Best TWAS P=1.08e-99 · Best GWAS P=3.92e-255 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | GTEx | Brain Hypothalamus | HHIP-AS1 | 0.12 | 0.02 | enet | 16 | 0.04 | 4.6e-02 | 5.91 | 21.2 | 1.1e-99 | 0.72 | 0.04 | 0.42 | TRUE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | OTUD4 | 0.04 | 0.03 | lasso | 2 | 0.03 | 1.4e-04 | 8.95 | -8.9 | 3.6e-19 | -0.27 | 0.25 | 0.64 | TRUE |
| 3 | CommonMind | Brain Pre-frontal Cortex | OTUD4 | 0.06 | 0.04 | bslmm | 272 | 0.04 | 2.6e-05 | -12.15 | -8.6 | 5.7e-18 | -0.35 | 0.01 | 0.99 | TRUE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | RP11-673E1.1 | 0.08 | 0.09 | blup | 257 | 0.09 | 4.1e-12 | 4.16 | -7.7 | 1.5e-14 | -0.07 | 1.00 | 0.00 | TRUE |
| 12 | The Cancer Genome Atlas | Esophageal Carcinoma | OTUD4 | 0.15 | 0.06 | blup | 31 | 0.05 | 8.3e-03 | 4.69 | -5.9 | 3.0e-09 | -0.20 | 0.02 | 0.12 | TRUE |
| 6 | GTEx | Vagina | HHIP-AS1 | 0.16 | 0.10 | lasso | 7 | 0.06 | 1.8e-02 | 5.25 | 5.7 | 1.6e-08 | 0.15 | 0.11 | 0.06 | TRUE |
| 1 | CommonMind | Brain Pre-frontal Cortex | GYPA | 0.20 | 0.06 | blup | 293 | 0.10 | 4.0e-12 | -2.31 | -8.9 | 3.6e-19 | -0.36 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Tibial | RP11-673E1.3 | 0.12 | 0.00 | enet | 16 | 0.04 | 4.0e-04 | -0.72 | 6.6 | 4.0e-11 | 0.10 | 0.10 | 0.07 | FALSE |
| 7 | METSIM | Adipose | RP11-673E1.1 | 0.10 | 0.13 | bslmm | 260 | 0.15 | 5.0e-22 | 5.12 | -6.5 | 6.7e-11 | -0.02 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | GYPE | 0.28 | 0.26 | bslmm | 263 | 0.35 | 1.0e-44 | 4.37 | -6.2 | 4.9e-10 | -0.11 | 1.00 | 0.00 | FALSE |
| 11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | GYPE | 0.08 | 0.07 | lasso | 2 | 0.07 | 3.4e-06 | -5.23 | 5.3 | 1.2e-07 | 0.00 | 0.00 | 0.99 | FALSE |
| 10 | YFS | Blood | GYPE | 0.09 | 0.17 | bslmm | 255 | 0.19 | 1.5e-60 | 3.95 | 5.2 | 1.7e-07 | 0.00 | 1.00 | 0.00 | FALSE |