Best TWAS P=2.31e-15 · Best GWAS P=2e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | NDUFB2 | 0.06 | 0.02 | lasso | 3 | 0.03 | 1.4e-03 | 5.4 | -5.7 | 1.0e-08 | -0.44 | 0.22 | 0.38 | TRUE |
| 2 | GTEx | Esophagus Mucosa | MRPS33 | 0.14 | 0.06 | lasso | 8 | 0.06 | 6.1e-05 | 5.7 | -5.9 | 3.5e-09 | -0.52 | 0.24 | 0.62 | TRUE |
| 3 | GTEx | Esophagus Muscularis | NDUFB2-AS1 | 0.08 | 0.00 | enet | 11 | 0.00 | 3.5e-01 | 5.6 | -6.7 | 1.9e-11 | -0.48 | 0.10 | 0.22 | TRUE |
| 4 | GTEx | Muscle Skeletal | NDUFB2 | 0.13 | 0.06 | lasso | 8 | 0.05 | 1.1e-05 | 5.5 | -6.1 | 9.1e-10 | -0.45 | 0.77 | 0.04 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | MRPS33 | 0.10 | 0.06 | lasso | 5 | 0.03 | 1.7e-03 | 5.7 | -5.3 | 1.2e-07 | -0.55 | 0.53 | 0.17 | TRUE |
| 6 | METSIM | Adipose | MRPS33 | 0.06 | 0.01 | lasso | 13 | 0.03 | 3.2e-05 | 5.9 | -6.2 | 4.0e-10 | -0.49 | 0.80 | 0.08 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | NDUFB2 | 0.05 | 0.05 | enet | 9 | 0.04 | 7.4e-06 | 5.2 | -6.0 | 2.5e-09 | -0.39 | 0.98 | 0.00 | FALSE |
| 8 | YFS | Blood | BRAF | 0.01 | 0.02 | enet | 2 | 0.01 | 1.6e-04 | 7.9 | 7.9 | 2.3e-15 | 1.00 | 0.00 | 1.00 | TRUE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MRPS33 | 0.03 | 0.05 | blup | 28 | 0.04 | 1.7e-09 | 5.7 | -5.4 | 5.5e-08 | -0.57 | 0.77 | 0.23 | FALSE |
| 10 | The Cancer Genome Atlas | Esophageal Carcinoma | MRPS33 | 0.09 | 0.04 | blup | 28 | 0.07 | 4.0e-03 | 7.7 | -6.7 | 2.3e-11 | -0.60 | 0.00 | 0.86 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NDUFB2 | 0.07 | 0.03 | blup | 26 | 0.04 | 6.6e-05 | 5.9 | -7.2 | 4.9e-13 | -0.54 | 0.00 | 0.98 | TRUE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NDUFB2 | 0.04 | 0.04 | lasso | 4 | 0.05 | 7.0e-06 | 4.7 | -5.3 | 1.3e-07 | -0.34 | 0.04 | 0.95 | FALSE |
| 13 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MRPS33 | 0.03 | 0.01 | blup | 29 | 0.01 | 3.5e-02 | 5.8 | -5.8 | 5.9e-09 | -0.60 | 0.01 | 0.37 | FALSE |
| 14 | The Cancer Genome Atlas | Thyroid Carcinoma | ADCK2 | 0.05 | 0.03 | lasso | 2 | 0.03 | 1.1e-03 | 5.2 | 5.2 | 2.6e-07 | 0.35 | 0.08 | 0.53 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | MRPS33 | 0.06 | 0.07 | blup | 28 | 0.08 | 6.8e-08 | 5.7 | -5.5 | 4.5e-08 | -0.58 | 0.15 | 0.85 | FALSE |