[Hub]/) : Traits : Lung FEV1/FVC ratio :

chr4:139,253,139-141,220,335

Best TWAS P=1.04e-15 · Best GWAS P=2.27e-15 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Aorta NDUFC1 0.09 0.02 enet 31 0.01 9.6e-02 -7.6 -5.6 1.8e-08 0.70 0.04 0.61 FALSE
2 GTEx Brain Cerebellum ELF2 0.26 0.03 lasso 7 0.04 2.8e-02 4.7 6.3 2.4e-10 -0.40 0.25 0.10 FALSE
3 GTEx Cells EBV-transformed lymphocytes NDUFC1 0.22 0.09 lasso 3 0.14 2.4e-05 -7.2 -7.0 2.2e-12 0.73 0.10 0.86 FALSE
4 GTEx Cells Transformed fibroblasts RAB33B 0.16 0.21 lasso 3 0.20 4.5e-15 -7.3 7.4 1.1e-13 -0.78 0.13 0.87 FALSE
5 GTEx Esophagus Gastroesophageal Junction RAB33B 0.22 0.01 lasso 5 0.02 6.0e-02 -7.3 -7.4 1.9e-13 0.72 0.08 0.48 FALSE
6 GTEx Esophagus Mucosa NDUFC1 0.27 0.17 enet 21 0.22 5.3e-15 -7.2 -7.3 3.0e-13 0.80 0.27 0.73 FALSE
7 GTEx Esophagus Muscularis SETD7 0.13 0.05 lasso 4 0.02 2.2e-02 -7.3 -7.1 9.1e-13 0.78 0.05 0.86 FALSE
8 GTEx Esophagus Muscularis RAB33B 0.27 0.26 enet 17 0.28 6.1e-17 -7.0 -7.5 6.1e-14 0.81 0.25 0.75 FALSE
9 GTEx Lung NDUFC1 0.09 0.07 lasso 5 0.06 3.6e-05 -7.4 -7.5 6.4e-14 0.92 0.03 0.96 FALSE
10 GTEx Muscle Skeletal SETD7 0.26 0.13 lasso 6 0.13 2.1e-12 -6.7 -6.9 4.2e-12 0.69 0.92 0.08 FALSE
11 GTEx Skin Not Sun Exposed Suprapubic NDUFC1 0.15 0.08 enet 21 0.09 9.7e-06 -7.2 -7.6 3.7e-14 0.85 0.04 0.95 FALSE
12 GTEx Skin Sun Exposed Lower leg NDUFC1 0.16 0.13 enet 15 0.12 1.5e-10 -7.2 -7.5 6.2e-14 0.84 0.26 0.74 FALSE
13 GTEx Thyroid NDUFC1 0.08 0.04 lasso 3 0.04 5.6e-04 -7.3 -7.4 1.1e-13 0.91 0.02 0.96 FALSE
14 YFS Blood NDUFC1 0.02 0.01 blup 399 0.01 1.2e-05 -6.6 -6.8 1.5e-11 0.81 0.02 0.98 FALSE
15 YFS Blood RAB33B 0.03 0.04 enet 15 0.04 9.5e-14 -7.3 7.8 5.8e-15 -0.77 0.11 0.89 FALSE
16 The Cancer Genome Atlas Bladder Urothelial Carcinoma RAB33B 0.03 0.01 blup 38 0.01 4.2e-02 -7.3 6.5 6.5e-11 -0.82 0.02 0.55 FALSE
17 The Cancer Genome Atlas Breast Invasive Carcinoma NDUFC1 0.01 0.01 blup 40 0.01 9.1e-03 -7.6 -8.0 1.6e-15 0.82 0.01 0.81 FALSE
18 The Cancer Genome Atlas Breast Invasive Carcinoma RAB33B 0.02 0.02 blup 38 0.02 5.6e-05 -7.4 7.6 2.7e-14 -0.86 0.02 0.98 FALSE
19 The Cancer Genome Atlas Colon Adenocarcinoma RAB33B 0.07 0.12 lasso 1 0.11 9.9e-07 -7.4 7.4 1.4e-13 -0.78 0.11 0.89 FALSE
20 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma NAA15 0.02 0.02 lasso 2 0.01 6.4e-02 -7.4 -7.4 1.1e-13 0.78 0.02 0.77 FALSE
21 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma NDUFC1 0.04 0.06 lasso 3 0.03 1.1e-04 -7.4 -7.6 2.8e-14 0.77 0.02 0.98 FALSE
22 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RAB33B 0.03 0.02 lasso 3 0.03 4.2e-04 -7.9 8.0 1.0e-15 -0.98 0.00 0.98 TRUE
23 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma RAB33B 0.05 0.04 blup 38 0.04 1.8e-03 -7.3 7.3 3.0e-13 -0.84 0.04 0.60 FALSE
24 The Cancer Genome Atlas Lung Adenocarcinoma RAB33B 0.03 0.03 lasso 3 0.03 2.6e-04 -7.3 7.8 9.0e-15 -0.86 0.02 0.98 FALSE
25 The Cancer Genome Atlas Lung Squamous Cell Carcinoma NDUFC1 0.03 0.02 blup 40 0.04 1.5e-05 -7.4 -6.1 9.9e-10 0.75 0.03 0.96 FALSE
26 The Cancer Genome Atlas Lung Squamous Cell Carcinoma RAB33B 0.03 0.03 lasso 5 0.02 1.4e-03 -7.3 7.5 5.6e-14 -0.81 0.10 0.81 FALSE
27 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma RAB33B 0.08 0.07 blup 38 0.07 1.5e-05 -7.0 6.8 1.3e-11 -0.71 0.16 0.81 FALSE
28 The Cancer Genome Atlas Prostate Adenocarcinoma C4orf49 0.04 0.02 enet 3 0.04 3.6e-05 -7.3 6.4 1.5e-10 -0.84 0.00 0.99 FALSE
29 The Cancer Genome Atlas Prostate Adenocarcinoma ELF2 0.03 0.00 blup 51 0.01 1.1e-02 -5.9 6.7 2.6e-11 -0.47 0.04 0.41 FALSE
30 The Cancer Genome Atlas Soft Tissue Sarcoma NDUFC1 0.06 0.02 blup 40 0.01 4.3e-02 -7.4 -7.0 2.6e-12 0.83 0.01 0.84 FALSE