TWAS hub - SFRP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0294	0.0097	2.3e-06	0.018	0.011	0.011	0.012	0.014	1.0e-06	9.6e-05	1.5e-04	4.2e-05	1.6e-05
2	TCGA	Lung Squamous Cell Carcinoma	0.0289	0.0226	7.7e-03	0.027	0.015	0.036	NA	0.025	4.6e-04	6.1e-03	5.1e-05	NA	7.3e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Lung FEV1/FVC ratio	10.3	52.2	53.1	-7.2	-7.3
Breast cancer (self-reported)	6.4	7.6	10.9	3.3	2.1
Smoking status: Current	4.3	6.8	7.6	2.5	2.8
Emphysema/chronic bronchitis	4.2	4.7	8.1	1.1	2.8
Current tobacco smoking	4.1	6.7	7.6	2.4	2.8
Supplements: Fish oil (including cod liver oil)	3.4	4.4	4.9	2.2	2.0
Migraine (self-reported)	3.3	4.1	4.2	-2.0	-2.0
Respiratory disease	3.2	7.1	8.5	2.4	2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.1	6.5	7.1	-2.7	-2.4
Unable to work because of sickness or disability	3.1	4.0	5.6	1.5	2.4
Ever highly irritable/argumentative for 2 days	3.0	3.6	6.5	-0.9	-2.6
Qualifications: nursing, teaching	2.9	4.5	5.0	-2.0	-2.2
High cholesterol (Self-reported)	2.9	5.2	6.2	-2.5	-2.1
Family relationship satisfaction	2.8	3.4	5.2	2.3	1.3
Wheeze or whistling in the chest in last year	2.7	4.9	5.5	2.1	2.3
Tinnitus: Yes, but not now, but have in the past	2.6	2.8	2.9	-1.7	-1.7
Happiness	2.6	3.1	3.9	2.0	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.2	11.8	-3.4	-2.1
Ever had bowel cancer screening	2.6	3.1	3.6	1.9	1.6
Lupus	2.4	3.7	4.9	-2.2	-1.6
Schizophrenia (2014)	2.3	5.2	8.8	1.2	3.0
Pulse wave peak to peak time	2.3	2.7	3.2	-1.8	-1.5
Serious illness, injury or assault to yourself	2.1	2.5	3.5	1.2	1.9
Qualifications: A levels/AS levels or equivalent	2.1	4.7	6.1	-1.8	-2.5
Neuroticism	2.0	4.7	5.0	-2.1	-2.2
Diabetes (mother)	2.0	2.5	3.3	-1.3	-1.8
Pulse wave Arterial Stiffness index	2.0	2.3	2.6	1.6	1.4
Shortness of breath walking on level ground	2.0	2.4	3.4	1.1	1.9
Mineral and other dietary supplements	1.9	2.5	2.8	-1.7	-1.5
Number of treatments/medications taken	1.8	3.3	4.4	2.1	1.5
Smoking Status	1.7	4.0	4.2	1.9	2.0
Commuting to job workplace: Walk	1.7	1.8	1.8	1.3	1.3
Back pain experienced in last month	1.7	2.5	4.9	-0.1	-2.2
Illnesses of father: None of the above (group 1)	1.7	2.1	2.6	-1.3	-1.6
Ovarian Cancer	1.6	2.1	4.2	-0.1	2.1
Sensitivity / hurt feelings	1.6	2.7	4.1	-1.1	-2.0
Forced expiratory volume in 1-second (FEV1)	1.6	5.3	7.3	-2.7	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	2.6	1.6	1.3
Had major operations	1.6	1.9	3.0	0.8	1.7
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	5.1	-2.3	-0.1
Asthma (self-reported)	1.6	3.1	4.2	1.4	2.0
Number of operations (self-reported)	1.6	2.3	2.9	1.7	1.3
Alzheimer’s Disease (in mother)	1.5	1.8	2.0	1.4	1.3
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	2.3	-1.5	-1.1
Medication: Co-codamol	1.5	1.8	2.7	1.6	0.9
Worrier / anxious feelings	1.5	2.8	4.5	-1.0	-2.1
Hair/balding pattern: Pattern 4	1.5	3.6	4.9	-2.2	-1.5
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	2.7	1.7	1.0
Age started oral contraceptive pill	1.5	1.8	2.0	-1.4	-1.3
Mouth/teeth dental problems	1.4	2.1	4.2	2.0	0.3
Leg pain on walking	1.4	1.7	2.0	-1.2	-1.4
Commuting to job workplace: Public transport	1.4	1.7	2.5	1.0	1.6
Schizophrenia (2018)	1.3	2.6	4.7	0.7	2.2
Hand grip strength (right)	1.3	3.6	4.1	-1.8	-2.0
Stomach or abdominal pain in last month	1.3	1.6	2.6	1.6	0.7
Average weekly red wine intake	1.3	2.0	2.7	1.6	1.1
LDL Cholesterol	1.2	1.8	1.9	1.3	1.4
Average weekly fortified wine intake	1.2	1.4	2.4	-1.5	-0.6
Asthma	1.2	2.4	3.0	1.3	1.7
Depression (self-reported)	1.2	1.4	2.8	1.7	0.2
Pulse wave reflection index	1.2	1.5	1.5	1.2	1.2
Headache pain in last month	1.2	2.1	3.0	-1.1	-1.7
Overall health rating	1.2	2.6	2.6	1.6	1.6
Chest pain or discomfort	1.2	1.7	1.8	1.4	1.2
Ever depressed for a whole week	1.2	1.4	2.8	0.3	-1.7
Triglycerides	1.1	1.8	2.1	1.2	1.4
Ever used hormone-replacement therapy (HRT)	1.1	1.4	1.9	-1.4	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	1.8	1.3	1.1
Medication: Atenolol	1.1	1.3	2.6	-0.1	-1.6
Neuroticism score	1.1	2.2	3.6	-0.9	-1.9
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.5	0.6	1.6
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.1	1.5	0.7
Number of children fathered	1.1	1.3	1.6	1.0	1.2
Angina (self-reported)	1.1	1.4	2.0	1.4	0.9
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.0	-1.4	-0.7
Osteoarthritis (self-reported)	1.1	1.4	2.3	0.8	1.5
Mother’s age at death	1.1	1.4	2.8	1.7	0.2
Average weekly spirits intake	1.0	1.2	2.1	0.6	1.5
Fed-up feelings	1.0	1.7	2.3	-1.5	-1.1
Qualifications: CSEs or equivalent	1.0	1.4	2.0	0.8	1.4
Nervous feelings	1.0	1.8	3.0	-0.7	-1.7
Hair/balding pattern: Pattern 2	1.0	1.3	2.2	0.6	1.5
Mood swings	1.0	1.7	2.1	-1.5	-1.2
Taking other prescription medications	0.9	1.4	2.3	1.5	0.7
Time employed in main current job	0.9	1.1	1.4	-1.2	-0.9
Pulse rate	0.9	1.5	1.6	1.1	1.3
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.2	-0.2	-1.5
Knee pain experienced in last month	0.9	1.3	2.4	-1.5	-0.5
Illnesses of siblings: Diabetes	0.9	1.1	1.9	-1.4	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.6	0.8	1.3
Medication: Gliclazide	0.9	1.0	1.7	1.3	0.6
Commuting to job workplace: Cycle	0.9	1.1	1.3	1.2	0.9
Chronotype (morning person)	0.8	1.9	3.3	-1.8	-0.6
Hand grip strength (left)	0.8	2.2	2.3	-1.5	-1.5
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.6	-1.3	-0.7
Medication: Allopurinol	0.8	1.1	1.5	-1.2	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	0.9	0.9	1.0
Medication: Atorvastatin	0.8	1.0	1.4	-1.2	-0.7
Fractured/broken bones in last 5 years	0.8	1.0	2.0	-1.4	0.4
Verbal and Numeric Reasoning (VNR)	0.7	1.7	2.6	1.6	0.9
Angina	0.7	1.0	1.4	1.2	0.7
High blood pressure (mother)	0.7	1.0	1.1	-1.0	-1.1
Breastfed as a baby	0.7	0.9	1.4	-0.7	-1.2
Tense / ‘highly strung’	0.7	1.1	1.8	-0.7	-1.4
Medication: Paracetamol	0.7	1.2	2.2	-1.5	-0.4
Medication: Aspirin	0.7	1.0	1.3	0.8	1.1
Wears glasses or contact lenses	0.7	0.8	1.5	1.2	0.2
Risk taking	0.7	1.0	2.0	0.1	1.4
Bipolar Disorder or Schizophrenia	0.6	1.4	2.7	0.2	1.6
Neuroticism (Nagel 2018)	0.6	1.4	1.4	-1.2	-1.1
Bipolar Disorder (2011)	0.6	0.6	1.1	-1.0	-0.4
Primary Biliary Cirrhosis	0.6	0.9	0.9	0.9	1.0
Ever had hysterectomy (womb removed)	0.6	0.7	0.8	-0.7	-0.9
Supplements: Zinc	0.6	0.6	1.0	-0.5	-1.0
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.0	1.0	-0.7
Medication: Lansoprazole	0.6	0.7	0.9	0.7	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	1.4	-0.7	-1.2
Medication for pain relief, constipation, heartburn	0.6	1.0	1.7	-0.5	-1.3
Medication: Seretide 50 evohaler	0.6	0.7	0.7	0.8	0.8
Age at last live birth	0.6	0.9	1.1	1.1	0.8
Pain experienced in last month	0.6	0.9	1.6	0.5	1.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	0.8	0.9	0.9
Depressed Affect (Nagel 2018)	0.5	1.0	1.3	-1.2	-0.8
Depression (Nagel 2018)	0.5	0.7	0.9	0.9	0.8
Schizophrenia vs Biploar Disorder	0.5	0.7	0.8	0.9	0.7
Major Depression (MDD)	0.5	0.6	1.0	-0.5	-1.0
HDL Cholesterol	0.5	0.9	1.4	-1.2	-0.7
Pack years adult smoking proportion	0.5	0.7	1.4	-0.0	1.2
Illnesses of mother	0.5	0.6	0.8	-0.6	0.9
Exposure to tobacco smoke at home	0.5	0.6	1.1	-0.2	-1.1
Peak expiratory flow (PEF)	0.5	1.1	1.7	-1.3	-0.7
Loud music exposure frequency	0.5	0.5	0.8	0.5	0.9
Arm fat-free mass (right)	0.5	2.8	5.1	-2.3	-0.7
Arm predicted mass (right)	0.5	2.4	4.5	-2.1	-0.6
Supplements: Vitamin C	0.5	0.6	1.1	-0.0	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	1.5	-1.2	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.7	0.5	0.8
Average weekly champagne plus white wine intake	0.5	0.6	1.2	-1.1	-0.2
Miserableness	0.5	0.8	0.9	-0.9	-0.9
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.1	1.1	0.4
Alcohol drinker status: Never	0.5	0.6	1.0	-0.3	-1.0
Crohns Disease (2012)	0.4	0.7	0.8	-0.8	-0.9
Neuroticism (2016)	0.4	0.6	0.8	-0.6	-0.9
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.0	1.0	0.4
Severe depression (siblings)	0.4	0.4	0.8	0.2	0.9
Supplements: Glucosamine	0.4	0.5	0.9	1.0	-0.2
Waist circumference	0.4	1.3	2.1	-1.4	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.6	-1.3	-0.5
Heart attack	0.4	0.5	0.5	0.7	0.7
Illnesses of siblings	0.4	0.6	1.0	1.0	0.3
Trunk fat-free mass	0.4	2.0	3.4	-1.9	-0.8
Hair/balding pattern: Pattern 3	0.4	0.6	1.0	0.3	-1.0
Medication: Cholesterol lowering	0.4	0.6	0.8	-0.7	-0.9
Lung cancer (father)	0.4	0.5	0.5	0.7	0.7
Trunk predicted mass	0.4	2.0	3.4	-1.9	-0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.2	-0.5	-1.1
High blood pressure (siblings)	0.4	0.6	0.6	-0.7	-0.7
Forced vital capacity (FVC), Best measure	0.4	1.6	2.8	-1.7	-0.6
Worry too long after embarrassment	0.4	0.6	1.0	0.4	-1.0
Pulse rate, automated reading	0.4	1.4	2.1	0.9	1.4
Handedness (chirality/laterality): Left-handed	0.4	0.4	0.7	-0.5	0.8
Osteoporosis (self-reported)	0.4	0.5	1.0	0.3	1.0
Guilty feelings	0.4	0.6	1.1	-0.2	-1.1
Medication: Paracetamol	0.4	0.6	0.8	-0.9	-0.7
Medication: Lisinopril	0.4	0.6	1.0	-0.4	-1.0
Cholesterol lowering medication	0.4	0.6	0.9	-0.9	-0.5
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	-0.1	1.0
Alcohol drinker status: Previous	0.4	0.5	0.8	-0.9	-0.4
Worry (Nagel 2018)	0.3	0.7	1.3	-0.1	-1.1
Prostate Cancer	0.3	0.5	0.6	-0.8	0.6
Fasting Glucose	0.3	0.3	0.4	-0.5	-0.7
HbA1C	0.3	0.4	0.7	0.8	0.3
Allergy or Eczema	0.3	0.8	1.4	-1.2	-0.4
Hypothyroidism (self reported)	0.3	0.7	0.8	0.7	0.9
Hearing difficulty/problems: Yes	0.3	0.5	0.5	-0.6	-0.7
Medication: Metformin	0.3	0.4	0.7	0.8	0.4
Townsend deprivation index at recruitment	0.3	0.5	0.9	-0.3	0.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.5	0.7	-0.4
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.1	-1.0	-0.5
Medication: Levothyroxine sodium	0.3	0.4	0.7	0.4	0.8
Leg predicted mass (left)	0.3	1.4	2.6	-1.6	-0.5
Had other major operations	0.3	0.3	0.4	0.6	0.6
Qualifications: None of the above	0.3	0.6	0.7	0.8	0.7
Medication: Simvastatin	0.3	0.4	0.6	-0.8	-0.5
Fluid intelligence score	0.3	0.7	1.3	1.1	0.3
Impedance of arm (right)	0.3	1.6	2.8	1.7	0.6
Hip circumference	0.3	1.4	2.4	-1.6	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.4	-0.5	-0.6
Prospective memory result	0.3	0.4	0.7	0.8	0.2
Impedance of arm (left)	0.3	1.2	1.8	1.4	0.7
Health satisfaction	0.3	0.4	0.7	0.8	0.3
Qualifications: College or University degree	0.3	1.0	1.9	-1.4	-0.0
Mean time to correctly identify matches	0.3	0.6	1.1	0.2	-1.1
Heart disease (mother)	0.3	0.3	0.6	-0.8	-0.2
Alcohol intake frequency.	0.3	0.6	0.8	-0.9	-0.6
Whole body fat-free mass	0.3	1.7	3.2	-1.8	-0.5
Medication for cholesterol	0.3	0.5	0.8	0.5	0.9
Medication: Aspirin	0.3	0.5	0.5	0.7	0.6
Whole body water mass	0.3	1.5	2.8	-1.7	-0.5
Ever taken oral contraceptive pill	0.3	0.3	0.3	-0.6	0.5
Medication: Blood pressure	0.3	0.6	1.1	-0.2	-1.0
Basal metabolic rate	0.3	1.5	2.9	-1.7	-0.4
Arm fat-free mass (left)	0.3	1.8	3.3	-1.8	-0.4
Average weekly beer plus cider intake	0.3	0.5	0.9	-1.0	-0.3
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.3	-0.6	-0.5
Heart disease (siblings)	0.3	0.4	0.6	-0.8	-0.4
Pack years of smoking	0.3	0.5	0.9	0.1	0.9
Arm predicted mass (left)	0.3	1.6	3.1	-1.8	-0.3
Crohns Disease (2017)	0.2	0.4	0.8	-0.9	0.1
Reaction Time	0.2	0.4	0.7	-0.2	-0.8
Breast Cancer	0.2	0.6	1.1	-0.2	1.1
Rheumatoid Arthritis	0.2	0.3	0.5	-0.7	-0.1
Ulcerative Colitis	0.2	0.3	0.5	0.7	0.4
Blood Eosinophil Count	0.2	1.7	1.8	-1.2	-1.4
Hair Pigment	0.2	4.6	5.1	-2.0	-2.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.3	0.4	0.5
Medication for hormone replacement therapy	0.2	0.2	0.3	0.3	-0.5
Diabetes (father)	0.2	0.2	0.4	-0.6	-0.4
Leg fat-free mass (left)	0.2	1.2	2.3	-1.5	-0.4
Maternal smoking around birth	0.2	0.3	0.4	0.6	0.4
Relative age voice broke	0.2	0.3	0.3	0.6	-0.5
Pain all over the body in last month	0.2	0.2	0.2	0.4	0.4
Weight	0.2	0.8	1.6	-1.3	-0.0
Noisy workplace	0.2	0.3	0.3	0.5	0.6
Mouth/teeth dental problems: Dentures	0.2	0.3	0.3	0.5	0.6
Birth weight of first child	0.2	0.3	0.6	0.7	0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.3	-0.6	0.4
Gout (self-reported)	0.2	0.3	0.5	-0.2	-0.7
Birth weight	0.2	0.4	0.8	-0.9	0.1
Eye problems/disorders: None of the above	0.2	0.2	0.5	0.7	-0.1
Medication: Blood pressure	0.2	0.4	0.5	0.5	-0.7
Suffer from ‘nerves’	0.2	0.3	0.5	0.0	-0.7
Smoking status: Previous	0.2	0.3	0.4	-0.7	-0.3
Leg fat-free mass (right)	0.2	0.8	1.7	-1.3	-0.0
Loneliness, isolation	0.2	0.3	0.4	0.6	0.5
Friendships satisfaction	0.2	0.3	0.5	0.7	-0.1
Eye problems/disorders: Cataract	0.2	0.2	0.3	0.6	0.3
Leg predicted mass (right)	0.2	0.9	1.8	-1.3	-0.1
Financial situation satisfaction	0.2	0.2	0.5	0.7	0.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	0.2	0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.2	-0.4	0.5
Illnesses of father: High blood pressure	0.2	0.2	0.4	-0.2	-0.6
Ever smoked	0.2	0.3	0.3	0.4	0.6
Diastolic blood pressure, automated reading	0.2	0.7	1.1	0.5	1.0
Myopia	0.2	0.3	0.6	0.8	0.3
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.0	-1.0	-0.6
Bipolar Disorder (2018)	0.1	0.2	0.4	-0.6	0.1
Alzheimer’s Disease (in father)	0.1	0.2	0.2	-0.3	-0.4
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.4	0.2
Age at First Birth	0.1	0.1	0.1	-0.2	-0.4
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	-0.6	-0.1
Coronary Artery Disease (CAD)	0.1	0.1	0.2	-0.3	0.4
Mean Putamen Volume	0.1	0.1	0.2	0.1	0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.2	0.5
Blood Platelet Count	0.1	1.7	2.6	1.6	0.8
Blood White Count	0.1	0.4	0.5	0.7	0.6
Heel T-Score	0.1	0.4	0.8	-0.1	0.9
BMI	0.1	0.4	0.5	-0.7	-0.6
Waist Hip Ratio (WHR)	0.1	0.3	0.5	-0.1	-0.7
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.2	-0.5	0.5
Relative age of first facial hair	0.1	0.1	0.2	0.3	0.4
Systolic blood pressure, automated reading	0.1	0.2	0.4	0.6	0.3
Vitamin and mineral supplements	0.1	0.2	0.3	0.5	-0.3
Trunk fat percentage	0.1	0.4	0.7	-0.2	0.9
Age when periods started (menarche)	0.1	0.2	0.4	-0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	-0.2	0.7
Multivitamins +/- minerals	0.1	0.1	0.2	-0.4	0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.3	0.4
Sitting height	0.1	0.4	0.8	-0.3	0.9
Body mass index (BMI)	0.1	0.3	0.5	-0.7	0.3
Trunk fat mass	0.1	0.4	0.5	-0.7	0.5
Past tobacco smoking	0.1	0.2	0.4	-0.0	-0.6
Had menopause	0.1	0.2	0.2	0.4	-0.5
Forced vital capacity (FVC)	0.1	0.3	0.5	-0.7	-0.1
Allergy	0.1	0.1	0.2	0.3	-0.5
Medication: Ramipril	0.1	0.2	0.2	0.5	0.3
Arm fat percentage (right)	0.1	0.5	0.8	0.3	0.9
Father’s age at death	0.1	0.1	0.1	-0.3	0.3
Falls in the last year	0.1	0.2	0.4	-0.1	0.6
Number of live births	0.1	0.1	0.2	0.2	0.4
Arm fat mass (right)	0.1	0.3	0.4	-0.6	0.5
Standing height	0.1	1.2	1.7	-1.3	-0.9
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.0	0.7
Medication: Amlodipine	0.1	0.1	0.2	0.4	0.0
Leg fat percentage (right)	0.1	0.2	0.4	-0.6	0.1
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.2	0.4
Number of full brothers	0.1	0.2	0.3	-0.6	0.1
Neck or shoulder pain in last month	0.1	0.1	0.2	0.1	0.4
Medication: Ibuprofen	0.1	0.1	0.1	0.4	0.2
Whole body fat mass	0.1	0.3	0.5	-0.7	0.3
Leg fat mass (right)	0.1	0.4	0.7	-0.8	0.1
Comparative height size at age 10	0.1	0.6	0.8	-0.9	-0.6
Illnesses of father: Heart disease	0.1	0.2	0.2	-0.3	0.5
Arm fat percentage (left)	0.1	0.3	0.5	0.1	0.7
Long-standing illness, disability or infirmity	0.1	0.1	0.2	0.4	-0.0
Diabetes diagnosed by doctor	0.1	0.1	0.2	-0.4	0.1
Arm fat mass (left)	0.1	0.3	0.4	-0.6	0.5
Hearing aid user	0.1	0.1	0.2	0.4	0.2
Medication: Bendroflumethiazide	0.1	0.1	0.1	0.3	-0.3
Leg fat percentage (left)	0.1	0.2	0.4	-0.6	0.1
Irritability	0.1	0.1	0.2	-0.5	-0.2
Supplements: Calcium	0.1	0.1	0.2	-0.0	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.5	0.2
Impedance of whole body	0.1	0.6	1.0	1.0	0.4
Leg fat mass (left)	0.1	0.4	0.8	-0.9	0.1
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.0	0.2	0.0
Irritable Bowel Disease (IBD)	0.0	0.0	0.0	0.0	0.1
Ulcerative Colitis (UC)	0.0	0.0	0.0	0.2	-0.2
Blood Red Count	0.0	0.3	0.3	-0.6	0.6
Height	0.0	0.8	0.9	-0.8	-1.0
Systolic Blood Pressure	0.0	0.2	0.2	0.5	0.3
Cardiovascular Disease	0.0	0.1	0.2	0.4	0.4
Lung FVC	0.0	0.2	0.4	-0.7	-0.1
Tanning	0.0	0.1	0.1	-0.2	-0.3
Impedance of leg (right)	0.0	0.1	0.2	-0.1	-0.4
High blood pressure	0.0	0.1	0.1	0.4	-0.0
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	0.1	-0.0
Impedance of leg (left)	0.0	0.0	0.0	0.2	-0.0
Number of incorrect matches in round	0.0	0.0	0.1	-0.1	-0.3
Alcohol usually taken with meals	0.0	0.1	0.1	0.0	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	0.1	0.4
Hearing difficulty/problems with background noise	0.0	0.0	0.1	0.0	0.2
Financial difficulties in last 2 years	0.0	0.1	0.1	0.3	0.1
Diabetes (self-reported)	0.0	0.0	0.1	-0.3	-0.1
Alcohol intake versus 10 years previously	0.0	0.0	0.1	-0.0	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	0.3	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	-0.1	0.3
Length of working week for main job	0.0	0.0	0.0	-0.1	0.0
Blood clot in the leg (DVT)	0.0	0.0	0.0	0.1	0.1
Glaucoma (self-reported)	0.0	0.0	0.0	-0.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	-0.0	-0.2
Body fat percentage	0.0	0.2	0.4	-0.1	0.6
Comparative body size at age 10	0.0	0.1	0.1	0.2	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	-0.2	-0.1
Age at first live birth	0.0	0.0	0.0	0.1	0.2
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	-0.1	0.0
Medication: Omeprazole	0.0	0.0	0.1	0.2	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	-0.0	-0.0
Number of full sisters	0.0	0.0	0.1	-0.2	-0.2
Hypertension (Self-reported)	0.0	0.1	0.1	0.4	-0.0
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	0.1	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.1	-0.1	-0.3

Hub : Genes

SFRP2

Models

Trait associations