Hub : Genes

BRAF

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0770	0.0300	0.0030	0.000	0.006	0.001	0.006	-0.002	3.5e-01	0.057	0.22000	0.055	0.6900
2	ROSMAP	Brain Pre-frontal Cortex	0.0315	0.0142	0.0042	0.019	0.008	0.006	0.011	0.009	1.4e-03	0.025	0.04700	0.012	0.0200
3	YFS	Blood	0.0111	0.0060	0.0100	0.018	0.004	0.010	0.003	0.005	8.3e-07	0.012	0.00016	0.030	0.0064

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	3.9	6.1	17.6	0.4	0.8	-4.2
Bipolar Disorder or Schizophrenia	3.7	9.0	26.5	0.6	0.0	-5.2
Depressed Affect (Nagel 2018)	2.2	4.7	13.2	-0.8	0.1	-3.6
Depression (Nagel 2018)	1.2	1.8	3.3	0.7	-1.3	-1.8
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.3	0.0	0.4	-1.5
Neuroticism (Nagel 2018)	1.8	4.2	12.0	0.6	-0.4	-3.5
Schizophrenia (2018)	1.8	3.7	10.5	0.5	-0.6	-3.2
Schizophrenia vs Biploar Disorder	2.9	3.9	7.8	-1.7	-1.0	2.8
Worry (Nagel 2018)	1.1	2.3	4.5	1.0	-1.2	-2.1
Alzheimer’s Disease (in mother)	3.9	4.6	7.6	1.7	2.8	-1.8
Alzheimer’s Disease (in father)	0.5	0.6	0.7	0.9	0.7	0.7
Alzheimer’s Disease (including proxy)	2.2	3.3	5.8	1.6	2.4	-1.2
Crohns Disease (2017)	0.4	0.9	2.0	-1.4	-0.4	0.8
Irritable Bowel Disease (IBD)	0.6	1.4	3.7	-1.9	-0.4	0.6
Ulcerative Colitis (UC)	0.6	1.2	3.0	-1.7	-0.6	0.4
Major Depression (MDD)	0.2	0.3	0.5	-0.0	-0.7	-0.5
Reaction Time	0.4	0.8	1.1	-1.1	-1.0	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.6	0.7	0.1	-0.8
Breast Cancer	1.4	3.5	5.7	2.2	2.4	0.0
Ovarian Cancer	0.8	1.1	2.2	0.8	1.5	-0.7
Prostate Cancer	0.1	0.1	0.2	0.2	-0.5	-0.3
Age at First Birth	2.5	3.6	7.0	1.7	-0.9	2.6
Bipolar Disorder (2011)	4.3	4.1	12.2	-0.2	0.3	-3.5
Body Mass Index (BMI) (2010)	0.6	0.9	1.4	-0.9	0.6	-1.2
Coronary Artery Disease (CAD)	0.3	0.4	1.0	-1.0	-0.4	-0.1
Crohns Disease (2012)	1.6	2.6	5.2	-2.3	-0.5	1.6
Mean Putamen Volume	1.0	1.2	3.4	-0.3	-1.8	-0.2
Fasting Glucose	0.7	0.8	2.4	-1.5	-0.2	0.1
HbA1C	1.4	1.6	4.0	0.6	-0.6	-2.0
HDL Cholesterol	0.4	0.6	1.6	-1.3	-0.2	0.5
LDL Cholesterol	0.8	1.2	3.5	-1.9	-0.4	-0.1
Lupus	0.5	0.8	1.0	1.0	0.8	0.8
Neuroticism (2016)	1.7	2.5	5.6	-0.3	1.3	-2.4
Primary Biliary Cirrhosis	0.8	1.1	2.8	-1.7	-0.6	-0.3
Rheumatoid Arthritis	0.2	0.2	0.4	-0.6	-0.3	0.5
Schizophrenia (2014)	1.4	3.1	9.1	0.2	-0.4	-3.0
Triglycerides	0.8	1.3	3.7	-0.3	-1.9	0.3
Type 2 Diabetes (T2D) (2012)	4.1	4.7	11.0	-1.3	-3.3	1.2
Ulcerative Colitis	1.1	1.6	3.6	-1.9	0.0	-1.1
Blood Eosinophil Count	0.2	1.5	2.2	-1.4	-0.6	-1.5
Blood Platelet Count	0.0	0.4	0.9	0.1	-0.5	-1.0
Blood Red Count	0.4	4.2	10.4	3.2	-1.0	-1.1
Blood White Count	0.7	5.4	9.0	-2.6	-0.6	-3.0
Heel T-Score	0.2	2.0	3.2	-0.3	1.6	-1.8
BMI	1.4	8.4	14.5	-3.8	-1.8	-2.7
Height	1.4	26.8	60.4	-1.5	-4.2	7.8
Waist Hip Ratio (WHR)	1.1	4.8	9.2	-0.7	-3.0	2.1
Systolic Blood Pressure	0.6	3.1	5.0	-1.5	-1.4	-2.2
Smoking Status	1.7	4.2	8.2	-1.9	-0.7	-2.9
Allergy or Eczema	1.8	4.6	9.4	1.7	1.4	-3.1
Cardiovascular Disease	3.1	10.2	12.7	-3.0	-2.9	-3.6
Hypothyroidism (self reported)	0.0	0.0	0.1	-0.1	0.2	-0.3
Respiratory disease	0.3	0.7	1.0	1.0	1.0	-0.5
Type 2 Diabetes (T2D) (2018)	2.2	4.2	6.6	-2.6	-2.0	-1.4
Lung FEV1/FVC ratio	0.8	4.0	7.3	1.1	1.9	-2.7
Lung FVC	5.5	27.8	62.7	1.9	-4.1	7.9
Neuroticism	2.1	5.2	14.5	1.0	0.1	-3.8
Chronotype (morning person)	1.7	3.9	10.4	1.1	0.3	3.2
Hair Pigment	0.4	10.4	20.3	1.2	3.0	-4.5
Tanning	0.4	5.0	12.7	1.1	-0.9	3.6
Hand grip strength (left)	4.0	10.4	24.0	-0.8	-2.6	4.9
Number of treatments/medications taken	3.1	5.6	11.2	-2.3	-0.2	-3.4
Average weekly spirits intake	1.7	2.1	5.5	-0.1	-0.8	2.3
Sensitivity / hurt feelings	1.7	3.0	8.4	0.3	0.7	-2.9
Frequency of depressed mood in last 2 weeks	2.2	3.1	7.7	1.2	0.5	-2.8
Hearing difficulty/problems: Yes	0.4	0.6	0.8	0.6	0.9	-0.9
Relative age of first facial hair	3.3	6.8	14.9	0.7	-2.2	3.9
Other serious medical condition/disability diagnosed by doctor	4.1	5.4	9.0	-3.0	-0.3	-2.6
Ever used hormone-replacement therapy (HRT)	1.5	1.9	5.4	-2.3	-0.0	0.4
Ever had hysterectomy (womb removed)	0.7	0.7	1.2	1.0	0.4	1.1
Systolic blood pressure, automated reading	0.9	2.5	3.8	-1.9	-1.3	-1.4
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.1	-0.4	-1.8	0.1
Angina	1.2	1.6	2.9	-1.7	-1.3	-0.3
Medication for hormone replacement therapy	0.7	0.7	2.1	0.2	0.2	1.4
Vitamin and mineral supplements	0.5	0.7	1.1	-1.1	-0.4	-0.9
Supplements: Zinc	0.0	0.0	0.0	0.1	0.0	-0.2
Medication: Co-codamol	0.4	0.5	0.8	0.3	0.8	-0.9
Medication: Metformin	1.6	2.2	5.3	-2.3	-1.1	-0.3
Diabetes (father)	1.5	1.9	2.9	-1.6	-0.5	-1.7
Diabetes (mother)	0.4	0.6	1.6	-1.3	0.1	0.2
Severe depression (siblings)	2.8	3.2	6.1	0.7	1.7	-2.5
Pack years adult smoking proportion	0.6	0.8	1.1	-1.1	1.0	-0.7
Impedance of leg (right)	0.0	0.2	0.2	0.5	0.5	-0.1
Leg fat-free mass (left)	0.9	4.5	6.1	-2.5	-2.4	1.3
Trunk fat percentage	1.5	5.8	9.7	-2.8	0.4	-3.1
Hand grip strength (right)	2.1	5.8	12.3	-0.3	-2.2	3.5
Townsend deprivation index at recruitment	0.6	0.9	2.4	0.1	0.4	-1.5
Current tobacco smoking	1.9	3.2	4.0	-1.6	-1.7	-2.0
Average weekly fortified wine intake	0.1	0.2	0.2	-0.3	0.5	-0.3
Maternal smoking around birth	0.9	1.2	2.7	-0.5	0.9	-1.6
Fed-up feelings	2.5	4.5	11.6	0.0	1.4	-3.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.6	-0.2	-1.1	-1.3
Relative age voice broke	1.1	1.6	4.8	0.1	-0.3	2.2
Taking other prescription medications	0.9	1.4	2.5	-1.2	0.4	-1.6
Age when periods started (menarche)	1.4	3.3	7.0	-1.0	-1.4	2.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.1	0.0	-1.0	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	0.8	0.6	-0.9	-0.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	0.9	-0.3	0.6
Qualifications: CSEs or equivalent	0.3	0.3	0.4	-0.6	-0.5	-0.6
Serious illness, injury or assault to yourself	1.1	1.4	2.4	-1.5	-0.4	-1.3
High blood pressure	1.6	4.5	5.7	-2.1	-2.4	-1.9
Hayfever, allergic rhinitis or eczema	3.2	7.0	10.1	3.2	1.7	-2.8
Multivitamins +/- minerals	1.1	1.4	1.8	1.3	1.3	0.9
Stomach or abdominal pain in last month	0.5	0.6	0.7	0.8	0.8	-0.7
Supplements: Glucosamine	0.5	0.7	0.8	-0.7	0.8	-0.9
Diverticular disease/diverticulitis (self-reported)	2.0	2.3	4.9	-2.2	-1.3	-0.6
Medication: Atenolol	0.9	1.1	1.5	-1.2	-0.9	-1.0
Medication: Levothyroxine sodium	0.0	0.1	0.1	-0.1	-0.3	0.2
Sitting height	1.0	7.3	13.3	-0.2	-2.9	3.6
Chronic bronchitis/emphysema (father)	1.7	2.0	4.3	-2.1	-1.0	-0.8
High blood pressure (mother)	0.1	0.1	0.3	-0.0	-0.4	-0.5
Body mass index (BMI)	1.6	6.6	10.7	-3.3	-0.5	-3.0
Impedance of leg (left)	0.1	0.3	0.7	0.8	0.5	-0.3
Leg predicted mass (left)	0.9	4.5	6.0	-2.4	-2.4	1.3
Trunk fat mass	1.0	4.5	9.3	-3.0	-0.8	-1.9
Waist circumference	1.0	3.8	8.1	-2.9	-1.5	-1.0
Number of incorrect matches in round	0.1	0.1	0.2	0.0	0.4	-0.4
Past tobacco smoking	2.0	3.8	5.9	2.3	2.4	0.1
Alcohol usually taken with meals	1.5	2.4	5.5	2.4	1.3	-0.4
Nervous feelings	1.5	2.9	6.4	1.4	0.5	-2.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.2	1.5	-0.6	-1.3
Hearing difficulty/problems with background noise	0.5	0.8	1.6	1.3	0.9	-0.1
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.5	0.0	-0.2
Had menopause	3.1	3.9	9.0	-0.4	-1.6	3.0
Had other major operations	0.7	0.9	0.9	-0.9	1.0	0.9
Forced vital capacity (FVC)	4.9	18.7	41.6	1.0	-3.7	6.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.0	-0.1	-1.4	-0.7
Ever unenthusiastic/disinterested for a whole week	3.1	3.8	10.0	-1.1	0.1	-3.2
Qualifications: None of the above	0.4	0.9	2.3	-1.5	-0.3	0.4
Financial difficulties in last 2 years	0.4	0.5	0.8	-0.1	-0.9	-0.9
Mouth/teeth dental problems	1.2	1.8	4.8	2.2	-0.2	0.8
Heart attack	0.6	0.8	1.5	0.7	-0.5	-1.2
Allergy	1.9	4.3	5.7	-2.3	-1.5	2.4
Pain all over the body in last month	1.9	2.0	5.3	0.1	0.8	-2.3
Diabetes (self-reported)	1.1	1.7	2.9	-1.7	-1.4	-0.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.6	1.9	0.4	0.3
Medication: Ramipril	0.5	0.6	1.6	-0.3	-0.4	-1.2
Medication: Simvastatin	0.6	0.8	2.3	-0.4	-1.5	-0.1
Fluid intelligence score	0.6	1.2	1.4	1.2	1.1	-1.0
Illnesses of siblings	0.6	0.8	1.5	1.2	-0.0	1.0
Neuroticism score	2.5	5.2	15.1	0.6	-0.3	-3.9
Weight	1.0	4.7	9.4	-3.1	-2.2	-0.0
Impedance of arm (right)	0.5	2.6	5.6	1.4	2.4	-0.3
Arm fat percentage (right)	1.3	5.0	7.7	-2.8	-0.0	-2.7
Trunk fat-free mass	2.0	11.7	17.4	-1.6	-4.2	3.9
Hip circumference	0.7	3.2	7.6	-2.8	-0.4	-1.3
Time employed in main current job	1.1	1.3	2.0	0.2	-1.4	1.4
Alcohol intake versus 10 years previously	2.8	4.1	9.0	-3.0	-1.5	-1.1
Father’s age at death	0.9	1.2	2.0	1.4	0.5	1.2
Worrier / anxious feelings	0.6	1.1	2.9	0.1	-0.6	-1.7
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.8	0.3	0.6	-2.2
Falls in the last year	1.9	2.5	6.7	-2.6	-0.7	0.6
Hair/balding pattern: Pattern 3	1.0	1.4	3.7	0.5	-0.6	1.9
Number of live births	0.9	1.2	3.3	1.8	0.5	0.4
Forced expiratory volume in 1-second (FEV1)	3.3	11.1	23.2	1.5	-2.8	4.8
Pulse rate	0.4	0.7	1.4	-0.1	-1.2	-0.8
Happiness	2.2	2.6	6.6	1.0	0.6	-2.6
Noisy workplace	0.6	0.7	1.5	-1.2	-0.1	0.8
Qualifications: A levels/AS levels or equivalent	1.0	2.3	6.2	2.5	0.8	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	0.4	0.5	-0.5
Mouth/teeth dental problems: Dentures	1.6	2.7	6.6	-2.6	-0.9	0.8
Asthma	0.9	1.8	3.3	1.3	1.8	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	0.8	0.7	0.4
Medication: Cholesterol lowering	2.0	3.0	5.1	-2.0	-2.3	0.4
Depression (self-reported)	0.5	0.6	0.8	0.9	0.8	-0.6
Medication: Lansoprazole	3.1	3.5	5.6	-2.4	-2.2	-0.5
Prospective memory result	0.0	0.1	0.1	0.3	0.2	-0.1
Lung cancer (father)	1.4	1.7	3.0	-1.7	-0.4	-1.4
Illnesses of mother	0.5	0.6	1.0	1.0	-0.1	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	3.2	10.1	21.9	0.1	-2.9	4.7
Pulse wave Arterial Stiffness index	1.3	1.6	2.4	-0.0	-1.6	1.5
Impedance of arm (left)	0.7	3.5	8.4	1.2	2.9	-0.7
Arm fat mass (right)	1.2	5.0	10.1	-3.2	-1.2	-1.9
Trunk predicted mass	2.0	11.5	17.3	-1.5	-4.2	3.9
Standing height	1.9	18.6	38.4	-0.4	-4.2	6.2
Length of working week for main job	0.4	0.4	0.6	0.4	-0.8	0.6
Exposure to tobacco smoke at home	0.2	0.2	0.4	0.6	0.3	0.2
Breastfed as a baby	3.0	3.7	7.9	2.8	1.7	0.6
Tense / ‘highly strung’	2.6	4.3	12.5	0.0	0.5	-3.5
Seen doctor (GP) for nerves, anxiety, tension or depression	3.0	4.6	11.6	-1.5	0.1	-3.4
Hair/balding pattern: Pattern 4	0.5	1.2	2.8	0.5	0.6	1.7
Birth weight of first child	0.6	1.0	1.9	-0.1	1.4	-1.1
Peak expiratory flow (PEF)	0.4	1.0	2.7	0.2	-0.6	1.6
Pulse wave reflection index	0.7	0.8	1.9	-0.6	-0.3	1.4
Ever highly irritable/argumentative for 2 days	1.9	2.2	6.2	-0.3	0.7	-2.5
Loud music exposure frequency	0.3	0.3	0.9	-1.0	0.1	-0.2
Qualifications: O levels/GCSEs or equivalent	2.1	3.3	4.8	2.2	0.8	-2.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.6	-0.3	0.8	0.3
Blood clot in the leg (DVT)	0.6	0.7	1.0	-0.6	-1.0	-1.0
Medication: Paracetamol	2.0	3.3	8.5	-0.8	0.8	-2.9
Headache pain in last month	1.0	1.6	2.8	-1.1	1.0	-1.7
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	5.1	2.0	2.2	0.4
Glaucoma (self-reported)	0.3	0.4	0.7	0.6	0.5	0.8
Gout (self-reported)	0.6	0.9	2.5	-0.1	0.3	-1.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.3	0.0	0.2	-0.5
Medication: Amlodipine	0.9	1.3	2.7	-1.6	-0.3	-1.1
Medication: Ventolin 100micrograms inhaler	1.3	1.6	2.1	1.4	1.5	-0.8
Birth weight	1.3	2.8	4.6	2.1	1.9	0.4
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.3	0.4	0.5	-0.1
High blood pressure (siblings)	1.2	1.8	2.9	-1.3	-0.8	-1.7
Forced vital capacity (FVC), Best measure	5.0	18.3	39.5	-0.4	-3.9	6.3
Body fat percentage	1.6	6.2	9.9	-2.9	0.0	-3.1
Leg fat percentage (right)	1.8	6.4	11.0	-3.3	-0.5	-2.8
Arm fat-free mass (right)	1.6	8.3	14.9	-2.2	-3.9	2.2
Exposure to tobacco smoke outside home	0.4	0.6	0.9	-0.2	0.9	-0.9
Comparative body size at age 10	3.8	10.5	14.4	1.9	3.8	-3.7
Number of full brothers	0.2	0.2	0.3	0.1	0.6	-0.6
Worry too long after embarrassment	0.9	1.4	3.2	1.1	0.2	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.6	-0.7	-0.4	-1.9
Wheeze or whistling in the chest in last year	1.6	2.8	8.0	-0.6	0.3	-2.8
Number of children fathered	1.2	1.3	3.2	-0.7	0.5	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.0	1.4	-0.3	1.4
Age at first live birth	2.3	4.1	9.4	3.1	0.7	1.6
Pulse wave peak to peak time	0.9	1.1	1.9	-0.0	1.4	-1.2
Health satisfaction	0.6	0.8	2.2	-0.5	-0.3	-1.5
Shortness of breath walking on level ground	0.9	1.1	1.5	1.1	0.7	-1.2
Qualifications: College or University degree	1.3	4.1	7.3	2.7	1.9	1.3
Eye problems/disorders: None of the above	1.8	2.1	5.1	0.7	0.9	-2.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.4	-0.4	-1.2	0.3
Emphysema/chronic bronchitis	0.4	0.5	1.4	-1.2	-0.2	0.1
Medication for pain relief, constipation, heartburn	2.1	3.5	5.9	2.1	-0.6	2.4
Neck or shoulder pain in last month	1.5	2.1	3.8	0.2	1.6	-2.0
Medication: Blood pressure	1.3	2.2	3.6	-1.3	-1.9	-1.2
Angina (self-reported)	1.4	1.9	3.2	-1.8	-1.6	-0.2
Migraine (self-reported)	1.7	2.1	4.6	-1.3	-2.1	-0.0
Medication: Ibuprofen	0.6	0.8	0.9	0.9	0.9	0.7
Medication: Allopurinol	0.8	1.0	1.5	-1.2	-0.9	-0.9
Medication: Omeprazole	0.5	0.5	1.2	-0.6	-0.3	-1.1
Medication: Seretide 50 evohaler	2.4	2.8	6.0	1.5	2.4	-0.1
Mean time to correctly identify matches	0.6	1.1	2.3	-0.9	-1.5	-0.3
Heart disease (mother)	2.2	2.6	4.9	-1.7	-2.2	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	1.8	-0.8	1.4	-1.2
Whole body fat mass	1.4	5.7	12.2	-3.5	-1.2	-1.8
Leg fat mass (right)	1.7	6.7	14.0	-3.7	-1.4	-2.0
Arm predicted mass (right)	1.4	7.3	13.2	-2.0	-3.6	2.2
Pulse rate, automated reading	1.8	5.9	14.1	-0.5	-3.8	-1.9
Alcohol intake frequency.	2.1	4.9	7.6	-2.6	-0.0	-2.8
Comparative height size at age 10	0.9	4.8	7.5	-1.3	-2.3	2.7
Number of full sisters	0.1	0.1	0.2	0.3	-0.2	0.4
Suffer from ‘nerves’	0.9	1.4	1.8	1.2	-1.3	-1.1
Overall health rating	3.0	6.4	11.1	-3.3	0.8	-2.7
Chest pain or discomfort	0.4	0.6	1.3	-0.7	-0.2	-1.1
Had major operations	0.5	0.5	1.5	0.1	0.4	-1.2
Age at last live birth	2.1	3.1	8.4	2.9	-0.0	0.9
Family relationship satisfaction	2.5	3.0	8.7	0.5	-0.4	-2.9
Leg pain on walking	0.6	0.7	1.5	-0.0	-1.2	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.9	-1.2	-0.0	-1.4
Commuting to job workplace: Car/motor vehicle	0.8	1.0	2.6	-0.1	-1.6	0.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.6	0.8	-0.6	0.6
Medication: Aspirin	2.3	3.0	5.9	-2.4	-1.2	-1.3
Supplements: Vitamin C	0.9	1.0	2.1	1.4	0.6	-0.8
Knee pain experienced in last month	0.0	0.0	0.1	-0.2	-0.1	-0.3
Hypertension (Self-reported)	2.1	5.8	6.7	-2.6	-2.4	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	-0.1	0.3	-0.7
Illnesses of father: Heart disease	1.7	2.4	5.2	-0.8	-2.3	1.1
Illnesses of siblings: Diabetes	0.7	0.8	1.5	0.4	1.2	0.9
Smoking status: Previous	0.5	0.7	1.3	-1.1	-0.9	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	2.8	-1.3	-1.7	1.5
Whole body fat-free mass	1.5	8.4	13.3	-2.0	-3.6	2.8
Leg fat-free mass (right)	0.7	4.0	5.5	-2.0	-2.4	1.5
Arm fat percentage (left)	1.4	5.7	9.3	-2.7	0.5	-3.0
Average weekly red wine intake	0.7	1.1	2.7	1.6	0.4	-0.6
Handedness (chirality/laterality): Left-handed	0.9	1.0	1.4	1.2	-0.8	1.0
Mood swings	1.6	2.9	7.7	-0.9	0.3	-2.8
Loneliness, isolation	1.5	2.1	4.5	-0.4	-1.3	-2.1
Long-standing illness, disability or infirmity	3.3	5.0	11.1	-3.3	0.3	-1.9
Ever had bowel cancer screening	0.4	0.5	1.0	1.0	-0.7	-0.2
Diabetes diagnosed by doctor	1.4	2.4	5.3	-2.3	-1.0	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	1.4	0.9	0.9	-1.2
Friendships satisfaction	3.2	4.0	7.2	0.6	-2.1	-2.7
Qualifications: nursing, teaching	0.3	0.5	1.4	1.2	0.0	0.4
Commuting to job workplace: Walk	1.6	1.7	3.1	1.8	1.4	-0.2
Eye problems/disorders: Cataract	0.3	0.4	1.0	-0.4	1.0	0.1
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	2.3	1.1	1.5	-1.3
Medication for cholesterol	1.2	1.8	4.0	2.0	0.0	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	4.1	-1.7	1.3	-2.0
Back pain experienced in last month	0.9	1.3	2.8	-1.7	-1.1	-0.3
Mineral and other dietary supplements	0.1	0.1	0.3	-0.2	-0.5	-0.2
Breast cancer (self-reported)	0.6	0.7	1.3	0.3	1.1	0.9
Asthma (self-reported)	0.8	1.5	2.2	1.4	1.5	-0.6
Osteoporosis (self-reported)	0.9	1.1	1.5	-0.8	-1.2	-1.0
Osteoarthritis (self-reported)	0.4	0.6	1.6	-1.3	-0.3	0.1
Medication: Aspirin	2.7	3.5	7.3	-2.7	-1.3	-1.2
Medication: Gliclazide	2.1	2.4	6.6	-0.7	-2.6	0.4
Illnesses of father: None of the above (group 1)	2.1	2.6	4.9	2.2	1.0	-1.4
Smoking status: Current	1.9	3.0	3.4	-1.7	-1.6	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	4.8	1.3	-1.5	2.2
Whole body water mass	1.5	8.3	13.4	-1.9	-3.7	2.8
Leg predicted mass (right)	0.8	4.1	5.7	-2.0	-2.4	1.6
Arm fat mass (left)	1.1	4.5	8.8	-3.0	-1.0	-1.9
Number of self-reported non-cancer illnesses	2.6	4.5	11.9	-1.2	-0.5	-3.4
Average weekly champagne plus white wine intake	0.2	0.3	0.5	0.7	0.2	0.5
Miserableness	2.7	4.7	12.8	-1.0	0.4	-3.6
Guilty feelings	0.2	0.3	0.4	0.5	-0.5	-0.7
Wears glasses or contact lenses	0.2	0.2	0.5	0.2	0.7	-0.4
Ever taken oral contraceptive pill	0.6	0.7	1.9	-0.3	1.4	-0.2
Hearing aid user	0.5	0.6	1.2	-0.4	0.6	1.1
Mother’s age at death	1.5	1.9	4.2	1.2	2.0	0.3
Financial situation satisfaction	0.3	0.4	0.7	0.7	-0.3	-0.8
Tinnitus: Yes, now most or all of the time	1.7	2.0	4.1	0.6	1.2	-2.0
Commuting to job workplace: Public transport	0.7	0.8	0.9	1.0	0.8	-0.9
Eye problems/disorders: Glaucoma	1.2	1.4	3.0	0.5	0.9	1.7
Medication: Blood pressure	2.0	3.8	5.9	-2.3	-0.5	-2.4
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.0	-0.8	0.7	-1.0
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.6	0.3	0.0	0.8
High cholesterol (Self-reported)	1.3	2.3	3.2	-1.8	-1.4	-1.4
Medication: Bendroflumethiazide	1.9	2.8	3.8	-1.9	-1.1	-1.9
Medication: Paracetamol	1.4	2.1	4.4	-1.4	-0.2	-2.1
Medication: Lisinopril	0.5	0.7	1.3	0.9	-0.0	-1.1
Medication: Atorvastatin	1.0	1.2	3.2	-1.8	-0.7	-0.0
Illnesses of father: High blood pressure	0.5	0.6	1.0	-1.0	-0.8	0.4
Alcohol drinker status: Never	0.3	0.4	0.8	0.9	0.1	-0.5
Ever smoked	1.4	2.4	3.8	-2.0	-1.7	0.6
Basal metabolic rate	1.2	6.6	10.6	-2.3	-3.2	2.0
Leg fat percentage (left)	1.8	6.7	10.7	-3.3	-0.6	-3.0
Arm fat-free mass (left)	1.8	8.9	16.6	-2.1	-4.1	2.3
Number of operations (self-reported)	0.9	1.3	2.2	-0.8	1.5	-1.1
Average weekly beer plus cider intake	1.2	1.7	2.4	-0.7	-1.5	-1.5
Irritability	1.6	2.8	5.9	1.5	-0.3	-2.4
Risk taking	0.7	1.0	2.9	-1.7	-0.5	0.2
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.1	-0.1	0.7	1.0
Fractured/broken bones in last 5 years	0.9	1.2	3.5	-1.9	-0.4	-0.1
Age started oral contraceptive pill	1.5	1.9	2.7	-1.0	-1.4	1.6
Diastolic blood pressure, automated reading	1.7	5.2	7.4	-1.7	-2.3	-2.7
Ever depressed for a whole week	3.6	4.4	9.4	-0.6	1.8	-3.1
Unable to work because of sickness or disability	0.2	0.2	0.5	0.3	0.7	0.0
Commuting to job workplace: Cycle	3.2	3.9	7.5	2.7	2.0	-0.6
Myopia	1.4	2.0	4.0	1.4	2.0	-0.4
Vascular/heart problems diagnosed by doctor	1.5	4.0	4.7	2.2	2.0	1.9
Cholesterol lowering medication	1.4	2.1	5.9	-2.4	-0.7	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.9	-0.1	-0.9	-1.0
Pain experienced in last month	0.5	0.8	2.2	0.2	-0.5	1.5
Supplements: Calcium	1.7	1.9	3.0	1.1	1.2	1.7
Basal cell carcinoma (self-reported)	0.8	0.9	1.3	0.5	1.1	1.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.0	0.6	-0.3	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.1	-0.7	-1.1	-0.8
Heart disease (siblings)	2.6	3.1	8.6	-2.9	-0.7	-0.6
Alcohol drinker status: Previous	0.7	0.8	0.9	-0.9	1.0	-0.8
Pack years of smoking	0.6	0.9	1.4	-1.2	0.9	-0.7
Impedance of whole body	0.5	2.4	4.6	1.3	2.2	-0.9
Leg fat mass (left)	1.8	6.9	13.9	-3.7	-1.3	-2.2
Arm predicted mass (left)	1.6	8.0	14.1	-2.3	-3.8	2.1