Best TWAS P=9.53e-10 · Best GWAS P=2.45e-12 conditioned to 0.00038
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | PDE8B | 0.13 | 0.00 | lasso | 2 | 0.01 | 1.2e-01 | -6.0 | -5.4 | 6.5e-08 | 0.87 | 0.05 | 0.86 | FALSE |
| 2 | GTEx | Pituitary | WDR41 | 0.35 | 0.26 | enet | 27 | 0.08 | 4.5e-03 | -5.6 | -5.4 | 6.7e-08 | 0.85 | 0.29 | 0.48 | FALSE |
| 3 | GTEx | Testis | CTD-2037K23.2 | 0.20 | 0.19 | lasso | 2 | 0.18 | 2.7e-08 | -5.4 | 5.4 | 8.0e-08 | 0.01 | 0.02 | 0.98 | FALSE |
| 4 | NTR | Blood | PDE8B | 0.04 | 0.03 | lasso | 2 | 0.03 | 2.7e-09 | -5.9 | 6.1 | 9.5e-10 | -0.89 | 0.04 | 0.96 | TRUE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PDE8B | 0.17 | 0.03 | lasso | 6 | 0.02 | 7.1e-04 | -5.9 | -5.8 | 7.3e-09 | 0.72 | 0.11 | 0.43 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | LHFPL2 | 0.06 | 0.06 | lasso | 2 | 0.05 | 1.2e-05 | -5.4 | 5.4 | 6.1e-08 | 0.01 | 0.01 | 0.98 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | PDE8B | 0.05 | 0.02 | blup | 185 | 0.03 | 3.5e-04 | -5.2 | 5.5 | 4.0e-08 | -0.43 | 0.67 | 0.17 | FALSE |