Best TWAS P=2.46e-12 · Best GWAS P=5.27e-13 conditioned to 0.0546
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Hypothalamus | RP11-317J10.2 | 0.33 | 0.05 | enet | 16 | 0.15 | 2.6e-04 | 7.1 | -6.5 | 6.2e-11 | -0.69 | 0.02 | 0.68 | FALSE |
| 2 | GTEx | Brain Putamen basal ganglia | RP11-317J10.2 | 0.24 | 0.22 | lasso | 2 | 0.20 | 1.6e-05 | 7.1 | -7.0 | 2.5e-12 | -0.93 | 0.02 | 0.94 | TRUE |
| 3 | GTEx | Colon Transverse | RP11-317J10.2 | 0.10 | 0.12 | lasso | 3 | 0.09 | 3.6e-05 | 6.7 | -6.7 | 2.4e-11 | -0.90 | 0.03 | 0.95 | FALSE |
| 4 | GTEx | Muscle Skeletal | CA2 | 0.06 | 0.00 | enet | 17 | 0.02 | 7.0e-03 | 7.0 | -5.4 | 7.0e-08 | -0.70 | 0.04 | 0.86 | FALSE |
| 5 | GTEx | Muscle Skeletal | CA3 | 0.06 | 0.00 | lasso | 4 | 0.01 | 8.5e-02 | 6.2 | 5.4 | 7.1e-08 | 0.78 | 0.03 | 0.75 | FALSE |
| 6 | GTEx | Thyroid | RP11-317J10.2 | 0.05 | 0.02 | lasso | 5 | 0.03 | 3.3e-03 | 7.1 | -5.4 | 6.1e-08 | -0.82 | 0.07 | 0.81 | FALSE |