Hub : Genes

PDE8B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0640	0.0230	4.1e-04	0.003	0.034	0.007	0.033	0.001	1.1e-01	4.8e-05	3.6e-02	6.8e-05	2.2e-01
2	GTEx	Artery Aorta	0.1260	0.0430	1.1e-03	0.003	NA	-0.005	NA	0.007	2.0e-01	NA	9.0e-01	NA	1.2e-01
3	GTEx	Colon Sigmoid	0.2660	0.0760	2.1e-04	0.177	NA	0.184	NA	0.177	7.6e-07	NA	4.3e-07	NA	7.8e-07
4	GTEx	Thyroid	0.3760	0.0640	2.1e-11	0.348	NA	0.329	NA	0.344	1.5e-27	NA	7.6e-26	NA	3.3e-27
5	METSIM	Adipose	0.0919	0.0290	4.7e-04	0.027	0.016	0.052	0.027	0.045	4.8e-05	1.7e-03	3.0e-08	5.4e-05	2.4e-07
6	NTR	Blood	0.0433	0.0125	2.8e-07	0.030	0.022	0.024	0.022	0.027	5.0e-10	8.8e-08	2.4e-08	9.9e-08	2.7e-09
7	ROSMAP	Brain Pre-frontal Cortex	0.0981	0.0318	3.6e-04	0.060	0.027	0.040	0.039	0.051	3.8e-08	1.9e-04	6.1e-06	8.1e-06	3.5e-07
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.1713	0.0583	9.3e-04	0.030	0.017	0.018	NA	0.025	2.3e-04	4.7e-03	3.3e-03	NA	7.1e-04
9	TCGA	Brain Lower Grade Glioma	0.0857	0.0338	8.1e-04	0.005	0.020	0.018	NA	0.002	7.0e-02	2.4e-03	3.4e-03	NA	1.8e-01
10	TCGA	Thyroid Carcinoma	0.0480	0.0210	4.1e-04	0.017	0.033	0.016	NA	0.011	7.3e-03	3.5e-04	9.2e-03	NA	2.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.4	0.6	2.0	0.8	0.2	-0.9	0.3	0.5	-0.9	0.9	1.4	0.5	-0.8
Bipolar Disorder or Schizophrenia	0.6	1.5	4.0	0.5	1.2	-0.7	-0.6	2.0	-1.8	0.9	1.5	0.3	-1.6
Depressed Affect (Nagel 2018)	0.4	0.9	2.6	1.5	-0.2	-1.6	0.7	-1.4	0.5	0.1	-0.8	-0.8	-0.2
Depression (Nagel 2018)	0.8	1.3	6.4	0.1	1.0	-2.5	-0.1	-0.2	-0.9	-0.1	-0.2	0.6	-2.0
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.9	0.7	-1.7	0.9	-0.1	-0.3	0.9	1.2	-0.4	0.4	-0.4
Neuroticism (Nagel 2018)	0.3	0.7	1.8	1.0	1.1	-1.3	0.9	-0.4	-0.3	-0.8	-0.2	0.7	-0.5
Schizophrenia (2018)	0.6	1.3	4.8	0.0	1.3	-0.2	-1.0	2.2	-1.6	0.5	0.8	0.1	-1.4
Schizophrenia vs Biploar Disorder	1.0	1.3	10.9	0.7	-0.1	0.4	-1.0	3.3	0.0	-0.3	0.1	-0.1	0.4
Worry (Nagel 2018)	0.4	0.8	2.4	-0.0	1.4	-1.3	1.3	-0.5	-0.5	-1.6	0.1	0.1	0.0
Alzheimer’s Disease (in mother)	0.9	1.0	2.5	-0.5	0.3	-0.8	-0.7	0.0	-1.3	0.5	1.6	1.4	-1.5
Alzheimer’s Disease (in father)	0.9	1.0	5.3	1.4	-0.6	-0.4	-0.2	-1.1	-0.1	2.3	0.1	-1.1	-0.1
Alzheimer’s Disease (including proxy)	0.8	1.1	3.2	-0.2	1.0	-0.9	-0.4	-0.5	-1.8	1.4	1.8	-0.1	-0.9
Crohns Disease (2017)	0.4	0.9	3.1	1.3	-0.0	-0.9	-1.7	-0.5	0.3	0.6	0.2	-0.1	-1.8
Irritable Bowel Disease (IBD)	0.2	0.5	2.0	0.8	0.4	-1.4	0.2	-0.8	0.1	0.5	0.2	-0.4	-0.9
Ulcerative Colitis (UC)	0.4	0.8	2.3	-0.3	1.0	-1.5	1.5	-1.1	-0.5	0.8	0.4	-0.3	-0.4
Major Depression (MDD)	2.3	2.8	8.7	1.9	-2.1	-1.0	1.1	-0.4	2.4	0.1	-3.0	-0.5	1.5
Reaction Time	1.7	3.2	7.0	-1.8	2.0	-2.5	0.7	-0.2	-2.6	0.3	2.3	-2.1	-1.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.8	1.3	-1.9	-0.1	-0.2	-1.0	1.5	0.6	-1.1	-0.3	-0.1
Breast Cancer	1.2	3.0	7.7	2.0	-2.8	0.4	0.6	-1.0	2.5	0.3	-2.2	0.1	2.3
Ovarian Cancer	0.6	0.8	5.1	-1.1	0.3	-1.2	2.2	0.2	-0.5	-0.3	0.3	-0.1	0.1
Prostate Cancer	0.7	1.0	2.9	-0.5	1.7	0.8	-0.8	1.1	-0.9	-0.4	0.3	0.9	-1.4
Age at First Birth	0.5	0.7	3.1	0.5	-0.9	1.8	-1.2	-0.3	0.5	0.0	0.0	-0.1	-0.8
Bipolar Disorder (2011)	1.7	1.6	4.8	-0.3	2.2	-1.9	-0.1	0.6	-1.6	0.7	0.9	-0.1	-1.9
Body Mass Index (BMI) (2010)	0.5	0.7	2.4	-1.0	0.3	-0.8	-0.3	-0.8	-0.1	0.3	-0.3	-1.3	-1.5
Coronary Artery Disease (CAD)	1.0	1.2	2.9	-0.9	1.2	-0.2	0.1	1.1	-1.2	1.0	1.2	1.2	-1.7
Crohns Disease (2012)	0.8	1.4	4.4	-1.2	2.1	-0.5	-1.7	-0.4	-1.0	-0.3	1.1	0.0	-1.4
Mean Putamen Volume	2.6	2.9	6.5	0.5	-2.0	-1.7	1.3	-2.2	2.1	0.0	-2.5	-2.2	0.7
Fasting Glucose	1.3	1.6	9.6	1.2	-1.0	-0.4	-0.3	3.1	-0.2	1.4	0.3	1.1	-0.7
HbA1C	2.5	2.8	8.0	2.8	-0.7	1.6	-0.1	-2.6	1.7	-0.5	-2.4	-0.3	1.3
HDL Cholesterol	0.2	0.3	1.4	-0.1	0.4	0.4	0.5	0.3	-0.8	1.2	0.5	-0.3	0.6
LDL Cholesterol	0.5	0.7	3.2	-0.1	0.4	-0.2	0.2	1.8	-0.7	1.5	0.6	-0.4	-0.6
Lupus	1.0	1.5	3.7	0.6	-1.0	0.9	-1.3	0.4	1.8	-1.1	-1.2	1.9	1.3
Neuroticism (2016)	1.0	1.5	4.7	1.7	-0.7	0.9	0.1	0.1	2.0	-1.1	-2.2	0.3	0.7
Primary Biliary Cirrhosis	0.8	1.1	3.8	-0.3	2.0	-1.2	-0.7	-0.2	-1.5	-0.3	1.4	0.5	-0.9
Rheumatoid Arthritis	1.2	1.7	5.9	-0.0	0.9	-0.0	-1.0	0.1	-1.7	1.3	2.1	0.6	-2.4
Schizophrenia (2014)	0.9	2.0	7.3	0.7	1.0	0.7	-1.4	2.7	-1.6	1.3	1.4	0.0	-1.4
Triglycerides	0.4	0.7	1.9	1.4	-0.8	0.8	-0.4	0.5	1.0	-0.9	-0.5	0.8	0.6
Type 2 Diabetes (T2D) (2012)	1.8	2.1	5.4	2.3	-1.9	-0.6	-1.1	2.2	0.9	0.8	-0.9	1.3	-1.1
Ulcerative Colitis	0.4	0.5	2.5	0.3	0.7	-0.5	1.6	-0.3	0.4	-0.4	-0.5	-0.6	0.9
Blood Eosinophil Count	0.7	5.5	25.5	-2.0	1.6	-0.1	-3.5	0.7	-1.6	1.6	2.3	0.4	-5.0
Blood Platelet Count	0.9	9.9	43.0	1.5	2.7	-0.2	-0.4	1.2	-4.6	4.8	6.6	0.2	-0.6
Blood Red Count	0.3	2.9	12.2	-1.6	-2.4	1.2	-3.5	-0.3	1.3	0.2	-0.9	2.0	-0.6
Blood White Count	1.4	10.5	26.5	-0.8	2.3	0.9	-4.2	0.9	-3.6	4.1	4.1	2.6	-5.2
Heel T-Score	0.3	2.4	11.8	0.6	-1.6	-0.3	0.2	3.4	1.4	-2.3	-0.9	0.7	0.7
BMI	0.2	1.4	5.7	-0.3	-0.4	0.4	-1.6	-1.2	-0.3	-0.4	1.1	2.4	-1.4
Height	0.1	2.9	14.0	1.2	-1.3	1.1	-3.7	-0.7	1.2	-0.7	-0.8	0.3	-2.7
Waist Hip Ratio (WHR)	2.3	10.5	32.7	1.1	2.9	1.8	-2.6	5.7	-2.8	2.0	2.4	5.1	-3.0
Systolic Blood Pressure	0.7	3.4	11.9	2.1	-0.7	3.4	-3.1	0.3	1.2	1.2	-0.7	2.1	0.4
Smoking Status	0.3	0.8	3.2	1.4	0.6	-0.4	-0.8	-1.0	-0.4	1.8	-0.1	0.8	0.0
Allergy or Eczema	0.5	1.3	6.2	-0.4	0.3	-2.5	-0.2	0.1	-0.9	0.5	1.0	-0.8	-1.9
Cardiovascular Disease	1.3	4.3	10.3	0.3	1.0	1.4	-2.4	0.6	-1.9	2.5	2.6	2.6	-3.2
Hypothyroidism (self reported)	5.3	12.2	45.9	3.0	-3.0	-1.9	6.8	1.5	2.6	-0.2	-3.7	-3.5	4.3
Respiratory disease	0.9	2.1	6.1	-2.1	0.5	-2.5	0.7	-0.7	-1.8	1.0	1.5	0.1	-1.5
Type 2 Diabetes (T2D) (2018)	2.9	5.5	14.4	3.8	-2.8	1.5	-1.9	2.7	2.3	2.1	-1.4	2.6	-0.9
Lung FEV1/FVC ratio	3.1	15.8	37.5	4.5	-5.4	0.8	2.3	1.2	6.1	0.5	-5.8	0.6	5.5
Lung FVC	1.2	5.9	21.4	-1.4	1.8	-2.8	4.6	-1.2	-2.3	2.9	0.6	-2.9	-0.3
Neuroticism	0.7	1.8	5.6	1.9	-0.2	-2.1	2.4	-1.2	0.6	-0.1	-1.2	-0.9	0.6
Chronotype (morning person)	1.1	2.6	6.5	-2.5	0.6	-0.0	2.4	1.5	-0.7	-1.4	0.9	-2.0	2.1
Hair Pigment	0.2	7.0	18.4	4.3	-4.0	2.0	-0.1	0.9	4.0	-0.9	-2.6	-0.3	2.9
Tanning	0.1	1.7	4.5	-1.4	2.0	-0.6	1.3	-0.4	-0.9	-1.7	0.3	-2.1	1.1
Hand grip strength (left)	0.3	0.7	2.0	-1.0	0.7	-0.1	1.4	-0.5	-0.3	1.1	0.1	-1.4	0.4
Number of treatments/medications taken	0.9	1.6	4.8	-0.7	0.0	-2.2	0.5	1.4	-0.8	0.5	0.7	1.6	-2.2
Average weekly spirits intake	0.6	0.7	1.8	-0.9	0.4	-1.0	0.0	-1.3	-0.7	0.5	1.0	-0.5	1.1
Sensitivity / hurt feelings	1.4	2.4	7.8	0.4	-0.9	-1.9	2.8	1.4	1.3	-2.0	-1.8	0.2	1.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	2.0	0.9	0.3	-1.3	0.1	-1.4	-0.4	-0.2	-0.5	0.1	0.1
Hearing difficulty/problems: Yes	0.9	1.4	6.2	0.6	-0.8	-0.9	-1.7	0.0	-0.1	0.5	-0.2	1.7	-2.5
Relative age of first facial hair	0.4	0.9	2.6	1.6	-0.9	-0.1	1.3	-0.4	-0.7	1.4	0.5	0.1	0.8
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	6.2	-0.1	0.0	-0.6	-0.2	-0.3	-1.2	2.5	1.1	1.2	-1.7
Ever used hormone-replacement therapy (HRT)	0.9	1.1	3.6	-0.1	-0.0	-1.9	1.2	-1.4	0.3	0.8	-0.9	-1.2	-1.1
Ever had hysterectomy (womb removed)	0.6	0.7	2.2	-0.6	0.6	-0.3	-0.5	-0.8	-1.2	1.0	1.5	0.6	-0.5
Systolic blood pressure, automated reading	0.7	2.2	8.6	1.5	-1.0	2.9	-2.1	0.1	1.0	-0.0	-0.6	1.9	0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	2.1	-0.0	0.4	-0.2	-1.4	0.2	-0.1	0.2	0.3	0.0	-0.7
Angina	0.1	0.2	0.8	0.0	-0.7	-0.0	-0.4	0.3	0.3	-0.5	-0.1	0.1	-0.9
Medication for hormone replacement therapy	1.0	1.1	2.3	-0.6	-0.5	-1.5	1.3	-0.8	0.1	-0.7	-1.2	-1.4	1.5
Vitamin and mineral supplements	0.5	0.7	2.4	0.7	-0.4	-1.5	1.2	-1.0	-0.1	-0.3	-0.0	-0.1	1.1
Supplements: Zinc	0.9	1.0	2.5	0.6	-1.5	1.2	-0.7	0.0	1.6	0.5	-1.4	0.6	-0.1
Medication: Co-codamol	0.9	1.0	2.8	0.3	-0.6	-0.7	-1.2	-1.6	0.3	1.7	-0.1	-0.6	-1.4
Medication: Metformin	1.3	1.9	6.2	2.5	-1.5	0.4	-0.1	1.2	1.7	0.8	-1.7	1.5	0.3
Diabetes (father)	0.9	1.1	7.1	1.1	-0.8	0.2	-1.0	0.1	0.6	-0.5	-0.4	2.7	-0.5
Diabetes (mother)	2.5	3.2	13.0	0.2	-0.1	2.0	-2.7	-1.1	-0.9	1.4	0.9	3.6	-1.7
Severe depression (siblings)	0.6	0.6	1.9	-1.1	1.2	-0.4	0.9	-1.4	-0.4	-0.7	0.1	0.3	-0.3
Pack years adult smoking proportion	0.6	0.9	4.6	-1.4	0.2	0.9	0.2	2.1	-0.3	-0.1	1.0	0.4	0.1
Impedance of leg (right)	0.6	2.8	7.9	-1.9	2.7	-0.2	-0.5	1.3	-2.8	0.3	2.4	-0.2	-1.4
Leg fat-free mass (left)	0.3	1.8	3.5	0.8	-1.8	0.6	-1.4	-1.1	1.9	-0.4	-1.1	1.8	-1.6
Trunk fat percentage	1.1	4.5	13.1	-0.6	1.0	1.1	-3.1	0.2	-1.8	0.4	2.4	3.3	-3.6
Hand grip strength (right)	0.2	0.6	2.8	-1.0	0.3	-0.3	0.6	-1.3	0.2	0.1	-0.2	-1.7	-0.3
Townsend deprivation index at recruitment	0.3	0.5	1.8	0.5	0.1	0.3	-0.7	0.6	0.0	-1.3	0.0	1.3	-0.1
Current tobacco smoking	0.5	0.8	2.5	0.9	0.5	-0.5	0.1	-1.6	0.4	1.2	-1.3	-0.8	0.3
Average weekly fortified wine intake	0.4	0.5	1.4	-1.2	0.6	-0.9	-0.2	0.9	-0.5	0.0	0.2	-0.0	0.9
Maternal smoking around birth	1.0	1.5	4.9	-1.0	0.2	-1.6	0.5	-0.4	-1.3	2.2	0.8	1.8	-0.7
Fed-up feelings	0.3	0.5	2.4	1.5	-0.0	-0.4	0.1	-1.0	0.4	0.7	-0.7	0.9	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.5	0.6	0.6	-1.8	-1.0	-1.4	-0.8	0.7	0.4	1.0	-1.9
Relative age voice broke	0.3	0.5	1.9	-0.4	1.2	0.1	-0.2	-0.2	-1.4	0.3	1.1	0.1	-0.6
Taking other prescription medications	1.2	1.9	9.8	0.1	-0.4	-0.6	1.9	3.1	-0.5	1.2	1.0	1.1	-1.2
Age when periods started (menarche)	1.6	3.8	11.3	-0.8	0.9	-3.4	1.6	0.9	-2.2	1.7	1.3	-2.9	-1.8
Bilateral oophorectomy (both ovaries removed)	1.2	1.3	5.6	-1.2	0.1	-2.4	0.3	-1.5	-1.0	0.2	1.3	-1.1	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.5	-1.9	1.3	-0.7	0.8	0.7	-0.7	-1.9	-0.1	-1.4	0.2
Tinnitus: Yes, but not now, but have in the past	2.4	2.6	6.9	2.6	-1.9	0.1	-0.1	1.1	2.4	-1.3	-2.5	0.3	0.6
Qualifications: CSEs or equivalent	1.3	1.8	3.7	-1.9	1.5	0.7	0.8	-1.6	-1.8	1.0	1.9	0.1	0.6
Serious illness, injury or assault to yourself	0.8	1.0	2.7	-0.8	0.7	-1.2	-1.1	-0.4	-0.9	0.5	0.2	1.3	-1.6
High blood pressure	1.4	3.8	10.0	0.7	0.2	2.6	-2.3	1.5	-0.9	1.7	1.9	3.2	-2.4
Hayfever, allergic rhinitis or eczema	0.5	1.1	6.8	-0.2	-0.5	-2.6	-0.3	0.2	-0.1	0.7	0.6	0.1	-1.6
Multivitamins +/- minerals	0.9	1.1	2.4	-0.7	0.0	1.3	-1.5	1.0	0.9	-1.2	-0.9	0.1	-1.6
Stomach or abdominal pain in last month	1.1	1.4	3.6	-0.9	0.7	-0.8	-0.3	-0.2	-1.8	1.6	1.4	-0.1	-1.9
Supplements: Glucosamine	1.5	2.0	4.7	-1.9	2.2	-1.5	0.0	-1.1	-1.9	0.6	1.0	-0.0	-1.8
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	5.6	-1.6	1.3	-2.4	1.2	-0.6	-1.1	-1.0	0.0	-1.5	-0.7
Medication: Atenolol	0.2	0.3	0.5	-0.6	0.0	-0.5	-0.7	0.5	0.2	-0.6	-0.5	0.7	-0.7
Medication: Levothyroxine sodium	3.0	5.0	17.0	1.8	-1.3	0.9	4.1	1.6	1.5	0.3	-2.6	-2.5	3.1
Sitting height	0.2	1.2	2.9	1.2	-1.5	1.0	-1.4	-0.3	1.7	-0.3	-1.2	0.2	-0.8
Chronic bronchitis/emphysema (father)	1.0	1.1	3.8	-0.2	-1.2	-2.0	0.3	-1.0	0.5	-0.9	-0.7	-1.5	-1.3
High blood pressure (mother)	1.0	1.5	5.9	0.6	-0.6	0.3	-0.7	-1.0	2.1	-1.3	-2.4	-0.5	0.0
Body mass index (BMI)	0.3	1.3	5.2	-0.6	-0.4	-0.6	-1.1	-0.6	-0.4	0.7	0.6	2.3	-2.0
Impedance of leg (left)	0.5	2.4	7.1	-1.3	2.6	0.0	-0.3	1.6	-2.7	0.6	2.2	-0.3	-0.6
Leg predicted mass (left)	0.3	1.8	3.5	0.8	-1.8	0.6	-1.4	-1.1	1.9	-0.4	-1.2	1.8	-1.5
Trunk fat mass	0.9	3.7	11.8	-0.4	0.4	0.9	-3.0	-0.1	-1.1	0.2	1.8	3.3	-3.4
Waist circumference	1.2	4.5	16.8	-0.7	0.8	0.0	-2.7	1.0	-1.5	0.8	1.6	3.7	-4.1
Number of incorrect matches in round	0.5	0.9	1.9	1.1	-0.5	1.3	-0.6	1.3	0.9	-1.4	-0.4	0.5	0.4
Past tobacco smoking	0.7	1.3	6.0	-1.0	0.7	0.1	1.2	0.5	-0.2	-2.4	0.4	-1.4	1.1
Alcohol usually taken with meals	0.6	1.0	4.5	-1.2	0.1	-0.8	1.5	-0.7	0.1	0.2	-0.5	-2.1	0.7
Nervous feelings	0.5	1.0	3.5	0.5	0.4	0.8	0.6	-0.8	0.5	-1.9	-0.7	0.6	1.8
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	12.0	-1.3	0.9	-3.5	1.8	-1.6	-0.9	-1.1	-0.6	-1.3	-0.8
Hearing difficulty/problems with background noise	0.5	0.8	3.8	-0.1	-0.5	-1.2	-1.3	-0.5	0.1	-0.0	-0.7	-0.3	-1.9
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	-0.6	-0.8	-0.5	-0.7	0.6	-0.4	0.1	0.6	0.5	-0.8
Had menopause	0.6	0.8	3.8	-1.9	0.8	-1.0	-0.0	-1.1	-0.6	-0.5	0.1	-0.7	-0.7
Had other major operations	1.6	1.9	5.5	-2.0	0.8	-1.7	-1.2	0.2	-1.6	-0.1	1.5	-0.5	-2.4
Forced vital capacity (FVC)	0.5	1.9	9.4	-0.8	0.4	-1.0	3.1	-1.5	-0.1	-0.3	-0.8	-2.1	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	6.4	-1.3	1.0	-0.4	0.8	-0.3	0.2	-2.5	-1.3	-1.6	0.7
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	6.6	1.8	-2.6	-1.8	1.0	0.9	0.4	1.7	0.9	1.5	-1.0
Qualifications: None of the above	0.4	0.8	2.2	1.5	-0.8	0.7	-0.8	1.0	0.3	1.1	0.7	1.2	-0.3
Financial difficulties in last 2 years	1.3	1.8	5.4	-0.5	0.5	0.6	-1.6	-1.1	-1.2	1.6	1.4	2.3	-1.4
Mouth/teeth dental problems	0.1	0.2	0.7	-0.5	0.2	-0.2	0.2	-0.2	-0.5	0.8	0.2	-0.5	0.5
Heart attack	0.3	0.4	0.9	-0.4	0.9	-0.4	0.6	0.4	-0.9	0.5	0.7	0.8	0.5
Allergy	0.7	1.6	7.9	0.8	0.8	2.8	0.4	-0.8	0.5	-0.7	-0.9	-0.3	2.2
Pain all over the body in last month	0.3	0.3	1.0	1.0	-0.4	-0.9	-0.5	0.1	0.3	0.5	0.1	0.3	-0.9
Diabetes (self-reported)	1.4	2.2	5.5	2.3	-1.8	0.5	-0.8	1.3	1.7	2.0	-1.7	0.8	-0.2
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	8.2	-0.3	0.7	-2.9	0.5	-0.0	-1.1	0.2	1.2	-0.6	-1.7
Medication: Ramipril	1.3	1.6	4.2	0.9	-2.1	1.1	-1.2	1.7	1.1	1.5	-0.1	1.4	-0.4
Medication: Simvastatin	0.7	1.1	4.3	1.7	-1.1	0.5	-0.0	2.1	1.1	-0.1	-0.6	0.7	0.0
Fluid intelligence score	0.3	0.6	2.1	0.7	-1.4	0.8	-0.5	-0.1	0.6	1.2	-0.2	-0.0	-0.8
Illnesses of siblings	0.8	1.1	2.2	-1.0	1.1	0.6	1.3	-0.1	-1.0	0.1	1.4	-1.3	1.5
Neuroticism score	1.0	2.0	5.5	2.0	-1.1	-1.0	1.5	-1.1	1.9	-0.6	-2.4	-0.1	0.9
Weight	0.5	2.4	9.4	-0.4	-0.7	0.1	-2.5	-0.9	0.2	-0.0	0.3	2.5	-3.1
Impedance of arm (right)	0.4	1.8	5.8	-0.4	1.8	1.3	-2.4	-0.3	-1.4	-0.7	1.4	0.7	-1.6
Arm fat percentage (right)	0.8	3.3	11.2	-0.8	0.9	0.2	-2.5	-0.4	-1.4	0.4	1.6	3.4	-3.1
Trunk fat-free mass	0.3	1.6	4.1	0.4	-2.0	-0.5	-1.0	-0.4	1.9	-0.6	-1.4	1.3	-1.5
Hip circumference	0.5	2.3	10.4	-1.1	-0.2	-0.8	-2.0	-1.9	-0.6	0.1	1.0	1.3	-3.2
Time employed in main current job	0.9	1.0	3.3	1.8	-1.7	-0.3	0.4	-0.1	1.1	0.8	-0.7	0.8	0.8
Alcohol intake versus 10 years previously	0.2	0.2	0.4	-0.6	0.2	-0.1	-0.5	-0.6	-0.4	-0.4	-0.0	-0.7	-0.7
Father’s age at death	0.5	0.6	2.7	0.2	-0.5	-1.2	0.0	0.3	0.8	-1.7	-0.1	-0.9	0.5
Worrier / anxious feelings	0.6	1.2	4.4	-0.4	1.8	-0.4	2.1	-0.3	-0.2	-1.8	-0.2	-0.5	0.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	5.2	2.0	0.6	-0.1	-0.6	-1.4	-0.6	2.3	-0.2	1.5	-1.6
Falls in the last year	0.7	1.0	3.7	-0.6	0.3	-0.3	-1.9	-0.3	-1.1	0.6	1.0	0.3	-1.8
Hair/balding pattern: Pattern 3	0.3	0.4	1.6	-0.1	0.9	1.3	-0.0	0.6	0.8	-0.9	-0.3	-0.0	0.4
Number of live births	3.6	5.1	11.3	-2.7	2.2	-3.2	0.3	1.3	-3.4	0.6	2.6	-1.1	-2.7
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	14.9	0.7	-1.3	-0.8	3.9	-0.9	1.7	0.2	-2.4	-1.9	2.2
Pulse rate	0.4	0.7	2.3	0.4	-0.8	1.2	-0.9	-0.5	0.5	1.5	-0.6	-0.4	-0.0
Happiness	0.1	0.2	0.7	0.9	0.1	-0.1	0.2	-0.0	0.1	-0.6	-0.1	0.4	0.6
Noisy workplace	1.6	2.0	5.6	-0.5	-1.2	-2.0	2.4	0.4	0.9	0.7	-1.5	-0.2	2.2
Qualifications: A levels/AS levels or equivalent	0.3	0.6	3.4	1.3	-0.1	-0.1	-0.0	-1.8	0.3	-0.2	-0.8	0.1	-0.4
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	7.4	-1.0	0.1	-1.2	-1.0	-2.1	-0.3	0.1	0.1	0.8	-2.7
Mouth/teeth dental problems: Dentures	0.2	0.3	1.1	0.7	-0.2	0.8	-0.8	0.4	0.5	-0.1	0.3	1.1	-0.2
Asthma	0.4	0.8	2.8	-1.3	0.1	-1.7	0.4	-0.4	-1.2	0.5	0.9	-0.6	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.8	-1.0	-0.1	-1.4	1.7	-0.2	-0.3	0.0	-0.6	-1.1	-0.3
Medication: Cholesterol lowering	0.5	0.8	3.4	0.7	-1.1	-0.3	1.0	1.9	-0.2	0.8	0.4	0.4	0.8
Depression (self-reported)	0.9	1.1	4.0	0.5	1.0	-0.0	1.5	0.2	-1.1	1.0	0.6	2.0	0.8
Medication: Lansoprazole	1.4	1.6	5.1	-0.2	1.0	0.6	-1.9	0.6	-1.6	0.7	1.6	0.2	-2.2
Prospective memory result	0.8	1.0	3.9	-0.9	0.2	-0.4	2.0	-0.6	-0.2	-1.1	-0.4	-1.6	1.1
Lung cancer (father)	0.5	0.5	1.9	-0.9	0.8	-0.3	-0.2	0.5	-0.5	1.4	0.5	1.0	0.3
Illnesses of mother	0.8	1.0	3.1	0.9	-1.0	-0.1	1.6	1.8	0.6	-0.5	-0.3	-0.3	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	8.0	0.1	-1.0	-1.4	2.8	-0.8	1.2	0.5	-1.7	-1.3	1.3
Pulse wave Arterial Stiffness index	1.2	1.4	3.0	-1.1	1.2	-1.6	-0.3	-0.1	-1.6	1.3	1.2	0.1	-1.7
Impedance of arm (left)	0.3	1.5	4.7	-0.1	1.3	1.4	-2.2	-0.2	-1.3	0.0	1.3	0.3	-1.6
Arm fat mass (right)	0.6	2.5	8.7	-0.6	0.2	-0.1	-2.3	-0.5	-0.7	0.3	1.0	3.0	-2.9
Trunk predicted mass	0.3	1.5	3.8	0.3	-1.9	-0.6	-1.0	-0.3	1.9	-0.6	-1.3	1.3	-1.6
Standing height	0.3	2.5	10.0	0.6	-0.8	1.3	-3.2	-0.5	1.4	-1.4	-0.6	1.0	-2.7
Length of working week for main job	0.3	0.3	1.5	-0.0	0.4	-0.2	0.8	1.2	-0.5	0.2	-0.1	0.5	0.2
Exposure to tobacco smoke at home	0.8	0.9	3.9	-0.0	-0.1	0.2	-0.2	2.0	-0.3	1.6	0.3	1.5	-0.4
Breastfed as a baby	1.0	1.3	3.5	-0.2	1.3	0.3	-1.1	-0.3	-1.0	1.9	1.6	0.6	-1.6
Tense / ‘highly strung’	1.7	2.8	6.7	-0.6	-0.0	-2.2	2.6	-1.4	0.6	-2.1	-1.8	-1.6	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	7.7	2.8	-0.1	1.0	0.4	-0.6	0.8	-0.2	-0.6	1.2	2.0
Hair/balding pattern: Pattern 4	0.2	0.6	2.0	-0.2	-0.4	-0.2	0.9	0.9	-1.1	0.9	1.4	0.2	-0.2
Birth weight of first child	1.5	2.7	7.5	2.7	-2.2	0.8	0.7	1.8	2.1	-0.6	-1.7	1.0	1.5
Peak expiratory flow (PEF)	0.6	1.3	3.6	1.8	-1.9	0.9	0.5	-0.2	1.8	0.6	-1.1	0.8	0.4
Pulse wave reflection index	1.0	1.3	4.6	-0.3	0.4	-1.2	2.1	-1.5	-0.2	0.5	0.0	-0.8	1.9
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.5	0.3	0.9	-1.1	0.7	-0.5	-0.8	1.2	0.9	0.4	0.2
Loud music exposure frequency	0.2	0.3	0.9	-0.1	-0.9	-0.5	-0.4	-1.0	0.1	-0.1	0.6	0.1	-0.0
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.5	0.1	1.4	-0.5	-0.5	-1.9	-1.0	-1.4	0.4	0.8	-0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	-0.4	0.7	0.4	-0.6	-1.0	-0.5	-0.7	0.9	-0.2	0.2
Blood clot in the leg (DVT)	1.3	1.6	3.2	-1.5	1.4	-0.9	-0.9	1.8	-1.8	0.5	0.9	0.9	-1.5
Medication: Paracetamol	0.8	1.3	5.4	-1.6	-0.2	-2.3	-0.7	-0.6	-1.2	-0.3	0.1	0.5	-1.6
Headache pain in last month	0.5	0.8	3.3	-0.5	0.7	-1.8	1.3	-1.2	-0.4	0.4	-1.0	-0.4	0.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	4.4	0.2	0.2	-0.0	0.2	-2.1	0.9	-1.5	-1.5	-1.3	0.2
Glaucoma (self-reported)	0.6	0.7	2.8	-1.4	1.1	-0.0	-0.4	-0.1	-0.6	-0.5	0.0	0.2	-1.7
Gout (self-reported)	0.1	0.1	0.4	0.1	-0.4	0.1	-0.3	0.7	0.6	-0.1	-0.0	0.5	0.0
Hypothyroidism/myxoedema (self-reported)	3.6	7.1	28.1	2.2	-1.9	-0.8	5.3	1.4	1.8	0.4	-2.7	-3.1	3.4
Medication: Amlodipine	0.8	1.2	2.8	-1.5	1.4	0.5	-0.4	0.2	-1.7	1.4	1.3	0.4	-0.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.8	-1.5	-0.4	-1.9	-1.0	-1.3	0.1	1.4	-0.1	-0.9	-1.2
Birth weight	0.9	2.0	4.6	2.1	-2.0	0.1	1.1	0.4	1.9	-0.5	-1.5	-1.0	1.8
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.4	-1.2	1.1	-0.6	-0.1	-1.1	-1.2	0.3	1.0	-0.6	0.6
High blood pressure (siblings)	1.3	1.8	5.2	1.1	-2.3	0.4	-1.4	-0.6	1.6	0.3	-1.3	1.8	-1.3
Forced vital capacity (FVC), Best measure	0.5	1.7	5.6	-1.5	0.9	-1.5	2.4	-1.1	-0.8	0.3	0.2	-2.0	-0.2
Body fat percentage	1.0	3.8	10.5	-1.0	1.2	0.7	-2.5	0.3	-1.9	0.5	2.2	3.2	-3.2
Leg fat percentage (right)	0.8	2.9	7.2	-1.8	1.2	-0.5	-1.5	0.3	-2.0	0.7	1.9	2.7	-2.5
Arm fat-free mass (right)	0.2	1.0	2.8	0.1	-1.6	-0.5	-0.7	-0.3	1.5	-0.4	-1.0	0.8	-1.7
Exposure to tobacco smoke outside home	1.0	1.4	4.8	-0.0	0.6	1.3	-2.2	-0.7	-0.6	1.6	0.7	1.6	-0.8
Comparative body size at age 10	0.4	1.2	4.1	1.3	-0.7	0.7	-1.7	0.2	0.6	-1.1	-0.3	2.0	-0.7
Number of full brothers	0.6	0.7	1.3	-0.8	0.6	-1.1	0.5	-1.1	-1.0	1.0	0.8	-0.4	-0.8
Worry too long after embarrassment	0.7	1.2	3.3	1.8	-0.2	1.2	0.8	1.1	1.5	-0.3	-1.2	1.3	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	11.1	3.3	0.1	1.0	-0.9	0.1	0.8	0.3	-0.5	0.6	0.9
Wheeze or whistling in the chest in last year	0.7	1.3	3.2	0.3	0.5	-0.4	-1.2	1.2	-0.9	1.3	1.5	1.8	-1.3
Number of children fathered	0.4	0.5	1.3	-0.9	0.1	-0.4	1.1	0.9	-0.6	-0.1	0.3	-0.6	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	5.3	0.8	-1.9	2.3	-0.5	-0.7	1.3	0.7	-0.6	-0.7	0.8
Age at first live birth	0.4	0.8	3.8	1.9	-0.7	0.6	1.0	1.0	0.5	-0.3	0.1	0.0	0.7
Pulse wave peak to peak time	1.2	1.4	3.5	1.2	-1.2	1.9	-0.1	-0.3	1.6	-1.3	-1.1	-0.1	1.4
Health satisfaction	0.7	0.8	4.2	-0.4	-0.5	-2.1	0.2	0.1	-0.3	-0.5	0.4	1.4	-1.1
Shortness of breath walking on level ground	0.5	0.6	3.8	0.3	-0.2	-0.6	0.3	-2.0	-0.4	0.8	0.2	0.5	-0.5
Qualifications: College or University degree	0.3	0.9	2.3	1.2	-1.1	0.3	0.3	-1.0	1.4	-0.6	-1.5	-0.6	0.5
Eye problems/disorders: None of the above	0.8	0.9	2.9	-0.0	-0.0	-0.4	0.8	1.7	-0.9	0.9	1.7	-0.0	1.0
Mouth/teeth dental problems: Loose teeth	1.2	1.4	4.4	-0.8	1.3	-1.5	-0.0	0.2	-1.6	0.4	1.1	1.3	-2.1
Emphysema/chronic bronchitis	0.6	0.7	2.9	-0.2	-0.9	-0.7	-0.1	-1.7	0.9	-0.5	-1.2	0.6	0.2
Medication for pain relief, constipation, heartburn	0.8	1.4	6.5	0.8	0.4	2.5	0.1	-1.2	0.9	-0.1	-0.3	-1.4	1.6
Neck or shoulder pain in last month	1.6	2.3	7.5	-2.7	1.1	-0.3	-1.2	0.0	-2.0	-0.3	2.3	0.6	-1.7
Medication: Blood pressure	0.6	1.1	3.1	0.6	-0.7	1.2	-0.2	1.8	-0.0	1.5	1.0	1.5	0.1
Angina (self-reported)	0.1	0.2	0.7	0.0	-0.5	0.3	-0.5	0.1	0.4	-0.4	-0.2	-0.0	-0.9
Migraine (self-reported)	1.2	1.5	6.6	0.1	-1.3	-0.8	0.7	-0.6	2.1	-0.5	-2.6	0.7	0.2
Medication: Ibuprofen	0.4	0.5	2.6	-0.5	-0.3	-0.9	1.6	0.0	0.1	-0.1	-1.0	-0.6	-0.0
Medication: Allopurinol	0.2	0.3	1.1	-0.5	1.0	0.6	0.4	0.5	-0.4	0.3	0.6	-0.2	-0.5
Medication: Omeprazole	0.6	0.7	1.7	-0.3	0.7	-0.7	-0.5	-0.4	-1.0	-0.9	0.7	1.3	-1.3
Medication: Seretide 50 evohaler	1.2	1.3	5.9	-0.3	2.4	0.6	-0.3	-1.0	-1.5	-0.4	1.5	1.2	-0.0
Mean time to correctly identify matches	2.3	4.4	10.4	-2.6	2.0	-2.4	-0.4	0.2	-3.2	0.2	3.2	-1.4	-2.3
Heart disease (mother)	2.0	2.4	11.9	-1.2	0.4	-0.5	-2.4	-0.9	-0.9	1.4	1.0	0.2	-3.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	3.3	0.7	-1.4	-1.8	0.0	-0.2	-0.3	0.8	0.7	0.3	0.1
Whole body fat mass	0.7	3.0	9.9	-0.6	0.3	0.5	-2.5	0.1	-1.0	0.4	1.5	3.1	-3.1
Leg fat mass (right)	0.6	2.1	7.8	-0.9	0.4	0.0	-1.9	-0.1	-0.9	0.5	1.2	2.8	-2.6
Arm predicted mass (right)	0.1	0.8	3.1	-0.2	-1.2	-0.4	-0.7	-0.1	1.0	-0.1	-0.5	1.0	-1.8
Pulse rate, automated reading	0.9	2.8	13.7	1.3	-0.2	2.8	-1.2	-0.3	-1.0	3.7	1.1	0.8	-0.4
Alcohol intake frequency.	0.4	0.9	3.6	-0.2	0.1	-0.0	-1.6	0.1	-0.3	-0.2	0.0	1.9	-1.7
Comparative height size at age 10	0.7	3.8	15.8	0.3	-0.9	2.5	-4.0	-1.5	1.7	-2.0	-1.0	1.0	-2.0
Number of full sisters	0.2	0.3	1.0	-0.1	-0.6	-1.0	0.1	-0.4	0.1	0.5	-0.9	0.5	0.3
Suffer from ‘nerves’	0.4	0.6	1.5	-0.1	1.2	-0.7	-0.0	-0.6	-1.0	0.5	0.5	1.1	-1.1
Overall health rating	1.6	3.4	11.1	1.8	-0.9	-0.1	-1.9	0.9	-0.3	2.2	0.9	3.3	-3.0
Chest pain or discomfort	1.4	2.0	6.2	2.0	-1.2	-0.6	-2.2	0.5	0.2	1.2	0.4	1.1	-2.5
Had major operations	0.4	0.5	2.6	-0.7	0.7	0.7	-1.6	0.0	-0.3	0.2	0.3	0.6	-0.4
Age at last live birth	0.8	1.2	4.4	1.2	1.0	-0.1	2.1	0.9	-1.1	-0.2	1.1	1.0	0.5
Family relationship satisfaction	0.6	0.7	3.9	0.4	0.3	-1.4	2.0	-0.3	-0.7	-0.5	0.3	0.5	-0.1
Leg pain on walking	0.6	0.8	2.8	-0.6	0.5	-1.5	1.0	-0.3	-0.6	1.7	-0.1	0.7	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.5	0.3	-0.4	0.7	-0.4	-0.9	0.9	0.0	-1.2	-0.0	1.2
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.1	-0.7	-0.6	-1.3	0.8	-1.1	-0.2	0.1	-0.5	-1.4	0.4
Illness, injury, bereavement, stress in last 2 years	2.7	3.3	10.4	1.9	-1.2	0.6	2.2	1.8	1.5	-1.6	-1.6	-1.4	3.2
Medication: Aspirin	0.5	0.7	1.8	0.6	-0.3	0.3	-1.2	1.1	-0.0	-0.6	0.5	1.4	-0.9
Supplements: Vitamin C	0.4	0.5	2.0	-0.4	0.3	1.4	-0.0	1.3	0.4	0.2	-0.2	-0.6	0.2
Knee pain experienced in last month	0.3	0.5	1.1	-1.1	-1.0	-0.9	-0.3	-0.6	0.0	0.8	0.1	0.1	-0.9
Hypertension (Self-reported)	1.2	3.4	8.1	0.3	0.5	2.3	-2.0	1.7	-1.2	1.7	2.1	2.9	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	4.7	-0.2	0.0	0.9	-1.4	1.4	-0.5	-0.2	1.1	2.2	-2.0
Illnesses of father: Heart disease	1.9	2.7	9.4	-0.8	-0.6	-0.5	-2.6	-0.1	-0.5	0.4	1.7	2.5	-3.1
Illnesses of siblings: Diabetes	0.6	0.7	2.1	0.4	-0.2	-0.1	-1.3	1.4	0.3	0.1	-0.3	1.5	-1.0
Smoking status: Previous	0.4	0.6	2.0	1.1	-1.0	-0.2	-0.6	0.1	0.1	1.4	-0.2	1.0	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.2	1.0	-0.8	0.2	-0.7	-1.1	1.1	0.4	-0.5	0.0	-0.3
Whole body fat-free mass	0.3	1.7	3.9	0.6	-2.0	-0.0	-1.3	-0.7	2.0	-0.6	-1.3	1.6	-1.6
Leg fat-free mass (right)	0.4	1.9	4.5	1.3	-2.0	0.8	-1.3	-1.1	2.1	-0.4	-1.4	1.5	-1.1
Arm fat percentage (left)	0.7	2.9	9.6	-0.6	0.6	0.5	-2.5	-0.4	-1.2	0.5	1.5	3.1	-2.9
Average weekly red wine intake	1.4	2.1	7.0	-1.1	0.8	-0.5	-0.4	-1.3	-2.0	1.7	2.6	1.2	-1.1
Handedness (chirality/laterality): Left-handed	1.2	1.5	3.8	1.7	-1.6	1.0	0.2	-0.8	1.9	0.6	-1.1	-0.7	1.3
Mood swings	0.6	1.2	4.8	2.2	-1.1	-0.6	0.1	-0.8	1.0	1.4	-1.1	-0.6	0.4
Loneliness, isolation	0.4	0.5	1.8	0.9	-0.1	-1.0	0.6	-1.3	0.3	0.1	-1.0	-0.4	-0.2
Long-standing illness, disability or infirmity	1.5	2.2	6.2	0.5	-1.3	-1.2	-1.3	1.2	0.6	1.9	-1.0	2.1	-2.5
Ever had bowel cancer screening	1.0	1.1	4.0	-0.1	0.4	-0.7	0.8	2.0	-1.6	1.3	1.1	0.1	-0.8
Diabetes diagnosed by doctor	2.1	3.4	8.0	2.8	-2.6	0.7	-1.2	1.7	2.4	1.7	-2.0	1.3	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.8	12.5	0.5	0.2	-0.5	0.3	1.9	-1.7	3.5	2.4	1.4	-0.4
Friendships satisfaction	1.5	1.9	4.2	-0.5	1.7	-1.2	0.1	-2.0	-1.9	1.0	1.7	0.4	-1.6
Qualifications: nursing, teaching	0.8	1.3	3.2	-0.2	1.8	-0.6	-0.5	-1.6	-1.7	-0.1	1.0	0.2	-1.7
Commuting to job workplace: Walk	1.5	1.6	7.4	-0.0	-1.3	0.1	-1.3	2.7	0.7	-0.4	0.1	1.6	-1.2
Eye problems/disorders: Cataract	0.3	0.4	1.1	1.0	-0.4	0.1	1.0	-1.1	-0.0	0.5	-0.4	0.3	0.5
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.5	-1.4	1.1	-1.9	1.5	-0.0	-1.2	-0.2	0.3	-0.7	-1.4
Medication for cholesterol	0.6	0.9	3.3	0.4	-1.0	-0.3	1.2	-0.9	1.1	-0.3	-1.0	-0.7	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.4	0.7	0.1	-0.9	1.0	0.3	-1.0	1.2	1.0	0.2	0.3
Back pain experienced in last month	0.4	0.6	2.5	-1.3	-0.0	-0.9	-0.1	-1.6	-0.0	0.6	-0.1	0.0	-0.3
Mineral and other dietary supplements	0.5	0.6	4.0	2.0	-0.7	-0.0	0.7	-0.8	0.1	0.4	-0.0	0.5	0.3
Breast cancer (self-reported)	1.6	1.9	5.5	-0.0	1.4	0.8	-2.1	-1.3	-1.2	0.9	1.5	0.4	-2.4
Asthma (self-reported)	0.5	1.0	3.1	-1.5	0.4	-1.8	0.5	-0.2	-1.3	0.4	0.9	-0.7	-0.9
Osteoporosis (self-reported)	0.4	0.5	1.5	-0.1	-0.9	-0.9	0.6	1.2	0.4	0.8	0.3	0.0	-0.5
Osteoarthritis (self-reported)	0.8	1.1	4.3	1.1	-0.6	-1.5	-0.1	-0.6	-0.2	1.5	0.1	2.1	-0.3
Medication: Aspirin	0.4	0.5	1.6	0.3	-0.3	0.1	-1.1	0.9	-0.0	-0.5	0.3	0.8	-1.2
Medication: Gliclazide	1.6	1.8	3.6	1.9	-1.6	-0.5	1.3	-0.4	1.9	0.1	-1.8	-0.5	1.7
Illnesses of father: None of the above (group 1)	1.1	1.4	5.0	-1.3	1.1	-0.0	1.3	1.2	-0.3	-0.5	-0.2	-2.2	1.5
Smoking status: Current	0.6	1.0	2.9	0.7	0.7	-0.6	-0.1	-1.7	0.1	1.7	-1.2	-1.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	5.9	1.0	-1.0	-1.5	2.4	0.5	1.2	1.7	-1.4	-0.0	1.3
Whole body water mass	0.3	1.6	3.6	0.5	-1.8	-0.0	-1.2	-0.6	1.9	-0.6	-1.2	1.6	-1.6
Leg predicted mass (right)	0.4	1.9	4.7	1.3	-2.0	0.7	-1.2	-1.1	2.2	-0.4	-1.5	1.4	-1.0
Arm fat mass (left)	0.7	2.7	9.6	-0.6	0.2	0.2	-2.4	-0.4	-0.7	0.4	1.1	3.1	-3.0
Number of self-reported non-cancer illnesses	0.8	1.4	7.3	-0.0	-0.6	-1.3	-0.6	0.6	-0.6	1.3	1.2	0.6	-2.7
Average weekly champagne plus white wine intake	1.5	2.1	6.0	0.5	-0.8	0.0	1.9	-0.7	1.4	-0.3	-1.8	-2.2	2.4
Miserableness	0.5	0.8	4.2	2.0	-0.8	-1.0	0.7	-0.8	0.6	0.3	-0.2	0.8	0.3
Guilty feelings	0.3	0.4	1.7	1.3	0.3	-0.5	-0.0	-0.2	-0.0	0.5	0.2	1.3	-0.3
Wears glasses or contact lenses	0.4	0.4	2.1	-0.4	0.4	-0.6	-0.3	0.2	-0.8	0.1	0.4	-1.4	-0.8
Ever taken oral contraceptive pill	0.9	1.0	3.1	0.3	0.6	-0.5	1.8	-0.2	-1.4	1.5	0.9	-0.5	-0.6
Hearing aid user	1.3	1.5	5.4	0.6	-1.1	-1.7	-0.8	-2.3	0.3	0.5	-0.9	1.2	-1.2
Mother’s age at death	0.7	0.9	2.5	-1.4	1.6	0.1	0.3	0.1	-1.6	-0.6	1.1	-0.2	-0.2
Financial situation satisfaction	0.5	0.6	2.7	-0.8	0.7	-0.4	0.2	-0.2	-0.8	0.6	0.7	1.7	-0.5
Tinnitus: Yes, now most or all of the time	1.3	1.5	7.5	0.7	0.5	1.3	-1.1	-0.2	-0.3	2.7	0.0	1.5	-1.3
Commuting to job workplace: Public transport	0.5	0.6	1.4	-0.5	0.5	0.6	-1.0	1.2	0.1	-0.9	0.3	0.5	-1.1
Eye problems/disorders: Glaucoma	0.7	0.8	3.6	-1.3	1.1	-0.2	-0.5	-0.5	-1.0	0.4	0.5	0.4	-1.9
Medication: Blood pressure	1.4	2.7	9.2	-1.0	0.7	0.9	-2.0	2.4	-0.6	-0.2	0.9	2.2	-3.0
Pain type(s) experienced in last month: Hip pain	1.7	2.1	5.8	-1.6	1.8	1.4	-0.6	-0.6	-2.3	0.7	2.4	1.0	-0.5
Supplements: Fish oil (including cod liver oil)	1.1	1.4	3.2	0.1	-0.3	1.8	-1.0	1.8	1.5	-1.5	-1.4	0.1	0.6
High cholesterol (Self-reported)	0.4	0.6	1.9	0.1	0.1	-1.1	0.3	1.4	-0.8	0.6	0.8	-0.1	-1.2
Medication: Bendroflumethiazide	2.4	3.6	13.3	0.1	1.0	2.1	-1.0	3.7	-1.2	2.0	1.7	2.8	-0.9
Medication: Paracetamol	0.8	1.2	3.9	-1.1	0.0	-2.0	-0.8	-0.6	-1.0	-0.1	-0.1	1.1	-1.9
Medication: Lisinopril	0.7	0.9	2.4	-0.8	0.0	1.3	-1.5	0.4	-0.3	0.7	0.8	1.1	-1.3
Medication: Atorvastatin	1.2	1.5	7.0	0.7	-0.5	0.0	-0.7	-1.4	-1.1	2.6	1.4	1.5	-0.2
Illnesses of father: High blood pressure	1.0	1.3	4.9	1.3	-0.4	1.7	-0.4	-1.0	0.6	0.6	-0.9	2.2	0.7
Alcohol drinker status: Never	0.4	0.5	2.5	1.0	0.1	0.2	0.4	0.4	0.2	-1.6	-0.2	0.5	1.0
Ever smoked	0.6	1.0	6.0	0.6	0.0	-0.0	-0.9	-0.5	-0.3	2.4	0.3	1.3	-1.0
Basal metabolic rate	0.3	1.5	3.2	0.4	-1.6	-0.0	-1.4	-0.7	1.6	-0.5	-1.0	1.6	-1.8
Leg fat percentage (left)	0.6	2.1	6.0	-1.3	1.1	-0.3	-1.2	0.5	-1.8	0.9	1.7	2.5	-1.8
Arm fat-free mass (left)	0.2	0.8	3.2	-0.2	-0.9	-0.4	-1.0	0.0	0.9	-0.4	-0.4	1.4	-1.8
Number of operations (self-reported)	1.6	2.4	6.2	-1.5	0.3	-2.5	-0.9	-2.2	-0.5	1.5	0.4	-1.3	-2.3
Average weekly beer plus cider intake	0.3	0.5	1.4	0.8	-0.5	-0.4	0.6	-0.3	-0.5	1.2	0.2	-1.0	0.9
Irritability	0.5	0.9	3.0	0.8	-0.1	-1.7	1.0	-0.5	0.7	0.5	-1.7	-0.2	0.6
Risk taking	0.7	1.0	5.4	-0.1	-0.3	-2.3	0.2	-1.3	0.0	0.6	-0.5	-1.2	0.4
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.3	-0.5	-0.8	-1.2	0.3	1.1	1.5	-0.7	-1.4	-0.8	0.0
Fractured/broken bones in last 5 years	0.7	0.9	3.4	-1.2	-0.0	-1.0	-1.0	-0.3	-0.5	1.0	1.0	0.4	-1.8
Age started oral contraceptive pill	0.9	1.1	4.0	1.1	-0.7	0.6	-1.3	0.3	0.1	-0.1	0.6	1.7	-2.0
Diastolic blood pressure, automated reading	0.2	0.7	2.6	-0.1	0.3	-0.1	-0.3	-1.1	-1.1	1.6	0.4	1.1	-0.9
Ever depressed for a whole week	0.7	0.9	2.9	0.9	-1.7	-1.4	0.6	0.9	1.2	-0.2	-0.5	-0.3	-0.7
Unable to work because of sickness or disability	0.7	0.9	2.6	1.6	-1.1	0.3	-1.2	0.1	0.5	1.4	-0.4	0.8	-0.6
Commuting to job workplace: Cycle	0.6	0.7	2.5	-1.3	-0.6	-1.6	-0.2	0.9	0.6	-0.3	-0.8	-0.7	-0.6
Myopia	0.6	0.9	2.8	0.5	-1.1	0.4	0.7	0.5	1.1	-0.6	-1.1	-1.0	1.7
Vascular/heart problems diagnosed by doctor	1.4	3.9	10.2	-0.1	-0.2	-2.1	2.2	-1.7	1.2	-2.0	-2.2	-3.2	2.5
Cholesterol lowering medication	0.6	1.0	2.5	0.4	0.7	-0.3	-0.9	0.7	-0.9	1.5	1.2	0.6	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.3	-0.9	0.4	-1.4	-0.4	0.8	-1.0	-0.9	0.7	0.5	-1.5
Pain experienced in last month	0.8	1.4	4.6	2.0	-0.2	2.1	-0.3	0.9	1.3	-0.7	-0.9	-0.0	1.3
Supplements: Calcium	1.0	1.1	5.3	-2.3	0.1	-1.1	-0.2	0.2	-0.2	0.2	0.8	1.0	-1.5
Basal cell carcinoma (self-reported)	0.8	0.9	5.8	0.3	0.9	-0.6	0.4	-2.4	0.5	-0.8	-0.8	-0.1	0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	-0.2	0.6	-0.2	0.5	0.4	-0.6	0.6	0.5	0.8	0.5
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	3.9	-1.5	1.6	-0.6	-0.9	1.7	-2.0	0.9	1.2	1.1	-1.7
Heart disease (siblings)	0.3	0.3	0.8	0.3	-0.4	-0.1	-0.9	0.2	-0.4	0.1	0.7	0.8	-0.9
Alcohol drinker status: Previous	1.3	1.5	4.8	-1.3	-0.3	-2.2	-0.5	0.5	-0.8	1.6	0.5	1.2	-1.7
Pack years of smoking	0.8	1.2	5.8	-1.9	0.6	0.7	0.4	2.4	-0.6	-0.5	1.2	0.4	-0.1
Impedance of whole body	0.5	2.5	6.3	-0.7	2.5	1.2	-1.5	0.9	-2.5	0.4	2.4	0.2	-1.4
Leg fat mass (left)	0.4	1.6	6.1	-0.8	0.3	0.1	-1.6	-0.2	-0.8	0.7	1.1	2.5	-2.1
Arm predicted mass (left)	0.2	1.0	3.6	-0.2	-1.0	-0.3	-1.1	-0.0	1.0	-0.1	-0.6	1.5	-1.9