Hub : Genes

CA2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.0618 0.0321 1.2e-03 0.001 NA 0.017 NA 0.009 2.4e-01 NA 7.0e-03 NA 3.7e-02
2 NTR Blood 0.0462 0.0211 2.8e-05 0.006 0.024 0.025 0.027 0.018 2.6e-03 2.0e-08 1.2e-08 4.6e-09 9.1e-07
3 YFS Blood 0.5987 0.0447 0.0e+00 0.075 0.208 0.231 0.191 0.190 2.9e-23 3.5e-66 4.4e-74 2.7e-60 7.2e-60

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.9 1.4 3.1 0.2 1.8 1.0
Bipolar Disorder or Schizophrenia 0.1 0.1 0.4 -0.2 -0.0 0.6
Depressed Affect (Nagel 2018) 0.4 0.9 1.3 -1.1 1.1 0.2
Depression (Nagel 2018) 0.4 0.6 1.3 -0.1 -1.1 -0.8
Intelligence (Savage-Jansen 2018) 0.4 1.1 1.2 1.1 -1.0 -1.0
Neuroticism (Nagel 2018) 0.4 1.0 1.7 -0.3 1.3 1.1
Schizophrenia (2018) 0.3 0.7 2.1 0.2 -1.4 -0.1
Schizophrenia vs Biploar Disorder 0.1 0.2 0.3 -0.5 0.4 -0.3
Worry (Nagel 2018) 0.5 1.1 2.0 0.9 0.6 1.4
Alzheimer’s Disease (in mother) 0.3 0.4 0.9 0.2 -0.9 -0.4
Alzheimer’s Disease (in father) 2.4 2.6 3.7 1.9 -1.8 -1.1
Alzheimer’s Disease (including proxy) 0.8 1.2 1.7 1.3 -1.3 -0.5
Crohns Disease (2017) 3.8 8.3 10.8 -3.3 2.8 2.4
Irritable Bowel Disease (IBD) 2.9 6.9 11.2 -2.2 2.1 3.3
Ulcerative Colitis (UC) 1.0 1.9 5.4 -0.4 0.3 2.3
Major Depression (MDD) 0.8 1.0 1.7 0.5 1.0 1.3
Reaction Time 0.7 1.4 3.2 -0.9 1.8 -0.0
Verbal and Numeric Reasoning (VNR) 0.3 0.6 1.0 1.0 -0.6 -0.7
Breast Cancer 0.9 2.2 3.4 1.8 -1.7 -0.5
Ovarian Cancer 0.9 1.2 2.1 1.1 -1.4 -0.6
Prostate Cancer 1.1 1.5 3.4 -1.0 0.2 1.8
Age at First Birth 0.8 1.1 2.4 1.6 -0.9 -0.1
Bipolar Disorder (2011) 0.4 0.4 0.6 0.5 0.6 0.8
Body Mass Index (BMI) (2010) 0.9 1.2 2.4 -0.2 1.1 1.5
Coronary Artery Disease (CAD) 0.5 0.5 0.9 -1.0 0.1 -0.8
Crohns Disease (2012) 1.0 1.7 2.3 -0.8 1.4 1.5
Mean Putamen Volume 0.7 0.7 2.0 0.0 0.5 1.4
Fasting Glucose 0.4 0.5 1.0 0.7 0.3 -1.0
HbA1C 0.2 0.2 0.5 0.7 -0.0 -0.4
HDL Cholesterol 0.7 1.1 2.0 -0.3 -1.4 -1.1
LDL Cholesterol 1.7 2.7 5.6 2.4 -1.5 0.6
Lupus 0.5 0.8 2.0 1.4 -0.3 -0.6
Neuroticism (2016) 0.8 1.1 2.4 1.5 -0.9 -0.5
Primary Biliary Cirrhosis 0.3 0.5 1.0 0.6 -0.2 -1.0
Rheumatoid Arthritis 0.1 0.2 0.5 -0.7 0.1 0.2
Schizophrenia (2014) 0.3 0.6 1.1 0.8 -1.1 0.1
Triglycerides 0.1 0.2 0.3 -0.0 -0.6 -0.6
Type 2 Diabetes (T2D) (2012) 1.3 1.5 4.2 2.0 0.2 0.4
Ulcerative Colitis 0.5 0.7 2.1 0.3 0.2 1.4
Blood Eosinophil Count 0.1 0.7 1.5 -0.2 0.7 1.2
Blood Platelet Count 0.2 2.5 6.8 -0.8 2.6 0.2
Blood Red Count 0.1 0.9 2.6 0.5 -0.0 -1.6
Blood White Count 1.3 9.8 13.4 -3.7 3.5 2.0
Heel T-Score 0.2 1.7 5.0 -0.1 -0.2 2.2
BMI 1.3 7.7 16.5 -4.1 2.0 1.5
Height 0.1 2.8 5.1 2.3 -1.5 1.0
Waist Hip Ratio (WHR) 0.7 2.9 8.4 2.9 0.1 -0.7
Systolic Blood Pressure 0.1 0.6 1.5 -0.5 1.2 -0.1
Smoking Status 0.3 0.8 2.0 -0.3 1.4 0.5
Allergy or Eczema 0.6 1.6 2.7 0.1 1.7 1.4
Cardiovascular Disease 0.3 0.9 2.5 -0.1 -0.2 -1.6
Hypothyroidism (self reported) 0.1 0.2 0.6 -0.2 -0.2 0.8
Respiratory disease 0.3 0.6 1.4 0.2 -1.2 -0.5
Type 2 Diabetes (T2D) (2018) 0.7 1.3 2.1 1.4 -0.9 -1.0
Lung FEV1/FVC ratio 0.0 0.2 0.6 0.7 0.4 0.1
Lung FVC 3.8 19.2 29.1 -5.4 5.0 2.0
Neuroticism 0.6 1.3 3.4 0.1 0.8 1.8
Chronotype (morning person) 1.5 3.5 7.6 -0.8 2.8 1.5
Hair Pigment 0.0 0.5 1.0 0.6 -1.0 -0.0
Tanning 0.0 0.5 1.0 0.5 1.0 0.6
Hand grip strength (left) 2.3 6.0 8.3 -1.9 2.9 2.4
Number of treatments/medications taken 0.3 0.5 0.8 0.3 0.7 0.9
Average weekly spirits intake 0.3 0.4 0.9 0.9 -0.5 -0.4
Sensitivity / hurt feelings 0.8 1.4 2.4 -1.6 1.1 0.8
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.2 -0.4 -0.4 -0.5
Hearing difficulty/problems: Yes 0.4 0.7 1.8 -1.4 0.3 -0.3
Relative age of first facial hair 1.1 2.4 2.9 -1.2 1.6 1.7
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 1.9 -0.4 -0.4 -1.4
Ever used hormone-replacement therapy (HRT) 1.5 1.8 3.3 -0.9 1.8 1.2
Ever had hysterectomy (womb removed) 0.3 0.3 0.6 -0.8 -0.2 -0.6
Systolic blood pressure, automated reading 0.5 1.5 2.5 -1.0 1.6 0.9
Eye problems/disorders: Diabetes related eye disease 3.4 3.8 4.9 2.2 -1.8 -1.8
Angina 1.2 1.6 3.8 -1.9 1.0 0.3
Medication for hormone replacement therapy 0.6 0.7 1.4 -1.2 0.8 0.2
Vitamin and mineral supplements 0.9 1.3 2.3 -1.5 1.1 0.5
Supplements: Zinc 0.9 0.9 2.7 1.7 0.0 0.3
Medication: Co-codamol 1.0 1.2 1.5 -1.2 0.7 1.2
Medication: Metformin 0.2 0.3 0.6 0.8 0.3 -0.3
Diabetes (father) 0.9 1.1 1.7 1.3 -0.9 0.8
Diabetes (mother) 1.0 1.2 3.6 0.1 -0.2 1.9
Severe depression (siblings) 1.5 1.7 4.0 1.0 0.1 2.0
Pack years adult smoking proportion 0.2 0.3 0.6 -0.7 0.0 0.8
Impedance of leg (right) 0.1 0.5 1.0 1.0 -0.3 -0.6
Leg fat-free mass (left) 0.2 1.2 2.5 -1.1 0.2 1.6
Trunk fat percentage 0.8 3.4 7.6 -2.8 0.9 1.3
Hand grip strength (right) 4.7 12.7 16.8 -3.4 4.1 3.2
Townsend deprivation index at recruitment 0.4 0.6 1.6 -0.5 -0.0 -1.3
Current tobacco smoking 0.2 0.2 0.6 -0.7 -0.3 0.3
Average weekly fortified wine intake 4.5 5.3 7.3 1.4 -2.6 -2.7
Maternal smoking around birth 0.3 0.5 1.1 0.4 -1.0 -0.5
Fed-up feelings 0.5 1.0 2.4 -1.5 0.5 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 3.6 0.1 -1.9 -1.2
Relative age voice broke 0.8 1.3 2.5 -0.0 1.2 1.6
Taking other prescription medications 0.8 1.3 2.0 -0.3 1.4 1.3
Age when periods started (menarche) 0.5 1.1 2.4 -0.3 -0.9 -1.6
Bilateral oophorectomy (both ovaries removed) 4.7 5.4 7.5 -2.7 2.6 1.5
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 2.0 -0.9 0.5 1.4
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.0 0.0 -0.2 1.0
Qualifications: CSEs or equivalent 0.4 0.5 1.2 0.3 -1.1 0.4
Serious illness, injury or assault to yourself 0.2 0.2 0.4 -0.5 -0.6 0.1
High blood pressure 0.2 0.5 0.6 -0.7 -0.5 -0.8
Hayfever, allergic rhinitis or eczema 0.9 2.0 3.4 -0.7 1.8 1.5
Multivitamins +/- minerals 0.3 0.3 0.5 0.6 -0.7 0.1
Stomach or abdominal pain in last month 0.2 0.3 0.5 0.3 -0.7 -0.4
Supplements: Glucosamine 0.2 0.3 0.5 0.7 0.6 -0.1
Diverticular disease/diverticulitis (self-reported) 2.0 2.4 4.9 1.4 -0.7 -2.2
Medication: Atenolol 1.1 1.3 3.2 0.4 -0.8 -1.8
Medication: Levothyroxine sodium 0.4 0.6 1.0 -1.0 -0.2 0.9
Sitting height 0.1 0.6 0.7 0.5 -0.9 0.8
Chronic bronchitis/emphysema (father) 0.3 0.4 1.1 -0.2 -0.0 1.0
High blood pressure (mother) 0.6 0.8 1.5 0.4 0.8 1.2
Body mass index (BMI) 1.4 6.1 11.4 -3.4 1.9 1.8
Impedance of leg (left) 0.1 0.3 0.6 0.8 -0.1 -0.4
Leg predicted mass (left) 0.2 1.1 2.4 -1.0 0.2 1.5
Trunk fat mass 0.9 3.9 7.4 -2.7 1.0 1.8
Waist circumference 0.5 1.7 2.0 -1.4 1.0 1.4
Number of incorrect matches in round 1.1 1.9 2.8 -0.0 1.7 1.6
Past tobacco smoking 2.0 3.7 8.6 -0.0 -2.9 -1.6
Alcohol usually taken with meals 1.1 1.8 2.1 1.4 -1.4 -1.1
Nervous feelings 0.9 1.7 3.4 1.2 -1.8 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.1 0.1 -0.2 -0.3 -0.3
Hearing difficulty/problems with background noise 0.9 1.5 2.1 -1.2 1.0 1.5
Hair/balding pattern: Pattern 2 5.1 6.5 9.0 -1.5 3.0 2.9
Had menopause 0.3 0.4 0.9 -1.0 0.3 0.2
Had other major operations 0.4 0.4 1.0 -1.0 0.2 -0.5
Forced vital capacity (FVC) 0.9 3.6 4.8 -2.2 1.7 1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.4 0.0 -1.2 0.9
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.2 -0.5 -1.5 -0.9
Qualifications: None of the above 0.6 1.4 2.8 -1.1 1.7 0.3
Financial difficulties in last 2 years 1.0 1.4 3.1 -0.4 -1.8 -1.0
Mouth/teeth dental problems 0.2 0.3 0.8 -0.3 0.9 0.3
Heart attack 0.4 0.6 1.6 0.1 -0.2 -1.3
Allergy 0.2 0.6 1.4 -0.2 -0.5 -1.2
Pain all over the body in last month 2.0 2.1 3.7 0.9 -1.9 -1.3
Diabetes (self-reported) 0.2 0.4 0.6 0.7 0.8 -0.1
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.8 0.5 0.8 0.9
Medication: Ramipril 1.1 1.5 4.0 -0.1 -0.6 -2.0
Medication: Simvastatin 2.1 3.1 3.8 1.8 -1.4 -1.9
Fluid intelligence score 0.2 0.3 0.7 0.8 -0.6 -0.1
Illnesses of siblings 0.8 1.1 2.1 -1.0 1.5 0.2
Neuroticism score 0.3 0.7 1.9 -0.1 0.5 1.4
Weight 0.8 3.8 5.7 -2.4 1.2 2.1
Impedance of arm (right) 1.5 7.0 8.5 2.9 -2.9 -2.1
Arm fat percentage (right) 0.9 3.4 7.6 -2.8 0.9 1.4
Trunk fat-free mass 0.4 2.2 3.9 -1.2 1.1 2.0
Hip circumference 0.5 2.4 4.4 -2.1 0.3 1.6
Time employed in main current job 2.5 2.9 3.7 1.7 -1.4 -1.9
Alcohol intake versus 10 years previously 1.4 2.1 2.6 1.6 -1.4 -1.4
Father’s age at death 0.4 0.5 1.4 0.0 0.1 1.2
Worrier / anxious feelings 0.1 0.2 0.4 0.6 0.4 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.5 -0.2 -0.7 0.1
Falls in the last year 0.0 0.0 0.1 0.1 0.3 0.1
Hair/balding pattern: Pattern 3 1.2 1.8 3.0 0.9 -1.7 -1.2
Number of live births 0.3 0.4 0.6 -0.5 0.6 0.8
Forced expiratory volume in 1-second (FEV1) 1.1 3.7 4.2 -2.1 1.9 1.8
Pulse rate 0.2 0.4 0.5 0.7 -0.7 -0.3
Happiness 0.4 0.5 1.1 0.1 0.6 1.0
Noisy workplace 0.4 0.5 0.7 -0.7 -0.6 -0.8
Qualifications: A levels/AS levels or equivalent 0.9 1.9 2.5 1.4 -1.1 -1.6
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 2.4 1.1 -1.0 -1.6
Mouth/teeth dental problems: Dentures 0.1 0.1 0.2 -0.1 -0.5 -0.3
Asthma 0.4 0.7 1.4 0.8 -1.2 0.3
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 1.7 -1.0 1.3 1.1
Medication: Cholesterol lowering 0.2 0.3 0.7 0.3 0.8 0.2
Depression (self-reported) 0.3 0.4 0.8 -0.6 0.1 0.9
Medication: Lansoprazole 0.5 0.6 1.2 -1.1 0.4 0.7
Prospective memory result 2.2 2.8 5.6 -1.4 2.4 0.9
Lung cancer (father) 0.5 0.6 1.3 -1.1 0.3 0.7
Illnesses of mother 0.5 0.6 1.1 -0.8 -0.2 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.4 4.6 5.1 -2.3 2.2 2.0
Pulse wave Arterial Stiffness index 0.7 0.9 1.9 -0.5 -1.4 -0.7
Impedance of arm (left) 1.2 5.8 6.9 2.4 -2.6 -2.1
Arm fat mass (right) 1.1 4.7 9.3 -3.1 1.1 1.9
Trunk predicted mass 0.3 1.9 3.6 -1.0 1.0 1.9
Standing height 0.2 1.9 2.9 1.7 -1.3 1.0
Length of working week for main job 0.4 0.4 0.6 -0.8 0.4 -0.7
Exposure to tobacco smoke at home 0.6 0.7 1.1 -1.0 1.0 -0.2
Breastfed as a baby 1.1 1.4 3.1 -0.8 1.8 0.6
Tense / ‘highly strung’ 0.2 0.4 0.5 0.7 -0.7 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 0.9 0.6 -0.9 0.9
Hair/balding pattern: Pattern 4 0.7 1.8 3.2 -0.5 -1.4 -1.8
Birth weight of first child 0.2 0.3 0.4 -0.6 0.4 0.6
Peak expiratory flow (PEF) 0.2 0.4 0.6 -0.8 0.4 0.6
Pulse wave reflection index 1.7 2.1 5.2 -0.4 -1.0 -2.3
Ever highly irritable/argumentative for 2 days 1.6 1.9 4.0 -1.3 -0.3 2.0
Loud music exposure frequency 0.9 1.0 2.1 0.9 -1.5 0.3
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 3.5 1.4 -1.9 -1.0
Mouth/teeth dental problems: Bleeding gums 0.0 0.0 0.0 -0.2 -0.2 0.2
Blood clot in the leg (DVT) 1.8 2.3 3.1 1.5 -1.8 -1.3
Medication: Paracetamol 1.0 1.7 3.5 -0.5 1.1 1.9
Headache pain in last month 0.9 1.6 2.0 -1.4 1.2 1.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 0.9 -0.9 -0.6 -0.5
Glaucoma (self-reported) 1.1 1.3 3.6 0.1 -0.6 -1.9
Gout (self-reported) 0.4 0.6 1.4 -0.6 1.2 0.0
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.8 -1.1 0.3 1.3
Medication: Amlodipine 0.2 0.3 0.5 0.4 0.7 -0.5
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.3 -0.0 -0.5 -0.3
Birth weight 0.9 1.9 3.2 0.3 -1.8 -1.6
Chronic bronchitis/emphysema (mother) 3.6 4.2 7.9 -2.8 2.1 -0.1
High blood pressure (siblings) 0.7 1.0 2.5 0.6 -1.6 0.0
Forced vital capacity (FVC), Best measure 1.0 3.5 4.4 -2.1 1.8 1.7
Body fat percentage 1.2 4.9 10.3 -3.2 1.2 1.7
Leg fat percentage (right) 1.8 6.6 12.6 -3.5 1.9 1.9
Arm fat-free mass (right) 0.7 3.4 4.8 -1.9 1.4 2.2
Exposure to tobacco smoke outside home 0.6 0.8 1.3 1.2 0.6 0.9
Comparative body size at age 10 0.5 1.4 2.3 -1.2 0.7 1.5
Number of full brothers 1.1 1.4 2.7 1.1 -1.7 0.4
Worry too long after embarrassment 1.9 3.2 4.8 -1.7 1.4 2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.5 -0.2 -1.6 -0.4
Wheeze or whistling in the chest in last year 1.1 1.9 4.9 0.8 -0.2 2.2
Number of children fathered 2.2 2.5 6.1 -0.3 1.1 2.5
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.1 -1.1 0.6 0.6
Age at first live birth 0.8 1.4 2.2 1.5 -1.0 -1.0
Pulse wave peak to peak time 1.0 1.2 1.9 0.6 1.4 1.1
Health satisfaction 0.5 0.6 1.2 -0.1 -1.1 -0.8
Shortness of breath walking on level ground 0.2 0.3 0.4 -0.4 -0.6 0.6
Qualifications: College or University degree 0.7 2.1 5.5 2.3 -0.5 -0.8
Eye problems/disorders: None of the above 2.4 2.8 7.0 0.5 1.1 2.6
Mouth/teeth dental problems: Loose teeth 2.3 2.7 4.5 0.7 -1.8 -2.1
Emphysema/chronic bronchitis 1.0 1.1 2.2 -0.4 0.9 1.5
Medication for pain relief, constipation, heartburn 2.2 3.8 6.6 0.9 -2.0 -2.6
Neck or shoulder pain in last month 3.4 4.9 10.2 -1.4 3.2 1.5
Medication: Blood pressure 0.2 0.3 0.7 0.8 0.3 -0.2
Angina (self-reported) 1.1 1.5 3.7 -1.9 0.9 0.1
Migraine (self-reported) 2.5 3.1 4.7 0.9 2.2 1.9
Medication: Ibuprofen 1.7 2.1 2.5 -1.4 1.6 1.3
Medication: Allopurinol 3.0 4.0 6.3 -2.3 2.5 0.7
Medication: Omeprazole 0.4 0.5 0.8 0.9 -0.5 -0.6
Medication: Seretide 50 evohaler 0.8 0.9 2.7 0.0 -0.3 1.6
Mean time to correctly identify matches 1.2 2.3 4.6 -1.6 2.1 0.1
Heart disease (mother) 0.7 0.9 1.7 0.8 0.5 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.4 -0.5 0.1 0.6
Whole body fat mass 1.0 4.2 8.2 -2.9 1.1 1.8
Leg fat mass (right) 1.6 6.3 9.8 -3.1 1.7 2.5
Arm predicted mass (right) 0.6 3.3 4.1 -1.9 1.4 2.0
Pulse rate, automated reading 0.1 0.3 0.5 0.7 0.5 -0.1
Alcohol intake frequency. 0.3 0.8 1.3 -0.7 -1.1 -0.7
Comparative height size at age 10 0.1 0.5 0.8 0.5 -0.7 0.9
Number of full sisters 2.4 2.9 4.5 -2.0 2.1 0.7
Suffer from ‘nerves’ 1.7 2.6 4.8 2.2 -1.6 0.8
Overall health rating 0.1 0.2 0.6 -0.8 -0.1 -0.2
Chest pain or discomfort 0.6 0.8 0.9 0.9 -1.0 0.8
Had major operations 0.5 0.6 1.0 0.6 -1.0 -0.6
Age at last live birth 0.6 0.8 1.0 1.0 -0.9 -0.8
Family relationship satisfaction 1.5 1.9 5.2 0.7 -0.0 2.3
Leg pain on walking 0.2 0.3 0.4 -0.6 -0.3 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.3 -1.2 0.3 0.2
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.0 -0.8 -0.3 -1.0
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.0 -0.4 1.0 0.1
Medication: Aspirin 1.3 1.8 2.9 0.5 1.5 1.7
Supplements: Vitamin C 0.6 0.7 1.6 0.6 -0.3 1.3
Knee pain experienced in last month 4.0 6.2 9.3 -3.0 2.5 1.7
Hypertension (Self-reported) 0.1 0.4 0.5 -0.7 -0.5 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.4 0.1 0.7 -0.0
Illnesses of father: Heart disease 0.3 0.4 0.8 0.9 -0.5 -0.2
Illnesses of siblings: Diabetes 0.0 0.0 0.0 -0.2 0.1 -0.0
Smoking status: Previous 2.4 3.6 8.4 0.3 2.9 1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 2.3 1.2 -1.5 0.5
Whole body fat-free mass 0.4 2.1 3.8 -1.2 0.9 1.9
Leg fat-free mass (right) 0.2 1.1 2.4 -1.0 0.2 1.5
Arm fat percentage (left) 0.9 3.5 8.1 -2.8 0.8 1.3
Average weekly red wine intake 0.7 1.1 2.0 1.4 -0.8 -0.8
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.6 0.1 1.2 1.6
Mood swings 0.6 1.1 2.5 -0.6 0.6 1.6
Loneliness, isolation 0.2 0.3 0.5 -0.5 0.4 0.7
Long-standing illness, disability or infirmity 0.4 0.6 1.7 -1.3 0.3 0.0
Ever had bowel cancer screening 0.6 0.7 1.2 0.3 0.9 1.1
Diabetes diagnosed by doctor 0.7 1.1 2.9 1.7 -0.6 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.1 1.6 0.6 1.3 1.2
Friendships satisfaction 0.6 0.7 1.0 -1.0 0.9 0.5
Qualifications: nursing, teaching 0.7 1.2 2.3 0.5 -1.5 -0.9
Commuting to job workplace: Walk 1.2 1.2 3.2 1.8 -0.7 -0.3
Eye problems/disorders: Cataract 0.9 1.0 1.9 0.4 -0.9 -1.4
Mouth/teeth dental problems: Mouth ulcers 3.1 4.9 8.0 2.8 -2.3 -1.2
Medication for cholesterol 1.0 1.5 2.9 1.7 -1.1 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.3 3.9 7.8 -1.4 1.4 2.8
Back pain experienced in last month 2.5 3.7 6.2 -1.4 1.7 2.5
Mineral and other dietary supplements 0.3 0.4 1.2 -1.1 -0.1 -0.0
Breast cancer (self-reported) 0.3 0.4 0.7 -0.8 -0.2 -0.6
Asthma (self-reported) 0.3 0.6 1.0 0.8 -1.0 0.6
Osteoporosis (self-reported) 0.1 0.1 0.3 0.1 -0.5 -0.3
Osteoarthritis (self-reported) 1.8 2.3 3.9 -2.0 1.4 1.2
Medication: Aspirin 1.2 1.6 2.5 0.4 1.4 1.6
Medication: Gliclazide 1.7 1.9 4.0 2.0 -0.3 -1.3
Illnesses of father: None of the above (group 1) 0.5 0.6 1.3 -0.6 1.1 -0.4
Smoking status: Current 0.2 0.3 0.5 -0.7 -0.6 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 2.9 -1.7 1.4 0.3
Whole body water mass 0.4 2.3 4.1 -1.3 0.9 2.0
Leg predicted mass (right) 0.2 1.1 2.3 -1.0 0.2 1.5
Arm fat mass (left) 1.1 4.4 8.8 -3.0 1.1 1.8
Number of self-reported non-cancer illnesses 0.1 0.1 0.4 0.6 0.1 -0.0
Average weekly champagne plus white wine intake 0.3 0.4 0.6 0.3 0.7 -0.8
Miserableness 0.2 0.3 0.7 0.1 -0.6 -0.8
Guilty feelings 0.3 0.4 1.0 1.0 -0.5 0.1
Wears glasses or contact lenses 0.2 0.2 0.6 -0.8 0.1 -0.1
Ever taken oral contraceptive pill 0.8 0.9 2.2 0.8 -0.1 -1.5
Hearing aid user 1.3 1.5 3.2 0.9 -1.8 -0.6
Mother’s age at death 0.3 0.4 0.8 -0.3 -0.9 -0.4
Financial situation satisfaction 0.2 0.3 0.7 -0.5 0.2 0.8
Tinnitus: Yes, now most or all of the time 1.0 1.1 3.3 0.3 0.0 -1.8
Commuting to job workplace: Public transport 1.1 1.3 2.0 1.3 0.7 1.4
Eye problems/disorders: Glaucoma 1.4 1.6 3.6 -1.1 0.2 -1.9
Medication: Blood pressure 0.8 1.5 3.4 -1.8 0.3 -1.0
Pain type(s) experienced in last month: Hip pain 1.9 2.3 3.3 -1.1 1.8 1.6
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.1 0.3 0.4 -0.3
High cholesterol (Self-reported) 0.2 0.4 1.3 -0.1 1.1 -0.1
Medication: Bendroflumethiazide 1.3 2.0 3.7 -1.9 -1.2 -0.8
Medication: Paracetamol 1.7 2.6 5.0 -0.4 1.7 2.2
Medication: Lisinopril 1.0 1.3 1.9 0.9 1.4 1.2
Medication: Atorvastatin 0.8 1.0 1.8 -0.9 0.7 1.3
Illnesses of father: High blood pressure 0.0 0.0 0.1 -0.2 0.1 0.3
Alcohol drinker status: Never 1.1 1.3 2.3 -1.1 -1.5 -0.6
Ever smoked 1.4 2.4 4.6 -0.4 2.1 1.6
Basal metabolic rate 0.5 2.7 4.5 -1.6 1.0 2.1
Leg fat percentage (left) 1.7 6.0 11.9 -3.5 1.7 1.8
Arm fat-free mass (left) 0.7 3.7 5.5 -1.8 1.5 2.4
Number of operations (self-reported) 0.1 0.2 0.3 -0.5 -0.2 -0.6
Average weekly beer plus cider intake 0.1 0.2 0.5 0.3 -0.7 -0.3
Irritability 1.0 1.6 4.4 0.2 0.7 2.1
Risk taking 0.6 0.9 2.2 0.6 -1.5 -0.1
Ever had prostate specific antigen (PSA) test 3.5 4.0 9.2 -1.4 3.0 0.9
Fractured/broken bones in last 5 years 3.5 4.5 7.5 1.2 -2.7 -2.1
Age started oral contraceptive pill 1.1 1.3 3.3 0.0 -0.9 -1.8
Diastolic blood pressure, automated reading 0.6 1.9 3.0 -0.5 1.7 1.6
Ever depressed for a whole week 1.7 2.1 2.2 1.5 -1.5 -1.4
Unable to work because of sickness or disability 1.0 1.3 3.4 -0.2 -0.6 -1.9
Commuting to job workplace: Cycle 0.2 0.2 0.3 0.4 0.5 0.5
Myopia 0.2 0.2 0.4 -0.5 0.7 0.1
Vascular/heart problems diagnosed by doctor 0.2 0.5 0.7 0.9 0.2 0.8
Cholesterol lowering medication 0.2 0.3 0.9 0.2 0.1 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.5 0.7 0.3 0.1
Pain experienced in last month 4.0 6.7 8.4 1.9 -2.8 -2.9
Supplements: Calcium 0.0 0.0 0.1 -0.1 -0.3 -0.0
Basal cell carcinoma (self-reported) 0.6 0.7 1.0 0.4 1.0 1.0
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.9 0.5 -0.6 -1.7
Deep venous thrombosis (DVT) (self-reported) 1.3 1.6 2.1 1.4 -1.4 -1.0
Heart disease (siblings) 0.3 0.4 0.8 0.4 -0.3 -0.9
Alcohol drinker status: Previous 1.9 2.1 4.5 2.1 -0.3 -1.3
Pack years of smoking 0.5 0.7 1.6 -0.6 0.4 1.3
Impedance of whole body 0.8 3.9 4.5 2.1 -2.0 -1.8
Leg fat mass (left) 1.5 5.8 9.7 -3.1 1.5 2.3
Arm predicted mass (left) 0.7 3.4 4.6 -1.9 1.4 2.1