Hub : Genes

KCNAB1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0620	0.0300	2.2e-02	0.037	0.001	0.013	0.010	0.027	2.1e-05	2.0e-01	8.9e-03	2.0e-02	2.6e-04
2	GTEx	Artery Aorta	0.1530	0.0470	3.2e-05	0.138	NA	0.132	NA	0.135	5.0e-08	NA	9.5e-08	NA	7.4e-08
3	GTEx	Artery Tibial	0.1370	0.0424	8.0e-05	0.044	NA	0.065	NA	0.039	2.1e-04	NA	7.5e-06	NA	4.5e-04
4	GTEx	Thyroid	0.2200	0.0720	1.6e-03	0.011	NA	0.048	NA	0.060	4.8e-02	NA	1.4e-04	NA	2.3e-05
5	NTR	Blood	0.0468	0.0150	3.5e-05	0.025	0.013	0.031	0.021	0.030	1.5e-08	2.4e-05	1.9e-10	1.4e-07	3.6e-10
6	YFS	Blood	0.0473	0.0133	6.0e-07	0.043	0.021	0.030	0.035	0.035	7.3e-14	1.0e-07	4.8e-10	1.6e-11	1.1e-11
7	TCGA	Colon Adenocarcinoma	0.1760	0.0670	1.8e-04	0.015	0.035	0.017	NA	0.014	4.6e-02	4.0e-03	3.3e-02	NA	4.8e-02
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0765	0.0229	7.2e-08	0.103	0.081	0.098	NA	0.098	1.3e-11	2.1e-09	4.3e-11	NA	4.5e-11
9	TCGA	Lung Adenocarcinoma	0.0627	0.0291	5.8e-04	0.015	0.028	0.045	NA	0.022	5.5e-03	2.8e-04	4.5e-06	NA	1.1e-03
10	TCGA	Lung Squamous Cell Carcinoma	0.0366	0.0179	7.7e-03	-0.001	0.014	0.008	NA	-0.002	4.5e-01	9.6e-03	3.5e-02	NA	7.8e-01
11	TCGA	Prostate Adenocarcinoma	0.2465	0.0492	0.0e+00	0.216	0.205	0.220	NA	0.229	2.9e-22	4.7e-21	1.1e-22	NA	1.3e-23

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	1.1	1.7	5.3	-1.4	0.7	1.7	-0.5	-2.3	-1.5	-1.3	-0.7	-1.7	-0.7	0.2
Bipolar Disorder or Schizophrenia	0.3	0.8	2.0	0.6	0.5	1.0	-1.1	-1.2	0.3	-0.6	-1.1	-1.4	-0.2	-0.6
Depressed Affect (Nagel 2018)	0.9	2.0	7.2	0.9	-2.3	-1.3	1.1	0.5	1.0	-0.1	1.2	0.1	2.7	-1.7
Depression (Nagel 2018)	0.8	1.2	3.4	0.1	-1.9	-1.1	-0.7	1.0	0.5	-1.5	0.5	0.3	1.5	-1.4
Intelligence (Savage-Jansen 2018)	0.7	2.2	8.9	-3.0	1.0	0.9	1.2	-0.0	-2.7	-0.4	0.7	-0.9	-1.1	1.5
Neuroticism (Nagel 2018)	0.4	0.9	2.2	0.8	-1.3	-0.6	1.5	0.5	0.9	-0.2	0.3	0.7	1.3	-0.9
Schizophrenia (2018)	0.4	0.9	3.7	1.9	0.1	-0.0	-1.1	0.3	1.6	0.2	-0.8	-0.5	0.3	-1.0
Schizophrenia vs Biploar Disorder	1.5	1.9	5.0	1.9	-1.8	-1.3	-1.5	0.4	1.4	-1.0	-0.4	-0.8	1.4	-2.2
Worry (Nagel 2018)	0.5	1.0	2.6	0.8	-1.5	-0.4	1.0	-0.1	1.0	-0.5	-0.2	1.1	1.6	-1.4
Alzheimer’s Disease (in mother)	0.3	0.4	1.3	-0.0	0.9	-0.2	-0.3	-1.1	0.4	0.9	0.1	-0.0	-0.2	0.8
Alzheimer’s Disease (in father)	0.6	0.7	3.3	-0.1	-1.2	-0.2	-0.2	-0.3	-0.5	-1.2	-0.7	0.4	0.3	-1.8
Alzheimer’s Disease (including proxy)	0.4	0.6	1.5	-0.2	1.0	0.8	-0.2	-1.2	-0.2	-0.2	-1.1	-0.5	-1.1	0.6
Crohns Disease (2017)	0.4	1.0	3.0	1.7	-0.4	-1.4	0.7	-0.9	1.2	1.1	0.6	1.1	0.1	0.2
Irritable Bowel Disease (IBD)	0.4	0.9	2.4	1.2	0.3	-0.7	-0.2	-1.3	0.8	0.7	-0.5	1.4	-1.5	0.1
Ulcerative Colitis (UC)	0.4	0.8	4.0	-0.1	0.7	0.2	-0.2	-1.2	-0.4	-0.5	-1.1	1.0	-2.0	0.1
Major Depression (MDD)	0.7	0.8	4.2	0.9	-1.2	0.2	0.2	0.3	0.7	-0.6	-1.2	-0.7	-0.0	-2.1
Reaction Time	1.7	3.2	9.4	0.5	2.0	2.4	-0.3	-0.6	-0.1	-0.9	-3.0	-3.1	-2.2	0.1
Verbal and Numeric Reasoning (VNR)	0.9	2.2	7.7	-2.8	1.3	0.7	1.3	1.2	-2.2	-0.1	0.7	0.0	-1.0	2.1
Breast Cancer	0.5	1.2	5.9	-0.9	-0.3	0.1	2.0	2.4	-0.9	0.1	0.9	-0.2	0.5	-0.2
Ovarian Cancer	0.8	1.0	2.5	0.6	1.3	0.9	0.3	-0.4	-0.2	1.6	-0.8	1.4	-1.5	0.7
Prostate Cancer	1.1	1.5	4.8	0.3	-1.6	-0.8	1.9	0.1	-0.1	0.6	1.8	0.7	2.2	-0.6
Age at First Birth	0.4	0.6	2.2	-0.5	-0.8	0.6	0.1	-0.7	-0.9	-0.5	-0.9	-1.5	-0.2	-0.9
Bipolar Disorder (2011)	4.5	4.4	9.9	-1.1	2.8	3.1	0.5	-2.5	-1.4	-0.6	-2.3	-1.9	-2.8	1.9
Body Mass Index (BMI) (2010)	1.2	1.6	3.9	1.9	1.1	0.3	0.4	1.4	1.6	1.2	0.0	1.8	0.3	2.0
Coronary Artery Disease (CAD)	0.5	0.6	1.8	1.0	-1.0	-1.3	0.5	-0.4	0.5	0.7	1.1	0.3	0.4	-0.2
Crohns Disease (2012)	1.0	1.6	4.9	1.2	-0.2	-1.4	1.4	0.3	0.9	1.2	1.9	2.2	0.7	1.1
Mean Putamen Volume	1.2	1.3	4.8	-0.1	0.8	-0.1	-1.9	1.0	0.1	1.3	1.3	1.1	-0.5	2.2
Fasting Glucose	0.7	0.9	2.7	-0.2	1.5	-0.2	1.0	0.6	-0.1	1.6	0.5	1.0	0.1	1.4
HbA1C	0.7	0.8	1.9	-1.4	0.4	0.7	0.6	0.1	-1.3	-1.4	0.4	0.3	0.3	1.3
HDL Cholesterol	0.2	0.3	1.2	-1.1	0.1	0.3	-0.2	0.7	-0.9	-0.6	-0.4	-0.6	0.1	-0.3
LDL Cholesterol	1.0	1.5	4.3	-0.2	-1.2	0.9	0.5	-0.7	-0.6	-2.0	-1.6	-1.3	1.1	-2.1
Lupus	0.5	0.7	2.5	-0.8	-0.9	0.5	0.3	-0.7	-1.1	-1.0	-0.1	-0.9	0.1	-1.6
Neuroticism (2016)	0.6	0.9	3.8	-0.7	-0.1	-0.3	1.1	0.9	-0.1	-0.8	1.1	0.4	1.9	1.0
Primary Biliary Cirrhosis	0.6	0.9	5.6	0.5	0.3	-0.0	2.4	0.5	-0.5	-0.2	-0.2	-0.3	1.7	-0.5
Rheumatoid Arthritis	0.9	1.2	4.5	-2.1	0.4	0.7	0.4	0.3	-1.9	-1.7	-0.7	-0.4	-0.7	0.4
Schizophrenia (2014)	0.2	0.5	2.2	0.9	0.2	0.2	-1.5	-0.3	0.9	-0.1	-0.8	-0.6	-0.7	-0.5
Triglycerides	0.5	0.7	1.8	-1.3	0.3	0.8	0.8	-1.2	-0.9	-1.3	-0.0	-0.0	0.8	0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.3	0.5	-0.2	-0.4	0.5	0.1	0.5	-0.3	-0.3	1.1	0.0	-0.0
Ulcerative Colitis	0.5	0.8	3.2	0.2	0.7	0.2	-0.3	-1.8	0.1	0.4	-0.5	1.0	-1.6	0.6
Blood Eosinophil Count	0.2	1.5	2.7	-0.0	-1.5	-1.7	1.3	1.5	0.4	0.9	1.3	0.2	1.6	-1.6
Blood Platelet Count	0.1	1.2	6.0	-1.5	0.0	0.8	2.4	-0.2	-1.4	-0.0	0.5	-1.3	0.4	-0.2
Blood Red Count	0.1	0.5	1.9	0.7	0.8	-0.4	0.4	1.4	0.3	-0.0	-0.1	-0.0	1.1	1.1
Blood White Count	0.3	2.1	5.6	0.2	-1.5	-1.9	0.4	2.0	0.7	0.6	2.1	1.4	2.4	-0.5
Heel T-Score	0.6	4.4	16.9	3.0	-1.3	-1.4	-1.2	-4.1	2.7	1.0	-0.7	-0.6	-1.9	-2.1
BMI	0.8	4.4	8.6	2.5	0.9	-1.8	-0.5	2.9	2.5	2.4	2.1	2.6	0.5	2.5
Height	0.8	16.3	39.6	-3.1	5.7	5.7	1.0	-3.4	-3.5	-0.1	-4.3	-3.2	-6.3	3.4
Waist Hip Ratio (WHR)	1.2	5.4	16.3	3.1	-1.7	-1.9	-4.0	1.9	3.7	-0.7	-0.4	0.9	2.0	-1.9
Systolic Blood Pressure	0.2	0.9	3.3	1.4	-0.9	-1.2	0.5	-0.4	0.8	-0.2	1.3	0.3	1.8	-0.2
Smoking Status	0.4	1.0	3.7	-0.0	-0.1	0.8	0.5	1.8	-0.5	-1.9	-1.0	-0.9	0.8	-0.2
Allergy or Eczema	0.2	0.5	2.0	0.3	-0.8	-0.6	0.7	0.4	0.2	-0.4	1.0	0.2	1.4	-0.4
Cardiovascular Disease	0.7	2.2	4.8	2.1	1.4	0.3	0.9	0.5	1.9	2.0	1.0	1.3	1.2	2.2
Hypothyroidism (self reported)	0.8	1.9	5.9	1.8	-0.3	-1.2	-1.1	-0.9	2.4	2.0	1.0	1.2	1.1	0.6
Respiratory disease	2.3	5.1	11.3	2.2	-0.9	-2.9	-1.3	3.4	2.5	1.5	3.0	2.4	2.3	1.0
Type 2 Diabetes (T2D) (2018)	0.5	1.0	5.0	-0.9	0.3	1.3	0.3	-0.4	-1.1	-2.2	-1.0	-0.5	-0.4	0.3
Lung FEV1/FVC ratio	2.6	13.0	27.5	-3.2	2.6	5.2	0.7	-3.7	-3.6	-3.8	-4.6	-5.1	-3.0	0.8
Lung FVC	0.2	1.1	4.5	0.4	0.8	-0.1	-0.7	2.1	0.4	1.5	0.7	1.4	-0.9	0.8
Neuroticism	0.9	2.1	3.8	1.7	-1.9	-1.7	0.7	1.3	1.9	0.2	0.7	1.3	1.9	-1.5
Chronotype (morning person)	2.2	5.2	15.7	-3.6	1.6	2.0	3.2	-1.7	-4.0	-0.5	-1.5	-0.8	-2.2	0.9
Hair Pigment	0.0	1.1	2.7	1.3	-0.3	-1.6	-1.1	0.0	1.1	1.2	1.1	0.9	0.8	0.9
Tanning	0.5	5.5	12.7	-2.6	1.0	3.5	2.9	-1.6	-3.6	-2.0	-2.3	-2.5	-0.7	-0.2
Hand grip strength (left)	0.3	0.8	2.5	1.0	0.2	-0.5	-1.3	0.1	1.3	1.6	0.9	0.4	0.0	0.2
Number of treatments/medications taken	0.7	1.2	5.1	-0.2	1.1	-0.0	-0.4	-1.6	0.4	1.4	1.0	1.2	-0.3	2.3
Average weekly spirits intake	0.6	0.7	3.4	-1.1	0.4	0.2	1.8	0.1	-1.4	0.1	0.3	-0.5	0.2	0.8
Sensitivity / hurt feelings	0.8	1.5	3.4	1.7	-1.2	-1.6	0.5	1.1	1.9	0.8	0.9	1.4	0.6	-0.4
Frequency of depressed mood in last 2 weeks	0.9	1.2	4.3	-0.4	-1.4	-0.8	-0.5	2.1	0.0	-0.7	1.1	0.9	1.6	-0.8
Hearing difficulty/problems: Yes	3.7	5.7	21.1	3.9	1.8	-0.9	-2.7	2.4	4.6	1.6	0.3	0.7	0.0	2.6
Relative age of first facial hair	0.3	0.7	2.5	0.5	0.2	-0.4	-0.8	-1.6	1.1	0.7	-0.0	-1.5	0.1	-0.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.8	0.9	0.8	-0.1	-0.6	0.1	1.4	1.0	0.4	0.8	1.0	1.7
Ever used hormone-replacement therapy (HRT)	1.1	1.3	6.1	-0.7	1.3	1.0	1.6	-0.9	-0.7	0.2	1.1	-0.0	0.3	2.5
Ever had hysterectomy (womb removed)	1.3	1.4	4.6	-0.5	2.2	0.9	0.5	-1.5	-0.1	-0.0	-0.8	-0.8	-1.4	2.0
Systolic blood pressure, automated reading	0.1	0.4	1.1	0.8	-0.1	-0.9	-0.5	-0.1	0.7	-0.7	0.8	0.1	1.1	0.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	3.1	-1.8	-0.2	0.5	-0.2	0.4	-1.4	-1.0	0.9	0.5	-0.0	-0.0
Angina	0.5	0.6	1.4	-0.8	0.3	1.0	1.2	-1.1	-0.6	-0.9	-1.0	0.3	-0.6	-0.0
Medication for hormone replacement therapy	2.4	2.6	9.8	-1.2	2.6	1.9	0.8	-0.5	-1.4	0.3	0.1	-0.1	-2.1	3.1
Vitamin and mineral supplements	0.9	1.2	2.6	0.4	0.6	1.6	1.4	-1.3	-0.5	-1.4	-1.2	-1.4	-0.5	0.5
Supplements: Zinc	1.7	1.9	6.2	-0.3	-1.0	-2.4	-0.5	0.2	0.1	0.5	2.4	2.5	1.0	0.7
Medication: Co-codamol	1.0	1.2	5.9	-0.4	0.7	-0.8	1.2	0.6	-0.3	0.9	1.3	1.2	-0.3	2.4
Medication: Metformin	1.0	1.4	7.8	-1.0	-1.3	0.4	0.3	-0.3	-0.7	-2.8	-0.5	-0.5	1.3	-1.2
Diabetes (father)	0.8	1.0	2.4	-1.5	0.9	1.0	-0.3	-1.0	-1.5	0.2	0.4	0.4	-1.0	1.5
Diabetes (mother)	0.2	0.2	1.0	0.1	0.5	-0.0	-0.4	-0.7	0.0	-0.4	-0.5	0.1	-0.1	1.0
Severe depression (siblings)	0.8	0.9	2.3	0.0	1.5	0.9	1.3	1.4	0.5	-0.1	-1.0	-0.5	0.4	1.3
Pack years adult smoking proportion	0.7	1.1	4.7	-1.1	1.7	0.8	-1.2	0.6	-0.2	-0.1	-0.2	-0.3	-1.0	2.2
Impedance of leg (right)	0.3	1.3	3.7	0.0	-1.1	0.4	0.2	-1.6	-0.4	-1.9	-1.5	-1.1	0.4	-1.6
Leg fat-free mass (left)	0.3	1.5	3.8	0.5	1.9	0.9	-0.5	0.1	0.4	1.9	0.3	0.5	-2.0	1.9
Trunk fat percentage	0.6	2.3	4.3	1.7	-0.6	-1.9	-0.8	1.9	1.6	1.5	2.0	2.1	0.7	0.7
Hand grip strength (right)	0.4	1.1	6.1	0.9	1.0	-0.2	-0.6	-0.0	1.0	2.5	0.8	0.3	-0.6	1.2
Townsend deprivation index at recruitment	1.2	1.7	4.8	-0.3	0.1	-1.4	0.6	0.9	0.1	1.3	2.2	2.0	1.4	1.8
Current tobacco smoking	0.2	0.3	2.4	-0.2	0.0	-0.1	0.2	1.6	-0.0	-0.4	-0.7	0.0	0.4	0.2
Average weekly fortified wine intake	0.7	0.8	3.0	0.5	-0.5	-0.7	-1.0	0.4	0.8	0.2	0.9	1.5	1.7	0.0
Maternal smoking around birth	0.6	0.9	2.7	1.6	0.8	-0.1	-1.3	-0.0	1.6	0.5	-0.4	0.8	-0.8	0.6
Fed-up feelings	1.0	1.9	5.9	1.4	-1.3	-1.6	1.5	0.7	1.4	1.0	1.5	0.8	2.4	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.1	2.2	0.5	-1.5	-1.5	-1.3	1.5	0.8	-0.8	0.7	0.6	1.0	-0.9
Relative age voice broke	0.6	0.9	2.8	1.5	-0.6	-1.2	-1.3	-0.2	1.7	0.6	0.6	-0.0	0.6	-0.8
Taking other prescription medications	1.2	1.9	5.1	1.3	0.1	-1.0	0.0	1.1	1.6	2.3	1.7	1.7	1.3	1.2
Age when periods started (menarche)	0.3	0.7	3.5	-0.1	-0.4	0.7	1.0	-1.9	-0.1	-0.5	-0.6	-0.7	-0.4	-1.1
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	4.4	0.9	0.9	-0.3	-1.6	2.1	1.3	-0.1	0.6	0.6	0.0	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	4.0	1.7	-0.6	-1.2	0.2	-2.0	1.1	1.1	0.2	0.3	-1.4	-0.9
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	3.1	0.3	0.1	-0.2	-0.7	-1.7	0.1	-0.4	1.1	-0.6	0.6	0.7
Qualifications: CSEs or equivalent	1.0	1.3	6.0	0.7	0.8	-0.4	0.5	-0.7	0.5	2.4	1.3	1.4	-0.7	1.3
Serious illness, injury or assault to yourself	0.9	1.0	2.8	1.3	1.1	0.3	-1.1	-0.7	1.1	0.3	-0.4	-1.7	0.5	1.5
High blood pressure	0.8	2.1	6.2	2.4	2.2	0.3	-0.2	-0.2	2.2	1.1	0.2	0.4	-0.1	2.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.7	0.2	-1.0	-0.8	0.7	0.2	0.1	-0.1	1.1	0.1	1.6	-0.7
Multivitamins +/- minerals	1.2	1.5	4.5	-0.5	-0.9	-1.6	-1.4	1.9	0.3	0.8	1.4	2.1	0.6	-0.5
Stomach or abdominal pain in last month	0.7	0.9	3.1	1.8	-0.4	-0.6	-0.9	1.2	1.7	0.6	-0.1	-0.3	-0.0	-0.6
Supplements: Glucosamine	2.1	2.7	6.5	-0.7	2.5	1.8	0.5	-2.4	-0.4	1.0	-1.1	-1.4	-2.2	2.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	3.2	0.1	0.3	0.1	-1.8	-0.1	0.1	0.5	0.8	0.2	-1.1	1.1
Medication: Atenolol	0.7	0.8	4.9	0.5	-0.9	-0.5	0.6	-0.5	0.8	0.1	-0.2	0.5	1.2	-2.2
Medication: Levothyroxine sodium	2.1	3.5	8.2	2.3	-0.1	-2.0	-1.3	0.2	2.9	2.3	2.0	2.1	1.7	1.6
Sitting height	0.4	2.5	8.5	-0.3	1.1	2.6	0.3	-1.2	-0.4	-0.4	-2.9	-1.6	-2.4	-1.0
Chronic bronchitis/emphysema (father)	1.3	1.6	5.2	1.3	0.9	-0.9	1.0	2.3	1.0	1.0	1.2	0.5	-0.3	1.9
High blood pressure (mother)	0.7	0.9	2.7	-0.2	-1.6	0.2	1.0	-1.4	-0.3	-0.3	-0.3	1.1	0.2	-1.6
Body mass index (BMI)	0.8	3.2	5.7	1.7	0.2	-1.9	-1.5	2.4	2.0	1.6	2.4	2.3	0.5	1.8
Impedance of leg (left)	0.3	1.3	3.8	0.3	-1.3	0.2	-0.1	-1.1	-0.2	-1.8	-1.5	-1.2	0.5	-1.9
Leg predicted mass (left)	0.3	1.6	3.9	0.6	1.9	0.9	-0.5	0.0	0.5	1.9	0.4	0.4	-2.0	1.9
Trunk fat mass	0.4	1.8	2.8	1.7	0.1	-1.3	-1.1	1.6	1.6	1.5	1.6	1.6	-0.0	1.2
Waist circumference	1.3	4.9	12.4	3.2	0.2	-2.0	-2.7	2.6	3.5	1.7	1.7	2.2	0.8	1.4
Number of incorrect matches in round	0.5	0.9	2.3	-0.7	-1.5	-0.1	-0.2	-0.8	-1.1	-1.5	0.5	-1.2	0.6	-1.1
Past tobacco smoking	0.5	0.9	2.4	0.2	0.0	-1.3	-0.8	-1.5	0.7	1.6	1.3	0.3	-0.4	0.4
Alcohol usually taken with meals	1.1	1.8	7.5	-1.5	-1.2	0.2	-1.0	-2.7	-0.9	-1.5	-0.3	-1.4	0.4	-1.6
Nervous feelings	0.8	1.5	3.8	0.8	-1.3	-1.6	0.7	0.9	1.2	0.2	0.5	1.9	1.9	-1.0
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	5.1	0.4	-1.3	-1.9	-1.5	0.4	0.9	-0.4	1.8	0.9	2.3	-0.4
Hearing difficulty/problems with background noise	1.0	1.5	4.3	1.4	0.7	-0.5	-2.0	0.8	2.1	0.8	1.0	0.6	0.5	1.7
Hair/balding pattern: Pattern 2	4.5	5.7	19.4	1.4	-3.8	-2.5	-1.3	0.7	2.0	-0.9	1.9	-0.4	4.4	-3.3
Had menopause	1.0	1.2	6.2	-0.8	-0.1	0.6	0.4	-2.5	-0.6	-1.6	0.1	-1.2	1.3	0.4
Had other major operations	0.6	0.8	2.6	-0.1	0.4	-0.4	1.2	0.6	0.3	0.7	1.1	1.4	-0.0	1.6
Forced vital capacity (FVC)	0.4	1.7	8.3	-0.7	1.6	0.8	-0.0	-0.5	-0.7	2.2	-0.3	0.6	-2.9	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.5	1.8	-0.3	-0.5	0.5	-1.9	1.1	1.1	-0.6	-0.2	-1.8	-1.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.6	-0.2	-0.8	-0.4	-0.3	-0.3	-0.1	-0.8	0.1	-0.7	1.3	-1.2
Qualifications: None of the above	0.4	0.9	2.4	1.6	-0.5	-1.0	1.0	0.2	1.4	0.1	0.6	-0.4	1.5	-0.3
Financial difficulties in last 2 years	1.4	1.8	4.7	0.9	-2.0	-1.2	-0.3	1.3	1.1	-1.3	1.1	1.0	2.2	-1.5
Mouth/teeth dental problems	1.0	1.6	6.5	-2.0	-1.6	-0.7	-0.4	0.0	-1.8	0.0	0.0	-0.7	-0.1	-2.5
Heart attack	0.2	0.3	2.0	-0.1	0.4	0.3	0.3	-0.6	0.2	0.2	-1.4	-0.8	-0.2	-0.3
Allergy	0.7	1.5	3.2	-1.4	1.1	1.7	0.5	-1.0	-1.5	-0.6	-1.8	-0.8	-1.8	0.3
Pain all over the body in last month	1.0	1.0	3.2	-0.9	1.3	0.9	-0.2	0.8	-1.0	-0.1	-0.6	-0.2	-1.8	1.7
Diabetes (self-reported)	0.9	1.4	7.3	-1.9	-0.7	0.8	0.4	-0.9	-1.6	-2.7	-0.1	-0.4	0.0	-0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.3	-0.5	-0.5	-0.8	0.5	1.1	-0.4	0.6	1.1	0.7	0.1	0.3
Medication: Ramipril	1.1	1.5	3.5	-1.9	0.5	1.0	-0.5	-0.8	-1.8	-1.7	-1.0	-1.3	-1.2	0.3
Medication: Simvastatin	1.1	1.6	4.7	-0.8	0.8	1.2	2.0	-1.1	-0.5	-2.0	-0.5	-2.2	0.7	0.5
Fluid intelligence score	0.8	1.6	7.9	-2.8	-0.2	0.6	1.7	0.2	-2.2	-0.3	0.1	0.0	-1.0	-0.2
Illnesses of siblings	0.8	1.2	4.2	-0.5	-2.1	-0.4	0.4	-0.7	-0.9	0.5	1.2	-0.0	0.9	-2.0
Neuroticism score	1.4	2.8	7.6	1.1	-2.5	-2.0	1.2	1.1	1.3	0.6	1.4	1.5	2.8	-1.9
Weight	0.4	2.1	4.4	1.7	1.5	-0.3	-1.4	1.3	1.7	1.9	1.0	1.1	-1.3	2.1
Impedance of arm (right)	0.3	1.6	3.9	1.0	-2.0	-1.3	1.3	-1.0	0.7	0.3	0.5	0.4	1.8	-1.9
Arm fat percentage (right)	1.1	4.3	8.5	2.2	-1.0	-2.8	-1.0	2.5	2.3	1.5	2.9	2.6	1.8	0.9
Trunk fat-free mass	0.4	2.5	7.3	0.4	2.7	1.9	-1.6	-0.4	0.4	1.0	-0.8	-1.4	-2.5	1.9
Hip circumference	0.7	2.9	5.0	1.9	0.6	-1.6	-0.9	1.8	1.9	2.2	2.2	2.0	-0.2	1.9
Time employed in main current job	0.4	0.5	1.5	-0.5	0.7	0.1	0.4	-0.1	-0.6	1.2	-0.1	-0.0	-1.2	0.9
Alcohol intake versus 10 years previously	0.5	0.7	2.6	0.0	0.1	1.3	0.7	-1.6	-0.1	-0.6	-1.4	-0.4	-0.6	-0.3
Father’s age at death	1.1	1.4	3.5	-1.9	0.7	1.7	1.1	-1.5	-1.9	-0.0	-0.3	-1.1	-0.8	0.3
Worrier / anxious feelings	0.6	1.1	2.7	0.7	-1.4	-0.5	1.3	-0.9	0.6	0.4	0.5	1.4	1.6	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	3.0	0.9	0.8	-0.6	-1.1	1.0	1.4	1.1	0.9	1.3	0.1	1.7
Falls in the last year	1.5	2.1	5.2	2.2	1.7	0.3	-2.2	-0.1	1.9	0.7	-0.1	-0.9	-0.8	2.3
Hair/balding pattern: Pattern 3	0.4	0.6	2.5	-0.9	1.1	0.2	-0.2	0.5	-0.8	0.8	0.3	0.4	-0.7	1.6
Number of live births	0.2	0.3	1.7	-0.3	0.8	-0.0	-0.1	0.4	-0.1	-0.8	-0.1	0.1	0.2	1.3
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	13.5	-0.9	2.4	1.9	-0.1	-1.7	-1.1	1.4	-1.3	-0.0	-3.7	1.5
Pulse rate	0.3	0.4	1.0	1.0	-0.4	0.4	0.5	-0.6	0.9	-0.1	-0.7	-0.8	-0.4	-0.9
Happiness	0.6	0.7	2.0	0.4	-1.2	-0.3	-1.4	0.6	0.5	-0.9	-0.2	-0.6	0.5	-1.4
Noisy workplace	2.4	2.9	7.0	2.6	-1.7	-2.4	-1.1	0.3	2.5	0.6	0.9	1.5	1.8	-1.4
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.5	-1.4	0.5	1.2	0.1	-0.3	-1.6	-0.9	-1.1	-1.0	-0.6	-0.5
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	9.3	-3.0	1.2	0.9	0.6	-0.4	-2.3	0.1	0.8	-0.3	-0.1	1.5
Mouth/teeth dental problems: Dentures	1.3	2.2	13.5	0.3	2.5	1.1	1.1	-0.8	-0.1	-0.7	0.3	-0.3	-0.7	3.7
Asthma	1.4	2.7	5.7	0.8	0.6	-1.6	-0.7	2.3	1.4	1.3	2.2	2.2	1.0	2.4
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	9.2	1.3	1.5	0.0	-1.1	0.4	1.7	3.0	0.6	1.2	-0.7	1.9
Medication: Cholesterol lowering	1.0	1.6	3.5	-1.9	-0.1	1.5	1.0	-0.9	-1.7	-1.4	-0.9	-1.9	-0.1	-0.7
Depression (self-reported)	0.7	0.9	2.1	0.1	0.8	-0.7	-1.4	1.1	1.3	0.2	0.9	0.1	0.8	1.4
Medication: Lansoprazole	1.2	1.3	3.5	0.9	0.1	-1.4	0.3	1.1	1.1	1.8	1.5	1.9	0.3	0.4
Prospective memory result	0.6	0.8	3.6	1.0	1.2	0.2	-0.2	-0.7	0.6	1.1	0.4	-0.2	0.3	1.9
Lung cancer (father)	0.7	0.8	1.7	-0.4	1.1	1.2	1.3	-0.3	-1.2	-0.3	-0.8	0.7	-0.9	0.9
Illnesses of mother	0.4	0.5	2.7	-0.1	0.2	-0.7	-0.3	1.6	0.2	0.8	1.0	-0.0	-0.2	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.1	7.3	-0.2	1.9	0.9	-0.2	-1.4	-0.1	2.5	-0.2	0.9	-2.7	1.2
Pulse wave Arterial Stiffness index	3.3	3.9	8.9	0.9	-3.0	-2.9	-1.6	0.5	1.2	0.1	2.3	1.1	2.8	-2.4
Impedance of arm (left)	0.4	1.6	5.0	0.3	-2.2	-1.4	1.3	-1.2	0.1	0.2	0.6	1.1	1.5	-2.0
Arm fat mass (right)	0.7	3.0	5.2	2.1	0.4	-1.6	-1.7	2.3	2.2	1.6	1.9	1.9	0.1	1.7
Trunk predicted mass	0.4	2.2	6.3	0.5	2.5	1.8	-1.6	-0.4	0.5	1.1	-0.7	-1.3	-2.3	1.8
Standing height	0.5	4.9	13.2	-0.1	2.8	3.2	-0.0	-2.3	-0.4	0.7	-2.8	-2.8	-3.6	0.6
Length of working week for main job	0.7	0.8	3.8	1.0	-1.1	-0.3	-0.4	0.0	0.7	-1.0	-0.9	0.4	-0.2	-1.9
Exposure to tobacco smoke at home	1.1	1.2	8.0	-0.7	-0.1	0.9	0.2	-2.8	-0.7	-1.4	-0.5	0.7	-0.9	0.1
Breastfed as a baby	2.4	3.0	7.8	-0.9	0.6	1.8	0.5	-2.1	-1.0	-0.8	-2.8	-2.6	-2.0	-2.0
Tense / ‘highly strung’	0.4	0.7	2.6	0.7	-0.0	-0.7	-0.6	0.9	1.3	-0.1	0.1	1.6	0.8	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	3.1	1.8	0.0	0.9	0.2	-0.2	1.2	0.5	-0.5	-0.5	0.2	0.1
Hair/balding pattern: Pattern 4	0.7	1.7	4.6	-1.2	1.1	1.5	2.1	0.1	-1.6	-0.7	-1.6	-0.6	-1.8	0.7
Birth weight of first child	10.2	18.6	91.2	-0.4	7.7	4.4	0.9	-1.4	-1.5	3.1	-0.1	0.8	-4.3	9.6
Peak expiratory flow (PEF)	0.6	1.3	2.8	-1.1	1.0	0.0	0.9	-0.4	-1.2	1.7	0.7	1.7	-1.6	1.3
Pulse wave reflection index	2.2	2.7	8.9	-0.4	-3.0	-1.6	0.3	-0.5	-0.3	-0.0	1.9	0.4	2.8	-2.5
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.4	1.0	-0.1	-0.3	-0.6	0.4	1.5	0.1	-0.4	0.4	0.8	-0.2
Loud music exposure frequency	0.4	0.4	1.7	-0.5	0.6	-0.2	1.3	1.0	-0.5	0.3	0.1	-0.4	-0.1	0.7
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	5.2	-2.3	-0.4	1.1	0.5	-0.3	-1.6	-1.0	-1.7	-0.4	-0.4	-1.8
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	7.7	2.8	0.1	0.1	-0.3	0.2	2.4	1.0	-0.4	1.0	0.9	0.1
Blood clot in the leg (DVT)	1.8	2.3	10.2	2.9	-0.6	-1.2	-1.9	1.0	3.2	0.1	-0.0	-0.4	0.5	-0.5
Medication: Paracetamol	0.3	0.4	1.7	-0.1	-0.1	-0.6	-0.1	-0.3	0.1	1.3	1.2	0.7	-0.7	0.4
Headache pain in last month	0.7	1.2	2.9	-0.1	0.9	-1.0	-0.9	0.8	0.0	1.6	1.7	1.4	-0.5	1.6
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.6	1.1	-1.0	-1.6	-1.4	1.6	1.3	0.4	0.3	1.3	0.4	-1.1
Glaucoma (self-reported)	0.8	1.0	5.3	-0.8	-0.9	-0.1	-0.4	-0.1	-0.8	-2.3	-0.7	-0.8	0.2	-1.4
Gout (self-reported)	0.3	0.4	2.5	-0.2	-0.0	0.4	0.7	-0.3	0.1	0.7	0.6	1.6	0.0	0.3
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	5.1	1.7	-0.5	-1.3	-2.3	-0.6	2.2	1.6	1.1	0.9	1.2	0.3
Medication: Amlodipine	1.0	1.4	3.8	-1.4	-0.1	-0.4	1.4	0.8	-1.2	0.7	1.9	1.3	1.2	1.3
Medication: Ventolin 100micrograms inhaler	1.5	1.9	6.2	0.9	-1.4	-1.7	0.3	0.8	0.9	0.6	2.0	1.4	2.5	-0.9
Birth weight	1.3	2.9	10.7	-0.3	3.1	1.9	0.1	-0.2	-0.2	1.4	-0.6	-0.5	-2.3	3.3
Chronic bronchitis/emphysema (mother)	1.6	1.8	6.9	2.6	0.3	-1.2	-1.2	1.2	2.5	0.5	0.4	1.2	0.6	0.5
High blood pressure (siblings)	2.0	2.8	6.7	0.2	2.5	2.0	0.7	-0.8	-0.1	-1.2	-2.6	-2.0	-2.1	1.9
Forced vital capacity (FVC), Best measure	0.5	1.8	8.2	0.4	1.6	0.0	-0.8	-0.2	0.7	2.9	0.3	1.3	-2.2	1.1
Body fat percentage	0.7	2.7	5.0	1.8	-0.4	-2.0	-1.2	2.1	1.8	1.3	2.2	2.2	0.7	1.2
Leg fat percentage (right)	0.6	2.2	3.4	1.7	-0.2	-1.6	-1.5	1.9	1.7	0.5	1.8	1.8	0.8	1.7
Arm fat-free mass (right)	0.4	2.2	6.6	0.1	2.6	1.9	-1.2	-0.2	-0.0	0.6	-0.9	-1.0	-2.6	1.9
Exposure to tobacco smoke outside home	1.2	1.5	7.8	2.8	-0.3	-0.6	-0.7	-0.2	2.6	0.5	-0.1	0.5	0.8	-0.3
Comparative body size at age 10	0.8	2.1	7.8	0.8	2.1	-0.0	0.1	0.7	0.6	2.4	0.7	0.3	-1.8	2.8
Number of full brothers	1.9	2.3	7.0	1.5	-0.9	-2.3	-1.0	1.0	2.7	1.6	1.8	1.1	1.1	-0.3
Worry too long after embarrassment	0.6	1.0	4.0	1.0	-0.4	-0.9	0.9	2.0	1.1	1.3	0.8	1.1	0.1	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	5.7	2.4	0.2	-0.7	-1.5	0.6	2.4	1.3	0.4	-0.6	0.9	0.8
Wheeze or whistling in the chest in last year	1.5	2.7	7.6	2.4	0.7	-1.2	-0.4	2.8	2.4	1.5	1.2	0.7	1.3	1.6
Number of children fathered	1.5	1.7	4.3	-1.3	0.7	1.5	-0.5	-2.1	-1.2	-1.3	-1.4	-1.4	-1.7	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.9	0.1	0.6	0.0	-0.2	1.4	0.6	-0.4	-0.7	-0.5	-1.0	0.4
Age at first live birth	1.1	2.0	5.3	0.6	0.7	1.4	1.2	-2.3	-0.1	0.8	-2.2	-2.0	-1.7	-0.2
Pulse wave peak to peak time	3.8	4.4	9.9	-1.0	3.1	3.1	1.7	-0.6	-1.3	-0.3	-2.6	-1.5	-3.0	2.3
Health satisfaction	1.8	2.4	10.6	1.6	1.8	0.5	-3.3	0.0	2.5	0.1	-1.3	0.2	-0.5	1.2
Shortness of breath walking on level ground	1.5	1.8	9.2	3.0	0.1	-0.6	-1.5	0.0	2.7	0.4	-0.2	0.3	-0.1	0.0
Qualifications: College or University degree	0.2	0.6	2.3	0.0	-1.0	-0.4	-0.8	0.7	0.2	-0.2	-0.2	-0.8	1.2	-1.5
Eye problems/disorders: None of the above	3.4	3.9	11.6	0.9	-3.4	-2.6	-0.6	0.4	0.8	1.7	2.6	1.6	2.3	-2.3
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.3	1.5	1.4	0.3	-0.4	-0.3	1.1	0.8	-0.5	-1.5	-0.9	1.0
Emphysema/chronic bronchitis	0.6	0.7	1.6	1.2	0.8	-0.6	0.6	0.4	0.8	0.9	1.0	-0.0	0.8	1.3
Medication for pain relief, constipation, heartburn	1.0	1.6	4.9	-0.8	-0.8	0.5	1.4	0.8	-1.2	-2.2	-1.2	-1.2	1.2	-1.8
Neck or shoulder pain in last month	0.5	0.7	3.6	0.3	0.4	-0.9	-1.9	0.2	0.6	1.1	0.5	0.1	-0.7	0.7
Medication: Blood pressure	0.2	0.3	1.2	-0.1	0.7	0.5	1.1	-0.1	-0.1	0.2	0.0	-0.8	-0.2	0.9
Angina (self-reported)	0.4	0.5	1.4	-0.4	0.2	0.9	1.2	-1.2	-0.3	-0.8	-0.9	0.2	-0.6	0.1
Migraine (self-reported)	0.3	0.3	1.3	-0.2	-0.2	-0.2	-0.9	-0.8	-0.3	1.2	0.6	0.2	-0.7	0.1
Medication: Ibuprofen	1.0	1.2	6.8	1.0	0.8	-0.2	-0.3	-0.5	1.5	2.6	0.5	1.0	-0.1	1.0
Medication: Allopurinol	0.1	0.2	0.9	-0.2	-0.4	0.9	-0.3	-0.4	0.2	-0.5	-0.5	0.2	-0.2	-0.5
Medication: Omeprazole	0.6	0.7	3.0	0.8	1.0	-0.3	-0.7	0.1	1.1	1.7	0.2	0.2	-0.4	1.2
Medication: Seretide 50 evohaler	3.1	3.5	8.2	1.0	-1.5	-2.9	-2.2	1.7	1.7	0.6	2.7	2.2	2.1	-0.4
Mean time to correctly identify matches	1.5	2.9	12.7	0.1	1.7	2.1	-0.8	-0.4	-0.3	-1.3	-2.2	-3.6	-2.1	0.6
Heart disease (mother)	0.2	0.2	0.7	-0.5	-0.2	0.1	-0.2	-0.1	-0.8	-0.8	-0.5	0.3	-0.1	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.8	0.7	0.0	-0.8	-0.9	-0.3	1.2	0.5	-0.4	1.7	-0.2	-0.1
Whole body fat mass	0.5	2.1	3.3	1.7	0.4	-1.3	-1.4	1.8	1.7	1.3	1.6	1.8	-0.1	1.6
Leg fat mass (right)	0.5	1.8	3.6	1.6	0.6	-0.9	-1.6	1.8	1.5	0.8	1.4	1.6	-0.4	1.9
Arm predicted mass (right)	0.5	2.6	8.2	0.3	2.9	2.0	-1.3	-0.0	0.2	0.9	-0.9	-0.9	-2.6	2.2
Pulse rate, automated reading	0.5	1.7	4.8	1.7	-0.8	-2.1	-0.1	-0.2	1.6	1.2	2.2	0.8	0.9	0.7
Alcohol intake frequency.	0.7	1.7	6.8	1.6	-1.3	-1.1	-0.6	-2.6	1.4	0.5	0.3	0.8	0.9	-1.5
Comparative height size at age 10	0.3	1.4	4.8	0.4	2.2	1.1	0.6	-0.0	0.2	2.0	-0.4	-1.0	-1.6	1.3
Number of full sisters	1.0	1.2	5.4	-0.8	0.9	0.1	0.4	0.6	-0.7	-0.1	1.0	2.3	-0.0	2.0
Suffer from ‘nerves’	1.0	1.6	4.8	0.6	-2.2	-2.1	-0.2	0.3	0.9	-0.3	1.1	0.4	1.7	-1.6
Overall health rating	1.2	2.6	10.6	2.2	0.6	-1.1	-2.8	1.0	3.3	1.1	0.0	0.9	-0.1	1.1
Chest pain or discomfort	1.6	2.3	8.8	2.7	1.2	-0.5	-1.3	1.7	3.0	-0.2	0.1	-0.7	0.7	1.6
Had major operations	0.5	0.6	1.5	0.9	1.2	0.8	0.3	-0.5	0.8	0.4	-0.1	-0.9	-0.5	1.2
Age at last live birth	1.0	1.5	5.8	2.4	0.6	-0.3	-0.9	-0.7	2.3	1.6	-0.6	-0.2	-0.7	0.5
Family relationship satisfaction	1.2	1.4	7.1	0.5	-1.3	-0.3	-2.7	0.6	0.7	-1.0	-0.1	-0.5	0.5	-2.1
Leg pain on walking	0.8	1.0	3.7	0.9	0.7	0.2	-1.9	-0.2	1.2	-0.4	-1.5	-0.3	-1.1	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.5	1.9	-0.8	-1.4	-0.2	-0.2	0.3	-0.8	-1.1	0.9	0.8	0.2	-0.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.2	0.3	1.5	1.1	-0.6	-1.0	-0.1	-0.3	-0.5	-0.3	-0.7	1.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.4	-0.8	-0.3	0.3	1.0	-0.7	-1.2	-0.4	-0.9	-0.3	-0.7	-0.6
Medication: Aspirin	0.4	0.5	2.5	0.5	-0.7	-0.4	-0.0	-1.6	0.8	0.4	0.9	0.6	0.7	-0.0
Supplements: Vitamin C	3.1	3.6	7.3	1.4	-0.9	-2.7	-2.6	1.9	2.4	1.1	1.6	2.4	1.8	-0.1
Knee pain experienced in last month	1.1	1.7	4.7	2.2	1.0	-1.3	0.2	1.3	2.1	1.2	0.5	1.3	0.2	1.3
Hypertension (Self-reported)	0.7	1.9	6.0	2.5	2.0	0.4	-0.2	-0.2	2.3	0.9	-0.2	0.4	0.1	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.7	1.0	-0.7	-0.7	-0.8	0.4	0.8	1.0	0.3	-0.0	0.5	-1.3
Illnesses of father: Heart disease	0.2	0.3	1.3	-0.1	1.1	0.4	0.4	0.0	0.5	-0.1	-0.4	-0.0	-0.6	1.0
Illnesses of siblings: Diabetes	0.4	0.5	1.6	-0.9	0.4	-0.3	0.1	0.9	-0.9	-1.3	0.5	-0.2	0.3	1.1
Smoking status: Previous	0.4	0.6	1.8	-0.5	0.4	1.2	0.6	0.9	-0.8	-1.3	-0.7	-0.6	0.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	2.2	0.1	-0.4	-0.1	-0.0	-0.5	0.2	1.1	-0.2	0.5	-1.5	-1.3
Whole body fat-free mass	0.4	2.2	6.9	0.5	2.6	1.7	-1.1	-0.1	0.4	1.4	-0.5	-0.7	-2.5	2.0
Leg fat-free mass (right)	0.3	1.5	4.4	0.7	1.8	0.9	-0.5	0.2	0.6	2.1	0.3	0.3	-1.9	1.6
Arm fat percentage (left)	1.1	4.2	9.5	1.8	-1.0	-2.8	-0.9	2.5	2.0	1.5	3.0	3.1	1.5	0.9
Average weekly red wine intake	0.6	0.9	1.9	-0.6	-1.2	-0.4	1.4	-1.1	-0.7	0.0	0.6	-0.9	1.2	-1.2
Handedness (chirality/laterality): Left-handed	2.1	2.5	6.4	2.5	-0.7	-0.4	-0.7	2.4	2.2	-0.2	-0.9	-0.7	2.4	-1.7
Mood swings	0.6	1.1	4.8	0.2	-1.2	-0.7	1.1	0.3	0.5	0.5	1.6	1.1	2.2	-0.2
Loneliness, isolation	1.4	1.9	4.6	1.4	-2.1	-1.9	-0.3	0.1	1.5	0.3	1.1	0.4	2.1	-1.7
Long-standing illness, disability or infirmity	0.5	0.8	3.6	1.1	0.9	-0.2	-1.0	-0.1	1.3	-0.2	0.3	-0.3	-0.0	1.9
Ever had bowel cancer screening	0.7	0.8	3.5	0.4	-0.6	-1.0	0.1	0.5	0.3	0.4	1.9	0.8	1.4	0.9
Diabetes diagnosed by doctor	0.4	0.7	3.4	-1.2	-0.9	0.2	0.4	-0.3	-1.0	-1.8	0.5	0.4	0.8	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	2.6	0.9	-0.7	-1.6	-1.5	1.2	1.4	1.0	1.5	1.6	1.5	0.3
Friendships satisfaction	2.0	2.5	6.5	-2.0	-2.5	-1.2	-0.2	1.5	-1.1	-0.8	1.5	0.4	2.0	-2.3
Qualifications: nursing, teaching	0.5	0.8	4.0	-2.0	-0.5	0.6	-0.3	0.5	-1.5	-0.6	-0.4	-0.5	0.2	-0.8
Commuting to job workplace: Walk	0.6	0.7	2.7	-1.6	-0.7	0.2	-0.0	-0.5	-0.9	-1.4	-0.2	-0.9	-0.1	-0.6
Eye problems/disorders: Cataract	2.7	3.2	9.2	-0.6	3.0	2.2	-0.1	0.2	-0.5	-1.3	-2.2	-1.5	-2.7	2.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.3	-0.9	-1.2	0.2	-0.8	-1.0	-0.4	-1.5	-0.3	0.3	-0.1	-1.2
Medication for cholesterol	1.5	2.3	11.6	-1.2	-2.2	-0.4	0.4	0.5	-1.3	-0.9	-1.1	-1.6	0.5	-3.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.6	-1.2	-0.8	0.7	0.2	0.6	-1.6	-1.0	0.6	0.2	0.3	0.4
Back pain experienced in last month	2.9	4.2	10.7	3.1	2.4	-0.4	-2.2	1.5	3.3	1.8	0.5	0.6	0.3	3.0
Mineral and other dietary supplements	1.3	1.8	5.0	0.2	-1.7	0.2	1.8	1.3	-0.6	-2.2	-0.8	0.7	1.0	-2.1
Breast cancer (self-reported)	0.8	1.0	3.5	1.1	0.8	-0.2	-0.0	0.2	1.4	0.8	1.0	0.4	1.4	1.9
Asthma (self-reported)	1.2	2.4	4.8	0.7	0.4	-1.6	-0.5	2.2	1.3	1.1	2.1	2.1	1.2	2.2
Osteoporosis (self-reported)	1.0	1.3	4.0	1.5	-0.0	-1.4	0.4	0.5	1.1	1.2	2.0	0.1	1.5	0.7
Osteoarthritis (self-reported)	0.9	1.2	4.8	-0.9	1.5	0.1	-1.2	-0.9	-0.7	-0.3	-0.1	0.4	-2.2	1.6
Medication: Aspirin	0.5	0.6	5.1	0.5	-0.3	0.0	-0.1	-2.2	0.8	0.3	0.6	0.4	0.3	0.1
Medication: Gliclazide	1.0	1.1	4.2	0.7	-1.0	-0.0	1.6	0.6	0.5	-2.1	-0.3	-0.1	1.6	-0.9
Illnesses of father: None of the above (group 1)	0.4	0.5	2.2	0.4	-0.9	-0.7	-0.0	0.4	0.2	0.5	0.6	0.7	1.5	-1.0
Smoking status: Current	0.2	0.3	2.1	-0.1	-0.4	-0.3	0.2	1.4	0.1	-0.4	-0.5	0.3	0.8	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.8	-0.8	1.8	1.2	0.3	-1.5	-0.8	0.8	-0.7	-0.4	-2.2	1.4
Whole body water mass	0.4	2.2	7.0	0.5	2.6	1.8	-1.0	0.0	0.4	1.3	-0.6	-0.9	-2.4	2.0
Leg predicted mass (right)	0.3	1.5	4.8	0.6	1.9	0.9	-0.5	0.2	0.5	2.2	0.4	0.4	-1.9	1.7
Arm fat mass (left)	0.7	2.8	4.4	1.9	0.1	-1.8	-1.5	2.1	2.1	1.4	2.1	2.1	0.3	1.5
Number of self-reported non-cancer illnesses	1.8	3.2	6.3	1.9	0.7	-1.8	-1.9	1.4	2.5	2.1	2.1	1.3	1.0	2.1
Average weekly champagne plus white wine intake	0.7	0.9	3.1	-0.5	-1.7	-0.6	-0.5	-0.2	-0.3	-1.2	0.3	-0.9	0.9	-1.8
Miserableness	1.9	3.2	9.7	0.0	-2.3	-2.0	0.8	0.8	0.4	2.0	3.1	1.9	2.7	-0.9
Guilty feelings	0.6	0.9	3.1	-1.1	0.3	0.4	0.6	1.6	-0.7	-0.8	-0.8	-1.8	-0.2	-0.2
Wears glasses or contact lenses	0.3	0.4	1.3	-0.6	-0.5	-0.4	1.1	-0.5	-0.5	-0.0	0.6	-0.7	0.6	0.1
Ever taken oral contraceptive pill	1.0	1.1	5.6	-0.3	0.2	0.5	-0.8	2.4	-0.2	-0.8	-1.6	-0.3	-1.5	-0.1
Hearing aid user	1.0	1.1	3.4	1.8	-0.0	0.0	1.2	1.0	1.5	-0.5	-0.1	-1.2	1.5	0.4
Mother’s age at death	1.0	1.2	8.2	-0.9	-0.7	0.4	0.9	-2.9	-0.8	-0.2	-0.8	-0.6	-0.0	-1.2
Financial situation satisfaction	0.7	0.9	2.9	0.3	-1.3	-0.6	-0.1	0.8	0.3	-0.8	1.3	0.9	1.7	-0.7
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.3	1.8	1.3	0.3	-0.1	-0.5	0.8	1.2	-0.7	0.1	-0.7	0.8
Commuting to job workplace: Public transport	0.2	0.3	1.6	-0.6	0.4	0.2	0.1	-0.0	-0.1	1.3	0.3	0.6	-0.5	0.6
Eye problems/disorders: Glaucoma	1.4	1.6	8.3	-0.9	0.1	1.1	0.0	-0.8	-1.2	-2.9	-1.5	-1.6	-0.5	-0.7
Medication: Blood pressure	1.0	2.0	5.1	1.6	0.5	-1.6	-0.7	0.3	2.3	1.0	1.5	2.0	1.0	1.5
Pain type(s) experienced in last month: Hip pain	0.9	1.1	4.2	-0.8	1.5	0.9	-0.1	-0.1	-0.7	-0.9	-0.7	0.1	-2.0	1.6
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.2	-0.9	0.3	-0.3	-1.8	-0.8	0.4	1.5	0.7	-0.3	-0.6	0.5
High cholesterol (Self-reported)	0.6	1.0	4.5	1.8	-0.1	-0.2	0.1	-0.4	2.1	0.7	0.1	-0.5	1.5	-0.6
Medication: Bendroflumethiazide	1.1	1.7	12.1	-0.4	2.0	0.6	-0.5	0.0	-0.2	0.0	1.0	0.4	-0.4	3.5
Medication: Paracetamol	0.5	0.7	1.6	-0.6	0.3	-0.2	0.4	-1.3	-0.4	1.2	1.0	1.1	-1.1	1.0
Medication: Lisinopril	0.5	0.6	1.7	-1.2	0.5	0.5	0.8	-1.3	-1.0	-0.1	-0.2	-0.2	-0.8	1.0
Medication: Atorvastatin	0.9	1.2	6.1	1.5	-0.2	-0.1	-0.8	-2.5	1.1	1.0	-0.3	-0.1	-1.0	-0.7
Illnesses of father: High blood pressure	1.1	1.4	4.2	0.1	1.4	1.5	-0.1	-1.2	-0.4	-0.1	-1.4	-0.7	-2.1	1.6
Alcohol drinker status: Never	0.5	0.6	1.6	0.4	0.2	-0.6	-1.0	-1.1	0.8	0.8	1.3	0.4	0.5	1.0
Ever smoked	0.6	1.1	5.7	0.3	0.2	0.8	-0.7	2.4	0.1	-1.5	-1.5	-0.5	0.1	-0.2
Basal metabolic rate	0.4	2.1	6.0	0.9	2.4	1.3	-1.2	0.3	0.7	1.6	-0.2	-0.3	-2.4	2.1
Leg fat percentage (left)	0.7	2.7	4.3	1.9	-0.3	-1.9	-1.7	1.9	1.9	0.9	2.1	2.0	1.0	1.4
Arm fat-free mass (left)	0.4	2.3	7.1	0.5	2.7	1.7	-1.2	0.3	0.4	0.9	-0.7	-1.0	-2.4	2.2
Number of operations (self-reported)	0.7	1.1	3.0	1.1	0.7	-0.7	0.4	0.3	1.1	1.3	1.7	0.9	0.1	1.6
Average weekly beer plus cider intake	0.8	1.1	3.3	0.6	1.8	0.9	1.5	0.8	0.1	0.8	-1.0	-0.4	-0.7	1.6
Irritability	0.7	1.1	6.2	0.4	-0.8	-0.7	0.0	0.6	0.1	1.6	1.4	2.5	0.3	0.0
Risk taking	1.3	1.9	7.9	0.7	1.8	0.1	-2.3	1.5	0.8	0.2	0.4	-0.4	-0.7	2.8
Ever had prostate specific antigen (PSA) test	0.8	0.9	4.4	2.1	0.0	-0.4	-0.7	-0.5	1.6	1.2	0.2	0.2	0.3	-0.0
Fractured/broken bones in last 5 years	1.8	2.4	8.8	0.9	1.9	0.9	-3.0	0.8	0.7	-0.4	-0.1	1.1	-1.0	2.9
Age started oral contraceptive pill	0.1	0.2	0.5	0.3	0.5	-0.7	-0.7	0.0	0.3	0.1	0.3	-0.4	-0.0	0.4
Diastolic blood pressure, automated reading	0.2	0.6	2.1	1.2	1.0	-0.3	0.4	-0.6	0.7	0.7	0.4	-0.1	-0.2	1.4
Ever depressed for a whole week	0.2	0.3	1.2	-0.2	-0.0	0.2	1.1	0.6	0.1	-0.2	0.6	0.1	0.9	0.3
Unable to work because of sickness or disability	0.4	0.5	1.7	0.2	1.3	0.1	-0.3	0.8	0.5	1.0	0.2	-0.4	0.1	1.2
Commuting to job workplace: Cycle	0.4	0.5	1.8	0.4	0.4	0.8	-1.0	0.0	0.2	0.4	-1.2	1.3	-0.5	-0.6
Myopia	2.9	4.2	11.5	0.5	-3.1	-2.5	0.1	1.3	1.1	1.4	2.5	1.8	3.4	-2.1
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.1	-2.0	-1.6	-0.4	0.0	1.1	-1.8	-0.8	0.1	-0.3	0.2	-1.6
Cholesterol lowering medication	0.9	1.3	5.8	2.4	0.6	-0.5	-0.2	-0.4	2.4	0.6	0.8	0.4	0.3	0.8
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	3.8	0.6	0.6	-0.8	-1.0	0.1	0.9	1.9	0.7	0.6	-0.4	0.9
Pain experienced in last month	1.9	3.2	6.5	-1.9	-1.6	1.4	1.7	-2.1	-2.6	-2.5	-0.7	-1.6	0.7	-1.9
Supplements: Calcium	1.3	1.4	4.5	1.2	-0.9	-2.1	-0.9	1.1	1.3	0.7	1.1	0.8	1.5	-0.5
Basal cell carcinoma (self-reported)	0.7	0.9	3.2	-0.1	-1.0	-1.1	0.9	-0.7	-0.2	-0.2	1.0	-0.5	1.8	-1.0
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.3	0.1	0.3	0.0	0.4	-0.6	0.4	0.5	-1.1	-0.6	-0.2	-0.1
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	7.0	2.4	-0.3	-0.8	-1.6	1.0	2.6	0.1	-0.1	-0.6	0.2	-0.2
Heart disease (siblings)	0.6	0.7	2.3	-1.5	1.1	-0.1	-0.8	0.8	-0.4	0.2	0.0	0.5	-0.9	1.5
Alcohol drinker status: Previous	1.4	1.6	4.4	1.6	-1.9	-1.4	-0.1	-1.0	1.3	0.7	0.4	1.2	0.7	-2.1
Pack years of smoking	0.8	1.2	5.0	-1.0	1.8	0.7	-1.2	0.7	-0.2	0.2	-0.1	-0.6	-1.1	2.2
Impedance of whole body	0.3	1.3	5.3	0.3	-1.8	-0.5	1.0	-1.4	-0.1	-0.8	-0.8	-0.4	0.9	-2.3
Leg fat mass (left)	0.5	1.9	3.1	1.6	0.5	-1.1	-1.5	1.8	1.6	1.0	1.5	1.6	-0.3	1.7
Arm predicted mass (left)	0.5	2.5	7.4	0.4	2.7	1.9	-1.6	-0.1	0.3	0.7	-0.9	-1.2	-2.5	2.1