TWAS
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Models
Genes
Traits
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Traits
:
Lung FEV1/FVC ratio
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chr5:49,462,228-50,432,178
Best TWAS P=5.57e-09 · Best GWAS P=1.25e-08 conditioned to 1
49.6M
49.8M
50M
50.2M
50.4M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Lung Adenocarcinoma
EMB
0.04
0.04
blup
33
0.03
1.4e-04
-5.6
5.8
5.6e-09
-1.00
0.01
0.98
TRUE
1
GTEx
Adipose Subcutaneous
EMB
0.05
0.05
lasso
7
0.05
1.3e-04
-5.6
5.7
1.5e-08
-1.00
0.03
0.96
FALSE
3
The Cancer Genome Atlas
Thyroid Carcinoma
EMB
0.04
0.03
enet
20
0.04
5.6e-05
-5.6
5.3
8.6e-08
-0.86
0.01
0.98
FALSE