Best TWAS P=8.48e-16 · Best GWAS P=6.32e-58 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ITGA2 | 0.11 | 0.09 | lasso | 1 | 0.07 | 1.7e-06 | 5.86 | -5.9 | 4.6e-09 | -0.14 | 0.86 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | ITGA1 | 0.11 | 0.00 | enet | 31 | 0.02 | 1.2e-02 | -0.18 | -8.1 | 8.5e-16 | 0.06 | 0.16 | 0.03 | TRUE |
| 3 | GTEx | Artery Aorta | ITGA2 | 0.15 | 0.00 | enet | 23 | 0.00 | 3.4e-01 | -0.79 | -7.0 | 3.3e-12 | 0.16 | 0.17 | 0.04 | TRUE |
| 4 | GTEx | Artery Tibial | ITGA2 | 0.14 | 0.06 | enet | 18 | 0.08 | 1.5e-06 | -6.99 | -6.1 | 9.1e-10 | -0.04 | 1.00 | 0.00 | TRUE |
| 5 | GTEx | Cells Transformed fibroblasts | ITGA2 | 0.07 | 0.01 | lasso | 9 | 0.02 | 1.2e-02 | -5.37 | 5.4 | 8.5e-08 | -0.08 | 0.26 | 0.13 | TRUE |
| 6 | GTEx | Heart Left Ventricle | ITGA2 | 0.20 | 0.20 | lasso | 3 | 0.17 | 2.5e-09 | -6.99 | -7.0 | 3.4e-12 | -0.03 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Lung | ITGA2 | 0.17 | 0.21 | lasso | 2 | 0.20 | 2.8e-15 | -7.86 | -7.8 | 6.1e-15 | 0.01 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Lung | ITGA1 | 0.10 | 0.03 | lasso | 4 | 0.01 | 6.9e-02 | -6.64 | -7.0 | 3.3e-12 | 0.16 | 0.25 | 0.40 | TRUE |
| 9 | GTEx | Lung | CTD-2366F13.2 | 0.07 | 0.12 | lasso | 1 | 0.09 | 3.7e-07 | -7.86 | -7.9 | 3.8e-15 | 0.02 | 1.00 | 0.00 | TRUE |
| 10 | GTEx | Muscle Skeletal | ITGA1 | 0.13 | 0.00 | enet | 45 | 0.05 | 9.2e-06 | 3.78 | -7.9 | 2.7e-15 | 0.12 | 0.35 | 0.03 | FALSE |
| 11 | GTEx | Thyroid | ITGA1 | 0.11 | 0.02 | lasso | 12 | 0.03 | 4.7e-03 | -5.37 | -6.8 | 1.1e-11 | 0.02 | 0.46 | 0.02 | FALSE |
| 12 | METSIM | Adipose | ITGA2 | 0.06 | 0.04 | lasso | 6 | 0.02 | 1.9e-04 | 5.86 | -5.8 | 7.3e-09 | -0.16 | 0.96 | 0.00 | FALSE |
| 13 | METSIM | Adipose | MOCS2 | 0.04 | 0.01 | enet | 20 | 0.01 | 3.2e-03 | -2.55 | 5.6 | 1.8e-08 | 0.09 | 0.11 | 0.03 | TRUE |
| 14 | YFS | Blood | ITGA2 | 0.03 | 0.03 | lasso | 4 | 0.03 | 1.0e-09 | -5.42 | 6.4 | 1.3e-10 | 0.00 | 1.00 | 0.00 | TRUE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ITGA1 | 0.03 | 0.00 | blup | 196 | 0.01 | 1.0e-03 | -6.05 | 6.6 | 5.4e-11 | 0.05 | 0.09 | 0.02 | TRUE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ITGA1 | 0.05 | 0.03 | blup | 195 | 0.01 | 1.1e-02 | -6.28 | -6.8 | 7.9e-12 | 0.34 | 0.06 | 0.04 | TRUE |