TWAS hub - BRAF

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0770	0.0300	0.0030	0.000	0.006	0.001	0.006	-0.002	3.5e-01	0.057	0.22000	0.055	0.6900
2	ROSMAP	Brain Pre-frontal Cortex	0.0315	0.0142	0.0042	0.019	0.008	0.006	0.011	0.009	1.4e-03	0.025	0.04700	0.012	0.0200
3	YFS	Blood	0.0111	0.0060	0.0100	0.018	0.004	0.010	0.003	0.005	8.3e-07	0.012	0.00016	0.030	0.0064

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Lung FVC	5.5	27.8	62.7	1.9	-4.1	7.9
Forced vital capacity (FVC), Best measure	5.0	18.3	39.5	-0.4	-3.9	6.3
Forced vital capacity (FVC)	4.9	18.7	41.6	1.0	-3.7	6.5
Bipolar Disorder (2011)	4.3	4.1	12.2	-0.2	0.3	-3.5
Type 2 Diabetes (T2D) (2012)	4.1	4.7	11.0	-1.3	-3.3	1.2
Other serious medical condition/disability diagnosed by doctor	4.1	5.4	9.0	-3.0	-0.3	-2.6
Hand grip strength (left)	4.0	10.4	24.0	-0.8	-2.6	4.9
Bipolar Disorder (2018)	3.9	6.1	17.6	0.4	0.8	-4.2
Alzheimer’s Disease (in mother)	3.9	4.6	7.6	1.7	2.8	-1.8
Comparative body size at age 10	3.8	10.5	14.4	1.9	3.8	-3.7
Bipolar Disorder or Schizophrenia	3.7	9.0	26.5	0.6	0.0	-5.2
Ever depressed for a whole week	3.6	4.4	9.4	-0.6	1.8	-3.1
Relative age of first facial hair	3.3	6.8	14.9	0.7	-2.2	3.9
Forced expiratory volume in 1-second (FEV1)	3.3	11.1	23.2	1.5	-2.8	4.8
Long-standing illness, disability or infirmity	3.3	5.0	11.1	-3.3	0.3	-1.9
Hayfever, allergic rhinitis or eczema	3.2	7.0	10.1	3.2	1.7	-2.8
Forced expiratory volume in 1-second (FEV1), Best measure	3.2	10.1	21.9	0.1	-2.9	4.7
Friendships satisfaction	3.2	4.0	7.2	0.6	-2.1	-2.7
Commuting to job workplace: Cycle	3.2	3.9	7.5	2.7	2.0	-0.6
Cardiovascular Disease	3.1	10.2	12.7	-3.0	-2.9	-3.6
Number of treatments/medications taken	3.1	5.6	11.2	-2.3	-0.2	-3.4
Had menopause	3.1	3.9	9.0	-0.4	-1.6	3.0
Ever unenthusiastic/disinterested for a whole week	3.1	3.8	10.0	-1.1	0.1	-3.2
Medication: Lansoprazole	3.1	3.5	5.6	-2.4	-2.2	-0.5
Breastfed as a baby	3.0	3.7	7.9	2.8	1.7	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	3.0	4.6	11.6	-1.5	0.1	-3.4
Overall health rating	3.0	6.4	11.1	-3.3	0.8	-2.7
Schizophrenia vs Biploar Disorder	2.9	3.9	7.8	-1.7	-1.0	2.8
Severe depression (siblings)	2.8	3.2	6.1	0.7	1.7	-2.5
Alcohol intake versus 10 years previously	2.8	4.1	9.0	-3.0	-1.5	-1.1
Medication: Aspirin	2.7	3.5	7.3	-2.7	-1.3	-1.2
Miserableness	2.7	4.7	12.8	-1.0	0.4	-3.6
Tense / ‘highly strung’	2.6	4.3	12.5	0.0	0.5	-3.5
Number of self-reported non-cancer illnesses	2.6	4.5	11.9	-1.2	-0.5	-3.4
Heart disease (siblings)	2.6	3.1	8.6	-2.9	-0.7	-0.6
Age at First Birth	2.5	3.6	7.0	1.7	-0.9	2.6
Fed-up feelings	2.5	4.5	11.6	0.0	1.4	-3.4
Neuroticism score	2.5	5.2	15.1	0.6	-0.3	-3.9
Family relationship satisfaction	2.5	3.0	8.7	0.5	-0.4	-2.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	4.1	-1.7	1.3	-2.0
Medication: Seretide 50 evohaler	2.4	2.8	6.0	1.5	2.4	-0.1
Age at first live birth	2.3	4.1	9.4	3.1	0.7	1.6
Medication: Aspirin	2.3	3.0	5.9	-2.4	-1.2	-1.3
Depressed Affect (Nagel 2018)	2.2	4.7	13.2	-0.8	0.1	-3.6
Alzheimer’s Disease (including proxy)	2.2	3.3	5.8	1.6	2.4	-1.2
Type 2 Diabetes (T2D) (2018)	2.2	4.2	6.6	-2.6	-2.0	-1.4
Frequency of depressed mood in last 2 weeks	2.2	3.1	7.7	1.2	0.5	-2.8
Happiness	2.2	2.6	6.6	1.0	0.6	-2.6
Heart disease (mother)	2.2	2.6	4.9	-1.7	-2.2	-0.2
Neuroticism	2.1	5.2	14.5	1.0	0.1	-3.8
Hand grip strength (right)	2.1	5.8	12.3	-0.3	-2.2	3.5
Qualifications: O levels/GCSEs or equivalent	2.1	3.3	4.8	2.2	0.8	-2.1
Medication for pain relief, constipation, heartburn	2.1	3.5	5.9	2.1	-0.6	2.4
Alcohol intake frequency.	2.1	4.9	7.6	-2.6	-0.0	-2.8
Age at last live birth	2.1	3.1	8.4	2.9	-0.0	0.9
Hypertension (Self-reported)	2.1	5.8	6.7	-2.6	-2.4	-2.2
Medication: Gliclazide	2.1	2.4	6.6	-0.7	-2.6	0.4
Illnesses of father: None of the above (group 1)	2.1	2.6	4.9	2.2	1.0	-1.4
Diverticular disease/diverticulitis (self-reported)	2.0	2.3	4.9	-2.2	-1.3	-0.6
Past tobacco smoking	2.0	3.8	5.9	2.3	2.4	0.1
Trunk fat-free mass	2.0	11.7	17.4	-1.6	-4.2	3.9
Medication: Cholesterol lowering	2.0	3.0	5.1	-2.0	-2.3	0.4
Trunk predicted mass	2.0	11.5	17.3	-1.5	-4.2	3.9
Medication: Paracetamol	2.0	3.3	8.5	-0.8	0.8	-2.9
Medication: Blood pressure	2.0	3.8	5.9	-2.3	-0.5	-2.4
Current tobacco smoking	1.9	3.2	4.0	-1.6	-1.7	-2.0
Allergy	1.9	4.3	5.7	-2.3	-1.5	2.4
Pain all over the body in last month	1.9	2.0	5.3	0.1	0.8	-2.3
Falls in the last year	1.9	2.5	6.7	-2.6	-0.7	0.6
Standing height	1.9	18.6	38.4	-0.4	-4.2	6.2
Ever highly irritable/argumentative for 2 days	1.9	2.2	6.2	-0.3	0.7	-2.5
Smoking status: Current	1.9	3.0	3.4	-1.7	-1.6	-1.9
Medication: Bendroflumethiazide	1.9	2.8	3.8	-1.9	-1.1	-1.9
Neuroticism (Nagel 2018)	1.8	4.2	12.0	0.6	-0.4	-3.5
Schizophrenia (2018)	1.8	3.7	10.5	0.5	-0.6	-3.2
Allergy or Eczema	1.8	4.6	9.4	1.7	1.4	-3.1
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	5.1	2.0	2.2	0.4
Leg fat percentage (right)	1.8	6.4	11.0	-3.3	-0.5	-2.8
Eye problems/disorders: None of the above	1.8	2.1	5.1	0.7	0.9	-2.3
Pulse rate, automated reading	1.8	5.9	14.1	-0.5	-3.8	-1.9
Leg fat percentage (left)	1.8	6.7	10.7	-3.3	-0.6	-3.0
Arm fat-free mass (left)	1.8	8.9	16.6	-2.1	-4.1	2.3
Leg fat mass (left)	1.8	6.9	13.9	-3.7	-1.3	-2.2
Neuroticism (2016)	1.7	2.5	5.6	-0.3	1.3	-2.4
Smoking Status	1.7	4.2	8.2	-1.9	-0.7	-2.9
Chronotype (morning person)	1.7	3.9	10.4	1.1	0.3	3.2
Average weekly spirits intake	1.7	2.1	5.5	-0.1	-0.8	2.3
Sensitivity / hurt feelings	1.7	3.0	8.4	0.3	0.7	-2.9
Chronic bronchitis/emphysema (father)	1.7	2.0	4.3	-2.1	-1.0	-0.8
Migraine (self-reported)	1.7	2.1	4.6	-1.3	-2.1	-0.0
Leg fat mass (right)	1.7	6.7	14.0	-3.7	-1.4	-2.0
Illnesses of father: Heart disease	1.7	2.4	5.2	-0.8	-2.3	1.1
Tinnitus: Yes, now most or all of the time	1.7	2.0	4.1	0.6	1.2	-2.0
Diastolic blood pressure, automated reading	1.7	5.2	7.4	-1.7	-2.3	-2.7
Supplements: Calcium	1.7	1.9	3.0	1.1	1.2	1.7
Crohns Disease (2012)	1.6	2.6	5.2	-2.3	-0.5	1.6
Medication: Metformin	1.6	2.2	5.3	-2.3	-1.1	-0.3
High blood pressure	1.6	4.5	5.7	-2.1	-2.4	-1.9
Body mass index (BMI)	1.6	6.6	10.7	-3.3	-0.5	-3.0
Mouth/teeth dental problems: Dentures	1.6	2.7	6.6	-2.6	-0.9	0.8
Body fat percentage	1.6	6.2	9.9	-2.9	0.0	-3.1
Arm fat-free mass (right)	1.6	8.3	14.9	-2.2	-3.9	2.2
Wheeze or whistling in the chest in last year	1.6	2.8	8.0	-0.6	0.3	-2.8
Mood swings	1.6	2.9	7.7	-0.9	0.3	-2.8
Commuting to job workplace: Walk	1.6	1.7	3.1	1.8	1.4	-0.2
Irritability	1.6	2.8	5.9	1.5	-0.3	-2.4
Arm predicted mass (left)	1.6	8.0	14.1	-2.3	-3.8	2.1
Ever used hormone-replacement therapy (HRT)	1.5	1.9	5.4	-2.3	-0.0	0.4
Diabetes (father)	1.5	1.9	2.9	-1.6	-0.5	-1.7
Trunk fat percentage	1.5	5.8	9.7	-2.8	0.4	-3.1
Alcohol usually taken with meals	1.5	2.4	5.5	2.4	1.3	-0.4
Nervous feelings	1.5	2.9	6.4	1.4	0.5	-2.5
Neck or shoulder pain in last month	1.5	2.1	3.8	0.2	1.6	-2.0
Whole body fat-free mass	1.5	8.4	13.3	-2.0	-3.6	2.8
Loneliness, isolation	1.5	2.1	4.5	-0.4	-1.3	-2.1
Whole body water mass	1.5	8.3	13.4	-1.9	-3.7	2.8
Mother’s age at death	1.5	1.9	4.2	1.2	2.0	0.3
Age started oral contraceptive pill	1.5	1.9	2.7	-1.0	-1.4	1.6
Vascular/heart problems diagnosed by doctor	1.5	4.0	4.7	2.2	2.0	1.9
Breast Cancer	1.4	3.5	5.7	2.2	2.4	0.0
HbA1C	1.4	1.6	4.0	0.6	-0.6	-2.0
Schizophrenia (2014)	1.4	3.1	9.1	0.2	-0.4	-3.0
BMI	1.4	8.4	14.5	-3.8	-1.8	-2.7
Height	1.4	26.8	60.4	-1.5	-4.2	7.8
Age when periods started (menarche)	1.4	3.3	7.0	-1.0	-1.4	2.6
Lung cancer (father)	1.4	1.7	3.0	-1.7	-0.4	-1.4
Angina (self-reported)	1.4	1.9	3.2	-1.8	-1.6	-0.2
Whole body fat mass	1.4	5.7	12.2	-3.5	-1.2	-1.8
Arm predicted mass (right)	1.4	7.3	13.2	-2.0	-3.6	2.2
Arm fat percentage (left)	1.4	5.7	9.3	-2.7	0.5	-3.0
Diabetes diagnosed by doctor	1.4	2.4	5.3	-2.3	-1.0	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	4.8	1.3	-1.5	2.2
Medication: Paracetamol	1.4	2.1	4.4	-1.4	-0.2	-2.1
Ever smoked	1.4	2.4	3.8	-2.0	-1.7	0.6
Myopia	1.4	2.0	4.0	1.4	2.0	-0.4
Cholesterol lowering medication	1.4	2.1	5.9	-2.4	-0.7	-0.1
Arm fat percentage (right)	1.3	5.0	7.7	-2.8	-0.0	-2.7
Pulse wave Arterial Stiffness index	1.3	1.6	2.4	-0.0	-1.6	1.5
Medication: Ventolin 100micrograms inhaler	1.3	1.6	2.1	1.4	1.5	-0.8
Birth weight	1.3	2.8	4.6	2.1	1.9	0.4
Qualifications: College or University degree	1.3	4.1	7.3	2.7	1.9	1.3
Medication: Blood pressure	1.3	2.2	3.6	-1.3	-1.9	-1.2
High cholesterol (Self-reported)	1.3	2.3	3.2	-1.8	-1.4	-1.4
Depression (Nagel 2018)	1.2	1.8	3.3	0.7	-1.3	-1.8
Angina	1.2	1.6	2.9	-1.7	-1.3	-0.3
Mouth/teeth dental problems	1.2	1.8	4.8	2.2	-0.2	0.8
Arm fat mass (right)	1.2	5.0	10.1	-3.2	-1.2	-1.9
High blood pressure (siblings)	1.2	1.8	2.9	-1.3	-0.8	-1.7
Number of children fathered	1.2	1.3	3.2	-0.7	0.5	-1.8
Medication for cholesterol	1.2	1.8	4.0	2.0	0.0	1.2
Eye problems/disorders: Glaucoma	1.2	1.4	3.0	0.5	0.9	1.7
Basal metabolic rate	1.2	6.6	10.6	-2.3	-3.2	2.0
Average weekly beer plus cider intake	1.2	1.7	2.4	-0.7	-1.5	-1.5
Worry (Nagel 2018)	1.1	2.3	4.5	1.0	-1.2	-2.1
Ulcerative Colitis	1.1	1.6	3.6	-1.9	0.0	-1.1
Waist Hip Ratio (WHR)	1.1	4.8	9.2	-0.7	-3.0	2.1
Relative age voice broke	1.1	1.6	4.8	0.1	-0.3	2.2
Serious illness, injury or assault to yourself	1.1	1.4	2.4	-1.5	-0.4	-1.3
Multivitamins +/- minerals	1.1	1.4	1.8	1.3	1.3	0.9
Diabetes (self-reported)	1.1	1.7	2.9	-1.7	-1.4	-0.5
Time employed in main current job	1.1	1.3	2.0	0.2	-1.4	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.8	0.3	0.6	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.6	-0.7	-0.4	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.0	1.4	-0.3	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	1.8	-0.8	1.4	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	2.8	-1.3	-1.7	1.5
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	2.3	1.1	1.5	-1.3
Arm fat mass (left)	1.1	4.5	8.8	-3.0	-1.0	-1.9
Mean Putamen Volume	1.0	1.2	3.4	-0.3	-1.8	-0.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.1	-0.4	-1.8	0.1
Sitting height	1.0	7.3	13.3	-0.2	-2.9	3.6
Trunk fat mass	1.0	4.5	9.3	-3.0	-0.8	-1.9
Waist circumference	1.0	3.8	8.1	-2.9	-1.5	-1.0
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.6	1.9	0.4	0.3
Weight	1.0	4.7	9.4	-3.1	-2.2	-0.0
Hair/balding pattern: Pattern 3	1.0	1.4	3.7	0.5	-0.6	1.9
Qualifications: A levels/AS levels or equivalent	1.0	2.3	6.2	2.5	0.8	0.1
Headache pain in last month	1.0	1.6	2.8	-1.1	1.0	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	1.4	0.9	0.9	-1.2
Medication: Atorvastatin	1.0	1.2	3.2	-1.8	-0.7	-0.0
Systolic blood pressure, automated reading	0.9	2.5	3.8	-1.9	-1.3	-1.4
Leg fat-free mass (left)	0.9	4.5	6.1	-2.5	-2.4	1.3
Maternal smoking around birth	0.9	1.2	2.7	-0.5	0.9	-1.6
Taking other prescription medications	0.9	1.4	2.5	-1.2	0.4	-1.6
Medication: Atenolol	0.9	1.1	1.5	-1.2	-0.9	-1.0
Leg predicted mass (left)	0.9	4.5	6.0	-2.4	-2.4	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.2	1.5	-0.6	-1.3
Father’s age at death	0.9	1.2	2.0	1.4	0.5	1.2
Number of live births	0.9	1.2	3.3	1.8	0.5	0.4
Asthma	0.9	1.8	3.3	1.3	1.8	-0.7
Medication: Amlodipine	0.9	1.3	2.7	-1.6	-0.3	-1.1
Worry too long after embarrassment	0.9	1.4	3.2	1.1	0.2	-1.8
Pulse wave peak to peak time	0.9	1.1	1.9	-0.0	1.4	-1.2
Shortness of breath walking on level ground	0.9	1.1	1.5	1.1	0.7	-1.2
Comparative height size at age 10	0.9	4.8	7.5	-1.3	-2.3	2.7
Suffer from ‘nerves’	0.9	1.4	1.8	1.2	-1.3	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.9	-1.2	-0.0	-1.4
Supplements: Vitamin C	0.9	1.0	2.1	1.4	0.6	-0.8
Handedness (chirality/laterality): Left-handed	0.9	1.0	1.4	1.2	-0.8	1.0
Back pain experienced in last month	0.9	1.3	2.8	-1.7	-1.1	-0.3
Osteoporosis (self-reported)	0.9	1.1	1.5	-0.8	-1.2	-1.0
Number of operations (self-reported)	0.9	1.3	2.2	-0.8	1.5	-1.1
Fractured/broken bones in last 5 years	0.9	1.2	3.5	-1.9	-0.4	-0.1
Ovarian Cancer	0.8	1.1	2.2	0.8	1.5	-0.7
LDL Cholesterol	0.8	1.2	3.5	-1.9	-0.4	-0.1
Primary Biliary Cirrhosis	0.8	1.1	2.8	-1.7	-0.6	-0.3
Triglycerides	0.8	1.3	3.7	-0.3	-1.9	0.3
Lung FEV1/FVC ratio	0.8	4.0	7.3	1.1	1.9	-2.7
Medication: Allopurinol	0.8	1.0	1.5	-1.2	-0.9	-0.9
Commuting to job workplace: Car/motor vehicle	0.8	1.0	2.6	-0.1	-1.6	0.5
Asthma (self-reported)	0.8	1.5	2.2	1.4	1.5	-0.6
Leg predicted mass (right)	0.8	4.1	5.7	-2.0	-2.4	1.6
Basal cell carcinoma (self-reported)	0.8	0.9	1.3	0.5	1.1	1.1
Fasting Glucose	0.7	0.8	2.4	-1.5	-0.2	0.1
Blood White Count	0.7	5.4	9.0	-2.6	-0.6	-3.0
Ever had hysterectomy (womb removed)	0.7	0.7	1.2	1.0	0.4	1.1
Medication for hormone replacement therapy	0.7	0.7	2.1	0.2	0.2	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.6	-0.2	-1.1	-1.3
Had other major operations	0.7	0.9	0.9	-0.9	1.0	0.9
Hip circumference	0.7	3.2	7.6	-2.8	-0.4	-1.3
Impedance of arm (left)	0.7	3.5	8.4	1.2	2.9	-0.7
Pulse wave reflection index	0.7	0.8	1.9	-0.6	-0.3	1.4
Illnesses of siblings: Diabetes	0.7	0.8	1.5	0.4	1.2	0.9
Leg fat-free mass (right)	0.7	4.0	5.5	-2.0	-2.4	1.5
Average weekly red wine intake	0.7	1.1	2.7	1.6	0.4	-0.6
Commuting to job workplace: Public transport	0.7	0.8	0.9	1.0	0.8	-0.9
Risk taking	0.7	1.0	2.9	-1.7	-0.5	0.2
Alcohol drinker status: Previous	0.7	0.8	0.9	-0.9	1.0	-0.8
Irritable Bowel Disease (IBD)	0.6	1.4	3.7	-1.9	-0.4	0.6
Ulcerative Colitis (UC)	0.6	1.2	3.0	-1.7	-0.6	0.4
Body Mass Index (BMI) (2010)	0.6	0.9	1.4	-0.9	0.6	-1.2
Systolic Blood Pressure	0.6	3.1	5.0	-1.5	-1.4	-2.2
Pack years adult smoking proportion	0.6	0.8	1.1	-1.1	1.0	-0.7
Townsend deprivation index at recruitment	0.6	0.9	2.4	0.1	0.4	-1.5
Heart attack	0.6	0.8	1.5	0.7	-0.5	-1.2
Medication: Simvastatin	0.6	0.8	2.3	-0.4	-1.5	-0.1
Fluid intelligence score	0.6	1.2	1.4	1.2	1.1	-1.0
Illnesses of siblings	0.6	0.8	1.5	1.2	-0.0	1.0
Worrier / anxious feelings	0.6	1.1	2.9	0.1	-0.6	-1.7
Noisy workplace	0.6	0.7	1.5	-1.2	-0.1	0.8
Birth weight of first child	0.6	1.0	1.9	-0.1	1.4	-1.1
Blood clot in the leg (DVT)	0.6	0.7	1.0	-0.6	-1.0	-1.0
Gout (self-reported)	0.6	0.9	2.5	-0.1	0.3	-1.6
Health satisfaction	0.6	0.8	2.2	-0.5	-0.3	-1.5
Medication: Ibuprofen	0.6	0.8	0.9	0.9	0.9	0.7
Mean time to correctly identify matches	0.6	1.1	2.3	-0.9	-1.5	-0.3
Leg pain on walking	0.6	0.7	1.5	-0.0	-1.2	-0.7
Breast cancer (self-reported)	0.6	0.7	1.3	0.3	1.1	0.9
Ever taken oral contraceptive pill	0.6	0.7	1.9	-0.3	1.4	-0.2
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.0	0.6	-0.3	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.1	-0.7	-1.1	-0.8
Pack years of smoking	0.6	0.9	1.4	-1.2	0.9	-0.7
Alzheimer’s Disease (in father)	0.5	0.6	0.7	0.9	0.7	0.7
Lupus	0.5	0.8	1.0	1.0	0.8	0.8
Vitamin and mineral supplements	0.5	0.7	1.1	-1.1	-0.4	-0.9
Stomach or abdominal pain in last month	0.5	0.6	0.7	0.8	0.8	-0.7
Supplements: Glucosamine	0.5	0.7	0.8	-0.7	0.8	-0.9
Hearing difficulty/problems with background noise	0.5	0.8	1.6	1.3	0.9	-0.1
Medication: Ramipril	0.5	0.6	1.6	-0.3	-0.4	-1.2
Impedance of arm (right)	0.5	2.6	5.6	1.4	2.4	-0.3
Depression (self-reported)	0.5	0.6	0.8	0.9	0.8	-0.6
Illnesses of mother	0.5	0.6	1.0	1.0	-0.1	0.9
Hair/balding pattern: Pattern 4	0.5	1.2	2.8	0.5	0.6	1.7
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.4	-0.4	-1.2	0.3
Medication: Omeprazole	0.5	0.5	1.2	-0.6	-0.3	-1.1
Had major operations	0.5	0.5	1.5	0.1	0.4	-1.2
Smoking status: Previous	0.5	0.7	1.3	-1.1	-0.9	-0.3
Hearing aid user	0.5	0.6	1.2	-0.4	0.6	1.1
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.0	-0.8	0.7	-1.0
Medication: Lisinopril	0.5	0.7	1.3	0.9	-0.0	-1.1
Illnesses of father: High blood pressure	0.5	0.6	1.0	-1.0	-0.8	0.4
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.1	-0.1	0.7	1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.9	-0.1	-0.9	-1.0
Pain experienced in last month	0.5	0.8	2.2	0.2	-0.5	1.5
Impedance of whole body	0.5	2.4	4.6	1.3	2.2	-0.9
Crohns Disease (2017)	0.4	0.9	2.0	-1.4	-0.4	0.8
Reaction Time	0.4	0.8	1.1	-1.1	-1.0	-0.5
HDL Cholesterol	0.4	0.6	1.6	-1.3	-0.2	0.5
Blood Red Count	0.4	4.2	10.4	3.2	-1.0	-1.1
Hair Pigment	0.4	10.4	20.3	1.2	3.0	-4.5
Tanning	0.4	5.0	12.7	1.1	-0.9	3.6
Hearing difficulty/problems: Yes	0.4	0.6	0.8	0.6	0.9	-0.9
Medication: Co-codamol	0.4	0.5	0.8	0.3	0.8	-0.9
Diabetes (mother)	0.4	0.6	1.6	-1.3	0.1	0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	0.9	-0.3	0.6
Qualifications: None of the above	0.4	0.9	2.3	-1.5	-0.3	0.4
Financial difficulties in last 2 years	0.4	0.5	0.8	-0.1	-0.9	-0.9
Pulse rate	0.4	0.7	1.4	-0.1	-1.2	-0.8
Length of working week for main job	0.4	0.4	0.6	0.4	-0.8	0.6
Peak expiratory flow (PEF)	0.4	1.0	2.7	0.2	-0.6	1.6
Exposure to tobacco smoke outside home	0.4	0.6	0.9	-0.2	0.9	-0.9
Emphysema/chronic bronchitis	0.4	0.5	1.4	-1.2	-0.2	0.1
Chest pain or discomfort	0.4	0.6	1.3	-0.7	-0.2	-1.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.6	0.8	-0.6	0.6
Ever had bowel cancer screening	0.4	0.5	1.0	1.0	-0.7	-0.2
Osteoarthritis (self-reported)	0.4	0.6	1.6	-1.3	-0.3	0.1
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.3	0.0	0.4	-1.5
Coronary Artery Disease (CAD)	0.3	0.4	1.0	-1.0	-0.4	-0.1
Respiratory disease	0.3	0.7	1.0	1.0	1.0	-0.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.1	0.0	-1.0	0.1
Qualifications: CSEs or equivalent	0.3	0.3	0.4	-0.6	-0.5	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.0	-0.1	-1.4	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	0.8	0.7	0.4
Loud music exposure frequency	0.3	0.3	0.9	-1.0	0.1	-0.2
Glaucoma (self-reported)	0.3	0.4	0.7	0.6	0.5	0.8
Qualifications: nursing, teaching	0.3	0.5	1.4	1.2	0.0	0.4
Eye problems/disorders: Cataract	0.3	0.4	1.0	-0.4	1.0	0.1
Financial situation satisfaction	0.3	0.4	0.7	0.7	-0.3	-0.8
Alcohol drinker status: Never	0.3	0.4	0.8	0.9	0.1	-0.5
Major Depression (MDD)	0.2	0.3	0.5	-0.0	-0.7	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.6	0.7	0.1	-0.8
Rheumatoid Arthritis	0.2	0.2	0.4	-0.6	-0.3	0.5
Blood Eosinophil Count	0.2	1.5	2.2	-1.4	-0.6	-1.5
Heel T-Score	0.2	2.0	3.2	-0.3	1.6	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	0.8	0.6	-0.9	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	0.4	0.5	-0.5
Exposure to tobacco smoke at home	0.2	0.2	0.4	0.6	0.3	0.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.6	-0.3	0.8	0.3
Number of full brothers	0.2	0.2	0.3	0.1	0.6	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	-0.1	0.3	-0.7
Average weekly champagne plus white wine intake	0.2	0.3	0.5	0.7	0.2	0.5
Guilty feelings	0.2	0.3	0.4	0.5	-0.5	-0.7
Wears glasses or contact lenses	0.2	0.2	0.5	0.2	0.7	-0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.6	0.3	0.0	0.8
Unable to work because of sickness or disability	0.2	0.2	0.5	0.3	0.7	0.0
Prostate Cancer	0.1	0.1	0.2	0.2	-0.5	-0.3
Average weekly fortified wine intake	0.1	0.2	0.2	-0.3	0.5	-0.3
High blood pressure (mother)	0.1	0.1	0.3	-0.0	-0.4	-0.5
Impedance of leg (left)	0.1	0.3	0.7	0.8	0.5	-0.3
Number of incorrect matches in round	0.1	0.1	0.2	0.0	0.4	-0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.5	0.0	-0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.3	0.0	0.2	-0.5
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.3	0.4	0.5	-0.1
Number of full sisters	0.1	0.1	0.2	0.3	-0.2	0.4
Mineral and other dietary supplements	0.1	0.1	0.3	-0.2	-0.5	-0.2
Blood Platelet Count	0.0	0.4	0.9	0.1	-0.5	-1.0
Hypothyroidism (self reported)	0.0	0.0	0.1	-0.1	0.2	-0.3
Supplements: Zinc	0.0	0.0	0.0	0.1	0.0	-0.2
Impedance of leg (right)	0.0	0.2	0.2	0.5	0.5	-0.1
Medication: Levothyroxine sodium	0.0	0.1	0.1	-0.1	-0.3	0.2
Prospective memory result	0.0	0.1	0.1	0.3	0.2	-0.1
Knee pain experienced in last month	0.0	0.0	0.1	-0.2	-0.1	-0.3

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