[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr3:153,142,317-154,733,231

Best TWAS P=1.53e-13 · Best GWAS P=2.01e-12 conditioned to 0.118

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Artery Tibial	ARHGEF26	0.11	0.12	enet	12	0.12	5.9e-10	-6.8	7.4	1.5e-13	-0.84	0.06	0.94	TRUE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	DHX36	0.11	0.09	enet	11	0.10	6.4e-12	-5.9	-7.4	1.7e-13	0.83	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DHX36	0.05	0.06	blup	357	0.05	1.3e-06	-6.7	-7.2	5.3e-13	0.81	0.05	0.95	FALSE
15	METSIM	Adipose	ARHGEF26	0.07	0.08	lasso	6	0.07	3.5e-11	-6.7	7.1	1.0e-12	-0.66	0.05	0.95	FALSE
13	GTEx	Thyroid	ARHGEF26	0.09	0.07	enet	17	0.08	1.9e-06	-6.7	6.8	1.5e-11	-0.73	0.05	0.95	FALSE
6	GTEx	Esophagus Gastroesophageal Junction	DHX36	0.19	0.16	lasso	7	0.12	6.1e-05	-7.0	-6.6	5.0e-11	0.98	0.03	0.96	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SGEF	0.04	0.04	enet	12	0.04	1.1e-05	-6.8	6.5	8.7e-11	-0.72	0.05	0.94	FALSE
19	The Cancer Genome Atlas	Glioblastoma Multiforme	SGEF	0.17	0.13	blup	74	0.14	5.5e-05	-6.9	-6.5	9.0e-11	0.90	0.02	0.92	FALSE
14	GTEx	Thyroid	DHX36	0.06	0.01	lasso	4	0.02	1.7e-02	-5.5	-6.5	1.0e-10	0.75	0.10	0.75	FALSE
4	GTEx	Breast Mammary Tissue	DHX36	0.15	0.07	enet	14	0.05	9.4e-04	-7.0	-6.4	1.4e-10	0.91	0.04	0.95	FALSE
2	GTEx	Adipose Subcutaneous	ARHGEF26	0.10	0.06	enet	8	0.07	2.2e-06	-6.7	6.3	2.4e-10	-0.66	0.07	0.93	FALSE
10	GTEx	Pancreas	ARHGEF26	0.26	0.26	lasso	5	0.28	3.2e-12	-6.6	6.2	6.0e-10	-0.61	0.07	0.93	FALSE
26	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	DHX36	0.26	0.14	blup	50	0.16	6.5e-07	-5.3	-6.1	1.1e-09	0.85	0.08	0.88	FALSE
17	YFS	Blood	DHX36	0.11	0.19	lasso	11	0.21	9.1e-68	-5.3	-5.9	3.1e-09	0.83	1.00	0.00	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DHX36	0.07	0.06	lasso	6	0.08	4.8e-09	-5.2	-5.9	3.6e-09	0.83	0.04	0.96	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	DHX36	0.11	0.11	lasso	8	0.13	8.5e-14	-5.2	-5.8	5.3e-09	0.83	0.08	0.92	FALSE
5	GTEx	Breast Mammary Tissue (Female)	DHX36	0.14	0.08	lasso	2	0.08	2.0e-03	-5.5	-5.7	9.3e-09	0.63	0.07	0.43	FALSE
24	The Cancer Genome Atlas	Lung Adenocarcinoma	DHX36	0.09	0.07	blup	50	0.07	1.6e-08	-5.2	-5.7	9.7e-09	0.85	0.11	0.89	FALSE
11	GTEx	Skin Not Sun Exposed Suprapubic	ARHGEF26	0.13	0.11	lasso	4	0.07	6.8e-05	-6.6	5.7	1.4e-08	-0.54	0.07	0.93	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	DHX36	0.16	0.17	blup	50	0.19	7.7e-18	-5.2	-5.6	2.6e-08	0.81	0.08	0.92	FALSE
25	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DHX36	0.08	0.02	blup	50	0.03	1.4e-02	-5.6	-5.5	3.6e-08	0.74	0.01	0.89	FALSE
12	GTEx	Spleen	DHX36	0.39	0.09	enet	21	0.34	2.1e-09	-5.2	-5.4	5.5e-08	0.75	0.12	0.87	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	DHX36	0.07	0.07	blup	50	0.07	1.1e-13	-5.2	-5.3	9.7e-08	0.85	0.14	0.86	FALSE
7	GTEx	Esophagus Muscularis	DHX36	0.14	0.15	lasso	2	0.13	2.2e-08	-5.2	-5.3	1.5e-07	0.87	0.75	0.25	FALSE
8	GTEx	Nerve Tibial	DHX36	0.10	0.11	lasso	2	0.10	1.3e-07	-5.2	-5.2	1.6e-07	0.87	0.23	0.77	FALSE
22	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DHX36	0.09	0.10	lasso	1	0.09	4.8e-06	-5.2	-5.2	2.2e-07	0.87	0.13	0.85	FALSE
9	GTEx	Ovary	ARHGEF26	0.14	0.03	enet	15	0.06	1.4e-02	4.2	5.2	2.3e-07	-0.52	0.09	0.36	FALSE
16	METSIM	Adipose	DHX36	0.08	0.05	blup	358	0.05	3.5e-08	-7.0	-5.2	2.6e-07	0.87	0.03	0.97	FALSE