Best TWAS P=1.32e-10 · Best GWAS P=4.15e-12 conditioned to 2.31e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | MCM4 | 0.15 | 0.06 | enet | 9 | 0.12 | 1.2e-04 | -6.0 | 6.4 | 1.3e-10 | -0.51 | 0.07 | 0.09 | TRUE |
| 2 | GTEx | Skin Sun Exposed Lower leg | MCM4 | 0.14 | 0.04 | enet | 9 | 0.06 | 6.5e-06 | -5.4 | 5.4 | 6.5e-08 | -0.31 | 0.47 | 0.21 | FALSE |
| 3 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MCM4 | 0.05 | 0.04 | lasso | 2 | 0.04 | 5.1e-05 | -6.0 | 5.2 | 1.9e-07 | -0.26 | 0.00 | 0.97 | FALSE |
| 4 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | MCM4 | 0.19 | 0.10 | enet | 1 | 0.10 | 3.1e-05 | -6.0 | 6.0 | 1.5e-09 | -0.31 | 0.00 | 0.98 | FALSE |