Hub : Genes

XXyac-YX65C7_A.2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.157	0.0450	0.0003	0.015	NA	0.071	NA	0.020	1.9e-02	NA	1.9e-06	NA	9.0e-03
2	GTEx	Brain Cortex	0.343	0.0970	0.0033	0.041	NA	0.158	NA	0.134	2.8e-02	NA	3.9e-05	NA	1.5e-04
3	GTEx	Cells Transformed fibroblasts	0.112	0.0410	0.0074	-0.004	NA	-0.003	NA	-0.003	9.2e-01	NA	6.1e-01	NA	7.4e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.445	0.0436	0.0000	0.116	0.292	0.325	0.303	0.296	1.1e-14	8.2e-38	7.5e-43	1.5e-39	2.1e-38

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.9	1.4	2.2	-0.1	-1.4	-1.1	-1.5
Bipolar Disorder or Schizophrenia	0.9	2.1	5.2	1.7	-0.2	-0.5	-2.3
Depressed Affect (Nagel 2018)	0.2	0.3	0.5	0.7	0.7	-0.1	0.6
Depression (Nagel 2018)	0.1	0.2	0.5	-0.7	-0.0	-0.5	0.1
Intelligence (Savage-Jansen 2018)	1.3	3.9	6.2	-2.5	1.7	-0.6	2.5
Neuroticism (Nagel 2018)	0.1	0.3	0.5	0.2	-0.2	-0.7	0.7
Schizophrenia (2018)	1.0	2.1	5.1	2.2	0.3	0.3	-1.8
Schizophrenia vs Biploar Disorder	0.4	0.5	1.6	1.3	-0.5	0.2	0.0
Worry (Nagel 2018)	0.6	1.3	3.6	-0.6	-1.9	-1.0	0.3
Alzheimer’s Disease (in mother)	0.5	0.6	0.9	0.6	0.8	0.9	0.7
Alzheimer’s Disease (in father)	1.5	1.6	3.7	-0.9	1.9	-0.5	1.3
Alzheimer’s Disease (including proxy)	1.3	1.8	4.3	0.1	2.1	0.7	1.6
Crohns Disease (2017)	1.1	2.3	5.5	0.2	2.3	-1.6	1.1
Irritable Bowel Disease (IBD)	0.8	1.8	3.7	0.7	1.9	-1.6	0.6
Ulcerative Colitis (UC)	0.4	0.7	2.1	1.4	0.4	-0.3	-0.8
Major Depression (MDD)	0.5	0.6	1.0	-1.0	0.3	-0.8	0.7
Reaction Time	0.2	0.3	0.7	0.3	0.9	0.3	0.6
Verbal and Numeric Reasoning (VNR)	2.3	5.5	9.5	-3.1	1.3	-1.4	3.0
Breast Cancer	1.8	4.4	11.7	-3.4	1.6	-1.7	0.6
Ovarian Cancer	0.9	1.2	3.8	1.0	2.0	-0.3	0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.6	0.9	3.0	0.6	-0.2	1.7	-0.0
Bipolar Disorder (2011)	1.1	1.0	1.8	-1.2	-0.1	-1.4	-0.9
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.1	-0.4	-0.5	0.2
Coronary Artery Disease (CAD)	0.3	0.3	0.7	-0.5	0.6	0.0	0.8
Crohns Disease (2012)	1.0	1.7	3.7	-0.0	1.6	-1.9	0.7
Mean Putamen Volume	0.2	0.2	0.3	0.6	0.0	-0.5	0.5
Fasting Glucose	0.9	1.1	2.4	-0.3	0.7	-1.2	1.6
HbA1C	0.8	0.9	3.1	0.7	-0.2	-0.0	-1.8
HDL Cholesterol	0.1	0.1	0.2	-0.1	0.4	0.5	-0.0
LDL Cholesterol	0.8	1.3	3.3	0.7	-1.8	1.0	-0.8
Lupus	0.5	0.8	1.4	0.3	1.2	0.6	-1.2
Neuroticism (2016)	0.8	1.1	3.4	-0.2	-1.8	-1.0	-0.0
Primary Biliary Cirrhosis	0.5	0.8	2.7	0.3	-0.4	-0.2	-1.7
Rheumatoid Arthritis	1.3	1.8	4.8	-0.0	-0.5	1.5	-2.2
Schizophrenia (2014)	0.9	2.0	4.5	1.8	0.3	0.4	-2.1
Triglycerides	0.4	0.7	1.4	-0.0	-1.0	-1.2	0.6
Type 2 Diabetes (T2D) (2012)	1.5	1.7	3.1	-1.2	-1.8	-1.4	0.3
Ulcerative Colitis	0.4	0.5	1.9	0.3	1.4	-0.3	-0.1
Blood Eosinophil Count	0.1	0.5	1.5	-0.4	-0.5	1.2	-0.4
Blood Platelet Count	0.2	2.4	4.9	-0.1	-0.9	2.2	-2.0
Blood Red Count	0.1	1.4	2.9	-1.0	1.1	0.6	1.7
Blood White Count	0.9	6.7	12.3	2.8	-0.8	2.5	-3.5
Heel T-Score	0.7	5.7	16.8	1.7	-1.1	4.1	-1.4
BMI	0.1	0.3	0.5	0.5	0.7	0.7	0.2
Height	0.3	5.5	11.1	-2.7	-1.2	-3.3	1.5
Waist Hip Ratio (WHR)	0.4	1.9	3.6	1.5	0.9	0.9	-1.9
Systolic Blood Pressure	0.3	1.7	4.5	1.5	0.0	0.1	-2.1
Smoking Status	0.3	0.8	1.4	0.1	0.9	-1.2	-1.1
Allergy or Eczema	0.0	0.1	0.3	-0.1	0.1	-0.5	0.4
Cardiovascular Disease	0.5	1.7	2.7	0.8	-1.4	-1.6	1.2
Hypothyroidism (self reported)	0.3	0.7	2.4	0.5	0.5	1.6	0.0
Respiratory disease	0.5	1.1	1.9	-1.2	-1.4	-0.2	-0.9
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.2	0.1	0.3	-0.9	1.1
Lung FEV1/FVC ratio	0.3	1.7	3.2	1.8	-0.7	-0.6	-1.7
Lung FVC	3.0	15.2	46.6	-6.8	-1.0	-3.2	1.8
Neuroticism	0.3	0.7	1.2	0.4	-1.0	-0.7	1.1
Chronotype (morning person)	0.2	0.6	1.9	-1.4	-0.1	-0.4	0.5
Hair Pigment	0.0	1.2	4.0	-2.0	0.4	0.1	0.7
Tanning	0.1	0.8	1.6	0.5	-0.9	-0.7	-1.2
Hand grip strength (left)	0.6	1.5	4.5	0.1	0.8	2.1	1.0
Number of treatments/medications taken	0.3	0.6	0.9	-0.3	0.7	-0.9	0.9
Average weekly spirits intake	0.8	1.0	1.8	-1.0	1.0	1.3	0.2
Sensitivity / hurt feelings	0.3	0.5	1.9	-0.4	-0.1	-1.4	0.3
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	-0.2	0.3	-0.8	0.7
Hearing difficulty/problems: Yes	1.1	1.7	3.8	-0.3	-2.0	0.7	-1.6
Relative age of first facial hair	0.6	1.2	3.5	0.3	-1.9	-1.1	0.0
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	3.4	0.1	-0.6	1.8	0.4
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.2	0.5	0.2	0.1
Ever had hysterectomy (womb removed)	1.2	1.3	3.5	-1.9	-0.2	-1.2	0.5
Systolic blood pressure, automated reading	0.8	2.4	6.0	1.4	0.7	1.1	-2.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.3	-0.8	-0.8	-1.2	-0.9
Angina	0.4	0.6	1.0	1.0	0.8	-0.7	-0.2
Medication for hormone replacement therapy	1.1	1.2	2.1	-1.4	1.3	0.9	-0.3
Vitamin and mineral supplements	0.2	0.2	0.8	-0.4	-0.2	-0.9	0.0
Supplements: Zinc	0.6	0.7	1.2	0.6	1.1	0.7	0.8
Medication: Co-codamol	1.7	2.0	3.3	-1.5	1.0	-1.1	1.8
Medication: Metformin	0.8	1.1	1.7	1.2	-1.0	-0.3	-1.3
Diabetes (father)	0.7	0.9	3.4	-0.2	0.0	-0.5	1.9
Diabetes (mother)	0.6	0.7	2.0	0.1	0.7	0.6	-1.4
Severe depression (siblings)	0.2	0.2	0.4	0.6	-0.5	0.5	-0.3
Pack years adult smoking proportion	0.1	0.2	0.6	-0.8	-0.1	0.4	-0.2
Impedance of leg (right)	0.3	1.5	3.4	0.3	-1.9	-1.0	-1.2
Leg fat-free mass (left)	0.1	0.3	1.2	-0.3	-0.1	-0.0	1.1
Trunk fat percentage	0.1	0.3	1.0	-1.0	-0.1	-0.4	0.4
Hand grip strength (right)	0.2	0.6	1.7	0.3	0.6	1.3	-0.3
Townsend deprivation index at recruitment	0.2	0.3	0.9	0.9	0.3	-0.1	-0.4
Current tobacco smoking	0.5	0.8	1.7	-1.3	0.4	-0.9	0.9
Average weekly fortified wine intake	0.5	0.6	1.0	-1.0	-0.3	0.8	-0.8
Maternal smoking around birth	0.5	0.7	1.3	-1.0	0.7	-1.1	0.2
Fed-up feelings	0.2	0.3	0.8	-0.3	-0.0	-0.9	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	-0.9	0.3	-0.6	0.7
Relative age voice broke	1.1	1.7	3.4	0.6	-1.8	1.3	-1.1
Taking other prescription medications	1.0	1.6	3.7	-0.1	-1.9	-1.3	-0.9
Age when periods started (menarche)	0.7	1.6	2.4	1.5	1.2	0.8	-1.4
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.3	0.5	1.8	-1.6	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	3.9	-1.1	-2.0	0.2	-1.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.3	-0.3	0.6	1.1	-0.1
Qualifications: CSEs or equivalent	0.7	1.0	2.9	0.1	0.1	-1.0	1.7
Serious illness, injury or assault to yourself	0.1	0.2	0.5	0.7	0.2	0.2	0.3
High blood pressure	0.1	0.2	0.6	-0.2	-0.8	-0.4	-0.2
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	-0.4	-0.6	0.1	0.7
Multivitamins +/- minerals	0.3	0.4	1.3	-1.1	-0.6	0.1	0.2
Stomach or abdominal pain in last month	0.1	0.2	0.4	0.5	0.0	-0.6	-0.3
Supplements: Glucosamine	0.7	0.9	1.4	1.2	1.0	-1.0	0.5
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	4.1	-0.9	0.7	1.8	2.0
Medication: Atenolol	0.4	0.5	0.9	-0.5	1.0	0.1	1.0
Medication: Levothyroxine sodium	0.3	0.5	1.4	0.5	0.4	1.2	-0.1
Sitting height	0.5	3.8	8.2	-2.0	-1.5	-2.9	0.8
Chronic bronchitis/emphysema (father)	0.6	0.7	1.4	0.5	-1.2	-1.2	0.1
High blood pressure (mother)	0.9	1.2	2.5	1.0	-1.6	1.2	-0.1
Body mass index (BMI)	0.2	1.0	3.4	0.5	0.4	1.9	-0.2
Impedance of leg (left)	0.2	0.7	1.6	0.1	-1.3	-1.0	-0.5
Leg predicted mass (left)	0.1	0.4	1.2	-0.4	-0.1	-0.1	1.1
Trunk fat mass	0.0	0.2	0.6	-0.8	-0.1	-0.1	0.3
Waist circumference	0.2	0.7	1.7	0.8	0.2	1.3	-0.5
Number of incorrect matches in round	0.5	0.9	3.4	0.1	-0.4	-0.2	-1.8
Past tobacco smoking	0.8	1.4	5.3	-0.3	0.4	0.0	2.3
Alcohol usually taken with meals	0.3	0.4	0.6	-0.8	-0.8	-0.4	0.5
Nervous feelings	0.2	0.4	1.1	0.3	-0.8	0.0	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.4	-0.9	0.2	-0.6	1.6
Hearing difficulty/problems with background noise	0.1	0.1	0.1	0.3	-0.3	-0.3	0.3
Hair/balding pattern: Pattern 2	1.4	1.8	3.3	1.8	-0.9	1.0	-1.5
Had menopause	0.2	0.3	1.0	-0.3	-0.1	0.2	1.0
Had other major operations	0.4	0.5	1.1	-0.5	-0.1	-1.0	0.8
Forced vital capacity (FVC)	1.9	7.5	17.1	-4.1	-1.1	-2.8	1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.0	-0.7	-0.6	1.0	-0.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.5	-0.2	-0.6	-0.1	-1.2
Qualifications: None of the above	1.5	3.2	11.1	1.0	3.3	-0.8	-0.5
Financial difficulties in last 2 years	0.4	0.5	1.8	0.1	1.3	0.1	0.5
Mouth/teeth dental problems	0.3	0.4	1.1	0.7	-0.4	1.0	0.1
Heart attack	0.8	1.0	2.0	-1.3	1.4	-0.3	0.4
Allergy	0.5	1.0	2.1	1.4	1.4	0.3	0.1
Pain all over the body in last month	0.2	0.2	0.7	0.1	-0.8	0.2	-0.3
Diabetes (self-reported)	0.3	0.5	1.2	1.1	-0.5	-0.5	-0.6
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.4	-0.3	-0.2	0.2	0.6
Medication: Ramipril	0.2	0.3	0.7	-0.8	-0.3	-0.3	-0.6
Medication: Simvastatin	1.5	2.2	7.6	-0.1	-0.4	-2.8	1.0
Fluid intelligence score	1.3	2.7	4.1	-1.8	-0.3	-1.8	2.0
Illnesses of siblings	2.9	4.1	4.6	2.1	-2.1	1.7	-2.1
Neuroticism score	0.2	0.4	0.9	-0.3	-1.0	-0.6	0.6
Weight	0.0	0.2	0.4	-0.2	-0.2	0.6	0.5
Impedance of arm (right)	0.6	2.9	6.8	-1.7	-0.8	-2.6	1.0
Arm fat percentage (right)	0.1	0.3	0.6	-0.5	0.3	0.8	0.4
Trunk fat-free mass	0.0	0.1	0.2	0.0	-0.4	0.5	0.1
Hip circumference	0.1	0.2	0.6	-0.1	-0.1	0.5	0.8
Time employed in main current job	0.6	0.7	2.3	-1.5	0.3	-0.6	0.5
Alcohol intake versus 10 years previously	0.2	0.3	0.7	0.1	0.8	-0.2	-0.6
Father’s age at death	0.6	0.8	1.8	0.1	1.3	-0.5	1.1
Worrier / anxious feelings	1.2	2.3	7.6	-0.0	-2.8	-1.0	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.8	-1.3	-0.9	-0.4	0.0
Falls in the last year	1.0	1.4	4.6	0.0	-2.1	-0.4	-0.9
Hair/balding pattern: Pattern 3	2.7	4.1	5.4	-1.8	1.6	-2.2	2.3
Number of live births	1.0	1.4	3.9	-2.0	-0.3	-1.2	0.6
Forced expiratory volume in 1-second (FEV1)	1.9	6.5	11.0	-3.2	-0.8	-3.3	1.9
Pulse rate	1.2	2.0	6.5	1.2	0.4	2.5	0.4
Happiness	1.0	1.3	2.7	-1.4	-0.7	-1.6	0.2
Noisy workplace	0.1	0.2	0.4	0.3	-0.2	0.4	-0.6
Qualifications: A levels/AS levels or equivalent	1.2	2.6	4.5	1.3	-2.1	2.0	0.4
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.4	4.7	-0.8	-0.1	-2.2	2.0
Mouth/teeth dental problems: Dentures	0.2	0.4	0.6	-0.2	0.6	-0.7	0.8
Asthma	0.9	1.7	5.1	0.0	-2.3	1.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.0	7.2	-2.7	1.2	-0.6	1.7
Medication: Cholesterol lowering	0.4	0.7	1.6	0.2	0.9	-0.4	1.3
Depression (self-reported)	1.4	1.7	4.9	-0.5	2.2	-0.9	0.9
Medication: Lansoprazole	2.3	2.6	6.0	-0.9	1.1	-1.6	2.4
Prospective memory result	0.5	0.7	1.3	-1.1	0.6	0.9	-0.4
Lung cancer (father)	0.7	0.8	2.2	0.3	1.5	-0.2	0.9
Illnesses of mother	0.3	0.4	1.0	0.5	-0.3	0.2	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.8	12.0	-3.5	-1.4	-2.8	1.3
Pulse wave Arterial Stiffness index	1.0	1.2	3.0	0.3	1.7	0.1	1.2
Impedance of arm (left)	0.8	3.7	9.0	-1.7	-0.9	-3.0	1.4
Arm fat mass (right)	0.1	0.2	0.3	-0.4	0.3	0.5	0.6
Trunk predicted mass	0.0	0.1	0.3	-0.0	-0.3	0.5	0.1
Standing height	0.4	3.5	8.2	-1.4	-1.7	-2.9	1.1
Length of working week for main job	1.0	1.1	2.6	-0.2	-0.1	1.6	1.3
Exposure to tobacco smoke at home	0.1	0.2	0.4	0.4	-0.2	0.1	-0.7
Breastfed as a baby	1.6	2.0	6.2	0.5	-2.5	0.9	0.7
Tense / ‘highly strung’	0.4	0.7	2.2	0.5	-1.5	-0.3	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.3	-1.2	0.3	-0.8	1.5
Hair/balding pattern: Pattern 4	0.5	1.1	3.6	-0.2	1.9	-0.4	-0.7
Birth weight of first child	0.5	1.0	3.1	-0.8	-0.3	0.1	1.8
Peak expiratory flow (PEF)	1.2	2.8	5.9	-2.2	0.8	-0.2	2.4
Pulse wave reflection index	0.2	0.2	0.6	-0.4	-0.5	-0.8	0.1
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.5	-0.7	-0.1	0.3	-0.0
Loud music exposure frequency	0.7	0.7	1.4	-0.6	0.2	-1.2	-1.1
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	5.0	0.8	-2.2	1.3	2.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.6	-0.1	0.8	0.4	-0.4
Blood clot in the leg (DVT)	0.7	0.9	1.6	-0.5	-1.2	-0.6	1.3
Medication: Paracetamol	0.6	0.9	1.8	-0.1	1.3	-1.3	0.6
Headache pain in last month	0.5	0.9	3.6	-0.1	0.3	0.2	1.9
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.6	-0.8	-0.4	0.7	0.1
Glaucoma (self-reported)	0.5	0.6	1.7	0.7	0.3	0.5	-1.3
Gout (self-reported)	0.3	0.3	1.2	1.1	-0.1	-0.4	-0.0
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	3.0	0.7	-0.3	1.7	0.0
Medication: Amlodipine	0.5	0.7	1.9	0.4	1.4	-0.2	0.8
Medication: Ventolin 100micrograms inhaler	2.4	3.1	5.4	1.2	-2.3	1.8	-1.5
Birth weight	1.1	2.3	5.6	1.8	0.0	2.4	0.4
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.4	-0.4	0.6	-1.2	0.3
High blood pressure (siblings)	0.9	1.3	2.6	-1.6	0.5	-0.6	1.4
Forced vital capacity (FVC), Best measure	1.7	6.2	14.7	-3.8	-1.5	-2.6	1.1
Body fat percentage	0.0	0.1	0.4	-0.6	-0.3	0.3	0.1
Leg fat percentage (right)	0.2	0.9	2.0	0.5	-0.6	1.4	-0.9
Arm fat-free mass (right)	0.0	0.1	0.3	-0.1	-0.0	0.2	0.6
Exposure to tobacco smoke outside home	0.3	0.5	1.7	0.2	0.1	-0.2	1.3
Comparative body size at age 10	0.1	0.2	0.5	-0.7	0.3	-0.2	0.5
Number of full brothers	0.4	0.5	1.2	-0.6	0.5	-0.6	1.1
Worry too long after embarrassment	0.2	0.3	0.6	0.4	0.2	0.8	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.4	-0.0	-0.0	-0.9	1.2
Wheeze or whistling in the chest in last year	1.2	2.1	3.0	0.2	-1.7	1.7	-1.6
Number of children fathered	0.7	0.8	2.9	-0.0	-1.7	-0.4	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	6.6	-2.6	0.6	0.2	0.7
Age at first live birth	1.5	2.7	4.7	1.0	-1.2	1.9	-2.2
Pulse wave peak to peak time	0.8	0.9	2.4	-0.4	-1.5	-0.5	-0.9
Health satisfaction	1.9	2.4	4.4	-1.5	1.0	-2.1	1.5
Shortness of breath walking on level ground	0.7	0.9	1.7	-0.7	-1.1	-0.4	-1.3
Qualifications: College or University degree	0.1	0.4	0.7	0.8	-0.7	0.8	0.1
Eye problems/disorders: None of the above	0.7	0.8	2.3	1.5	0.2	0.4	0.9
Mouth/teeth dental problems: Loose teeth	2.6	3.0	6.0	-1.5	0.6	-1.9	2.4
Emphysema/chronic bronchitis	0.4	0.5	1.0	-1.0	0.6	0.3	0.7
Medication for pain relief, constipation, heartburn	1.5	2.5	4.6	1.5	-1.3	2.1	-1.1
Neck or shoulder pain in last month	0.4	0.5	0.9	0.7	0.3	0.8	-0.9
Medication: Blood pressure	0.1	0.2	0.4	0.6	-0.0	-0.6	-0.6
Angina (self-reported)	0.3	0.4	0.9	0.9	0.7	-0.6	0.2
Migraine (self-reported)	0.2	0.2	0.5	0.7	0.1	0.4	0.2
Medication: Ibuprofen	2.0	2.4	4.3	-2.0	1.0	-0.1	2.1
Medication: Allopurinol	0.4	0.5	1.1	0.7	-0.5	-0.3	-1.1
Medication: Omeprazole	0.6	0.8	2.1	-1.4	0.3	-0.9	-0.2
Medication: Seretide 50 evohaler	0.3	0.3	0.7	-0.6	-0.8	-0.2	-0.4
Mean time to correctly identify matches	0.0	0.0	0.1	0.1	0.3	-0.0	-0.1
Heart disease (mother)	0.1	0.1	0.3	0.5	0.1	0.4	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.6	-0.0	1.0	1.3	0.5
Whole body fat mass	0.0	0.1	0.4	-0.6	-0.1	0.3	0.2
Leg fat mass (right)	0.1	0.5	1.0	0.5	-0.3	1.0	-0.7
Arm predicted mass (right)	0.0	0.1	0.3	-0.1	0.0	0.4	0.5
Pulse rate, automated reading	1.0	3.3	7.8	1.0	1.5	2.8	-1.5
Alcohol intake frequency.	0.3	0.7	1.6	-0.7	0.8	-0.3	1.3
Comparative height size at age 10	0.5	2.7	7.7	-0.1	-1.7	-2.8	0.2
Number of full sisters	1.0	1.2	3.3	-1.8	-0.4	-0.9	0.8
Suffer from ‘nerves’	0.5	0.8	1.6	-0.8	-1.3	-0.7	0.6
Overall health rating	0.1	0.3	0.7	-0.4	0.8	0.2	0.5
Chest pain or discomfort	0.1	0.2	0.6	0.4	-0.0	-0.2	0.7
Had major operations	0.6	0.8	1.6	0.9	1.3	-0.1	0.7
Age at last live birth	1.5	2.2	3.5	1.6	-1.2	1.9	-1.0
Family relationship satisfaction	1.9	2.4	5.5	-2.4	0.2	-1.6	1.1
Leg pain on walking	0.6	0.8	1.5	-1.2	0.1	-1.2	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.4	-1.9	-1.2	-0.6	0.5
Commuting to job workplace: Car/motor vehicle	1.1	1.3	4.2	-0.9	-0.3	0.0	-2.0
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	4.9	0.5	-2.2	0.2	-1.7
Medication: Aspirin	0.2	0.2	0.7	0.0	0.8	-0.4	-0.2
Supplements: Vitamin C	0.8	1.0	3.1	1.8	0.1	0.8	0.4
Knee pain experienced in last month	2.3	3.5	8.5	-2.9	1.0	-2.0	0.8
Hypertension (Self-reported)	0.2	0.5	1.0	-0.5	-0.8	-1.0	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.8	0.0	0.9	-1.4	0.6
Illnesses of father: Heart disease	0.4	0.6	1.1	-0.7	1.1	0.8	0.4
Illnesses of siblings: Diabetes	0.9	1.1	3.7	-0.1	0.1	-0.7	1.9
Smoking status: Previous	1.0	1.5	4.4	0.9	-0.6	0.7	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.1	-0.9	-0.2	-0.1	1.5
Whole body fat-free mass	0.0	0.1	0.3	-0.2	-0.2	0.4	0.6
Leg fat-free mass (right)	0.1	0.7	2.6	-0.4	0.3	0.0	1.6
Arm fat percentage (left)	0.1	0.3	0.5	-0.6	0.4	0.4	0.7
Average weekly red wine intake	0.4	0.5	1.4	-0.6	-1.2	-0.4	-0.4
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.1	1.3	1.4	-0.3	1.2
Mood swings	0.5	0.9	1.9	-0.6	1.4	-0.5	0.9
Loneliness, isolation	0.6	0.8	1.5	-0.7	1.0	-0.1	1.2
Long-standing illness, disability or infirmity	0.2	0.4	0.7	0.4	0.3	-0.8	-0.7
Ever had bowel cancer screening	1.6	1.8	4.9	1.0	-2.2	0.8	0.9
Diabetes diagnosed by doctor	0.2	0.4	1.1	1.1	-0.4	-0.4	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	-0.6	-0.4	0.7	-0.6
Friendships satisfaction	2.1	2.7	8.1	-2.8	-0.4	-1.3	0.9
Qualifications: nursing, teaching	0.5	0.8	1.3	-0.6	0.9	1.1	0.7
Commuting to job workplace: Walk	2.0	2.1	4.3	0.7	0.4	-1.9	2.1
Eye problems/disorders: Cataract	0.6	0.6	1.1	-0.7	-0.4	0.9	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.7	0.1	0.4	-1.3	-0.6
Medication for cholesterol	0.6	0.9	1.8	0.8	-0.4	1.4	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	6.0	0.0	0.3	-2.5	1.2
Back pain experienced in last month	0.3	0.5	1.0	0.8	1.0	-0.6	0.0
Mineral and other dietary supplements	0.8	1.1	2.2	-0.2	-1.5	1.1	-1.0
Breast cancer (self-reported)	1.0	1.2	4.2	-0.1	0.7	0.4	2.0
Asthma (self-reported)	0.8	1.7	4.7	0.2	-2.2	1.0	-1.0
Osteoporosis (self-reported)	0.7	0.8	1.6	-0.9	-0.7	-1.3	0.7
Osteoarthritis (self-reported)	0.1	0.1	0.1	-0.3	-0.3	-0.4	0.1
Medication: Aspirin	0.1	0.1	0.3	-0.0	0.5	-0.1	0.1
Medication: Gliclazide	0.3	0.3	0.4	0.6	0.6	-0.2	-0.7
Illnesses of father: None of the above (group 1)	0.3	0.4	1.0	0.4	-0.4	0.6	-1.0
Smoking status: Current	0.4	0.6	1.0	-0.8	0.9	-1.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.5	9.6	-1.6	-1.1	-3.1	0.7
Whole body water mass	0.0	0.2	0.5	-0.3	-0.1	0.1	0.7
Leg predicted mass (right)	0.1	0.7	2.6	-0.5	0.3	-0.0	1.6
Arm fat mass (left)	0.1	0.3	0.4	-0.6	0.2	0.6	0.5
Number of self-reported non-cancer illnesses	0.4	0.7	1.6	0.4	-1.3	-0.9	0.2
Average weekly champagne plus white wine intake	1.2	1.7	4.6	-1.1	-2.1	0.7	-0.8
Miserableness	0.4	0.7	1.5	-0.3	1.2	-1.0	0.2
Guilty feelings	0.8	1.1	4.3	-0.4	-0.1	0.2	2.1
Wears glasses or contact lenses	0.4	0.5	0.9	0.1	0.8	0.4	1.0
Ever taken oral contraceptive pill	1.0	1.1	3.4	1.8	0.8	0.8	-0.1
Hearing aid user	0.4	0.4	0.9	-0.4	0.6	-0.5	-1.0
Mother’s age at death	0.1	0.1	0.5	-0.7	0.2	-0.1	-0.1
Financial situation satisfaction	0.5	0.6	1.9	-1.4	-0.5	0.5	0.5
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.6	0.9	-0.8	0.5	-1.9
Commuting to job workplace: Public transport	1.9	2.2	7.4	-0.1	0.9	-2.7	0.8
Eye problems/disorders: Glaucoma	0.9	1.0	3.8	0.5	-0.2	-0.3	-1.9
Medication: Blood pressure	0.4	0.8	1.6	-1.2	-0.5	-0.6	1.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	-0.1	0.9	-0.4	0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.0	1.0	0.2	-0.1	-0.3
High cholesterol (Self-reported)	1.6	2.8	7.8	-0.1	0.2	-2.8	1.8
Medication: Bendroflumethiazide	0.4	0.7	0.9	-0.2	-0.9	1.0	0.9
Medication: Paracetamol	0.9	1.4	4.2	-0.1	2.0	-0.9	0.8
Medication: Lisinopril	0.7	0.9	2.8	0.3	1.7	-0.8	0.3
Medication: Atorvastatin	0.8	1.0	3.1	-0.4	1.8	0.8	0.5
Illnesses of father: High blood pressure	0.7	0.8	2.2	1.5	0.1	1.0	-0.4
Alcohol drinker status: Never	0.9	1.1	3.1	-0.8	0.8	-0.2	1.8
Ever smoked	0.2	0.4	0.7	-0.9	0.0	-0.2	-0.8
Basal metabolic rate	0.0	0.2	0.5	-0.2	-0.2	0.3	0.7
Leg fat percentage (left)	0.2	0.7	2.2	0.5	-0.2	1.5	-0.5
Arm fat-free mass (left)	0.0	0.1	0.2	-0.1	-0.4	0.5	0.4
Number of operations (self-reported)	1.2	1.8	3.4	-1.5	1.3	-0.4	1.8
Average weekly beer plus cider intake	0.4	0.6	1.3	-1.2	0.7	-0.2	0.7
Irritability	0.5	0.9	2.2	-0.5	0.8	-1.5	0.7
Risk taking	0.4	0.6	1.4	0.2	0.6	1.2	-0.7
Ever had prostate specific antigen (PSA) test	2.0	2.3	4.2	2.1	-1.6	0.2	-1.5
Fractured/broken bones in last 5 years	0.5	0.6	1.9	-0.1	-0.4	1.4	0.7
Age started oral contraceptive pill	0.6	0.7	1.4	-0.3	1.1	-1.2	0.2
Diastolic blood pressure, automated reading	0.9	2.9	5.0	-2.0	-2.2	1.6	0.2
Ever depressed for a whole week	1.2	1.4	3.3	-0.8	-1.3	-1.8	-0.3
Unable to work because of sickness or disability	0.7	1.0	3.2	-1.8	0.4	0.3	0.6
Commuting to job workplace: Cycle	0.6	0.7	1.3	1.1	-0.7	0.1	1.0
Myopia	1.1	1.6	4.6	0.4	-2.1	-1.3	0.1
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.8	0.4	0.8	0.9	0.1
Cholesterol lowering medication	1.3	1.9	5.8	0.5	0.3	-2.4	1.2
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.8	-1.3	1.0	-1.0	0.0
Pain experienced in last month	0.2	0.3	0.9	0.3	0.5	1.0	-0.0
Supplements: Calcium	0.2	0.2	0.6	0.3	0.4	0.8	0.1
Basal cell carcinoma (self-reported)	0.6	0.7	2.1	-0.4	-0.6	0.5	-1.5
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.0	-1.4	1.4	-0.3	0.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.7	-0.7	-1.1	-0.7	1.3
Heart disease (siblings)	0.3	0.4	1.2	-1.1	0.3	-0.2	0.5
Alcohol drinker status: Previous	0.8	0.9	3.3	-0.4	-0.2	-1.8	0.2
Pack years of smoking	0.1	0.2	0.5	-0.7	0.1	0.2	-0.5
Impedance of whole body	0.4	2.0	5.1	-1.1	-1.2	-2.2	0.6
Leg fat mass (left)	0.1	0.3	0.9	0.4	0.1	0.9	-0.3
Arm predicted mass (left)	0.0	0.1	0.3	0.0	-0.5	0.2	0.3