[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr4:139,253,139-141,220,335

Best TWAS P=1.04e-15 · Best GWAS P=2.27e-15 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Aorta	NDUFC1	0.09	0.02	enet	31	0.01	9.6e-02	-7.6	-5.6	1.8e-08	0.70	0.04	0.61	FALSE
2	GTEx	Brain Cerebellum	ELF2	0.26	0.03	lasso	7	0.04	2.8e-02	4.7	6.3	2.4e-10	-0.40	0.25	0.10	FALSE
3	GTEx	Cells EBV-transformed lymphocytes	NDUFC1	0.22	0.09	lasso	3	0.14	2.4e-05	-7.2	-7.0	2.2e-12	0.73	0.10	0.86	FALSE
4	GTEx	Cells Transformed fibroblasts	RAB33B	0.16	0.21	lasso	3	0.20	4.5e-15	-7.3	7.4	1.1e-13	-0.78	0.13	0.87	FALSE
5	GTEx	Esophagus Gastroesophageal Junction	RAB33B	0.22	0.01	lasso	5	0.02	6.0e-02	-7.3	-7.4	1.9e-13	0.72	0.08	0.48	FALSE
6	GTEx	Esophagus Mucosa	NDUFC1	0.27	0.17	enet	21	0.22	5.3e-15	-7.2	-7.3	3.0e-13	0.80	0.27	0.73	FALSE
7	GTEx	Esophagus Muscularis	SETD7	0.13	0.05	lasso	4	0.02	2.2e-02	-7.3	-7.1	9.1e-13	0.78	0.05	0.86	FALSE
8	GTEx	Esophagus Muscularis	RAB33B	0.27	0.26	enet	17	0.28	6.1e-17	-7.0	-7.5	6.1e-14	0.81	0.25	0.75	FALSE
9	GTEx	Lung	NDUFC1	0.09	0.07	lasso	5	0.06	3.6e-05	-7.4	-7.5	6.4e-14	0.92	0.03	0.96	FALSE
10	GTEx	Muscle Skeletal	SETD7	0.26	0.13	lasso	6	0.13	2.1e-12	-6.7	-6.9	4.2e-12	0.69	0.92	0.08	FALSE
11	GTEx	Skin Not Sun Exposed Suprapubic	NDUFC1	0.15	0.08	enet	21	0.09	9.7e-06	-7.2	-7.6	3.7e-14	0.85	0.04	0.95	FALSE
12	GTEx	Skin Sun Exposed Lower leg	NDUFC1	0.16	0.13	enet	15	0.12	1.5e-10	-7.2	-7.5	6.2e-14	0.84	0.26	0.74	FALSE
13	GTEx	Thyroid	NDUFC1	0.08	0.04	lasso	3	0.04	5.6e-04	-7.3	-7.4	1.1e-13	0.91	0.02	0.96	FALSE
14	YFS	Blood	NDUFC1	0.02	0.01	blup	399	0.01	1.2e-05	-6.6	-6.8	1.5e-11	0.81	0.02	0.98	FALSE
15	YFS	Blood	RAB33B	0.03	0.04	enet	15	0.04	9.5e-14	-7.3	7.8	5.8e-15	-0.77	0.11	0.89	FALSE
16	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RAB33B	0.03	0.01	blup	38	0.01	4.2e-02	-7.3	6.5	6.5e-11	-0.82	0.02	0.55	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	NDUFC1	0.01	0.01	blup	40	0.01	9.1e-03	-7.6	-8.0	1.6e-15	0.82	0.01	0.81	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	RAB33B	0.02	0.02	blup	38	0.02	5.6e-05	-7.4	7.6	2.7e-14	-0.86	0.02	0.98	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	RAB33B	0.07	0.12	lasso	1	0.11	9.9e-07	-7.4	7.4	1.4e-13	-0.78	0.11	0.89	FALSE
20	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NAA15	0.02	0.02	lasso	2	0.01	6.4e-02	-7.4	-7.4	1.1e-13	0.78	0.02	0.77	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NDUFC1	0.04	0.06	lasso	3	0.03	1.1e-04	-7.4	-7.6	2.8e-14	0.77	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RAB33B	0.03	0.02	lasso	3	0.03	4.2e-04	-7.9	8.0	1.0e-15	-0.98	0.00	0.98	TRUE
23	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RAB33B	0.05	0.04	blup	38	0.04	1.8e-03	-7.3	7.3	3.0e-13	-0.84	0.04	0.60	FALSE
24	The Cancer Genome Atlas	Lung Adenocarcinoma	RAB33B	0.03	0.03	lasso	3	0.03	2.6e-04	-7.3	7.8	9.0e-15	-0.86	0.02	0.98	FALSE
25	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NDUFC1	0.03	0.02	blup	40	0.04	1.5e-05	-7.4	-6.1	9.9e-10	0.75	0.03	0.96	FALSE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RAB33B	0.03	0.03	lasso	5	0.02	1.4e-03	-7.3	7.5	5.6e-14	-0.81	0.10	0.81	FALSE
27	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RAB33B	0.08	0.07	blup	38	0.07	1.5e-05	-7.0	6.8	1.3e-11	-0.71	0.16	0.81	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	C4orf49	0.04	0.02	enet	3	0.04	3.6e-05	-7.3	6.4	1.5e-10	-0.84	0.00	0.99	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	ELF2	0.03	0.00	blup	51	0.01	1.1e-02	-5.9	6.7	2.6e-11	-0.47	0.04	0.41	FALSE
30	The Cancer Genome Atlas	Soft Tissue Sarcoma	NDUFC1	0.06	0.02	blup	40	0.01	4.3e-02	-7.4	-7.0	2.6e-12	0.83	0.01	0.84	FALSE