[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr4:112,366,943-113,899,790

Best TWAS P=5.48e-09 · Best GWAS P=3.86e-08 conditioned to 0.0668

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Thyroid	AP1AR	0.07	0.04	enet	18	0.05	1.5e-04	-4.8	-5.8	5.5e-09	0.73	0.11	0.87	TRUE
11	ROSMAP	Brain Pre-frontal Cortex	C4orf32	0.05	0.05	enet	13	0.05	6.7e-07	-5.0	5.6	2.1e-08	-0.72	0.09	0.91	FALSE
4	GTEx	Esophagus Muscularis	C4orf32	0.14	0.12	lasso	6	0.10	1.4e-06	-5.1	5.5	3.2e-08	-0.64	0.04	0.96	FALSE
15	The Cancer Genome Atlas	Thyroid Carcinoma	C4orf32	0.06	0.09	blup	48	0.08	3.1e-08	-5.1	5.5	3.9e-08	-0.66	0.01	0.99	FALSE
3	GTEx	Cells Transformed fibroblasts	C4orf32	0.21	0.24	enet	16	0.25	1.1e-18	-5.3	5.5	4.8e-08	-0.59	0.02	0.98	FALSE
5	GTEx	Lung	C4orf32	0.11	0.06	lasso	3	0.05	6.6e-05	-5.1	5.4	5.3e-08	-0.60	0.03	0.97	FALSE
14	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C4orf32	0.06	0.07	blup	47	0.04	6.9e-04	-4.3	5.4	6.0e-08	-0.69	0.04	0.83	FALSE
6	GTEx	Muscle Skeletal	C4orf32	0.10	0.12	lasso	4	0.12	1.8e-11	-5.3	5.3	1.0e-07	-0.53	0.02	0.98	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C4orf32	0.09	0.09	lasso	3	0.08	1.2e-09	-5.3	5.3	1.2e-07	-0.50	0.00	1.00	FALSE
2	GTEx	Brain Cerebellar Hemisphere	TIFA	0.17	0.08	lasso	6	0.06	1.2e-02	-4.6	5.3	1.3e-07	-0.74	0.08	0.72	FALSE
8	GTEx	Skin Sun Exposed Lower leg	C4orf32	0.07	0.03	enet	13	0.02	4.5e-03	-5.2	5.3	1.5e-07	-0.77	0.08	0.91	FALSE
12	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AP1AR	0.02	0.00	blup	40	0.02	1.6e-03	-3.9	-5.3	1.5e-07	0.72	0.02	0.68	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	TIFA	0.07	0.09	enet	13	0.09	4.3e-12	4.7	5.2	2.1e-07	-0.83	0.22	0.77	FALSE
7	GTEx	Nerve Tibial	C4orf32	0.11	0.12	lasso	5	0.10	6.7e-08	-5.1	5.2	2.3e-07	-0.60	0.04	0.96	FALSE
1	GTEx	Artery Aorta	C4orf32	0.12	0.11	lasso	5	0.10	6.3e-06	-5.0	5.1	2.8e-07	-0.57	0.04	0.96	FALSE