TWAS hub - SSR3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0850	0.0300	1.2e-04	0.013	0.048	0.029	0.050	0.015	7.7e-03	1.5e-06	1.5e-04	1.0e-06	5.0e-03
2	GTEx	Cells EBV-transformed lymphocytes	0.1280	0.0580	9.4e-03	0.014	NA	0.011	NA	0.026	1.1e-01	NA	1.4e-01	NA	4.8e-02
3	GTEx	Cells Transformed fibroblasts	0.0820	0.0340	2.4e-03	0.013	NA	0.015	NA	0.016	3.3e-02	NA	2.5e-02	NA	2.1e-02
4	GTEx	Colon Transverse	0.1100	0.0510	9.2e-03	-0.003	NA	0.011	NA	-0.005	5.2e-01	NA	9.2e-02	NA	7.6e-01
5	GTEx	Nerve Tibial	0.2135	0.0602	1.2e-05	0.008	NA	0.068	NA	0.048	7.9e-02	NA	1.5e-05	NA	2.4e-04
6	GTEx	Thyroid	0.0710	0.0320	9.6e-03	0.060	NA	0.052	NA	0.058	2.2e-05	NA	7.8e-05	NA	3.1e-05
7	METSIM	Adipose	0.0942	0.0265	2.7e-06	0.021	0.057	0.073	0.063	0.070	3.3e-04	5.4e-09	4.3e-11	9.4e-10	1.2e-10
8	NTR	Blood	0.0220	0.0091	2.5e-04	0.014	0.012	0.012	0.012	0.013	1.7e-05	6.5e-05	7.5e-05	6.1e-05	2.5e-05
9	YFS	Blood	0.1100	0.0229	0.0e+00	0.080	0.069	0.094	0.087	0.096	5.7e-25	1.4e-21	3.2e-29	4.7e-27	1.3e-29
10	TCGA	Breast Invasive Carcinoma	0.0385	0.0177	7.2e-04	0.014	0.012	0.016	NA	0.018	5.9e-04	1.2e-03	2.3e-04	NA	1.2e-04
11	TCGA	Brain Lower Grade Glioma	0.0583	0.0315	3.0e-04	0.038	0.016	0.023	NA	0.026	3.4e-05	5.6e-03	9.8e-04	NA	4.9e-04
12	TCGA	Prostate Adenocarcinoma	0.0439	0.0191	1.3e-04	0.040	0.022	0.029	NA	0.027	4.6e-05	2.0e-03	4.2e-04	NA	7.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Birth weight of first child	4.2	7.7	28.5	-0.2	-4.4	-2.0	4.1	-5.3	-1.0	1.1	-0.9	2.3	-1.8	-2.0	-2.8
Bipolar Disorder (2011)	3.9	3.8	9.0	-2.2	-2.0	-1.9	2.4	-1.9	-1.7	2.0	-0.5	0.8	-1.1	-3.0	-2.4
Lung FEV1/FVC ratio	3.6	18.5	57.0	-4.5	-3.1	-7.5	-0.6	-3.4	-3.7	2.2	-3.9	1.9	-4.1	-6.1	-5.6
Heel T-Score	3.2	25.3	82.1	9.1	2.1	6.9	7.3	5.1	0.6	2.2	7.3	-1.4	4.5	2.7	1.6
Supplements: Zinc	3.1	3.4	8.3	0.8	1.3	1.1	-0.2	0.2	2.8	1.8	2.4	-2.9	1.5	2.1	2.1
Serious illness, injury or assault of a close relative in last 2 years	3.0	3.4	10.4	-1.7	-1.8	-1.2	0.8	-0.8	-0.7	-1.1	-2.3	1.2	-3.2	-2.2	-2.8
Hearing difficulty/problems: Yes	2.9	4.5	16.1	4.0	-1.0	0.4	0.4	-1.4	-0.6	-2.3	-0.1	1.9	3.5	2.4	2.8
Breast Cancer	2.6	6.4	18.6	-1.7	-1.8	-3.8	-3.4	-2.2	-0.6	-1.7	-4.3	1.8	-3.3	-1.4	-1.4
Crohns Disease (2012)	2.5	4.1	7.7	2.1	1.4	2.5	1.6	0.7	2.4	0.9	2.8	-2.0	1.7	2.6	2.3
Supplements: Glucosamine	2.5	3.3	10.3	-1.1	-3.2	-0.5	2.8	-2.1	-1.8	1.0	0.3	1.7	-0.3	-2.1	-2.1
Handedness (chirality/laterality): Left-handed	2.5	3.1	11.0	-1.9	0.6	0.6	-1.7	-0.5	-1.7	-2.8	-3.3	2.6	-0.0	0.0	0.3
Overall health rating	2.4	5.2	18.9	2.0	2.3	4.4	0.8	1.8	0.2	-0.5	1.2	-1.0	3.5	2.6	2.9
Alcohol drinker status: Previous	2.4	2.7	6.1	1.9	2.2	2.2	-0.9	0.8	0.8	1.0	2.3	-0.8	2.5	1.2	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.0	7.4	0.9	2.7	1.2	-0.6	1.6	1.8	0.5	1.3	-2.5	1.1	2.2	2.5
Supplements: Vitamin C	2.3	2.7	8.2	0.1	1.3	2.0	-1.2	0.9	0.7	-1.9	0.8	-0.5	2.1	2.8	2.9
Noisy workplace	2.2	2.7	6.7	1.5	2.6	1.7	-0.1	1.0	1.1	-0.2	2.1	0.1	2.0	2.2	2.3
Pulse wave peak to peak time	2.2	2.6	6.4	-1.5	-0.9	-1.4	0.7	-1.9	-1.2	-0.7	-1.1	1.5	-2.3	-2.3	-2.5
Arm fat percentage (left)	2.2	8.7	24.1	2.0	3.3	4.9	0.3	2.3	2.6	-0.7	2.1	-2.5	2.8	4.2	4.0
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.8	14.4	3.6	1.6	3.2	2.9	1.7	0.5	1.0	3.8	-0.6	1.9	1.2	0.6
Medication: Levothyroxine sodium	2.1	3.6	12.0	3.5	-0.1	2.4	0.3	-0.9	0.8	-0.3	1.9	0.2	2.7	2.7	2.4
Shortness of breath walking on level ground	2.1	2.5	8.2	2.9	1.6	2.2	-1.1	0.9	-0.2	-0.9	0.8	0.6	2.1	1.9	1.5
Severe depression (siblings)	2.0	2.2	6.2	-1.5	-1.7	-0.8	-0.7	-1.1	-2.0	-2.0	-2.5	1.8	-0.6	-0.9	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	12.1	3.5	0.9	3.0	3.3	2.0	0.1	0.4	3.2	-0.3	1.6	1.1	0.5
Arm fat percentage (right)	1.9	7.6	22.7	1.7	3.0	4.8	0.1	1.9	2.1	-0.9	1.7	-1.9	3.0	4.0	3.9
Breastfed as a baby	1.9	2.4	7.2	-1.5	-1.5	0.7	1.1	1.5	-2.6	0.4	-0.8	0.7	-0.9	-2.7	-2.1
Qualifications: nursing, teaching	1.9	2.9	11.6	-3.4	2.0	-2.1	-1.4	0.1	-0.4	-1.0	-1.5	0.6	-2.1	-1.2	-1.6
Medication: Blood pressure	1.9	3.7	11.2	2.0	0.9	2.1	0.9	1.2	1.2	0.1	1.5	-1.3	3.3	2.8	2.8
Waist circumference	1.8	6.4	17.2	2.2	1.7	4.1	0.7	0.8	0.8	-1.8	0.9	-0.6	3.8	4.0	4.0
Number of full brothers	1.8	2.3	6.8	0.0	1.0	2.2	0.1	0.8	1.2	-0.9	1.6	-0.3	2.0	2.6	2.3
Knee pain experienced in last month	1.8	2.9	7.3	0.7	1.7	2.7	1.4	0.4	1.3	0.3	1.6	-1.0	1.9	2.4	2.6
Respiratory disease	1.7	3.9	11.4	1.0	1.5	3.1	-1.3	-0.0	1.1	-1.0	0.1	-1.0	2.7	3.2	3.4
Medication for hormone replacement therapy	1.7	1.9	11.2	1.4	-1.5	0.6	3.3	-1.2	0.8	1.7	0.6	-0.8	-0.8	-0.1	-0.8
Had other major operations	1.7	2.1	4.0	1.1	1.2	2.0	1.3	1.4	1.6	1.0	1.6	-1.8	0.6	1.8	1.5
Father’s age at death	1.7	2.2	6.4	-0.7	-2.1	-1.2	-0.2	-0.6	-1.2	0.4	-1.2	0.6	-2.1	-2.5	-2.4
Exposure to tobacco smoke at home	1.7	1.9	10.2	1.6	1.1	0.4	0.6	0.7	0.8	2.5	3.2	-1.0	0.0	-0.1	-0.4
Blood clot in the leg (DVT)	1.7	2.1	5.3	2.3	0.6	2.0	0.2	-0.0	-1.4	-1.9	-0.3	1.5	2.0	1.6	1.3
Health satisfaction	1.7	2.2	5.6	0.7	1.9	2.0	2.4	0.8	-0.2	-0.7	1.1	0.3	2.2	1.7	1.6
Medication: Seretide 50 evohaler	1.7	2.0	5.0	0.9	1.0	1.5	-1.9	-0.2	1.1	-0.7	0.7	-0.6	1.9	2.2	2.2
Medication for cholesterol	1.7	2.5	10.3	-3.2	0.4	-1.6	-1.5	0.9	-0.9	-1.4	-1.3	0.6	-1.9	-1.9	-1.4
Guilty feelings	1.7	2.5	7.5	-1.4	-0.9	-1.1	-1.0	0.1	-1.2	-2.5	-2.7	1.2	-2.3	-1.1	-1.3
Bipolar Disorder (2018)	1.6	2.5	5.8	-2.0	-0.4	-2.1	1.3	-1.1	-1.3	2.3	-0.3	-0.2	-1.0	-2.4	-2.1
Reaction Time	1.6	3.0	6.9	-1.5	-2.6	-2.1	-0.8	-0.3	-2.1	0.2	-2.5	1.8	-0.7	-2.1	-1.7
Tanning	1.6	19.8	44.6	-5.1	-0.9	-6.7	-3.6	-5.5	-2.7	2.1	-3.9	3.3	-4.6	-6.0	-5.3
Pulse wave Arterial Stiffness index	1.6	1.9	4.8	1.1	0.7	1.1	-0.7	1.7	0.8	0.6	1.0	-1.1	2.1	2.0	2.2
Body fat percentage	1.6	6.5	18.7	1.8	2.8	4.3	0.5	1.7	1.9	-0.5	1.9	-2.0	2.7	3.6	3.5
Leg pain on walking	1.6	2.0	7.8	0.6	0.8	2.8	0.7	2.2	0.4	1.5	1.1	-1.2	1.2	1.3	1.2
Back pain experienced in last month	1.6	2.4	5.1	1.0	-1.6	1.7	1.8	-2.3	-0.7	-1.1	-0.6	1.7	2.1	1.3	1.6
Breast cancer (self-reported)	1.6	1.8	8.2	1.1	-2.9	0.1	0.7	-2.5	-1.7	-0.7	-0.9	0.9	0.9	0.1	0.4
Hearing aid user	1.6	1.8	4.8	-0.8	-0.5	-2.2	-0.9	-2.1	-1.0	-1.5	-1.7	2.1	0.2	-0.1	0.0
Tinnitus: Yes, now most or all of the time	1.6	1.9	6.6	1.2	-1.2	-1.0	-0.4	-2.6	-2.2	-0.3	-1.4	1.9	0.1	-0.9	-0.7
Pain type(s) experienced in last month: Hip pain	1.6	2.0	5.7	0.8	0.3	1.0	1.9	0.5	1.5	2.4	1.8	-2.4	0.9	0.4	1.1
Leg fat percentage (left)	1.6	5.8	18.3	2.2	2.7	4.3	-1.0	1.0	1.6	-0.3	1.6	-1.7	2.7	3.2	3.3
Depression (Nagel 2018)	1.5	2.2	6.9	1.2	2.6	1.1	-0.2	1.6	1.9	0.2	1.1	-1.7	0.8	1.6	1.8
Ovarian Cancer	1.5	2.0	13.7	-0.2	1.1	-2.0	0.6	-3.7	0.4	0.3	1.5	1.0	-1.0	-0.3	-0.1
Primary Biliary Cirrhosis	1.5	2.1	6.7	-1.9	-0.8	-0.3	-2.1	-1.9	-1.6	-0.2	-2.6	1.2	-0.1	-1.3	-1.0
Had menopause	1.5	1.9	7.2	0.5	-1.5	-1.7	-1.2	-1.4	-1.4	2.7	0.6	0.0	0.5	-1.6	-1.2
Leg fat percentage (right)	1.5	5.4	16.1	2.4	2.6	4.0	-0.8	0.6	1.7	0.0	1.6	-1.8	2.5	3.0	3.2
Pulse rate, automated reading	1.5	4.9	11.8	3.3	1.1	3.4	1.3	-0.1	0.7	1.5	2.5	-1.9	3.3	1.9	2.4
Number of self-reported non-cancer illnesses	1.5	2.7	7.6	2.1	-0.6	2.8	0.1	-0.5	0.2	-1.5	-0.2	0.1	2.8	2.1	2.3
Pain experienced in last month	1.5	2.5	6.3	-0.5	0.3	-2.5	-1.9	-0.6	-0.3	2.0	0.0	0.3	-1.8	-2.5	-2.5
Crohns Disease (2017)	1.4	3.0	9.1	2.6	0.8	1.5	0.5	1.2	1.6	1.0	3.0	-1.1	2.2	1.8	1.6
Irritable Bowel Disease (IBD)	1.4	3.4	10.6	2.1	0.9	1.3	0.0	2.0	1.8	1.8	3.2	-1.7	2.3	1.4	1.8
Ulcerative Colitis	1.4	2.0	6.5	1.4	0.7	0.8	0.9	1.6	1.4	2.1	2.6	-1.3	1.3	0.5	1.0
Chronotype (morning person)	1.4	3.2	6.8	-1.7	-1.9	-2.4	0.7	0.4	1.2	2.1	-1.1	-1.1	-2.6	-2.3	-2.4
Trunk fat percentage	1.4	5.8	15.1	1.4	2.8	3.9	1.2	1.9	1.8	-0.8	1.9	-1.8	2.4	3.4	3.2
Asthma	1.4	2.7	9.6	0.7	0.9	3.1	0.2	0.5	1.3	-0.4	0.9	-1.4	1.8	2.6	2.5
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	12.2	0.7	-0.4	-0.0	3.5	-2.1	-0.6	-0.6	0.3	1.1	1.3	0.5	0.4
Medication: Lansoprazole	1.4	1.6	7.5	1.0	-0.5	2.7	0.5	0.4	-0.1	-1.1	0.0	-1.2	1.5	1.7	1.5
Medication: Ventolin 100micrograms inhaler	1.4	1.8	7.7	0.3	1.8	2.8	-1.2	1.1	0.7	0.0	0.7	-0.7	0.9	1.8	1.5
Chronic bronchitis/emphysema (mother)	1.4	1.6	4.2	2.1	0.1	1.2	1.3	-0.6	-0.1	-1.4	0.2	1.0	1.7	1.8	1.7
Exposure to tobacco smoke outside home	1.4	1.9	4.4	2.0	1.8	1.4	-0.3	1.1	-0.5	0.5	2.1	1.1	1.5	1.5	1.1
Mineral and other dietary supplements	1.4	1.8	9.1	-0.3	3.0	-0.6	-2.0	1.3	1.8	0.1	-0.3	-0.5	-1.4	0.9	0.5
Asthma (self-reported)	1.4	2.8	10.3	0.7	1.2	3.2	0.1	0.6	1.4	-0.4	0.9	-1.4	1.8	2.5	2.5
Smoking Status	1.3	3.2	10.8	-0.8	-0.1	-3.3	-2.0	-2.5	-0.4	-0.7	-2.5	1.8	-2.0	-1.1	-1.0
Serious illness, injury or assault to yourself	1.3	1.6	8.2	-0.8	-1.1	0.4	1.0	-1.5	-2.9	0.1	-1.1	1.2	1.5	-0.7	-0.5
Body mass index (BMI)	1.3	5.4	19.0	1.3	2.2	4.4	-0.5	1.1	1.5	-0.9	0.9	-1.9	2.7	3.3	3.5
Falls in the last year	1.3	1.8	7.4	0.5	0.6	1.8	1.8	-0.2	-0.1	1.4	1.1	-0.1	2.7	1.2	1.4
Medication: Cholesterol lowering	1.3	2.0	6.4	-1.5	-0.4	-0.2	-0.4	0.4	-1.1	-1.1	-1.5	0.9	-2.5	-2.1	-2.3
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	5.8	1.8	1.4	2.1	0.7	2.4	1.4	1.1	1.7	-1.3	0.4	0.5	0.4
Osteoarthritis (self-reported)	1.3	1.6	4.6	0.9	0.1	2.1	1.6	0.6	0.9	1.8	1.4	-2.1	0.6	0.5	0.6
Arm fat mass (left)	1.3	5.4	16.7	1.1	2.5	4.1	0.6	1.1	1.6	-0.7	1.5	-1.6	2.8	3.4	3.4
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.4	1.8	-1.5	-1.2	0.7	-1.5	-1.8	-0.7	-0.7	1.7	1.3	-0.0	-0.0
LDL Cholesterol	1.2	1.8	3.7	-1.2	-1.3	-1.8	-0.1	-0.2	-1.6	-0.4	-1.5	1.9	-1.1	-1.5	-1.8
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.4	1.4	1.8	1.8	-0.6	0.1	1.2	0.6	1.5	-0.8	0.6	1.2	1.1
Hair/balding pattern: Pattern 2	1.2	1.5	5.7	2.4	-1.8	0.9	-1.1	0.5	-1.1	-1.2	-1.2	0.9	1.1	0.8	0.5
Medication: Simvastatin	1.2	1.7	4.1	-0.3	-1.1	-0.9	-0.9	-1.5	-1.8	-0.2	-1.4	1.1	-1.3	-1.6	-2.0
Arm fat mass (right)	1.2	5.0	15.8	0.8	2.4	4.0	0.7	1.0	1.3	-0.9	1.3	-1.4	2.8	3.2	3.4
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	6.1	1.6	-1.0	-0.9	1.1	-2.5	-0.8	-0.3	-0.8	2.4	0.8	0.2	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	4.3	1.2	-0.8	1.2	0.6	-1.3	-1.9	-1.0	-1.2	1.1	2.1	0.6	0.9
Wheeze or whistling in the chest in last year	1.2	2.1	5.5	0.5	-1.3	1.6	-0.5	-1.2	-1.4	-2.3	-1.6	1.2	1.9	1.3	1.7
Number of children fathered	1.2	1.3	6.0	-1.0	-0.3	-1.2	0.7	-0.8	-0.8	2.5	0.8	-0.7	0.4	-1.8	-0.9
Age at first live birth	1.2	2.2	6.2	-1.4	-1.4	-2.5	0.7	-0.9	-2.0	0.6	-0.3	1.7	-0.1	-2.0	-1.7
Eye problems/disorders: None of the above	1.2	1.4	3.1	0.7	1.8	-0.9	0.6	-0.0	1.4	0.8	1.2	-1.1	1.4	1.4	1.5
Risk taking	1.2	1.7	9.5	-0.3	-2.0	-0.1	-1.0	-3.1	-0.9	0.4	-1.5	0.6	1.4	-0.6	0.5
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	4.4	2.1	0.2	1.4	0.2	-0.2	-1.4	-1.9	-0.7	1.5	1.4	1.1	0.9
Heart disease (siblings)	1.2	1.5	5.1	0.1	-0.1	2.3	0.7	1.4	1.2	-0.3	0.4	-2.0	1.1	1.3	1.4
Multivitamins +/- minerals	1.1	1.4	3.1	0.2	1.4	1.5	-1.1	0.4	1.3	-0.7	0.7	-1.4	0.6	1.8	1.7
Past tobacco smoking	1.1	2.1	9.3	0.1	-1.2	3.0	1.2	1.5	-0.4	0.6	1.2	-1.6	2.1	0.8	1.0
Peak expiratory flow (PEF)	1.1	2.5	5.2	-1.2	2.2	-1.1	1.9	-0.2	2.3	1.5	2.2	-2.3	-0.0	1.2	0.9
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	5.0	1.2	1.7	0.4	-0.9	0.9	1.0	-0.1	0.9	-1.1	1.8	2.1	2.2
Mean time to correctly identify matches	1.1	2.0	8.6	-0.5	-2.9	-1.5	-0.7	0.2	-1.6	0.3	-2.2	0.9	-0.4	-1.7	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	4.1	-0.2	2.0	0.4	0.8	1.8	1.0	0.1	1.6	0.1	0.8	1.4	1.1
Whole body fat mass	1.1	4.5	13.0	0.7	2.6	3.6	0.9	0.8	1.4	-0.4	1.6	-1.6	2.6	2.9	3.1
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	4.0	1.5	1.5	-0.3	-0.5	-0.7	2.0	0.7	1.5	-1.3	-0.9	0.4	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	5.3	0.6	-1.2	0.3	-1.5	-0.0	-1.3	-2.3	-1.7	1.4	-0.1	-0.2	-0.2
Ever taken oral contraceptive pill	1.1	1.2	5.4	-1.4	-0.5	-0.4	-1.0	1.0	0.6	-2.3	-1.7	0.0	-1.1	0.1	0.6
Number of operations (self-reported)	1.1	1.6	4.4	2.1	-0.1	1.8	1.4	-0.5	0.8	0.9	1.4	-0.7	1.4	1.3	1.5
Ulcerative Colitis (UC)	1.0	1.9	4.8	0.7	0.8	0.7	-0.7	1.7	1.6	2.1	2.2	-1.9	1.2	0.4	1.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.9	0.9	-0.1	-0.5	-0.3	-2.0	-0.7	1.2	0.9	1.4	-0.1	-1.3	-1.4
Chronic bronchitis/emphysema (father)	1.0	1.2	3.8	1.2	0.1	1.9	-0.6	0.2	1.3	-0.6	0.1	-0.8	0.6	1.7	1.7
Hip circumference	1.0	4.3	13.8	1.6	1.2	3.7	1.0	0.5	1.5	-1.0	1.4	-1.4	2.5	3.2	3.1
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	6.7	2.6	0.0	1.9	0.1	-0.0	-0.3	-0.2	1.5	0.4	2.4	1.6	1.5
Medication for pain relief, constipation, heartburn	1.0	1.7	9.7	-1.6	-0.7	-1.6	-3.1	-0.7	-0.5	-0.3	-1.2	0.2	-1.3	-0.8	-0.7
Medication: Ibuprofen	1.0	1.2	7.5	0.5	-0.2	0.1	2.7	-1.7	-0.6	0.2	0.7	1.1	1.3	0.1	-0.1
Leg fat mass (right)	1.0	4.0	13.5	1.3	2.3	3.7	-0.0	0.5	1.4	-0.1	1.4	-1.6	2.3	2.6	2.9
Chest pain or discomfort	1.0	1.5	5.2	1.6	0.1	1.2	0.1	-0.6	-0.4	-1.0	-0.1	0.9	2.3	1.6	1.8
Ever had bowel cancer screening	1.0	1.2	2.7	0.9	0.1	1.4	0.1	-0.6	0.7	0.9	0.7	-1.6	1.2	1.6	1.5
Medication: Aspirin	1.0	1.3	4.6	1.3	1.7	0.3	2.1	0.9	-0.7	1.3	1.4	0.0	0.9	-0.1	-0.4
Leg fat mass (left)	1.0	3.9	13.2	1.0	2.4	3.6	-0.1	0.6	1.3	-0.3	1.3	-1.5	2.4	2.7	2.9
Alzheimer’s Disease (in mother)	0.9	1.1	3.4	-0.9	0.6	1.2	1.8	1.6	-0.4	0.9	0.8	-0.8	1.6	0.4	0.5
Coronary Artery Disease (CAD)	0.9	1.1	2.3	0.7	0.9	1.4	0.2	0.3	1.3	1.3	1.5	-0.8	1.3	0.5	1.0
Triglycerides	0.9	1.4	4.0	-0.8	-0.9	-1.7	-1.3	-2.0	-0.6	0.8	-0.0	0.9	-1.0	-1.4	-1.4
Waist Hip Ratio (WHR)	0.9	4.3	11.0	1.8	2.2	2.6	-0.3	1.9	0.1	-1.6	0.6	0.6	3.3	3.0	3.0
Hypothyroidism (self reported)	0.9	2.2	7.2	2.5	0.0	2.0	-0.5	0.2	-0.1	-0.2	1.6	0.6	2.7	1.7	1.5
Sensitivity / hurt feelings	0.9	1.5	7.6	2.8	-0.9	-0.8	-0.9	-0.9	1.0	-0.5	0.1	0.2	0.9	1.5	1.6
Vitamin and mineral supplements	0.9	1.2	3.2	0.1	-1.4	-1.8	0.4	-1.4	-0.5	1.4	-0.6	0.8	-0.5	-1.5	-1.2
Medication: Co-codamol	0.9	1.0	3.2	0.9	0.3	0.6	0.6	0.2	1.8	0.4	1.0	-1.5	-0.4	1.5	1.0
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.3	1.1	0.6	0.9	0.5	0.4	1.1	1.5	1.4	-1.5	1.1	0.7	1.1
High blood pressure (mother)	0.9	1.2	4.3	2.1	1.0	0.7	0.8	1.2	0.8	1.4	1.6	-1.0	0.6	0.5	0.2
Trunk fat mass	0.9	4.0	11.6	0.5	2.6	3.4	1.3	1.0	1.2	-0.6	1.6	-1.3	2.4	2.8	2.8
Mouth/teeth dental problems	0.9	1.4	5.3	-2.3	0.8	-1.9	-1.5	0.6	-0.4	-0.4	-0.9	-0.8	-1.0	-1.1	-1.0
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	12.5	-3.0	1.2	-3.5	2.3	-1.6	0.7	1.1	1.7	0.1	-0.9	-0.5	-0.8
Depression (self-reported)	0.9	1.0	3.8	0.2	-0.6	1.0	-0.4	-0.6	0.3	-1.9	-0.4	0.1	1.6	1.4	1.5
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	4.3	-2.1	0.9	-0.9	0.2	1.5	-0.1	-1.2	-0.2	0.2	-2.0	-1.0	-1.3
Number of full sisters	0.9	1.1	4.1	-0.3	0.5	1.3	0.7	0.2	2.0	0.7	1.3	-1.2	-1.2	1.1	0.5
Smoking status: Previous	0.9	1.4	5.2	0.7	0.3	-2.3	-0.8	-1.2	0.4	-0.6	-0.9	1.4	-1.9	-0.6	-1.1
Eye problems/disorders: Cataract	0.9	1.0	3.3	-0.1	-1.8	1.0	-0.3	0.1	-1.2	-1.1	-1.0	0.7	-1.2	-1.0	-1.0
Medication: Bendroflumethiazide	0.9	1.4	7.4	1.3	-2.7	-0.3	0.2	-2.5	-0.4	0.1	-0.4	0.3	-0.5	-0.2	-0.7
Ever smoked	0.9	1.5	5.7	0.1	1.1	-2.4	-1.2	-1.5	0.5	-1.3	-1.4	1.3	-1.3	0.0	0.1
Fractured/broken bones in last 5 years	0.9	1.1	6.0	1.6	-0.6	-1.0	0.4	-2.4	0.6	0.2	0.7	0.4	0.5	1.3	0.9
Supplements: Calcium	0.9	1.0	3.5	-0.1	-0.4	-1.2	-1.9	-1.0	-0.4	-1.3	-0.8	0.7	1.1	0.7	1.0
Average weekly spirits intake	0.8	1.0	2.9	-0.5	-1.7	-0.1	1.1	-0.9	-0.3	0.9	-1.5	-0.5	-0.7	-1.5	-1.1
Ever had hysterectomy (womb removed)	0.8	0.9	4.7	-0.1	-1.0	-1.2	2.2	-1.0	-0.1	1.2	0.3	-0.1	0.8	-0.7	-0.2
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.6	-1.6	1.6	-0.1	-0.5	0.0	0.8	0.4	0.4	-1.3	-1.4	-0.4	-0.2
Diabetes (mother)	0.8	1.0	3.8	-0.3	0.5	0.7	-1.1	-0.3	1.0	1.9	0.7	-1.3	1.3	0.4	0.9
Nervous feelings	0.8	1.4	5.1	1.5	0.8	0.9	-1.1	2.3	0.7	-0.8	0.0	-0.7	1.0	1.8	1.3
Hearing difficulty/problems with background noise	0.8	1.2	6.9	1.3	-0.4	0.3	-0.6	-1.2	0.4	-0.1	0.2	0.9	2.6	0.8	1.6
Length of working week for main job	0.8	0.8	5.7	-0.3	2.4	-0.4	-0.0	0.4	0.4	0.4	1.3	0.1	0.8	0.9	0.7
Glaucoma (self-reported)	0.8	1.0	4.7	1.2	0.1	2.2	-1.5	1.3	0.5	0.6	0.5	-0.6	0.6	-0.2	0.1
Worry too long after embarrassment	0.8	1.3	5.3	1.5	-0.2	-1.3	0.4	-0.9	0.4	-2.3	-0.6	0.7	-1.7	1.0	0.4
Alcohol intake frequency.	0.8	1.8	7.7	0.5	0.7	1.4	0.4	0.8	-0.6	2.3	1.9	-0.4	2.8	0.4	0.6
Loneliness, isolation	0.8	1.1	3.9	1.3	2.0	0.1	-1.2	-0.5	-0.5	0.7	0.1	-0.2	1.8	0.6	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.5	1.4	0.3	0.2	0.5	-0.0	0.9	-1.4	0.4	0.2	0.7	1.6	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	4.6	1.0	-0.7	1.3	0.8	0.2	0.7	0.2	-0.7	-0.3	-2.1	-0.8	-1.2
Eye problems/disorders: Glaucoma	0.8	1.0	4.2	0.9	-1.0	2.1	-0.6	1.0	-0.5	0.9	0.2	-0.1	-0.3	-1.3	-1.0
High cholesterol (Self-reported)	0.8	1.4	6.6	0.7	-0.7	0.2	0.0	-0.6	-1.8	-1.8	-1.0	2.6	0.8	-0.0	-0.2
Medication: Paracetamol	0.8	1.3	2.8	0.7	0.3	0.6	1.7	1.0	1.5	1.5	1.7	-1.3	0.9	0.5	0.5
Medication: Atorvastatin	0.8	1.0	4.3	1.2	0.0	0.5	1.0	1.4	-0.3	0.9	1.3	0.3	2.1	-0.1	0.3
Myopia	0.8	1.2	3.8	1.5	0.7	-0.3	-1.9	-0.8	0.2	-1.6	-0.8	0.4	1.2	1.1	0.9
Schizophrenia vs Biploar Disorder	0.7	0.9	3.4	1.4	0.2	0.9	-1.0	0.1	-0.6	-1.6	-0.0	1.8	0.5	0.5	0.2
BMI	0.7	4.3	11.9	0.9	2.0	3.2	-1.4	-0.5	1.0	-1.6	0.2	-1.1	2.5	3.4	3.5
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.9	0.7	-1.5	-1.4	0.4	-1.4	-0.2	1.7	0.3	-0.5	-0.4	-0.6	-0.8
Systolic blood pressure, automated reading	0.7	2.1	9.3	3.1	-0.4	2.8	-1.2	1.2	-0.1	0.3	0.6	-0.5	1.7	0.6	0.9
Townsend deprivation index at recruitment	0.7	0.9	2.1	0.8	0.4	0.7	0.2	-1.3	1.3	0.5	0.9	-1.3	0.6	1.4	1.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.5	0.4	-1.0	1.6	-0.5	-0.1	0.2	-1.4	-1.1	0.2	-0.0	1.1	1.2
Alcohol usually taken with meals	0.7	1.2	2.9	-0.9	-1.7	-1.0	-0.7	-1.4	-1.0	1.2	0.5	0.2	-0.6	-1.1	-1.5
Medication: Ramipril	0.7	0.9	2.3	-1.1	0.2	-0.0	0.8	1.3	0.7	1.0	0.8	-1.5	-1.1	-1.0	-0.9
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.8	-2.2	-0.2	-0.6	0.3	-1.4	-1.2	-0.5	-1.6	0.4	-1.7	-1.4	-1.6
Standing height	0.7	6.8	21.9	-4.1	-1.0	-3.3	4.7	-2.6	-2.0	0.5	0.1	2.7	-0.9	-2.4	-2.4
Gout (self-reported)	0.7	0.9	3.6	0.2	0.7	0.5	1.9	-0.3	1.1	1.4	1.6	-0.4	0.3	0.7	0.3
Qualifications: College or University degree	0.7	2.1	6.2	-0.9	-0.1	-0.9	-1.3	-0.8	-2.0	-2.5	-2.2	1.8	-0.9	-0.9	-1.2
Medication: Omeprazole	0.7	0.9	2.2	0.2	-1.3	0.2	0.2	-0.8	-1.4	-1.4	-1.1	0.6	1.5	0.3	0.6
Medication: Aspirin	0.7	0.9	2.7	1.2	1.6	0.4	1.5	1.0	-0.5	1.0	1.1	-0.3	1.0	0.1	-0.1
Long-standing illness, disability or infirmity	0.7	1.0	4.8	1.2	0.2	2.2	0.6	-0.3	-0.2	0.8	0.6	-0.3	1.7	0.9	0.9
Mother’s age at death	0.7	0.9	3.4	0.1	-0.4	-1.5	0.2	0.3	-0.5	1.8	1.0	0.2	-0.0	-1.3	-1.4
Alcohol drinker status: Never	0.7	0.9	2.9	1.4	-1.7	1.0	0.1	-1.2	-0.3	0.8	0.8	0.4	1.3	0.0	0.1
Bipolar Disorder or Schizophrenia	0.6	1.5	3.5	-1.9	-0.5	-1.6	0.9	-1.4	-1.6	0.6	-0.6	1.3	-0.1	-1.6	-1.2
Height	0.6	10.6	30.7	-4.9	-1.9	-4.0	5.5	-2.6	-1.9	2.5	0.4	0.9	-2.1	-4.1	-3.7
Neuroticism	0.6	1.6	4.4	2.0	1.4	-0.7	0.1	0.6	1.4	-0.6	0.7	-0.1	1.0	2.1	1.8
Number of treatments/medications taken	0.6	1.2	3.4	1.6	-0.2	1.3	1.8	0.3	0.4	0.8	1.6	-0.8	1.1	0.9	0.3
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.3	0.6	1.5	0.7	-0.5	0.5	1.2	-0.9	-0.6	-1.1	-0.0	1.1	1.2
Relative age of first facial hair	0.6	1.2	5.0	-0.5	-0.9	-1.7	0.2	-0.7	-2.2	-0.5	-0.5	1.4	1.1	-0.7	-0.7
Medication: Metformin	0.6	0.8	6.8	-1.0	0.0	0.0	-2.6	0.1	0.0	1.0	-0.6	-0.5	-0.3	-0.6	-0.4
Hand grip strength (right)	0.6	1.6	4.6	-1.5	-1.5	-2.2	1.5	-1.9	-0.8	-0.5	-0.8	0.7	1.0	0.4	0.6
Average weekly fortified wine intake	0.6	0.6	2.5	1.6	0.3	-0.5	0.8	-0.1	-0.1	-1.2	-0.4	1.5	-0.6	0.2	-0.3
Taking other prescription medications	0.6	0.9	3.6	0.2	-0.0	1.9	0.7	0.6	-0.4	-1.5	-0.5	0.3	0.8	1.6	0.9
Forced vital capacity (FVC)	0.6	2.5	8.6	-2.9	1.9	-2.8	1.9	-0.9	1.2	-0.0	1.8	0.1	-0.9	0.3	-0.1
Allergy	0.6	1.3	4.0	-1.1	-1.8	-2.0	0.2	-0.1	-0.2	0.3	-0.4	0.2	-1.8	-1.5	-1.4
Diabetes (self-reported)	0.6	1.0	4.0	-0.2	0.2	-0.5	-2.0	0.3	1.1	1.6	0.1	-1.4	-0.8	-0.6	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.7	0.9	1.2	1.6	1.0	-0.5	0.2	-0.7	-0.1	-0.4	1.2	1.4	1.4
Mouth/teeth dental problems: Dentures	0.6	1.0	3.0	1.2	-0.9	1.7	0.5	-0.2	0.8	1.4	1.3	-0.5	0.8	0.6	0.5
Illnesses of mother	0.6	0.7	3.4	-1.0	-0.2	-1.0	-0.7	-0.5	0.5	-1.8	-0.4	-0.2	-0.6	1.1	0.7
Loud music exposure frequency	0.6	0.6	2.7	-1.6	0.0	-0.1	-0.2	-0.6	0.0	-0.7	-1.4	0.2	-1.0	-0.7	-0.5
Medication: Paracetamol	0.6	1.0	4.1	-0.0	0.8	0.8	2.0	1.2	1.2	0.7	0.9	-1.1	0.6	0.6	0.8
High blood pressure (siblings)	0.6	0.8	2.6	-0.4	-1.6	-0.6	0.7	-1.4	-1.3	0.3	-0.2	0.7	-0.3	-1.1	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.6	-1.1	1.6	0.6	-1.3	0.6	0.1	-1.1	-0.5	0.3	-0.1	0.1	0.8
Mouth/teeth dental problems: Loose teeth	0.6	0.8	4.0	-0.6	-0.1	-0.9	0.4	-1.0	-2.0	-0.4	-0.8	0.9	0.7	-0.8	-0.1
Comparative height size at age 10	0.6	3.2	8.9	-3.0	0.0	-1.6	2.4	-2.2	-2.0	-0.8	-1.7	2.1	-0.8	-1.2	-1.5
Illnesses of siblings: Diabetes	0.6	0.8	3.4	-0.1	0.1	1.1	-1.8	0.1	1.1	0.4	-0.9	-0.7	-1.3	0.1	-0.1
Friendships satisfaction	0.6	0.8	1.9	-0.9	1.3	0.1	-1.4	1.0	0.2	-1.0	-1.0	-1.3	-0.7	-0.0	0.2
Medication: Lisinopril	0.6	0.8	2.5	-1.4	-0.1	0.2	-1.6	-0.3	-0.8	1.3	-0.5	-0.8	-0.3	-1.1	-0.8
Illnesses of father: High blood pressure	0.6	0.8	2.6	1.6	-0.9	0.1	1.4	0.3	0.1	1.2	0.8	-0.5	0.2	-1.1	-0.4
Age started oral contraceptive pill	0.6	0.7	2.4	0.8	-1.0	1.2	-1.6	0.4	-1.1	-0.5	-0.7	0.0	1.0	-0.3	0.2
Unable to work because of sickness or disability	0.6	0.8	3.9	-2.0	0.2	-0.9	0.2	-1.1	-1.2	-0.0	-1.3	-0.0	0.1	-0.2	0.1
Cholesterol lowering medication	0.6	0.9	4.5	2.1	0.1	0.1	-0.2	-0.8	-0.5	0.3	0.4	0.4	1.6	1.3	1.0
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.2	0.0	-1.0	1.1	0.2	-0.3	-0.8	-1.3	-0.8	0.1	1.5	0.7	0.7
Prostate Cancer	0.5	0.7	7.0	-0.2	2.6	-0.1	0.0	-0.6	0.4	0.4	0.7	-0.1	-0.4	-0.1	-0.3
Body Mass Index (BMI) (2010)	0.5	0.6	2.2	1.0	-0.2	0.9	-0.0	0.4	0.4	-0.3	-0.3	0.7	1.2	1.0	1.5
Lupus	0.5	0.7	2.7	0.1	-0.4	0.5	0.3	-0.6	-0.9	0.6	-0.5	0.1	-0.9	-1.6	-1.6
Rheumatoid Arthritis	0.5	0.7	2.0	0.3	-0.1	1.4	0.0	1.4	0.7	-0.2	0.0	-1.4	-1.4	-0.2	-0.6
Type 2 Diabetes (T2D) (2018)	0.5	1.0	5.3	-1.1	-0.3	-0.8	-2.3	-0.2	0.2	1.3	-0.8	-0.5	-0.8	-1.0	-0.6
Hand grip strength (left)	0.5	1.4	4.4	-1.2	-0.6	-2.1	0.7	-2.0	-1.1	-0.7	-1.1	1.0	1.2	0.4	0.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.1	0.8	-0.8	0.9	-0.1	-1.0	-1.4	-0.5	-0.7	0.9	1.1	0.5	0.2
Diabetes (father)	0.5	0.7	1.8	-0.8	0.1	0.5	1.3	-0.1	-0.0	0.6	0.5	0.1	-1.2	-1.2	-1.4
Maternal smoking around birth	0.5	0.8	2.1	0.6	-0.6	-0.3	1.3	-1.2	-0.1	0.2	1.2	0.8	1.4	0.4	0.9
Fed-up feelings	0.5	0.9	2.3	1.5	1.5	1.2	1.1	0.1	0.5	-0.2	0.3	-0.1	0.8	1.2	1.0
Relative age voice broke	0.5	0.7	2.5	1.4	-0.8	-0.2	-0.9	-0.1	-0.7	-0.5	-0.2	0.9	1.6	0.8	0.8
Qualifications: CSEs or equivalent	0.5	0.7	1.6	-1.3	0.7	1.3	1.1	-0.7	0.1	1.1	1.1	-0.3	0.7	-0.2	0.3
Medication: Atenolol	0.5	0.6	2.3	-1.0	0.8	0.2	-0.1	0.3	-1.0	-1.0	-0.7	1.5	0.3	0.1	-0.3
Heart attack	0.5	0.6	2.8	-1.0	1.7	-0.7	0.8	-0.1	-0.7	0.8	0.1	0.3	0.2	-0.9	-0.4
Pain all over the body in last month	0.5	0.5	2.0	-0.1	0.5	1.2	-1.1	0.2	0.7	0.6	-0.5	-1.4	-0.1	0.4	0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.8	-0.3	1.7	0.5	-0.2	0.1	1.1	-0.3	-0.4	-1.1	0.5	0.4	1.0
Illnesses of siblings	0.5	0.7	4.5	-0.6	0.7	-2.1	-0.1	-0.2	0.0	1.0	-0.1	-0.2	-0.4	-0.8	-0.7
Weight	0.5	2.5	7.3	-0.5	1.6	2.7	1.6	-0.1	0.7	-0.5	1.0	-0.7	2.1	2.2	2.3
Alcohol intake versus 10 years previously	0.5	0.7	2.8	-1.7	0.5	-0.1	0.7	0.2	-1.5	0.6	1.0	0.4	0.3	-0.9	-0.9
Pulse rate	0.5	0.9	3.8	1.6	-0.2	1.3	0.9	-0.2	-0.5	0.5	0.5	0.1	1.9	-0.0	0.7
Lung cancer (father)	0.5	0.6	2.1	0.7	-0.7	0.6	-1.4	0.2	0.4	-0.1	0.1	0.4	-1.5	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	7.0	-1.7	1.2	-2.6	1.6	-1.6	0.3	0.5	1.7	0.3	0.1	0.0	-0.3
Impedance of arm (left)	0.5	2.3	7.3	1.8	0.7	-0.2	2.6	1.8	1.7	0.9	2.7	-0.5	0.3	1.2	0.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.8	-1.0	0.0	-0.3	0.9	-0.5	-0.3	-0.5	0.3	0.6	1.7	0.9	1.1
Headache pain in last month	0.5	0.9	2.6	-0.2	0.3	0.6	1.6	0.3	0.9	-1.1	0.7	-0.9	0.3	1.5	1.3
Medication: Amlodipine	0.5	0.6	2.4	-0.2	1.5	1.1	0.6	0.0	1.4	-0.1	-0.0	-1.1	-0.8	0.1	0.1
Emphysema/chronic bronchitis	0.5	0.5	3.1	-0.6	1.1	1.8	-0.1	-0.4	-0.7	-0.0	-0.1	0.9	0.5	0.1	0.1
Neck or shoulder pain in last month	0.5	0.8	3.3	0.6	0.3	1.0	1.8	-0.1	0.3	-0.3	0.7	-0.4	1.4	0.8	1.0
Suffer from ‘nerves’	0.5	0.7	1.6	0.7	0.8	0.3	-0.5	1.0	0.6	-0.1	0.6	-1.0	1.2	1.3	1.3
Age at last live birth	0.5	0.8	4.1	0.1	-0.4	-0.4	0.4	-0.9	-0.4	-0.4	0.6	1.2	2.0	0.8	1.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.7	0.7	-0.2	-0.6	-0.3	-1.7	-0.6	1.3	0.5	0.3	0.9	-0.5	-0.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	3.2	-0.1	0.7	0.4	-0.1	1.8	0.6	0.7	0.8	-1.5	-0.3	0.0	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	5.8	-0.9	1.1	-0.2	2.4	0.6	1.2	0.1	1.6	-0.0	0.0	0.7	0.2
Average weekly red wine intake	0.5	0.7	1.2	-0.4	-1.1	-1.1	-1.1	-0.6	-0.9	0.8	-0.4	0.6	-0.5	-0.9	-1.1
Commuting to job workplace: Walk	0.5	0.5	1.8	-1.3	0.1	-0.3	0.3	1.4	0.2	0.3	0.4	-1.1	-0.7	-0.3	-0.3
Osteoporosis (self-reported)	0.5	0.6	1.9	0.2	-0.6	0.4	-1.4	-1.1	-0.8	-0.6	-0.7	0.9	1.1	0.2	0.5
Medication: Gliclazide	0.5	0.6	1.5	0.2	0.9	0.3	-1.2	0.4	1.0	1.0	0.7	-0.6	0.2	0.5	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	4.8	-0.3	-0.2	-2.2	-0.1	-1.8	-0.7	0.1	0.3	0.7	-0.7	-1.1	-1.4
Commuting to job workplace: Public transport	0.5	0.5	1.3	1.0	-1.1	0.2	0.9	0.0	-0.9	-1.1	-0.6	0.5	-0.5	-0.3	-0.7
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.7	-0.2	-1.6	0.2	1.5	0.2	-0.9	-0.7	0.6	-0.1	1.0	-0.2	0.1
Irritability	0.5	0.8	3.6	0.8	1.9	-0.2	-0.0	-0.5	1.2	0.9	0.6	-0.9	0.2	0.9	0.8
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.8	-1.0	1.7	-0.7	1.1	-0.0	-0.5	0.7	0.4	0.3	0.5	-0.6	-0.1
Intelligence (Savage-Jansen 2018)	0.4	1.1	4.1	-2.0	-0.9	-0.4	0.6	-0.7	1.0	0.2	-0.2	-1.5	-1.6	-0.8	-0.9
Alzheimer’s Disease (in father)	0.4	0.4	3.4	-0.7	0.1	-0.2	-1.8	0.6	0.3	0.5	0.2	-0.5	-0.1	0.2	0.3
Alzheimer’s Disease (including proxy)	0.4	0.5	2.1	-1.5	-0.7	0.2	0.8	1.0	-0.8	0.8	0.2	-0.3	0.5	-0.3	-0.3
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.9	-1.2	-0.9	0.4	-0.2	-0.9	1.2	-0.6	-0.5	-1.4	-1.7	-0.4	-0.2
Age at First Birth	0.4	0.6	2.3	0.3	-0.4	-1.5	-0.2	-0.1	-0.9	0.4	-0.9	0.5	-0.7	-0.7	-1.0
Fasting Glucose	0.4	0.5	1.5	-0.6	-0.0	-1.0	0.8	-1.2	-0.2	-0.8	-0.8	0.5	-0.3	0.0	-0.5
HDL Cholesterol	0.4	0.7	2.6	-1.1	0.3	-1.6	1.1	-0.5	-0.3	-0.2	-1.0	-0.2	-1.0	-0.5	-0.6
Angina	0.4	0.5	1.7	0.5	1.1	0.5	0.4	1.3	0.0	1.1	0.7	-1.0	0.0	-0.0	-0.4
Current tobacco smoking	0.4	0.6	1.9	-1.4	0.6	-0.9	-0.8	-0.7	0.3	0.1	-1.3	-0.6	-0.2	0.1	0.7
High blood pressure	0.4	1.1	3.8	1.1	-1.2	0.7	0.4	-1.4	-0.9	-0.4	-0.1	1.5	1.9	0.7	0.8
Stomach or abdominal pain in last month	0.4	0.5	1.5	0.5	-0.4	1.2	0.4	0.4	-0.5	-0.9	-0.4	0.2	0.9	0.6	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	3.0	0.9	1.7	0.1	-0.0	-0.9	0.0	-0.2	0.6	-0.3	1.0	0.7	0.9
Qualifications: None of the above	0.4	0.9	4.2	1.1	-1.1	0.8	-0.6	-0.1	-0.3	0.2	-0.4	-0.3	2.0	0.9	1.2
Trunk fat-free mass	0.4	2.3	10.2	-3.2	0.1	-0.6	1.6	-2.2	-1.8	-0.1	-1.0	1.6	0.0	-1.2	-0.9
Worrier / anxious feelings	0.4	0.7	2.0	1.4	1.4	-0.6	1.0	0.9	0.5	0.1	1.1	-0.0	0.1	1.0	0.0
Prospective memory result	0.4	0.5	1.6	-1.0	0.7	-0.1	1.3	-0.8	-0.4	1.2	0.3	0.2	0.5	-0.3	-0.1
Trunk predicted mass	0.4	2.2	9.5	-3.1	0.1	-0.5	1.7	-2.1	-1.8	-0.1	-0.9	1.6	0.2	-1.2	-0.8
Hair/balding pattern: Pattern 4	0.4	0.9	5.0	-0.7	1.2	0.6	0.2	2.2	0.7	-0.1	0.3	-0.7	-1.3	-0.6	-0.5
Forced vital capacity (FVC), Best measure	0.4	1.5	3.5	-1.5	1.9	-1.7	1.3	-1.5	0.6	-0.4	1.6	0.3	0.6	0.9	0.6
Angina (self-reported)	0.4	0.5	1.6	0.7	0.9	0.5	0.6	1.2	-0.1	1.2	0.8	-0.8	0.3	0.1	-0.3
Medication: Allopurinol	0.4	0.5	4.3	0.2	-0.2	-0.4	2.1	0.7	0.4	0.4	0.7	0.7	-0.2	0.1	-0.3
Had major operations	0.4	0.5	2.1	0.6	-0.5	-0.2	0.4	-1.5	-0.8	0.7	-0.4	0.8	0.7	-0.3	-0.1
Family relationship satisfaction	0.4	0.5	3.6	0.0	-0.4	-1.9	0.3	-0.2	-0.6	-0.5	-1.2	0.3	0.5	0.2	0.4
Hypertension (Self-reported)	0.4	1.2	3.7	1.2	-0.8	0.6	0.2	-1.3	-1.1	-0.8	-0.3	1.8	1.9	0.7	0.7
Diabetes diagnosed by doctor	0.4	0.7	4.2	-0.2	0.2	-0.1	-2.1	0.5	0.8	1.1	-0.1	-1.2	-0.4	-0.4	-0.0
Illnesses of father: None of the above (group 1)	0.4	0.4	1.9	-1.2	0.5	-1.4	-0.4	-0.9	-0.1	-0.3	-0.5	0.5	0.1	0.2	0.0
Smoking status: Current	0.4	0.7	2.5	-1.6	1.1	-1.1	-1.0	-0.7	0.4	0.2	-0.9	-0.5	-0.0	0.2	0.7
Miserableness	0.4	0.6	1.9	0.7	1.4	-1.3	0.4	-0.7	0.2	-1.2	-0.7	0.5	-0.4	0.5	0.0
Financial situation satisfaction	0.4	0.5	1.6	0.5	1.3	-0.8	0.9	-0.3	1.1	0.9	0.2	-0.6	0.1	0.5	0.4
Depressed Affect (Nagel 2018)	0.3	0.7	4.0	1.2	2.0	-1.0	-0.3	-0.3	0.4	-0.7	-0.4	0.9	0.1	0.6	0.3
Neuroticism (Nagel 2018)	0.3	0.6	2.3	1.5	1.2	-1.2	-0.1	0.3	0.8	-0.5	-0.0	0.1	-0.1	1.0	0.5
Schizophrenia (2018)	0.3	0.6	3.6	-0.8	-0.3	-0.3	0.2	-0.8	-1.0	-1.0	-0.5	1.9	0.6	-0.1	0.2
Worry (Nagel 2018)	0.3	0.6	1.8	1.3	0.5	-1.2	0.9	1.0	0.3	-0.6	0.4	0.6	0.2	0.9	0.1
Mean Putamen Volume	0.3	0.3	0.9	1.0	-0.4	0.0	0.7	0.1	0.7	-0.7	0.1	-0.7	0.4	0.3	0.7
HbA1C	0.3	0.3	0.8	0.7	0.1	-0.9	0.1	-0.8	0.6	0.6	0.1	-0.5	-0.9	-0.4	-0.5
Blood Platelet Count	0.3	3.6	8.9	-2.4	-3.0	-2.5	-0.3	-1.4	-1.2	-0.1	-2.3	0.9	-2.1	-2.1	-1.9
Systolic Blood Pressure	0.3	1.3	6.2	2.5	0.5	2.5	-0.7	1.0	0.0	0.2	0.1	-0.0	1.1	0.6	0.5
Cardiovascular Disease	0.3	0.9	3.2	0.7	0.0	0.4	0.6	-1.2	-0.3	-1.4	0.1	1.8	1.0	1.1	0.6
Age when periods started (menarche)	0.3	0.8	2.7	1.1	0.2	0.8	1.4	0.9	-0.1	0.2	1.6	0.8	-0.4	-0.4	-1.2
Sitting height	0.3	2.5	13.1	-3.6	-0.0	-2.1	0.9	-1.2	-0.5	0.3	0.0	1.8	-1.5	-1.5	-1.4
Number of incorrect matches in round	0.3	0.5	3.9	0.7	0.3	-0.5	-2.0	0.6	-0.0	0.5	-0.1	-0.1	-0.4	-0.5	-0.8
Financial difficulties in last 2 years	0.3	0.3	1.0	0.7	1.0	0.6	-0.7	-0.9	0.4	-0.3	-0.0	-0.0	-0.0	0.3	0.8
Fluid intelligence score	0.3	0.7	2.7	-0.7	-0.4	-0.3	0.1	1.0	1.4	-0.3	0.4	-1.6	-1.1	-0.1	-0.2
Neuroticism score	0.3	0.7	2.2	1.5	1.2	-0.8	0.1	0.3	0.6	-0.9	-0.2	0.4	0.1	1.2	0.8
Impedance of arm (right)	0.3	1.2	5.1	1.3	0.5	-0.3	2.2	0.8	0.7	0.6	2.1	0.5	0.6	0.8	0.0
Time employed in main current job	0.3	0.4	1.3	0.2	-0.2	0.6	0.8	1.2	0.5	0.1	0.4	-0.9	0.6	0.5	0.5
Happiness	0.3	0.3	1.2	0.8	-0.1	-0.8	0.1	1.1	-0.1	-0.6	-0.6	-0.1	0.6	0.3	0.4
Tense / ‘highly strung’	0.3	0.5	1.8	1.3	-0.4	-0.6	0.2	-0.5	0.6	-0.5	0.2	0.6	0.5	1.3	0.8
Pulse wave reflection index	0.3	0.4	2.2	0.2	-0.1	-1.5	-1.3	0.3	-0.1	0.3	-0.4	0.3	-0.3	-0.2	-0.3
Birth weight	0.3	0.7	3.3	-1.1	-0.4	1.2	1.8	-0.7	0.1	-0.8	-0.0	1.0	-0.4	-0.2	-0.7
Medication: Blood pressure	0.3	0.5	1.3	-0.3	-1.1	0.5	0.9	0.0	-0.7	-1.1	-0.6	0.8	-0.4	-0.6	-0.6
Migraine (self-reported)	0.3	0.3	1.2	-0.1	0.5	0.8	1.1	1.0	0.2	0.2	0.8	0.2	-0.1	-0.2	-0.5
Whole body fat-free mass	0.3	1.7	9.1	-3.0	0.3	-0.2	2.1	-1.8	-1.4	-0.3	-0.7	1.1	0.1	-0.7	-0.5
Whole body water mass	0.3	1.9	9.5	-3.1	0.2	-0.3	1.9	-1.9	-1.5	-0.5	-1.0	1.3	-0.0	-0.7	-0.5
Wears glasses or contact lenses	0.3	0.4	1.5	-0.1	-1.2	-0.7	-0.6	-0.2	-0.4	-0.2	-1.0	0.3	-0.3	-0.4	-0.6
Average weekly beer plus cider intake	0.3	0.5	1.4	-0.9	0.9	0.8	-0.5	-0.8	-0.9	-0.0	-0.4	0.6	0.2	-1.2	0.1
Diastolic blood pressure, automated reading	0.3	1.1	5.5	2.3	-1.0	1.6	0.5	-0.1	-0.4	0.8	1.0	-0.1	1.2	-0.0	0.5
Commuting to job workplace: Cycle	0.3	0.3	2.3	-0.2	-0.4	0.2	1.5	0.9	-0.6	0.1	-0.1	0.4	-0.1	0.4	-0.4
Pack years of smoking	0.3	0.4	1.3	-0.5	-0.6	1.1	0.4	-0.2	0.5	-0.5	0.1	-1.1	0.7	0.4	0.7
Arm predicted mass (left)	0.3	1.3	6.9	-2.6	0.1	0.3	1.2	-1.6	-1.6	-0.1	-0.7	0.8	0.4	-0.8	-0.2
Neuroticism (2016)	0.2	0.3	0.8	-0.1	0.8	-0.7	-0.9	-0.8	0.5	-0.3	-0.5	-0.1	-0.5	0.5	0.1
Blood Eosinophil Count	0.2	1.3	5.0	-0.6	0.4	1.1	1.3	1.5	-0.6	-2.2	-1.9	0.4	-0.0	0.8	0.3
Blood Red Count	0.2	1.7	4.0	-1.4	-2.0	-1.7	-1.6	-1.9	-1.0	-0.8	-1.7	0.4	-0.3	0.2	0.2
Lung FVC	0.2	1.2	3.6	-0.9	1.4	-1.6	-1.1	-1.4	0.6	-1.9	-0.3	0.6	-0.8	0.8	0.6
Pack years adult smoking proportion	0.2	0.4	1.4	-0.4	-0.3	1.0	0.4	-0.2	0.6	-0.3	0.4	-1.2	0.6	0.4	0.7
Impedance of leg (right)	0.2	0.9	2.7	1.4	0.2	-1.2	-0.3	-0.1	0.0	1.6	1.5	0.6	-0.5	-1.0	-1.0
Leg fat-free mass (left)	0.2	1.1	6.3	-2.1	0.8	0.4	2.5	-1.0	-0.3	-0.5	-0.0	0.3	0.4	0.4	0.3
Leg predicted mass (left)	0.2	1.1	6.2	-2.0	0.7	0.5	2.5	-1.1	-0.4	-0.5	0.0	0.4	0.5	0.4	0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	-0.8	0.4	-0.2	0.6	0.6	-0.4	-0.5	-0.9	0.3	0.3	0.0	-0.4
Hair/balding pattern: Pattern 3	0.2	0.2	0.7	-0.2	-0.7	-0.0	-0.6	-0.9	0.5	-0.1	-0.8	-0.5	-0.4	-0.2	0.1
Number of live births	0.2	0.3	1.7	-0.2	-0.1	0.9	-1.3	0.5	0.6	0.1	0.0	-0.6	-0.4	0.7	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.7	0.3	-0.0	0.7	-0.6	-0.8	0.4	-0.4	1.0	0.2	-0.3	-0.2
Arm fat-free mass (right)	0.2	1.0	5.7	-2.4	0.2	0.3	1.1	-1.4	-1.3	-0.0	-0.6	0.7	0.2	-0.7	-0.3
Comparative body size at age 10	0.2	0.6	2.6	0.2	-0.2	0.4	0.6	-1.6	0.6	0.4	-0.0	-1.0	1.0	0.6	1.1
Heart disease (mother)	0.2	0.3	0.9	-0.3	0.6	0.2	0.2	0.2	0.1	0.9	-0.2	-0.3	-0.9	-0.8	-0.5
Arm predicted mass (right)	0.2	1.2	5.8	-2.4	0.1	0.3	1.2	-1.6	-1.6	-0.2	-0.9	0.9	0.3	-0.8	-0.4
Leg fat-free mass (right)	0.2	1.2	5.4	-2.3	0.7	0.6	2.3	-0.8	-0.5	-0.7	-0.2	0.5	0.5	0.5	0.3
Leg predicted mass (right)	0.2	1.2	5.5	-2.3	0.7	0.5	2.3	-0.8	-0.5	-0.7	-0.3	0.5	0.5	0.5	0.3
Basal metabolic rate	0.2	1.2	6.1	-2.5	0.7	0.5	2.0	-1.3	-0.9	-0.4	-0.3	0.7	0.6	0.1	0.3
Arm fat-free mass (left)	0.2	1.2	6.2	-2.5	0.3	0.5	0.9	-1.5	-1.5	-0.4	-0.9	0.8	0.4	-0.6	-0.0
Ever depressed for a whole week	0.2	0.2	0.6	-0.6	0.7	0.1	0.3	0.2	0.3	-0.7	-0.6	0.3	-0.5	0.2	-0.2
Vascular/heart problems diagnosed by doctor	0.2	0.6	3.0	-0.5	0.2	-0.2	-0.4	0.9	0.8	-0.3	-0.6	-1.0	-1.7	-0.5	-0.5
Basal cell carcinoma (self-reported)	0.2	0.3	0.7	0.7	-0.8	0.5	-0.4	0.1	-0.7	0.0	-0.3	0.3	-0.1	-0.7	-0.7
Impedance of whole body	0.2	1.1	4.7	1.2	0.7	-0.4	1.4	1.4	0.7	1.2	2.2	0.0	0.1	-0.0	-0.3
Major Depression (MDD)	0.1	0.1	0.6	0.3	0.0	-0.1	-0.8	0.5	-0.1	-0.7	-0.3	0.4	-0.0	-0.1	0.2
Schizophrenia (2014)	0.1	0.3	1.3	-0.4	-0.4	-0.4	0.7	-0.2	-0.7	-0.5	-0.2	1.2	0.4	-0.2	-0.1
Blood White Count	0.1	1.1	5.3	0.5	-0.0	0.6	0.6	0.4	0.6	-2.3	-1.3	-0.4	0.2	1.7	1.2
Allergy or Eczema	0.1	0.3	1.1	-0.2	1.0	-1.0	-0.5	-0.6	0.6	0.1	0.2	0.3	-0.1	0.6	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	2.2	-0.3	1.5	0.3	0.0	-0.2	-0.0	0.3	-0.2	-0.2	0.4	0.3	0.1
Impedance of leg (left)	0.1	0.6	1.6	1.2	0.4	-0.7	-0.7	0.5	-0.0	1.1	1.3	0.6	-0.2	-0.7	-0.7
Illnesses of father: Heart disease	0.1	0.2	0.8	-0.3	-0.7	-0.3	0.3	-0.9	-0.3	-0.3	-0.3	0.3	-0.5	0.2	-0.2
Mood swings	0.1	0.2	1.1	0.4	1.0	0.3	-0.1	-0.1	0.4	-0.0	-0.0	-0.0	0.2	0.7	0.5
Average weekly champagne plus white wine intake	0.1	0.1	0.4	0.5	0.1	0.4	-0.5	0.4	0.3	-0.0	0.6	-0.2	-0.1	-0.2	0.2
Hair Pigment	0.0	1.0	3.3	1.6	-0.0	-0.6	1.8	-0.5	-0.5	-0.5	0.9	-0.1	1.4	1.1	0.6

Hub : Genes

SSR3

Models

Trait associations