Best TWAS P=4.47e-14 · Best GWAS P=2.11e-13 conditioned to 0.244
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | GTEx | Cells Transformed fibroblasts | SSR3 | 0.08 | 0.01 | lasso | 6 | 0.02 | 2.1e-02 | 6.9 | -7.5 | 4.5e-14 | -0.87 | 0.01 | 0.97 | TRUE |
| 5 | GTEx | Heart Atrial Appendage | RP11-305K5.1 | 0.16 | 0.05 | lasso | 3 | 0.05 | 2.6e-03 | 5.2 | -6.0 | 1.5e-09 | -0.33 | 0.16 | 0.38 | TRUE |
| 10 | GTEx | Thyroid | TIPARP-AS1 | 0.15 | 0.13 | enet | 13 | 0.17 | 7.3e-13 | 3.9 | -6.5 | 7.6e-11 | -0.56 | 0.68 | 0.32 | FALSE |
| 9 | GTEx | Stomach | TIPARP-AS1 | 0.17 | 0.08 | enet | 7 | 0.11 | 6.4e-06 | 3.9 | -6.3 | 2.8e-10 | -0.70 | 0.11 | 0.79 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SSR3 | 0.06 | 0.04 | lasso | 5 | 0.03 | 4.9e-04 | -6.3 | -6.1 | 9.0e-10 | -0.31 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | TIPARP-AS1 | 0.17 | 0.16 | enet | 9 | 0.16 | 3.7e-09 | 3.9 | -5.7 | 1.4e-08 | -0.54 | 0.76 | 0.23 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SSR3 | 0.04 | 0.04 | enet | 3 | 0.03 | 4.2e-04 | 5.5 | -5.6 | 2.1e-08 | -0.30 | 0.05 | 0.92 | FALSE |
| 6 | GTEx | Muscle Skeletal | TIPARP-AS1 | 0.19 | 0.13 | enet | 20 | 0.13 | 1.1e-12 | 3.9 | -5.5 | 4.4e-08 | -0.59 | 0.98 | 0.02 | FALSE |
| 4 | GTEx | Esophagus Muscularis | TIPARP-AS1 | 0.23 | 0.14 | enet | 18 | 0.15 | 2.0e-09 | 3.9 | -5.5 | 4.9e-08 | -0.63 | 0.42 | 0.58 | FALSE |
| 1 | GTEx | Artery Aorta | LINC00886 | 0.40 | 0.24 | lasso | 9 | 0.22 | 2.7e-12 | 5.0 | 5.3 | 1.3e-07 | 0.38 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Tibial | KCNAB1 | 0.14 | 0.04 | enet | 14 | 0.07 | 7.5e-06 | 4.5 | 5.2 | 1.6e-07 | 0.28 | 0.91 | 0.02 | FALSE |
| 7 | GTEx | Nerve Tibial | TIPARP-AS1 | 0.09 | 0.10 | lasso | 3 | 0.10 | 1.7e-07 | 3.9 | -5.2 | 2.0e-07 | -0.62 | 0.09 | 0.90 | FALSE |