[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr4:105,598,022-107,931,444

Best TWAS P=1.02e-42 · Best GWAS P=5.49e-55 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	INTS12	0.06	0.06	enet	5	0.05	2.9e-07	11.6	-11.5	1.2e-30	-0.29	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TBCK	0.05	0.04	lasso	5	0.04	2.3e-05	-5.4	5.7	1.5e-08	-0.02	0.89	0.00	TRUE
3	GTEx	Adipose Subcutaneous	PPA2	0.15	0.02	enet	36	0.06	7.0e-06	3.3	-8.2	3.7e-16	-0.16	0.27	0.11	TRUE
4	GTEx	Adipose Subcutaneous	GSTCD	0.08	0.07	lasso	8	0.07	2.9e-06	9.9	12.0	3.3e-33	0.40	0.96	0.01	FALSE
5	GTEx	Adrenal Gland	INTS12	0.23	0.02	enet	21	0.04	1.4e-02	2.7	-10.0	1.2e-23	-0.37	0.18	0.08	TRUE
6	GTEx	Artery Aorta	PPA2	0.11	-0.01	enet	24	0.01	1.6e-01	-12.3	-10.0	1.6e-23	-0.16	0.10	0.04	FALSE
7	GTEx	Artery Aorta	INTS12	0.13	0.14	lasso	3	0.14	6.5e-08	10.1	-10.3	7.6e-25	-0.29	0.95	0.00	FALSE
8	GTEx	Artery Aorta	NPNT	0.28	0.01	enet	45	0.05	7.4e-04	5.7	6.7	3.0e-11	0.07	0.15	0.13	TRUE
9	GTEx	Brain Cortex	PPA2	0.14	0.09	lasso	9	0.09	1.6e-03	-8.4	-8.5	1.7e-17	-0.07	0.13	0.08	TRUE
10	GTEx	Breast Mammary Tissue	PPA2	0.26	0.06	lasso	5	0.04	2.7e-03	2.8	-5.4	6.9e-08	-0.11	0.17	0.04	TRUE
11	GTEx	Cells EBV-transformed lymphocytes	GSTCD	0.16	0.07	lasso	17	0.03	4.3e-02	9.9	10.4	2.2e-25	0.30	0.39	0.04	FALSE
12	GTEx	Cells Transformed fibroblasts	INTS12	0.15	0.16	lasso	9	0.17	9.5e-13	9.9	-10.9	1.4e-27	-0.29	1.00	0.00	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	PPA2	0.29	0.15	lasso	5	0.14	8.8e-06	-12.3	-10.6	3.1e-26	-0.05	0.58	0.02	TRUE
14	GTEx	Esophagus Mucosa	PPA2	0.18	0.06	enet	14	0.12	2.5e-08	8.4	-9.2	4.3e-20	-0.03	0.94	0.00	TRUE
15	GTEx	Esophagus Muscularis	INTS12	0.12	0.10	lasso	15	0.10	1.3e-06	11.3	-10.6	2.9e-26	-0.29	0.98	0.00	FALSE
16	GTEx	Heart Atrial Appendage	PPA2	0.15	0.05	lasso	7	0.06	7.4e-04	-8.4	-8.2	3.0e-16	-0.06	0.37	0.03	TRUE
17	GTEx	Lung	PPA2	0.09	0.02	enet	16	0.03	1.4e-03	5.7	-7.9	2.0e-15	0.13	0.27	0.06	TRUE
18	GTEx	Muscle Skeletal	PPA2	0.19	0.06	enet	28	0.11	8.7e-11	-8.0	-5.7	1.0e-08	-0.04	1.00	0.00	TRUE
19	GTEx	Nerve Tibial	GSTCD	0.09	0.03	enet	16	0.02	1.3e-02	9.8	12.2	2.8e-34	0.40	0.57	0.04	FALSE
20	GTEx	Pituitary	GSTCD	0.28	0.14	lasso	5	0.09	2.8e-03	10.1	10.3	9.1e-25	0.30	0.35	0.04	FALSE
21	GTEx	Skin Sun Exposed Lower leg	GSTCD	0.08	0.02	lasso	6	0.01	3.8e-02	10.3	12.8	1.4e-37	0.46	0.78	0.03	FALSE
22	GTEx	Thyroid	INTS12	0.07	0.05	lasso	7	0.03	1.2e-03	11.3	-11.5	2.3e-30	-0.29	0.86	0.01	FALSE
23	METSIM	Adipose	INTS12	0.05	0.02	blup	479	0.02	3.6e-04	11.4	-7.6	3.3e-14	-0.53	0.06	0.88	TRUE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	INTS12	0.04	0.03	blup	51	0.04	3.9e-04	9.9	-12.6	3.3e-36	-0.41	0.01	0.96	TRUE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	ARHGEF38	0.02	0.01	blup	82	0.01	2.0e-03	3.2	-5.3	1.4e-07	-0.24	0.01	0.19	TRUE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	INTS12	0.04	0.03	blup	49	0.04	7.1e-08	10.1	-12.0	4.1e-33	-0.35	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	INTS12	0.12	0.06	blup	50	0.08	1.2e-04	11.3	-12.4	1.7e-35	-0.38	0.01	0.98	FALSE
28	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	INTS12	0.03	0.02	blup	49	0.02	6.4e-03	11.3	-13.2	1.3e-39	-0.40	0.01	0.86	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	INTS12	0.08	0.10	lasso	2	0.10	2.9e-11	11.4	-11.4	7.1e-30	-0.29	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPA2	0.11	0.03	blup	84	0.03	4.7e-04	-7.2	-7.1	1.6e-12	0.00	0.44	0.23	FALSE
31	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INTS12	0.32	0.00	blup	49	0.06	1.8e-04	10.1	-13.7	1.0e-42	-0.46	0.01	0.80	TRUE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	GSTCD	0.07	0.05	lasso	4	0.04	6.6e-05	11.6	12.1	6.0e-34	0.33	0.81	0.02	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	NPNT	0.04	0.05	enet	6	0.04	6.3e-05	-5.2	7.5	9.7e-14	-0.02	0.61	0.01	TRUE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	INTS12	0.08	0.10	enet	11	0.10	9.9e-12	11.3	-11.4	4.4e-30	-0.32	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	INTS12	0.03	0.01	blup	49	0.03	6.0e-03	10.8	-12.1	1.1e-33	-0.47	0.02	0.64	TRUE
36	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	INTS12	0.22	0.15	lasso	6	0.16	2.3e-07	9.9	-9.7	3.3e-22	-0.25	0.02	0.96	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	INTS12	0.15	0.11	lasso	3	0.17	2.1e-17	9.9	-11.9	9.9e-33	-0.44	0.06	0.94	FALSE
38	The Cancer Genome Atlas	Stomach Adenocarcinoma	GSTCD	0.04	0.06	lasso	1	0.05	9.1e-05	11.6	11.6	3.4e-31	0.30	0.32	0.03	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	INTS12	0.11	0.09	blup	49	0.11	1.3e-10	11.3	-12.4	2.5e-35	-0.41	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	PPA2	0.04	0.02	blup	84	0.04	6.1e-05	-8.0	-6.5	1.2e-10	-0.07	0.38	0.06	FALSE