Best TWAS P=9.22e-17 · Best GWAS P=1.57e-17 conditioned to 0.00206
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | XXyac-YX65C7_A.2 | 0.16 | 0.02 | enet | 29 | 0.07 | 1.9e-06 | -7.9 | -6.8 | 8.7e-12 | -0.36 | 0.13 | 0.56 | FALSE |
| 2 | GTEx | Heart Left Ventricle | WDR27 | 0.20 | 0.08 | lasso | 8 | 0.08 | 8.0e-05 | 5.5 | -5.1 | 2.9e-07 | -0.08 | 0.93 | 0.00 | FALSE |
| 3 | METSIM | Adipose | WDR27 | 0.03 | 0.02 | blup | 679 | 0.02 | 5.5e-04 | 4.5 | -5.5 | 3.9e-08 | -0.18 | 0.94 | 0.00 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | RP1-137D17.1 | 0.07 | 0.02 | lasso | 12 | 0.05 | 8.3e-07 | -5.7 | 6.4 | 1.9e-10 | 0.07 | 1.00 | 0.00 | TRUE |
| 5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | THBS2 | 0.05 | 0.00 | blup | 81 | 0.02 | 5.1e-03 | 6.7 | -8.3 | 9.2e-17 | -0.71 | 0.01 | 0.66 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | THBS2 | 0.02 | 0.01 | blup | 81 | 0.01 | 1.0e-03 | 6.6 | -7.5 | 9.1e-14 | -0.68 | 0.01 | 0.67 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | THBS2 | 0.05 | 0.00 | enet | 12 | 0.03 | 8.9e-05 | 3.3 | -5.3 | 1.0e-07 | -0.60 | 0.02 | 0.72 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | WDR27 | 0.05 | 0.02 | blup | 147 | 0.03 | 3.9e-04 | 4.5 | -5.5 | 3.7e-08 | -0.06 | 0.09 | 0.56 | FALSE |