0.1 0.6 -0.2 1.1 -0.8 0.8 0.1 -0.2
Illnesses of siblings 0.6 0.8 3.4 -0.8 0.4 -1.8 0.1 0.2 0.6 0.0 -0.2 1.5 -1.3
Neuroticism score 0.2 0.3 0.7 0.8 -0.6 0.3 -0.3 -0.9 0.4 -0.5 0.7 -0.1 0.8
Weight 0.2 1.1 4.6 0.4 0.9 -1.4 0.5 -0.1 0.5 -1.2 -2.1 -0.4 1.4
Impedance of arm (right) 0.8 3.6 11.2 -2.7 -0.8 3.3 2.5 -1.6 -0.7 0.1 2.6 0.8 -0.3
Arm fat percentage (right) 0.2 0.9 2.9 -1.3 0.7 0.8 1.7 -0.9 -0.4 -0.8 -1.3 0.1 0.7
Trunk fat-free mass 0.8 4.4 16.2 1.9 0.4 -4.0 -2.2 0.7 2.3 -1.7 -2.2 -1.8 1.3
Hip circumference 0.3 1.3 3.9 -0.2 0.8 -0.1 0.8 -0.6 1.8 -2.0 -1.6 0.1 1.0
Time employed in main current job 0.5 0.6 2.3 -1.1 0.6 1.5 0.1 -0.5 -0.3 0.3 1.2 0.2 -0.1
Alcohol intake versus 10 years previously 0.4 0.7 1.6 -0.3 0.1 -1.2 -0.7 -0.5 -1.3 0.5 0.8 1.2 -0.6
Father’s age at death 0.7 1.0 2.8 1.7 -1.0 -0.9 -0.9 -0.5 0.3 -1.0 0.4 -0.2 1.6
Worrier / anxious feelings 0.2 0.4 0.9 -0.3 0.8 0.5 -0.9 -0.7 -0.5 0.6 0.6 0.0 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 4.6 1.1 1.7 0.6 0.3 0.4 1.2 -0.6 -1.4 -1.1 2.1
Falls in the last year 1.5 2.0 8.4 -0.3 -1.6 -0.0 0.9 -2.9 0.4 -1.4 0.5 -1.7 1.8
Hair/balding pattern: Pattern 3 0.6 0.8 2.2 -0.9 0.9 -0.4 -0.4 0.4 -0.7 1.5 1.2 1.1 -0.8
Number of live births 0.7 1.1 2.3 -1.0 1.5 1.2 -0.9 -0.0 1.2 -0.2 0.5 1.4 -1.2
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 13.4 -0.6 1.6 -0.3 -0.2 -0.4 3.7 -2.3 0.6 -0.6 0.2
Pulse rate 0.4 0.7 2.4 1.1 -1.4 -0.6 -0.2 -0.5 -1.6 0.6 -0.1 0.3 0.5
Happiness 0.8 1.0 1.8 -1.4 0.5 0.4 -1.1 -0.4 1.4 0.1 1.3 1.2 -1.2
Noisy workplace 1.3 1.6 6.2 0.4 2.5 -1.2 -0.9 2.1 0.4 0.9 -1.0 1.1 -0.2
Qualifications: A levels/AS levels or equivalent 0.8 1.8 7.1 1.2 0.0 -0.4 0.6 -0.3 2.7 -1.8 -0.8 -1.3 1.7
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.3 1.5 1.2 -0.3 -0.1 1.0 0.6 -0.3 -0.8 0.5 1.0
Mouth/teeth dental problems: Dentures 0.8 1.4 5.8 0.4 0.5 0.6 2.4 -0.2 -0.8 0.5 -1.1 -0.9 2.2
Asthma 0.4 0.9 2.8 -0.1 1.7 -0.3 -0.9 0.2 -1.6 1.4 -0.3 0.6 -0.0
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.1 5.6 1.5 -1.3 -0.8 -1.8 -0.2 2.4 -2.3 0.5 -0.9 -0.8
Medication: Cholesterol lowering 1.3 2.0 8.2 -1.4 -0.2 1.8 0.4 -0.7 -2.9 1.6 0.5 1.3 -0.9
Depression (self-reported) 1.1 1.3 6.2 1.0 -0.2 2.5 0.8 -0.2 1.3 -1.0 -1.2 -0.2 1.0
Medication: Lansoprazole 0.5 0.6 1.5 -0.2 0.5 0.5 1.2 -1.0 0.8 -0.8 0.4 -0.5 0.9
Prospective memory result 1.2 1.5 4.0 -0.3 0.5 -0.8 -0.3 1.7 -2.0 2.0 -1.4 0.7 -0.7
Lung cancer (father) 0.9 1.1 5.4 0.3 -0.3 0.8 -0.3 -0.1 1.8 -2.3 -0.2 -1.1 -0.1
Illnesses of mother 1.5 1.9 6.5 -0.6 1.4 -0.2 0.2 1.2 0.7 -0.1 2.4 2.6 -1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.7 6.7 0.2 1.4 -1.2 -0.3 -0.3 2.6 -2.2 -0.2 -0.8 0.7
Pulse wave Arterial Stiffness index 0.7 0.8 2.1 -0.3 1.1 -0.2 0.2 1.3 0.5 0.6 -1.0 1.1 -1.4
Impedance of arm (left) 1.0 4.6 12.0 -2.7 -1.2 3.5 3.3 -2.2 -1.3 0.4 2.6 1.2 -0.0
Arm fat mass (right) 0.2 0.7 2.4 -0.6 0.9 -0.1 1.1 -0.6 0.1 -1.1 -1.6 -0.1 1.1
Trunk predicted mass 0.8 4.6 17.1 2.0 0.5 -4.1 -2.3 0.8 2.3 -1.8 -2.2 -1.9 1.3
Standing height 0.1 0.8 3.1 0.2 -0.2 -1.6 0.4 -0.6 0.8 -0.8 0.1 -1.0 1.8
Length of working week for main job 0.3 0.3 0.9 -0.1 0.1 -0.0 0.4 0.3 0.7 -0.2 0.8 0.7 -0.9
Exposure to tobacco smoke at home 2.2 2.5 9.9 -2.1 0.5 0.2 0.3 1.7 0.0 1.6 1.0 1.9 -3.1
Breastfed as a baby 0.8 1.0 2.1 0.9 -1.1 0.7 -1.0 -1.3 -0.1 -0.7 1.5 -1.3 0.5
Tense / ‘highly strung’ 0.5 0.8 3.2 -0.1 -0.6 -1.0 -1.8 0.9 0.1 0.8 -0.5 1.0 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 1.6 -0.3 -1.2 1.0 -1.1 -1.1 0.4 -0.4 0.6 0.6 -0.7
Hair/balding pattern: Pattern 4 0.4 1.1 2.7 1.2 -1.6 -1.1 -1.2 -0.1 0.2 -1.6 -0.6 -0.9 0.3
Birth weight of first child 0.3 0.6 1.8 -0.1 0.2 -0.6 -0.7 -0.3 1.3 -1.1 -0.8 -1.0 -0.2
Peak expiratory flow (PEF) 0.2 0.4 1.3 -0.4 0.5 -0.5 -0.4 -0.9 1.1 -0.9 0.2 -0.3 -0.3
Pulse wave reflection index 1.2 1.4 4.3 0.1 1.8 -0.5 -0.9 2.1 1.4 0.2 -0.5 1.3 -1.4
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.9 -1.4 0.6 0.4 -0.5 -0.6 -0.9 1.2 -0.1 0.4 -0.7
Loud music exposure frequency 0.6 0.7 2.0 1.3 0.7 -1.4 0.1 0.6 -0.0 0.9 -0.3 0.4 0.9
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 8.3 0.1 -0.1 0.6 0.5 -0.2 2.9 -2.1 -0.9 -0.4 1.2
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.8 -0.3 1.4 -1.2 -0.5 0.1 -0.4 0.9 -1.1 0.7 0.2
Blood clot in the leg (DVT) 0.8 1.1 5.2 0.8 -2.3 -0.6 -0.1 -1.7 -0.9 -0.4 -0.0 0.6 -0.2
Medication: Paracetamol 0.6 0.9 2.3 0.9 0.3 -1.2 -1.5 0.5 1.5 -1.3 -0.1 0.2 0.8
Headache pain in last month 1.1 1.8 9.7 -0.2 1.3 -0.3 -0.9 1.0 3.1 -0.8 1.1 1.4 -0.9
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 3.8 0.3 0.4 -1.7 -0.1 0.9 2.0 -0.8 0.2 -1.2 0.3
Glaucoma (self-reported) 0.8 1.0 3.1 -1.0 1.8 -0.3 -0.9 1.2 1.0 0.7 0.4 0.7 -1.2
Gout (self-reported) 0.2 0.3 1.3 -1.1 0.3 -0.5 -0.1 -1.0 -0.2 -0.0 0.0 -0.3 0.2
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.1 -0.3 -0.1 -1.1 -0.4 0.9 -0.7 0.9 0.8 1.4 -1.2
Medication: Amlodipine 0.9 1.2 6.2 -0.1 0.0 2.5 0.1 -1.5 0.9 -1.3 0.5 -0.9 0.3
Medication: Ventolin 100micrograms inhaler 1.8 2.4 7.1 0.3 -2.3 -1.0 -0.8 -2.2 -0.1 -1.7 0.5 -2.7 1.3
Birth weight 0.2 0.4 1.7 1.3 -0.1 -0.1 -0.6 0.4 0.6 -0.6 0.1 0.6 -0.2
Chronic bronchitis/emphysema (mother) 1.2 1.4 5.8 -2.4 0.7 1.0 -0.1 -0.4 -1.7 1.1 0.9 -0.1 -1.4
High blood pressure (siblings) 0.5 0.7 4.8 -0.2 0.8 2.2 0.2 -0.2 0.2 0.5 0.1 -0.8 0.8
Forced vital capacity (FVC), Best measure 0.3 1.3 3.4 -0.0 1.1 -1.3 -0.5 -0.5 1.8 -1.8 -0.7 -1.0 1.1
Body fat percentage 0.4 1.4 5.0 -1.5 0.8 1.1 2.2 -1.1 -1.4 -0.3 -0.9 0.7 0.7
Leg fat percentage (right) 0.4 1.5 4.6 -0.8 1.6 1.4 1.8 0.1 -2.1 0.6 -1.0 0.7 0.5
Arm fat-free mass (right) 0.6 3.0 13.3 1.9 0.3 -3.6 -1.6 0.3 1.1 -1.3 -2.1 -1.1 1.2
Exposure to tobacco smoke outside home 1.4 1.8 4.3 -1.2 -2.1 -1.2 0.3 -2.0 -1.7 0.0 2.1 -0.2 0.2
Comparative body size at age 10 0.5 1.2 3.3 -1.4 1.4 -1.1 -0.5 0.7 1.7 0.2 -0.1 0.6 -1.8
Number of full brothers 0.9 1.1 4.4 1.6 -2.1 0.7 0.4 1.0 0.5 -0.4 -1.1 0.8 0.0
Worry too long after embarrassment 0.3 0.5 1.6 1.1 0.3 0.7 -0.3 -0.2 0.7 -1.2 0.4 -0.7 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.2 2.9 0.9 -1.7 -1.4 -1.7 -1.1 -1.0 -0.5 -0.2 -0.6 0.9
Wheeze or whistling in the chest in last year 0.1 0.2 1.0 0.1 0.7 -0.1 -0.3 -0.0 -0.1 -0.4 -1.0 -0.5 0.6
Number of children fathered 0.6 0.7 1.8 -1.0 1.0 -0.5 0.1 0.7 -0.7 0.9 -0.3 1.1 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 3.8 1.9 -0.8 0.6 -0.7 0.3 0.1 -0.6 -1.8 -0.3 1.0
Age at first live birth 0.4 0.7 2.9 -0.3 1.7 -1.4 -0.1 0.2 0.4 -0.3 0.1 -1.1 0.4
Pulse wave peak to peak time 0.8 1.0 2.7 0.3 -1.1 0.2 -0.0 -1.4 -0.4 -0.7 1.2 -1.4 1.6
Health satisfaction 1.3 1.7 4.7 -1.8 1.1 1.5 -0.4 0.5 1.4 0.1 1.2 1.3 -2.2
Shortness of breath walking on level ground 0.2 0.3 1.0 -0.6 -0.1 1.0 0.3 -0.3 0.7 -0.4 -0.7 0.1 0.2
Qualifications: College or University degree 0.5 1.6 3.5 0.4 -1.5 -1.8 0.0 -1.1 1.9 -1.8 0.7 -1.4 -0.3
Eye problems/disorders: None of the above 1.3 1.5 6.0 -2.4 0.5 0.4 -0.8 -1.1 1.4 -0.2 1.2 -1.4 -1.2
Mouth/teeth dental problems: Loose teeth 0.7 0.8 2.4 -0.2 -0.2 -0.0 1.4 0.4 -0.9 1.1 -1.6 0.9 -0.9
Emphysema/chronic bronchitis 0.9 1.0 4.6 -1.0 0.2 -0.9 -0.4 0.7 -0.8 2.1 0.2 1.0 -1.1
Medication for pain relief, constipation, heartburn 0.7 1.3 3.5 -1.0 0.7 -0.1 0.8 0.8 -1.4 1.9 0.5 1.8 -1.0
Neck or shoulder pain in last month 0.8 1.1 3.1 -0.4 0.0 0.1 -1.4 0.3 1.4 -1.0 1.8 0.5 -1.7
Medication: Blood pressure 0.4 0.7 2.4 0.1 -1.1 1.4 -0.4 -1.5 -0.5 -0.2 -0.5 1.0 0.2
Angina (self-reported) 0.9 1.2 5.9 -0.3 -0.9 2.4 0.6 -0.5 -0.3 0.2 1.1 1.4 -1.3
Migraine (self-reported) 1.8 2.2 8.2 2.9 0.1 -0.1 -1.0 1.0 2.4 -1.9 -1.4 -0.2 0.4
Medication: Ibuprofen 2.7 3.2 8.2 2.1 -2.2 -1.3 -2.2 -0.4 2.3 -2.9 1.0 -1.1 -0.5
Medication: Allopurinol 0.4 0.5 1.2 -1.1 0.5 -1.0 -0.0 0.0 -0.4 1.1 -0.6 0.5 -0.6
Medication: Omeprazole 0.2 0.2 0.7 -0.3 -0.3 -0.2 0.3 -0.1 -0.4 0.1 -0.7 -0.3 0.8
Medication: Seretide 50 evohaler 0.8 0.9 3.1 -1.3 -0.0 0.1 -1.4 0.8 -1.8 1.2 0.3 0.4 -0.6
Mean time to correctly identify matches 0.3 0.5 2.0 -0.6 0.8 1.0 0.3 0.1 1.4 -0.5 0.2 -1.0 0.0
Heart disease (mother) 0.5 0.6 2.6 0.7 0.4 0.7 -1.1 0.3 -0.0 0.6 -1.6 -0.5 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 2.1 -0.7 0.6 -0.4 0.9 -1.4 -1.3 0.9 0.9 0.3 1.2
Whole body fat mass 0.2 0.9 2.3 -0.7 0.7 -0.2 1.5 -0.9 -0.8 -0.8 -1.4 0.0 1.2
Leg fat mass (right) 0.3 1.1 3.1 -0.4 1.6 -0.2 1.6 -0.1 -1.1 -0.3 -1.8 0.3 1.3
Arm predicted mass (right) 0.6 3.3 13.5 2.1 0.3 -3.7 -1.4 0.6 1.4 -1.2 -2.4 -0.8 1.4
Pulse rate, automated reading 0.4 1.4 7.1 1.2 -1.5 -0.0 -0.6 0.1 -2.7 1.6 -0.7 0.2 0.2
Alcohol intake frequency. 0.6 1.3 6.3 1.0 0.5 -1.9 -0.3 0.1 2.5 -0.5 -0.7 0.6 0.8
Comparative height size at age 10 0.1 0.6 1.5 -1.2 0.6 -0.9 -0.9 0.0 -0.4 0.9 -0.5 -0.8 0.8
Number of full sisters 1.1 1.4 4.5 1.8 -0.9 0.2 -0.2 -1.2 -0.7 -1.4 0.6 -2.1 1.0
Suffer from ‘nerves’ 0.5 0.7 1.9 1.0 -0.7 -0.2 -1.1 -0.6 -1.4 -0.1 -0.6 -0.7 1.2
Overall health rating 0.3 0.7 2.2 -1.5 0.8 0.5 0.2 -0.1 -1.1 1.3 -0.7 0.3 -0.1
Chest pain or discomfort 0.2 0.4 1.3 -0.9 -0.3 -0.6 0.1 -0.6 0.5 -0.6 0.1 -1.1 0.1
Had major operations 0.5 0.5 2.3 -0.5 -0.2 -0.5 -0.6 0.2 1.5 -0.9 0.8 0.3 -0.7
Age at last live birth 0.5 0.7 3.5 -0.1 1.9 -0.7 -0.5 0.4 1.4 -0.2 0.1 0.8 -0.4
Family relationship satisfaction 0.3 0.4 2.0 -0.2 0.5 -0.7 -0.7 0.1 0.0 0.5 1.4 0.3 -0.6
Leg pain on walking 0.6 0.8 1.8 1.3 -0.0 -0.3 -0.3 -0.2 1.2 -1.3 -0.7 -0.9 1.3
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.0 11.7 0.0 1.3 3.4 2.2 0.1 -1.1 0.8 -0.3 0.3 -0.0
Commuting to job workplace: Car/motor vehicle 1.9 2.2 6.5 -1.6 2.5 0.8 1.2 -0.4 -2.5 1.8 0.2 1.0 -0.6
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 6.9 -1.1 0.5 2.6 0.8 0.8 -1.1 1.2 0.9 0.9 -1.3
Medication: Aspirin 1.5 1.9 5.7 -1.9 0.7 2.4 0.9 -0.8 -2.2 1.4 0.9 -0.2 -0.4
Supplements: Vitamin C 0.7 0.8 3.9 -0.9 -1.0 -2.0 -0.1 -1.1 -0.5 -0.2 0.7 -0.7 -0.1
Knee pain experienced in last month 0.8 1.3 4.1 1.3 -0.3 -0.7 -0.9 -0.3 1.4 -2.0 0.6 -1.4 1.2
Hypertension (Self-reported) 0.3 0.7 1.7 -0.2 -1.2 1.1 -0.7 -1.3 0.7 -1.0 -0.2 0.5 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 3.2 0.1 0.7 -0.4 1.3 -0.3 1.5 -1.2 -1.0 -1.2 1.8
Illnesses of father: Heart disease 0.9 1.2 3.2 0.1 0.3 -0.7 -1.8 -0.7 -1.4 0.5 -1.7 -1.6 0.3
Illnesses of siblings: Diabetes 2.6 3.2 11.7 1.4 -0.8 1.3 3.0 -0.8 -1.8 -0.3 -0.7 -1.6 3.4
Smoking status: Previous 0.5 0.8 1.6 -0.7 0.6 1.2 -0.2 -0.1 -1.1 1.1 0.6 1.0 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 0.7 0.2 0.8 -0.3 0.8 -0.2 0.7 -0.3 0.5 0.6 0.7
Whole body fat-free mass 0.7 4.2 15.5 1.8 0.1 -3.9 -1.8 0.3 2.2 -2.0 -2.4 -1.6 1.5
Leg fat-free mass (right) 0.7 3.7 12.8 1.2 -0.3 -3.6 -1.2 -0.3 2.2 -2.2 -2.8 -1.2 1.5
Arm fat percentage (left) 0.3 1.2 4.1 -1.1 0.5 0.6 2.0 -1.2 -0.7 -0.9 -1.4 0.2 1.0
Average weekly red wine intake 0.5 0.7 3.6 -1.9 0.7 -0.4 0.4 -0.1 -0.6 0.9 1.0 -0.2 -0.6
Handedness (chirality/laterality): Left-handed 1.3 1.6 5.8 0.0 1.3 -1.9 -1.1 0.9 2.4 -1.6 0.5 0.2 -0.2
Mood swings 0.6 1.1 3.7 1.3 0.3 0.1 -0.7 -0.5 1.5 -1.9 0.9 0.0 1.3
Loneliness, isolation 0.8 1.1 4.4 0.6 0.3 0.2 0.6 -1.0 1.1 -0.7 -1.6 -0.7 2.1
Long-standing illness, disability or infirmity 0.5 0.8 2.1 0.6 -0.6 0.3 -0.0 0.0 1.2 -1.2 -1.5 -1.2 0.9
Ever had bowel cancer screening 0.7 0.8 2.7 0.4 0.2 -1.6 -0.3 -0.8 0.7 -1.5 -0.8 -0.9 0.7
Diabetes diagnosed by doctor 0.7 1.2 4.2 -0.3 -0.4 -0.8 0.3 -0.6 -2.1 0.4 -1.8 -1.4 0.8
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.2 2.7 -0.7 1.3 1.4 -1.4 0.3 -0.7 1.3 0.6 0.8 -1.6
Friendships satisfaction 0.5 0.6 3.8 -0.9 0.6 -0.5 -0.7 -0.6 0.2 0.2 2.0 -0.2 0.1
Qualifications: nursing, teaching 1.7 2.6 8.4 0.6 0.9 -0.8 0.4 -1.0 1.5 -2.4 -0.6 -2.5 2.9
Commuting to job workplace: Walk 0.8 0.8 3.0 -0.1 -1.7 -0.4 0.1 -0.5 1.1 -0.4 1.4 0.7 -0.9
Eye problems/disorders: Cataract 1.8 2.1 12.6 3.5 -1.4 -0.2 -0.5 0.5 -0.9 -1.5 -1.1 0.0 1.3
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 1.1 0.4 -1.1 -0.8 -0.9 0.6 0.1 -0.6 -0.1 0.3 0.5
Medication for cholesterol 0.4 0.6 2.0 0.3 -0.2 -1.0 0.4 -0.5 -1.0 0.2 -1.4 0.9 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 1.0 -0.1 -0.7 0.0 -0.1 -0.5 0.3 0.4 0.1 0.5 -1.0
Back pain experienced in last month 0.1 0.1 0.5 0.2 0.4 0.7 -0.2 0.2 0.3 -0.2 0.1 0.3 -0.6
Mineral and other dietary supplements 0.7 1.0 5.6 0.5 -2.4 0.9 0.5 -1.3 -0.5 -0.2 -0.4 0.2 1.0
Breast cancer (self-reported) 0.6 0.7 3.1 0.6 -0.8 -1.8 -0.3 -0.2 -1.1 0.8 1.0 -0.3 0.1
Asthma (self-reported) 0.4 0.8 2.8 0.2 1.6 -0.3 -0.8 0.0 -1.7 1.3 -0.6 0.3 0.2
Osteoporosis (self-reported) 0.3 0.4 1.6 0.4 -0.3 -0.6 0.5 -0.1 1.1 -0.5 -0.1 -0.6 1.3
Osteoarthritis (self-reported) 1.1 1.4 4.9 0.4 -0.9 0.9 -1.0 -0.2 2.2 -2.2 -0.3 -1.0 -0.5
Medication: Aspirin 1.4 1.9 5.1 -1.8 0.7 2.2 0.9 -0.3 -2.2 1.6 1.2 0.1 -0.5
Medication: Gliclazide 0.9 1.0 2.9 0.7 -1.1 0.2 0.7 -1.3 0.2 -0.8 -1.2 -1.2 1.7
Illnesses of father: None of the above (group 1) 1.6 1.9 9.4 1.2 0.9 0.4 1.0 0.7 3.1 -1.7 0.5 1.7 0.4
Smoking status: Current 0.5 0.9 5.1 -2.2 -0.3 0.1 0.7 -0.9 0.1 0.6 0.6 0.6 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 10.2 -0.4 0.7 -0.5 -1.4 0.6 3.2 -1.7 0.3 -0.3 -0.7
Whole body water mass 0.7 4.2 15.5 1.6 0.1 -3.9 -1.9 0.2 2.3 -2.0 -2.5 -1.6 1.5
Leg predicted mass (right) 0.7 3.6 12.8 1.1 -0.3 -3.6 -1.2 -0.3 2.2 -2.2 -2.7 -1.2 1.5
Arm fat mass (left) 0.2 1.0 4.2 -0.3 0.7 -0.2 1.3 -0.6 -0.2 -1.0 -2.0 -0.0 1.3
Number of self-reported non-cancer illnesses 1.0 1.8 9.6 1.2 -3.1 -0.4 -0.9 -1.9 -0.0 -0.6 -0.2 -0.9 1.1
Average weekly champagne plus white wine intake 0.5 0.6 3.2 0.6 -1.0 -0.3 0.8 -0.6 0.4 -1.8 0.5 0.3 -0.2
Miserableness 0.3 0.5 1.4 -1.0 1.2 1.0 0.6 -0.4 -0.1 0.8 0.1 0.0 0.7
Guilty feelings 0.5 0.7 2.8 1.3 0.1 -1.7 -1.0 -0.1 -1.0 0.3 -0.2 0.4 0.9
Wears glasses or contact lenses 0.8 0.9 2.8 -0.7 -0.6 -0.1 -1.0 0.3 -0.5 1.0 0.7 1.5 -1.7
Ever taken oral contraceptive pill 0.3 0.4 1.6 1.3 -0.4 0.2 0.5 0.3 -0.8 -0.1 -0.7 0.2 0.4
Hearing aid user 0.4 0.5 1.3 0.1 0.8 -1.1 -0.1 1.1 0.2 0.8 -0.5 0.7 -0.1
Mother’s age at death 0.6 0.8 2.5 -1.0 -0.5 0.5 -0.5 -0.9 -1.3 0.8 1.6 -0.2 -0.7
Financial situation satisfaction 0.9 1.2 3.8 -2.0 -0.3 1.6 -0.4 -0.7 0.1 1.2 0.9 1.3 -0.7
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.2 -1.0 -0.7 -1.5 -0.1 -1.3 0.7 -0.6 1.0 -1.3 0.4
Commuting to job workplace: Public transport 0.9 1.1 3.8 1.3 -2.0 -0.7 0.1 0.5 1.4 -1.4 0.2 -0.8 0.7
Eye problems/disorders: Glaucoma 1.3 1.6 3.9 -1.2 1.2 0.4 0.2 1.4 1.1 1.1 0.8 2.0 -2.0
Medication: Blood pressure 0.3 0.6 1.9 -0.5 0.3 1.0 -0.6 0.4 1.4 -0.6 0.5 -0.8 -1.2
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.6 1.0 -0.7 -0.5 -0.7 -0.3 0.1 -1.1 -1.2 -0.5 0.9
Supplements: Fish oil (including cod liver oil) 0.7 0.9 5.9 -0.1 2.4 -1.0 -0.3 0.8 0.0 0.1 -0.1 -0.9 -0.3
High cholesterol (Self-reported) 0.2 0.4 1.0 0.4 -0.4 1.0 -0.4 0.7 -0.5 0.7 -0.1 0.7 -0.9
Medication: Bendroflumethiazide 1.3 1.9 4.0 -1.9 0.0 1.7 -1.9 -0.9 1.0 -0.1 1.5 0.9 -2.0
Medication: Paracetamol 0.9 1.3 3.7 1.1 -0.4 -1.3 -1.5 -0.1 1.8 -1.9 0.4 -0.1 0.9
Medication: Lisinopril 0.3 0.4 2.1 -0.6 -0.1 -0.6 -1.4 -0.3 -0.4 -0.1 0.6 0.5 -0.9
Medication: Atorvastatin 2.2 2.8 8.1 -1.8 0.6 2.8 1.6 -0.3 -2.2 2.0 0.5 1.5 -1.3
Illnesses of father: High blood pressure 0.8 1.0 3.5 -1.6 -0.4 0.9 0.1 -1.0 0.4 0.2 1.4 -1.9 -0.3
Alcohol drinker status: Never 0.6 0.8 3.1 0.7 -0.5 -0.2 0.7 -0.1 1.3 -0.6 -1.8 -0.4 0.9
Ever smoked 0.5 0.8 2.6 -1.6 -0.3 0.2 -0.6 -1.3 -0.9 0.5 1.0 0.5 -0.9
Basal metabolic rate 0.6 3.1 10.7 1.3 0.3 -3.3 -1.3 0.1 1.9 -1.9 -2.4 -1.3 1.5
Leg fat percentage (left) 0.4 1.5 5.3 -1.0 1.4 1.4 1.6 -0.2 -2.3 0.8 -1.0 0.6 0.4
Arm fat-free mass (left) 0.6 3.1 11.0 1.8 0.4 -3.3 -2.1 0.4 1.5 -1.4 -2.4 -1.1 1.1
Number of operations (self-reported) 0.5 0.7 2.1 -0.2 -0.4 -1.5 -1.0 0.5 0.6 -0.2 1.0 0.9 -1.3
Average weekly beer plus cider intake 0.5 0.8 4.1 -2.0 0.9 -0.4 -0.4 0.2 0.9 0.4 -0.5 -0.3 -1.1
Irritability 0.4 0.7 2.4 1.2 -1.1 -0.7 -1.6 0.0 0.5 -0.7 0.6 0.8 -0.6
Risk taking 1.3 2.0 7.5 0.2 -2.7 -1.3 1.0 -2.1 1.1 -1.0 0.8 0.0 1.4
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.0 -0.8 -0.4 -0.4 -0.5 0.1 -0.8 1.0 0.7 0.2 -1.0
Fractured/broken bones in last 5 years 0.9 1.1 3.2 0.5 1.7 -0.3 0.7 -0.4 0.1 -0.3 -1.7 -1.0 1.8
Age started oral contraceptive pill 0.3 0.3 1.0 -0.2 -1.0 -0.3 0.2 -1.0 -0.2 0.1 -1.0 -0.6 0.1
Diastolic blood pressure, automated reading 3.5 10.9 78.1 -2.2 0.7 0.2 -1.1 -0.1 8.8 -4.3 0.8 0.2 -2.2
Ever depressed for a whole week 0.2 0.3 0.7 0.3 -0.7 -0.9 -0.6 -0.3 0.7 -0.3 0.1 -0.1 -0.5
Unable to work because of sickness or disability 0.8 1.0 3.2 0.6 -1.0 -0.1 -1.6 -1.0 1.8 -1.3 -0.0 -0.1 -0.3
Commuting to job workplace: Cycle 2.1 2.6 7.0 0.8 -1.4 -2.7 -1.7 -2.1 0.6 -2.3 -0.1 -1.5 0.8
Myopia 1.2 1.7 4.1 -0.6 -1.0 -1.5 -1.3 -2.0 0.3 -1.4 1.3 -1.9 -0.2
Vascular/heart problems diagnosed by doctor 0.3 0.9 3.5 0.2 1.5 -1.9 0.6 1.2 -0.1 0.4 -0.2 -0.7 0.9
Cholesterol lowering medication 0.7 1.1 4.9 -0.6 0.5 0.5 -0.0 1.5 -0.1 1.0 0.3 1.2 -2.2
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 2.7 0.2 -0.7 -0.7 0.3 -1.0 -0.3 -0.8 -0.8 -1.3 1.6
Pain experienced in last month 1.5 2.5 6.8 0.6 -0.5 1.0 2.6 -0.7 -2.6 1.2 -0.8 -1.0 2.5
Supplements: Calcium 0.6 0.7 2.1 -0.8 1.1 -0.4 -0.5 1.5 1.1 0.7 -0.4 0.1 -0.7
Basal cell carcinoma (self-reported) 1.0 1.1 3.5 -1.0 -1.0 -0.1 -0.1 -1.7 1.6 -0.3 1.9 0.1 0.4
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.9 -0.6 0.5 -0.8 -0.1 -1.4 -0.8 0.3 0.7 1.2 -0.4
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 6.7 0.5 -2.6 -0.3 -0.2 -1.8 -0.9 -0.4 0.3 1.0 -0.6
Heart disease (siblings) 0.5 0.7 2.0 0.6 -1.1 1.4 0.2 -0.4 -0.2 -0.4 0.7 -1.4 -0.3
Alcohol drinker status: Previous 0.9 1.0 4.6 -0.1 -1.6 -2.1 0.2 -0.7 -0.8 0.8 -0.5 0.4 0.8
Pack years of smoking 0.6 0.9 1.9 0.9 -0.3 0.3 1.4 0.5 -0.7 1.4 -1.4 0.9 0.5
Impedance of whole body 1.1 5.7 16.9 -2.5 -0.7 4.1 2.9 -1.6 -2.6 1.4 3.3 1.5 -0.6
Leg fat mass (left) 0.3 1.1 3.1 -0.4 1.4 -0.0 1.4 -0.4 -1.3 -0.2 -1.8 0.2 1.4
Arm predicted mass (left) 0.6 3.1 9.4 1.8 0.6 -3.1 -2.0 0.5 1.7 -1.5 -2.5 -1.1 1.1