Hub : Genes

THBS2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2650	0.0490	4.8e-09	0.137	0.097	0.182	0.172	0.180	2.3e-16	8.2e-12	1.3e-21	2.2e-20	2.0e-21
2	GTEx	Artery Aorta	0.1430	0.0560	9.6e-03	0.001	NA	0.019	NA	-0.002	3.0e-01	NA	3.1e-02	NA	4.1e-01
3	ROSMAP	Brain Pre-frontal Cortex	0.3649	0.0509	6.7e-16	0.124	0.154	0.206	0.196	0.184	1.2e-15	2.8e-19	6.1e-26	1.3e-24	4.1e-23
4	TCGA	Bladder Urothelial Carcinoma	0.0450	0.0220	5.0e-03	0.003	0.022	0.005	NA	0.007	1.5e-01	5.1e-03	1.1e-01	NA	7.3e-02
5	TCGA	Breast Invasive Carcinoma	0.0185	0.0091	5.8e-03	0.007	0.012	0.008	NA	0.008	8.9e-03	1.0e-03	7.8e-03	NA	6.7e-03
6	TCGA	Brain Lower Grade Glioma	0.0473	0.0241	9.4e-03	0.033	0.003	0.029	NA	0.023	1.1e-04	1.3e-01	2.8e-04	NA	9.7e-04
7	TCGA	Lung Adenocarcinoma	0.0452	0.0217	1.1e-03	0.001	0.021	0.033	NA	0.018	2.2e-01	1.6e-03	8.9e-05	NA	3.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.5	0.8	1.3	-0.9	0.7	-1.1	0.7	1.0	-1.1	0.7
Bipolar Disorder or Schizophrenia	0.4	0.9	2.2	-1.0	0.5	-1.5	0.2	0.9	-1.2	0.6
Depressed Affect (Nagel 2018)	0.2	0.4	1.0	-0.5	0.8	-0.6	1.0	0.1	-0.5	0.3
Depression (Nagel 2018)	0.2	0.3	0.9	-0.4	-0.1	-0.6	-0.1	-0.2	-0.9	-0.5
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.9	1.7	1.1	0.3	0.8	-0.9	-0.2	-1.2
Neuroticism (Nagel 2018)	0.1	0.2	1.0	0.2	0.4	0.2	0.4	-0.0	1.0	-0.1
Schizophrenia (2018)	0.2	0.4	0.9	-0.5	0.1	-0.9	-0.2	0.7	-0.9	0.2
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	-0.9	-0.1	-0.9	-0.3	0.4	-0.8	-0.0
Worry (Nagel 2018)	0.2	0.4	1.7	0.4	-0.1	-0.4	0.2	0.5	0.4	-1.3
Alzheimer’s Disease (in mother)	1.7	2.0	5.4	1.8	-0.3	2.3	-0.1	-0.4	2.2	-0.1
Alzheimer’s Disease (in father)	1.0	1.1	2.2	1.0	0.9	1.5	-0.3	-1.3	0.5	1.4
Alzheimer’s Disease (including proxy)	1.2	1.8	4.9	1.6	0.0	2.2	-0.0	-0.7	1.9	0.9
Crohns Disease (2017)	0.2	0.4	1.2	0.8	-0.1	0.7	0.5	1.1	0.5	0.3
Irritable Bowel Disease (IBD)	0.3	0.7	1.3	0.5	0.4	0.9	1.0	1.1	0.2	1.1
Ulcerative Colitis (UC)	0.6	1.1	2.5	-0.6	0.3	0.4	1.6	1.5	-0.7	1.3
Major Depression (MDD)	0.3	0.3	0.7	0.3	-0.8	0.7	-0.0	0.0	0.5	-0.8
Reaction Time	0.5	0.9	2.0	1.1	0.3	1.4	0.6	-0.0	1.4	0.8
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.2	0.9	1.5	0.0	1.0	-1.3	-0.4	-0.7
Breast Cancer	1.5	3.7	8.0	2.5	-0.7	1.1	-2.5	-2.8	0.1	-1.8
Ovarian Cancer	0.6	0.8	2.0	-0.1	0.9	0.5	0.7	1.4	0.7	1.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.1	0.1	0.3	0.0	0.6	0.3	-0.0	-0.4	-0.1	-0.0
Bipolar Disorder (2011)	0.5	0.4	1.3	-0.8	1.1	-1.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.2	0.8	0.0	-0.2	-0.5	-0.5	-0.9	-0.1	0.2
Coronary Artery Disease (CAD)	0.2	0.3	1.0	0.4	-0.2	0.2	0.3	-0.6	-1.0	-0.5
Crohns Disease (2012)	0.1	0.2	0.7	0.3	-0.1	-0.3	0.3	0.8	0.4	-0.1
Mean Putamen Volume	0.8	0.9	2.9	0.7	-0.5	0.4	-0.8	-0.2	1.7	-1.4
Fasting Glucose	0.4	0.5	1.8	-0.2	1.4	0.0	0.8	-0.8	-0.5	0.3
HbA1C	0.7	0.8	2.1	-1.5	-0.4	-0.8	0.4	0.9	-0.5	1.1
HDL Cholesterol	1.6	2.7	7.9	1.0	-2.0	0.6	-2.0	-0.5	1.1	-2.8
LDL Cholesterol	0.5	0.9	2.0	-0.4	-1.4	-1.1	-0.5	0.1	-1.4	-0.7
Lupus	1.0	1.6	5.1	-1.2	0.2	-0.3	1.4	2.3	0.4	1.4
Neuroticism (2016)	1.2	1.7	4.7	-2.2	0.6	-1.9	0.9	0.6	-1.2	1.0
Primary Biliary Cirrhosis	0.7	1.0	2.5	-1.6	0.2	-0.5	0.6	1.3	-1.3	0.9
Rheumatoid Arthritis	1.1	1.5	4.7	-0.3	1.5	2.2	-0.6	0.8	0.8	1.4
Schizophrenia (2014)	0.5	1.0	2.5	-1.3	0.6	-1.6	-0.1	0.8	-1.2	0.6
Triglycerides	0.2	0.3	0.8	-0.2	0.7	-0.7	0.9	0.1	-0.5	0.6
Type 2 Diabetes (T2D) (2012)	1.7	2.0	4.0	1.6	-1.6	1.3	-1.2	-1.0	0.9	-2.0
Ulcerative Colitis	1.1	1.5	3.3	-0.1	1.6	1.3	1.8	1.1	0.1	1.5
Blood Eosinophil Count	0.1	1.0	2.7	0.8	-1.6	0.4	-0.9	0.1	0.2	-1.6
Blood Platelet Count	0.3	3.0	7.1	-1.7	-1.2	-2.2	0.7	1.9	-2.7	-0.8
Blood Red Count	0.2	1.9	4.7	1.9	-0.3	1.1	-0.9	-2.2	0.5	-1.5
Blood White Count	0.5	3.4	13.9	-1.7	0.1	-1.7	0.9	3.7	-1.8	0.6
Heel T-Score	0.4	3.1	11.5	-0.6	0.9	2.0	1.7	3.4	1.4	0.7
BMI	0.2	1.1	2.8	0.8	-0.0	1.3	-1.3	-1.7	0.4	0.8
Height	0.7	12.9	35.5	1.9	-4.1	-0.8	-5.1	-6.0	-0.4	-2.9
Waist Hip Ratio (WHR)	1.5	6.7	12.5	-3.1	0.8	-1.5	3.5	3.5	-2.1	2.2
Systolic Blood Pressure	1.8	9.0	23.3	-1.5	4.8	-2.1	3.2	3.1	-2.4	2.7
Smoking Status	0.0	0.1	0.4	-0.5	-0.2	-0.1	-0.1	0.2	-0.0	0.6
Allergy or Eczema	0.4	1.0	2.0	1.0	-1.3	1.4	0.8	0.2	1.1	-0.3
Cardiovascular Disease	0.2	0.7	1.5	-0.9	-1.1	-0.9	0.2	-0.4	-1.2	0.6
Hypothyroidism (self reported)	0.1	0.3	1.0	-1.0	0.4	-0.0	-0.1	-0.4	0.1	1.0
Respiratory disease	0.5	1.1	3.5	-1.9	-0.4	-1.4	0.1	0.8	-0.9	0.7
Type 2 Diabetes (T2D) (2018)	0.9	1.8	4.3	-2.0	0.9	-2.1	0.6	-0.4	-1.5	0.8
Lung FEV1/FVC ratio	0.6	3.0	4.7	-2.1	1.1	-1.6	1.8	1.3	-1.8	2.2
Lung FVC	5.1	26.2	69.1	3.9	-3.8	0.2	-8.3	-7.5	-0.1	-5.3
Neuroticism	0.2	0.4	1.4	-1.2	-0.5	-0.9	0.2	-0.1	-0.2	0.4
Chronotype (morning person)	0.1	0.3	1.3	1.1	-0.3	0.5	0.2	0.0	-0.4	-0.4
Hair Pigment	0.0	1.2	3.3	1.7	0.4	1.8	-0.5	-0.7	0.1	-1.1
Tanning	0.1	0.9	2.5	-1.1	1.2	-0.2	0.0	0.9	0.7	1.6
Hand grip strength (left)	0.3	0.7	3.9	0.4	-0.7	-0.0	-0.3	-0.4	0.4	-2.0
Number of treatments/medications taken	0.7	1.3	5.7	-0.3	0.2	-0.8	1.2	-0.2	-2.4	1.1
Average weekly spirits intake	0.9	1.1	3.1	1.4	-0.5	1.7	0.2	-0.4	1.4	-0.1
Sensitivity / hurt feelings	0.6	1.0	4.1	-0.9	0.3	0.6	-0.8	0.1	2.0	0.9
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.2	-0.4	0.2	-1.5	-0.0	-1.0	-1.4	-0.7
Hearing difficulty/problems: Yes	0.8	1.2	2.2	-1.2	-1.2	-1.5	-0.9	0.3	-1.4	-0.1
Relative age of first facial hair	0.8	1.7	3.8	-1.6	-1.9	-1.4	0.4	1.1	-1.4	-0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	-0.9	-0.1	-0.5	0.8	-0.5	-0.2	1.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.4	0.4	-0.6	0.2	0.2	-0.9	-1.2	0.4
Ever had hysterectomy (womb removed)	4.9	5.5	9.5	2.6	-1.8	2.1	-3.1	-2.8	1.3	-2.3
Systolic blood pressure, automated reading	2.6	7.4	22.5	-1.4	4.7	-0.4	3.0	3.2	-0.5	2.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.6	-0.4	0.1	0.4	-0.8	-0.1	1.2	1.3
Angina	0.2	0.3	1.0	0.4	0.6	1.0	-0.1	-0.3	0.3	-0.0
Medication for hormone replacement therapy	0.7	0.7	1.8	0.9	0.6	1.4	0.6	-0.1	0.9	1.0
Vitamin and mineral supplements	0.5	0.6	1.2	0.9	-1.1	1.0	-0.9	-0.5	0.7	0.2
Supplements: Zinc	0.9	1.0	3.6	1.0	-0.1	0.5	-1.0	-1.9	0.9	-0.5
Medication: Co-codamol	0.9	1.0	3.1	1.0	-0.8	1.4	-0.7	-1.8	0.4	0.2
Medication: Metformin	0.8	1.1	3.0	-1.7	0.7	-1.7	-0.3	0.0	-1.2	0.2
Diabetes (father)	1.2	1.5	4.5	-1.0	-0.7	-1.8	0.7	-0.2	-2.1	-0.7
Diabetes (mother)	0.9	1.1	1.9	1.3	1.2	1.2	-0.7	-0.2	1.4	-0.9
Severe depression (siblings)	0.3	0.4	1.6	-0.7	-1.3	-0.4	0.5	0.3	-0.3	-0.2
Pack years adult smoking proportion	0.3	0.5	2.0	0.6	1.4	0.6	-0.1	-0.4	-0.5	0.5
Impedance of leg (right)	0.4	2.0	6.1	-1.9	-0.1	-2.5	-0.2	0.5	-2.0	0.1
Leg fat-free mass (left)	0.6	3.1	9.4	1.2	-2.1	0.6	-2.2	-3.1	0.2	-1.3
Trunk fat percentage	1.3	5.4	17.1	0.4	-1.5	-0.6	-3.5	-4.1	-2.3	-0.5
Hand grip strength (right)	0.4	1.0	4.8	0.6	0.1	0.7	-0.0	0.2	1.1	-2.2
Townsend deprivation index at recruitment	1.7	2.3	3.8	-1.3	2.0	-1.1	1.2	0.9	-2.0	1.8
Current tobacco smoking	0.2	0.4	1.1	0.7	-1.1	0.1	-0.4	-0.6	-0.7	-0.4
Average weekly fortified wine intake	0.5	0.6	1.6	-0.7	-0.6	-0.9	-1.3	-0.7	0.9	0.1
Maternal smoking around birth	0.2	0.3	1.1	0.4	1.0	-0.6	-0.0	-0.5	-0.5	0.5
Fed-up feelings	0.5	0.9	2.7	-0.5	-0.8	-1.6	-0.9	-1.1	-0.9	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.7	-1.0	-0.1	-1.0	0.4	0.1	-1.3	-0.3
Relative age voice broke	1.2	1.8	4.5	-1.8	0.4	-1.9	0.4	1.0	-2.1	-0.1
Taking other prescription medications	1.0	1.5	3.8	-1.4	-0.9	-1.1	-0.7	0.2	-2.0	1.5
Age when periods started (menarche)	0.3	0.8	4.1	-0.1	2.0	-0.1	-0.4	0.2	0.4	1.0
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	4.4	2.1	1.1	1.7	0.7	0.0	1.1	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.2	0.0	-0.7	-0.4	-0.8	0.1	-1.1	-1.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.1	1.4	0.7	0.8	0.3	-0.6	0.2	0.9
Qualifications: CSEs or equivalent	1.4	1.9	6.9	-1.1	-0.1	-2.6	-0.1	-1.4	-1.7	0.1
Serious illness, injury or assault to yourself	0.6	0.7	2.1	-0.9	0.2	-1.4	0.6	-0.4	-1.2	0.3
High blood pressure	0.2	0.5	1.7	0.1	-1.3	0.7	-0.1	0.3	-0.7	0.7
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.2	0.2	-0.8	0.4	1.1	0.2	0.2	-0.9
Multivitamins +/- minerals	0.8	1.0	2.5	-0.7	-0.0	-1.6	-0.2	-0.4	-1.4	-1.2
Stomach or abdominal pain in last month	0.1	0.1	0.6	-0.2	-0.8	0.3	-0.2	0.2	0.4	0.1
Supplements: Glucosamine	0.4	0.5	1.3	0.6	0.2	1.0	-0.2	-0.5	1.1	0.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	4.8	0.3	-1.0	0.8	-0.3	-2.2	0.6	0.4
Medication: Atenolol	0.7	0.8	3.1	1.5	-0.3	1.8	0.1	-0.2	0.4	0.1
Medication: Levothyroxine sodium	0.3	0.4	1.4	-1.1	0.1	-0.5	0.4	0.2	0.0	1.2
Sitting height	0.6	4.0	11.1	0.5	-1.6	-0.7	-2.6	-3.3	-0.6	-2.5
Chronic bronchitis/emphysema (father)	1.0	1.1	3.9	0.5	-1.5	-0.3	-1.2	-0.1	0.2	-2.0
High blood pressure (mother)	0.5	0.7	2.3	0.3	-0.7	0.3	-0.2	0.5	1.5	-1.2
Body mass index (BMI)	0.1	0.5	1.5	-0.0	0.2	0.4	-0.6	-1.2	-0.9	0.8
Impedance of leg (left)	0.5	2.2	5.9	-1.9	0.5	-2.4	0.2	0.5	-2.3	0.1
Leg predicted mass (left)	0.6	3.1	9.1	1.2	-2.1	0.6	-2.2	-3.0	0.3	-1.3
Trunk fat mass	1.0	4.5	15.5	0.4	-1.3	-0.4	-3.1	-3.9	-1.9	-0.5
Waist circumference	0.3	0.9	3.7	-1.0	-0.1	-0.6	-0.4	-0.8	-1.9	0.7
Number of incorrect matches in round	0.5	0.8	3.3	0.1	1.1	0.4	0.2	1.8	0.7	0.8
Past tobacco smoking	0.3	0.6	2.4	1.6	-0.0	0.9	-0.1	-1.0	0.4	0.0
Alcohol usually taken with meals	0.2	0.4	1.0	0.5	-1.0	-0.0	-0.8	-0.6	0.0	-0.6
Nervous feelings	0.1	0.1	0.5	-0.1	0.0	-0.4	0.3	-0.3	0.4	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.9	3.6	-0.5	-0.7	-0.4	-0.6	-1.9	0.0	-1.1
Hearing difficulty/problems with background noise	0.2	0.3	1.0	0.1	-0.8	0.1	-0.7	0.0	1.0	0.2
Hair/balding pattern: Pattern 2	1.2	1.6	3.5	-1.8	-1.9	-1.4	-0.1	1.5	-0.0	-0.4
Had menopause	0.4	0.5	1.5	-0.1	-1.1	0.9	0.2	0.5	1.2	0.1
Had other major operations	1.2	1.4	3.6	1.3	-0.4	1.4	-1.1	-1.9	0.6	-0.9
Forced vital capacity (FVC)	5.3	20.6	42.5	2.3	-4.8	-1.3	-6.5	-6.4	-0.6	-5.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	0.4	-0.5	0.7	-0.4	-0.0	-0.3	-0.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.5	-1.3	-0.4	-0.5	-0.2	1.3	0.2	1.6
Qualifications: None of the above	0.9	2.0	6.4	0.7	2.5	1.9	0.9	0.3	0.8	1.5
Financial difficulties in last 2 years	0.5	0.6	1.4	0.3	0.7	-1.0	1.1	-0.3	-1.2	-0.4
Mouth/teeth dental problems	0.3	0.5	1.2	0.2	0.6	0.1	1.1	1.1	0.4	0.8
Heart attack	0.5	0.6	1.4	0.4	0.6	1.1	-0.6	-0.9	0.2	1.2
Allergy	0.0	0.1	0.4	0.2	0.6	0.0	0.1	-0.0	0.1	0.1
Pain all over the body in last month	1.0	1.1	1.9	-1.1	1.4	-1.4	-0.7	-0.7	-1.1	0.4
Diabetes (self-reported)	0.5	0.8	2.2	-1.5	0.5	-1.1	0.3	0.6	-0.9	0.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.9	-0.8	-1.7	-0.8	0.4	0.5	-0.2	-0.0
Medication: Ramipril	0.9	1.1	1.9	0.6	0.9	0.9	-1.4	-1.1	-0.8	1.4
Medication: Simvastatin	0.9	1.3	4.8	0.6	-1.6	-0.5	-2.2	-1.0	-0.1	-0.1
Fluid intelligence score	0.6	1.3	3.2	-0.7	0.5	-1.5	1.8	-0.5	-1.6	-0.0
Illnesses of siblings	1.4	2.0	6.7	-2.6	-1.3	-1.6	-0.3	1.2	-1.2	0.6
Neuroticism score	0.1	0.3	1.1	-1.1	0.1	-0.8	0.1	0.2	0.4	0.1
Weight	0.5	2.2	9.0	0.5	-1.0	-0.1	-2.0	-3.0	-1.1	-0.6
Impedance of arm (right)	0.9	4.1	8.9	0.2	-2.1	-1.7	-2.9	-3.0	-1.4	-1.4
Arm fat percentage (right)	0.6	2.3	8.2	0.4	-1.0	0.2	-2.2	-2.9	-1.5	0.2
Trunk fat-free mass	0.1	0.8	1.6	0.8	-0.9	0.9	-0.7	-1.3	0.7	-0.7
Hip circumference	0.7	3.0	11.2	0.7	-1.2	0.3	-2.2	-3.3	-1.2	-1.1
Time employed in main current job	0.9	1.0	1.7	0.8	-1.0	-0.2	-1.2	-1.3	-1.2	-0.9
Alcohol intake versus 10 years previously	0.3	0.5	1.3	0.4	0.7	1.0	-0.5	-0.3	1.1	0.1
Father’s age at death	0.5	0.7	1.4	1.2	0.9	1.1	0.3	-0.4	1.1	0.1
Worrier / anxious feelings	0.6	1.1	3.8	-1.5	0.0	-1.9	0.7	0.6	-0.7	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.0	-1.2	0.3	-1.7	-0.0	-0.5	-1.6	1.3
Falls in the last year	2.3	3.2	6.0	-2.4	0.8	-2.4	1.3	2.1	-1.4	1.3
Hair/balding pattern: Pattern 3	0.8	1.2	2.0	1.2	1.4	1.3	-0.3	-1.3	1.0	0.8
Number of live births	2.3	3.3	8.8	0.5	-1.0	-0.3	-2.6	-3.0	-1.6	-1.7
Forced expiratory volume in 1-second (FEV1)	4.7	15.7	33.5	2.1	-4.1	-1.2	-5.4	-5.8	-0.9	-4.9
Pulse rate	1.3	2.3	4.1	-2.0	1.7	-0.3	1.6	1.8	-1.5	1.0
Happiness	0.3	0.4	0.9	-0.2	-0.8	-0.4	-1.0	-0.6	-0.5	0.5
Noisy workplace	0.5	0.6	1.2	-0.8	0.9	-0.7	1.1	0.7	-0.2	-0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.5	-1.1	-1.6	-1.3	0.7	0.5	-1.0	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.6	0.1	-0.9	-0.4	0.1	-0.5	0.1	-1.2
Mouth/teeth dental problems: Dentures	0.2	0.4	1.4	-0.5	-0.5	0.2	-0.2	-0.2	-1.2	-0.8
Asthma	1.2	2.4	6.6	-2.6	0.4	-2.2	1.1	1.1	-1.5	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.5	0.6	-1.1	0.8	-0.8	-1.9	-0.4	-0.6
Medication: Cholesterol lowering	0.6	0.9	1.8	1.4	-0.2	1.1	-1.1	-1.3	-0.1	0.3
Depression (self-reported)	0.7	0.9	1.9	1.3	0.9	1.2	1.4	-0.2	-0.0	0.5
Medication: Lansoprazole	0.3	0.3	1.3	0.5	-0.2	0.3	-0.7	-1.1	-0.0	0.3
Prospective memory result	0.8	1.0	3.6	0.6	-0.6	1.4	-1.9	-0.5	0.8	0.3
Lung cancer (father)	0.7	0.8	2.1	0.6	1.0	0.9	-0.5	-1.4	0.9	-0.3
Illnesses of mother	2.7	3.3	6.0	-2.0	0.7	-1.1	2.2	1.2	-2.4	2.3
Forced expiratory volume in 1-second (FEV1), Best measure	3.9	12.5	28.2	1.8	-3.9	-1.2	-5.3	-5.0	-0.8	-3.7
Pulse wave Arterial Stiffness index	1.1	1.3	2.8	-0.5	1.4	0.2	1.6	1.3	0.2	1.7
Impedance of arm (left)	1.1	5.2	10.8	0.2	-2.3	-2.0	-3.1	-3.3	-1.7	-2.0
Arm fat mass (right)	0.6	2.3	9.2	0.5	-0.9	0.2	-2.1	-3.0	-1.2	-0.0
Trunk predicted mass	0.2	0.9	1.7	0.9	-1.0	1.0	-0.8	-1.3	0.9	-0.7
Standing height	0.7	7.2	17.2	0.9	-2.8	-1.1	-3.5	-4.2	-0.7	-3.2
Length of working week for main job	0.5	0.5	1.5	-0.6	-0.0	-0.9	1.2	0.6	-0.7	-0.2
Exposure to tobacco smoke at home	0.6	0.7	2.3	1.4	0.6	1.5	-0.3	-0.4	0.1	0.1
Breastfed as a baby	0.3	0.3	0.7	-0.5	-0.7	-0.8	-0.4	-0.7	-0.2	-0.3
Tense / ‘highly strung’	1.2	1.9	3.6	-1.9	0.6	-1.4	0.9	1.8	-0.2	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.4	-0.1	-0.4	-1.2	0.3	-0.8	-0.9	0.1
Hair/balding pattern: Pattern 4	0.9	2.1	5.3	1.7	2.0	2.3	0.1	0.2	1.6	-0.2
Birth weight of first child	0.5	0.8	1.9	-0.5	-1.4	-0.9	-0.6	-1.3	-0.3	-0.9
Peak expiratory flow (PEF)	1.6	3.6	10.0	1.4	-1.4	-0.7	-1.2	-3.2	-1.5	-2.7
Pulse wave reflection index	1.4	1.7	7.4	-0.8	-2.7	-0.7	-1.6	-0.8	0.3	0.1
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.2	-1.1	0.2	-0.1	0.3	0.5	-0.2	1.0
Loud music exposure frequency	0.9	1.0	2.4	1.0	0.7	1.6	-0.2	-0.8	1.2	-0.8
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.6	-1.3	-1.3	-1.9	0.8	-0.6	-1.7	-0.9
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.0	0.9	0.3	1.4	0.2	-0.0	1.2	-0.2
Blood clot in the leg (DVT)	3.8	4.9	8.9	2.2	-2.9	1.7	-2.7	-3.0	0.7	-1.3
Medication: Paracetamol	0.4	0.7	2.6	-0.4	0.3	-0.8	1.1	-0.6	-1.6	0.1
Headache pain in last month	0.8	1.3	3.0	-1.5	-1.2	-1.7	1.3	0.4	-0.8	-0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.9	-0.1	-0.5	-0.8	0.2	0.3	0.4	-1.4
Glaucoma (self-reported)	0.3	0.3	1.1	-0.6	-0.2	-0.6	0.4	1.1	0.2	-0.0
Gout (self-reported)	0.4	0.5	1.1	-0.6	-1.1	-0.2	-0.0	0.8	0.7	0.9
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	1.0	-1.0	-0.2	0.1	0.1	0.1	0.4	0.4
Medication: Amlodipine	0.6	0.9	2.6	1.6	0.7	1.3	0.9	0.0	0.4	-0.6
Medication: Ventolin 100micrograms inhaler	1.5	2.0	6.4	-2.5	-1.1	-1.8	0.3	1.1	-1.1	0.6
Birth weight	0.4	0.9	1.9	-0.7	-0.2	-1.4	0.4	-1.1	-1.1	-1.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.2	-1.0	-0.0	-1.5	0.2	-0.1	-0.6	0.9
High blood pressure (siblings)	0.5	0.7	2.1	1.4	1.3	0.5	0.4	-0.6	-0.0	-0.8
Forced vital capacity (FVC), Best measure	4.2	15.3	38.1	2.1	-4.4	-1.2	-6.2	-5.3	-0.2	-4.0
Body fat percentage	0.9	3.6	10.7	-0.2	-1.1	-0.7	-2.6	-3.3	-2.4	0.1
Leg fat percentage (right)	0.4	1.4	4.2	-1.1	-0.2	-0.8	-1.1	-1.2	-2.1	1.0
Arm fat-free mass (right)	0.2	0.8	2.7	0.8	-0.6	0.7	-0.8	-1.6	0.4	-0.7
Exposure to tobacco smoke outside home	0.2	0.3	0.9	0.3	0.8	0.4	0.2	-0.9	-0.6	-0.2
Comparative body size at age 10	0.4	1.1	2.6	-0.7	0.3	-0.1	1.6	1.4	-0.2	1.6
Number of full brothers	0.2	0.2	1.1	0.1	0.4	-0.4	-0.0	-1.0	-0.5	0.1
Worry too long after embarrassment	0.3	0.6	1.4	-0.5	0.6	0.2	1.2	0.5	0.9	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.6	-0.5	0.5	-0.2	0.4	-1.2	0.0	1.3
Wheeze or whistling in the chest in last year	2.0	3.5	9.8	-3.1	0.5	-2.6	1.1	1.1	-2.2	0.8
Number of children fathered	1.0	1.1	2.0	-1.4	-1.2	-0.8	-0.4	-0.1	-1.2	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.7	7.3	2.7	-0.4	2.2	-0.9	-1.7	1.6	-0.7
Age at first live birth	0.3	0.5	1.0	-0.6	-0.6	-0.8	-0.7	0.7	1.0	-0.3
Pulse wave peak to peak time	1.6	1.8	4.0	0.7	-1.4	-0.4	-1.8	-1.7	-0.3	-2.0
Health satisfaction	0.6	0.7	1.6	-0.2	-0.1	0.1	-1.3	-1.2	-1.1	0.8
Shortness of breath walking on level ground	0.7	0.9	4.6	-0.5	-0.4	-0.5	-2.1	-0.7	-0.5	0.0
Qualifications: College or University degree	0.3	0.9	2.5	-0.5	-0.0	-0.0	0.9	1.6	1.6	-0.5
Eye problems/disorders: None of the above	0.3	0.4	1.1	0.3	-0.1	-0.4	1.0	0.4	-0.6	-1.1
Mouth/teeth dental problems: Loose teeth	0.7	0.9	2.3	0.9	1.5	0.2	-0.6	-1.5	-0.5	-0.5
Emphysema/chronic bronchitis	0.7	0.8	2.0	0.4	-1.1	0.2	-1.4	-1.3	0.4	-0.1
Medication for pain relief, constipation, heartburn	0.6	1.0	4.2	-0.4	0.2	-0.1	-0.4	1.6	2.1	0.1
Neck or shoulder pain in last month	1.4	2.0	4.2	-1.8	1.4	-2.0	1.3	1.5	-0.4	0.8
Medication: Blood pressure	0.3	0.5	1.3	0.4	0.7	1.1	-0.0	-0.1	-0.4	1.1
Angina (self-reported)	0.2	0.3	1.2	0.5	0.6	1.1	-0.1	-0.5	0.3	-0.1
Migraine (self-reported)	1.5	1.9	10.0	0.6	-3.2	0.9	-0.7	0.5	1.1	-0.5
Medication: Ibuprofen	0.4	0.4	1.3	0.4	-0.6	0.7	0.3	-1.1	-0.9	-0.1
Medication: Allopurinol	0.7	0.9	2.1	-1.2	-1.5	-0.9	-1.1	0.4	0.5	0.7
Medication: Omeprazole	1.3	1.6	5.6	-0.1	-2.4	-0.3	-0.8	-1.0	-1.9	-0.2
Medication: Seretide 50 evohaler	1.7	2.0	3.6	1.6	-0.3	1.5	-1.9	-0.3	1.6	-1.7
Mean time to correctly identify matches	0.4	0.7	1.7	0.9	0.0	1.3	0.2	0.5	1.2	0.9
Heart disease (mother)	0.3	0.3	1.4	0.3	0.1	-0.6	-0.6	-0.3	-0.4	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.3	0.8	0.5	1.1	1.0	0.9	0.9	0.8
Whole body fat mass	0.8	3.2	11.2	0.0	-1.1	-0.4	-2.5	-3.3	-1.9	-0.0
Leg fat mass (right)	0.3	1.2	2.9	-0.7	-0.2	-0.6	-1.2	-1.7	-1.7	0.7
Arm predicted mass (right)	0.1	0.5	2.7	0.5	-0.3	0.4	-0.6	-1.6	0.1	-0.4
Pulse rate, automated reading	0.3	1.0	4.4	-1.0	2.1	-0.7	0.1	0.2	-1.0	-0.4
Alcohol intake frequency.	0.1	0.2	0.6	0.1	-0.1	-0.1	-0.8	-0.8	0.2	-0.0
Comparative height size at age 10	0.6	3.1	6.2	-0.3	-2.5	-1.4	-2.5	-2.2	-0.2	-1.6
Number of full sisters	1.2	1.5	5.6	-0.1	-0.1	-2.4	0.2	-0.6	-2.1	-0.0
Suffer from ‘nerves’	1.0	1.5	2.8	1.1	-1.2	0.5	-1.7	-0.9	1.3	-1.5
Overall health rating	0.2	0.3	0.8	0.2	0.8	0.3	0.1	-0.8	0.3	0.9
Chest pain or discomfort	0.2	0.2	0.7	-0.2	-0.8	-0.2	0.2	-0.7	-0.2	0.7
Had major operations	0.4	0.5	0.9	0.8	0.1	0.9	0.0	-0.6	1.0	0.8
Age at last live birth	0.9	1.3	3.8	-0.7	-1.9	-1.3	-0.8	0.1	0.1	-1.6
Family relationship satisfaction	0.7	0.8	3.7	0.1	-0.6	-0.6	-1.1	-1.9	-0.2	0.3
Leg pain on walking	1.0	1.2	6.5	0.1	-1.0	-0.5	-2.5	-0.8	-0.4	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	6.5	-0.1	-0.3	-2.5	0.2	-0.5	-2.4	-1.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.3	0.7	0.7	0.5	-1.1	0.6	1.2	-0.2
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.8	-1.9	0.4	-1.0	-0.2	1.2	-0.1	1.2
Medication: Aspirin	0.4	0.5	1.6	0.3	0.8	1.0	0.2	0.1	0.3	1.3
Supplements: Vitamin C	1.1	1.3	2.8	-1.5	0.1	-1.7	1.1	0.8	-1.2	0.4
Knee pain experienced in last month	1.2	1.9	6.8	1.1	-0.8	0.5	-2.0	-2.6	-0.3	0.1
Hypertension (Self-reported)	0.1	0.4	1.6	-0.0	-1.2	0.4	-0.1	0.0	-0.7	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.9	-0.7	0.2	0.4	1.7	1.0	0.2	0.6
Illnesses of father: Heart disease	0.1	0.2	0.3	0.4	-0.5	0.4	0.5	0.3	0.5	0.1
Illnesses of siblings: Diabetes	1.0	1.2	3.3	-0.0	-1.3	-1.3	0.1	-0.8	-1.1	-1.8
Smoking status: Previous	0.9	1.3	4.2	-2.1	0.6	-1.1	0.9	1.4	-0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted	2.4	4.9	12.7	2.3	-1.6	0.4	-2.0	-2.8	1.2	-3.6
Whole body fat-free mass	0.3	1.5	4.4	1.0	-1.3	0.8	-1.3	-2.1	0.5	-0.9
Leg fat-free mass (right)	0.5	2.8	9.5	1.2	-1.8	0.6	-1.8	-3.1	0.2	-1.3
Arm fat percentage (left)	0.7	2.8	10.4	0.5	-0.9	-0.0	-2.2	-3.2	-1.7	-0.0
Average weekly red wine intake	0.5	0.8	2.0	0.7	-0.1	-0.9	0.9	-0.8	-1.4	-1.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.6	-0.2	0.6	-0.2	1.0	0.8	0.2	1.2
Mood swings	0.5	0.9	2.2	-0.9	1.5	-0.8	0.5	0.4	-0.3	1.4
Loneliness, isolation	0.4	0.6	2.6	0.4	0.1	-0.5	0.1	-1.6	-0.9	-0.6
Long-standing illness, disability or infirmity	0.4	0.6	2.0	-1.2	-0.2	-0.4	-0.3	0.0	-0.7	1.4
Ever had bowel cancer screening	0.4	0.4	2.0	-0.5	-1.4	0.0	-0.4	-0.2	-0.7	0.2
Diabetes diagnosed by doctor	0.6	0.9	2.8	-1.7	0.9	-1.2	0.3	0.3	-0.9	0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.9	-0.4	-0.5	0.8	-1.7	-0.0	1.6	1.1
Friendships satisfaction	0.4	0.5	1.6	-0.2	-1.3	0.1	-0.9	-0.5	0.7	0.2
Qualifications: nursing, teaching	1.7	2.6	7.6	1.8	-0.6	2.8	-0.4	-0.5	2.5	-0.5
Commuting to job workplace: Walk	0.7	0.7	1.6	0.5	-0.8	-0.1	0.6	0.7	1.2	-1.3
Eye problems/disorders: Cataract	0.2	0.3	0.6	-0.7	-0.5	-0.2	-0.5	-0.0	-0.6	0.8
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.9	-1.0	-0.8	-1.4	-1.1	-1.2	-0.9	-0.3
Medication for cholesterol	0.3	0.4	1.6	0.4	-0.2	0.6	-0.3	0.8	0.4	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.9	1.0	0.6	0.7	0.3	-0.7	0.2	-0.3
Back pain experienced in last month	0.9	1.2	4.3	-1.2	0.7	-0.1	2.1	1.2	-0.0	1.0
Mineral and other dietary supplements	0.3	0.4	1.1	-0.3	-0.2	-0.3	1.1	0.9	-0.0	-0.7
Breast cancer (self-reported)	1.8	2.1	7.9	1.6	0.6	2.8	-0.1	-0.6	1.9	-0.2
Asthma (self-reported)	1.4	2.7	7.4	-2.7	0.6	-2.2	1.3	1.5	-1.5	0.7
Osteoporosis (self-reported)	1.8	2.2	5.5	-0.2	-1.6	-1.1	-1.4	-2.4	-2.0	0.1
Osteoarthritis (self-reported)	0.5	0.6	1.2	-0.5	-0.8	-0.2	-1.0	-1.1	-1.1	0.2
Medication: Aspirin	0.3	0.4	1.6	-0.1	0.4	0.8	0.2	-0.1	-0.3	1.3
Medication: Gliclazide	2.2	2.5	6.1	-1.0	2.2	-0.4	1.6	1.7	0.4	2.5
Illnesses of father: None of the above (group 1)	0.6	0.8	2.1	0.7	1.0	1.5	-0.2	-0.7	-0.2	1.2
Smoking status: Current	0.2	0.3	0.9	0.9	-0.8	0.4	-0.3	-0.2	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.3	11.6	1.1	-2.2	-1.1	-3.4	-3.3	-0.9	-2.6
Whole body water mass	0.3	1.6	4.5	1.1	-1.3	0.8	-1.3	-2.1	0.6	-0.9
Leg predicted mass (right)	0.5	2.7	9.3	1.2	-1.7	0.6	-1.8	-3.1	0.2	-1.3
Arm fat mass (left)	0.6	2.5	9.3	0.6	-1.0	0.1	-2.2	-3.0	-1.4	-0.2
Number of self-reported non-cancer illnesses	0.8	1.4	3.6	-1.4	-1.9	-1.0	-0.6	0.4	-1.0	1.4
Average weekly champagne plus white wine intake	0.8	1.0	3.0	-0.9	-1.7	-1.2	-1.1	0.1	-0.9	-0.4
Miserableness	0.6	1.0	4.4	-0.0	2.1	-0.3	1.5	0.2	0.5	0.0
Guilty feelings	0.4	0.6	2.2	0.4	-0.5	0.2	-0.4	-1.5	1.1	-0.6
Wears glasses or contact lenses	0.4	0.4	1.2	-0.3	0.7	1.0	1.1	0.2	-0.2	0.2
Ever taken oral contraceptive pill	0.1	0.1	0.3	0.0	0.4	-0.5	0.1	0.5	0.1	-0.5
Hearing aid user	0.4	0.4	2.4	-0.1	0.7	0.1	-0.3	-0.4	-1.5	0.3
Mother’s age at death	0.1	0.1	0.2	-0.4	0.3	-0.4	0.1	0.5	0.2	0.1
Financial situation satisfaction	1.4	1.7	3.7	0.7	-1.8	0.4	-1.9	-1.6	0.1	-1.4
Tinnitus: Yes, now most or all of the time	2.7	3.1	8.8	-2.5	-0.3	-1.2	1.7	3.0	-0.4	1.4
Commuting to job workplace: Public transport	0.2	0.3	0.7	0.1	0.4	-0.4	0.5	-0.8	-0.7	0.2
Eye problems/disorders: Glaucoma	0.2	0.2	0.8	-0.4	0.2	-0.4	-0.1	0.9	0.5	-0.2
Medication: Blood pressure	0.4	0.8	2.0	0.4	-1.4	-0.4	-1.1	-1.4	-0.5	-0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.4	0.3	-0.2	0.4	-1.2	-0.7	0.2	1.0
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.5	-0.6	-0.5	-0.2	-0.5	0.3	-0.2	0.7
High cholesterol (Self-reported)	0.2	0.4	1.7	0.0	0.3	-0.3	-0.8	-1.3	-0.3	-0.3
Medication: Bendroflumethiazide	0.1	0.2	0.4	0.1	-0.6	0.6	-0.4	-0.3	-0.5	-0.0
Medication: Paracetamol	0.8	1.2	4.3	0.3	1.2	-0.5	2.1	-0.4	-1.5	0.3
Medication: Lisinopril	0.7	0.9	2.4	0.6	0.5	0.6	1.5	0.6	1.4	1.0
Medication: Atorvastatin	0.9	1.1	4.7	0.1	2.2	0.5	1.3	-0.3	-0.1	1.0
Illnesses of father: High blood pressure	0.8	1.0	1.8	-1.3	1.3	-0.9	1.0	1.0	-0.8	0.1
Alcohol drinker status: Never	2.0	2.4	9.7	0.4	-0.7	-1.1	-1.0	-3.1	-1.2	-1.7
Ever smoked	0.0	0.1	0.2	-0.2	-0.4	0.0	-0.3	0.2	0.3	-0.4
Basal metabolic rate	0.3	1.9	6.2	1.0	-1.4	0.7	-1.6	-2.5	0.2	-1.0
Leg fat percentage (left)	0.4	1.4	4.9	-1.1	0.2	-0.7	-0.8	-1.1	-2.2	1.2
Arm fat-free mass (left)	0.2	0.9	3.1	0.7	-1.0	0.7	-1.0	-1.8	0.1	-0.5
Number of operations (self-reported)	2.6	3.9	9.3	2.8	-0.8	2.6	-1.3	-3.0	0.7	-0.7
Average weekly beer plus cider intake	0.0	0.1	0.3	-0.1	-0.6	-0.1	0.0	-0.3	0.1	0.1
Irritability	0.2	0.3	0.7	-0.7	0.4	-0.8	-0.0	-0.3	-0.4	0.6
Risk taking	1.4	2.0	4.6	-1.0	1.9	-0.3	1.9	0.8	-0.5	2.1
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.2	-1.8	-1.5	-1.7	-0.1	1.2	-0.6	-0.1
Fractured/broken bones in last 5 years	0.8	1.0	2.6	-1.3	0.6	-1.1	0.7	-0.0	-1.6	0.7
Age started oral contraceptive pill	0.6	0.8	1.9	-0.3	1.4	0.4	0.7	0.6	0.6	1.4
Diastolic blood pressure, automated reading	4.0	12.3	23.2	2.0	-4.8	2.0	-4.4	-2.9	2.0	-4.8
Ever depressed for a whole week	1.0	1.2	2.3	-1.5	-0.9	-1.4	0.3	0.7	-1.4	0.8
Unable to work because of sickness or disability	0.9	1.1	2.3	-0.9	1.5	-1.2	1.1	-0.5	-1.0	0.8
Commuting to job workplace: Cycle	0.3	0.3	0.9	0.1	0.7	-0.1	0.9	0.5	0.2	0.9
Myopia	0.9	1.3	5.4	-0.2	-2.3	-0.7	-0.4	0.6	0.3	-1.7
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.3	0.0	1.1	-0.9	0.3	-0.0	0.5	-1.0
Cholesterol lowering medication	0.3	0.4	1.8	-0.2	0.3	0.0	-0.4	-0.4	0.6	1.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.4	0.3	-1.5	0.3	-0.4	-0.4	-1.1	0.5
Pain experienced in last month	1.9	3.1	8.7	3.0	0.2	2.7	-0.8	-0.8	1.9	-0.9
Supplements: Calcium	1.0	1.1	3.8	-1.0	0.5	-1.3	-0.1	-0.8	-1.9	0.4
Basal cell carcinoma (self-reported)	1.0	1.2	2.9	-1.5	0.1	-1.7	1.0	0.7	-1.2	0.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.3	0.5	0.4	1.2	-0.8	-1.0	0.2	1.0
Deep venous thrombosis (DVT) (self-reported)	4.1	5.3	9.8	2.2	-3.1	1.7	-3.0	-2.9	0.9	-1.4
Heart disease (siblings)	1.4	1.7	2.7	1.6	-0.4	1.2	-1.6	-1.2	1.0	-1.6
Alcohol drinker status: Previous	0.4	0.5	0.8	-0.8	0.8	-0.8	-0.5	0.3	-0.6	0.9
Pack years of smoking	0.3	0.5	1.7	0.4	1.3	0.7	0.0	-0.0	-0.4	0.9
Impedance of whole body	0.6	3.0	5.0	-0.6	-1.3	-2.2	-2.0	-2.0	-2.1	-1.3
Leg fat mass (left)	0.3	1.2	3.0	-0.6	0.1	-0.5	-1.0	-1.7	-1.7	0.8
Arm predicted mass (left)	0.1	0.7	2.2	0.4	-1.1	0.6	-0.9	-1.5	0.3	-0.3