Hub : Genes

CA2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0618	0.0321	1.2e-03	0.001	NA	0.017	NA	0.009	2.4e-01	NA	7.0e-03	NA	3.7e-02
2	NTR	Blood	0.0462	0.0211	2.8e-05	0.006	0.024	0.025	0.027	0.018	2.6e-03	2.0e-08	1.2e-08	4.6e-09	9.1e-07
3	YFS	Blood	0.5987	0.0447	0.0e+00	0.075	0.208	0.231	0.191	0.190	2.9e-23	3.5e-66	4.4e-74	2.7e-60	7.2e-60

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.9	1.4	3.1	0.2	1.8	1.0
Bipolar Disorder or Schizophrenia	0.1	0.1	0.4	-0.2	-0.0	0.6
Depressed Affect (Nagel 2018)	0.4	0.9	1.3	-1.1	1.1	0.2
Depression (Nagel 2018)	0.4	0.6	1.3	-0.1	-1.1	-0.8
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.2	1.1	-1.0	-1.0
Neuroticism (Nagel 2018)	0.4	1.0	1.7	-0.3	1.3	1.1
Schizophrenia (2018)	0.3	0.7	2.1	0.2	-1.4	-0.1
Schizophrenia vs Biploar Disorder	0.1	0.2	0.3	-0.5	0.4	-0.3
Worry (Nagel 2018)	0.5	1.1	2.0	0.9	0.6	1.4
Alzheimer’s Disease (in mother)	0.3	0.4	0.9	0.2	-0.9	-0.4
Alzheimer’s Disease (in father)	2.4	2.6	3.7	1.9	-1.8	-1.1
Alzheimer’s Disease (including proxy)	0.8	1.2	1.7	1.3	-1.3	-0.5
Crohns Disease (2017)	3.8	8.3	10.8	-3.3	2.8	2.4
Irritable Bowel Disease (IBD)	2.9	6.9	11.2	-2.2	2.1	3.3
Ulcerative Colitis (UC)	1.0	1.9	5.4	-0.4	0.3	2.3
Major Depression (MDD)	0.8	1.0	1.7	0.5	1.0	1.3
Reaction Time	0.7	1.4	3.2	-0.9	1.8	-0.0
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.0	1.0	-0.6	-0.7
Breast Cancer	0.9	2.2	3.4	1.8	-1.7	-0.5
Ovarian Cancer	0.9	1.2	2.1	1.1	-1.4	-0.6
Prostate Cancer	1.1	1.5	3.4	-1.0	0.2	1.8
Age at First Birth	0.8	1.1	2.4	1.6	-0.9	-0.1
Bipolar Disorder (2011)	0.4	0.4	0.6	0.5	0.6	0.8
Body Mass Index (BMI) (2010)	0.9	1.2	2.4	-0.2	1.1	1.5
Coronary Artery Disease (CAD)	0.5	0.5	0.9	-1.0	0.1	-0.8
Crohns Disease (2012)	1.0	1.7	2.3	-0.8	1.4	1.5
Mean Putamen Volume	0.7	0.7	2.0	0.0	0.5	1.4
Fasting Glucose	0.4	0.5	1.0	0.7	0.3	-1.0
HbA1C	0.2	0.2	0.5	0.7	-0.0	-0.4
HDL Cholesterol	0.7	1.1	2.0	-0.3	-1.4	-1.1
LDL Cholesterol	1.7	2.7	5.6	2.4	-1.5	0.6
Lupus	0.5	0.8	2.0	1.4	-0.3	-0.6
Neuroticism (2016)	0.8	1.1	2.4	1.5	-0.9	-0.5
Primary Biliary Cirrhosis	0.3	0.5	1.0	0.6	-0.2	-1.0
Rheumatoid Arthritis	0.1	0.2	0.5	-0.7	0.1	0.2
Schizophrenia (2014)	0.3	0.6	1.1	0.8	-1.1	0.1
Triglycerides	0.1	0.2	0.3	-0.0	-0.6	-0.6
Type 2 Diabetes (T2D) (2012)	1.3	1.5	4.2	2.0	0.2	0.4
Ulcerative Colitis	0.5	0.7	2.1	0.3	0.2	1.4
Blood Eosinophil Count	0.1	0.7	1.5	-0.2	0.7	1.2
Blood Platelet Count	0.2	2.5	6.8	-0.8	2.6	0.2
Blood Red Count	0.1	0.9	2.6	0.5	-0.0	-1.6
Blood White Count	1.3	9.8	13.4	-3.7	3.5	2.0
Heel T-Score	0.2	1.7	5.0	-0.1	-0.2	2.2
BMI	1.3	7.7	16.5	-4.1	2.0	1.5
Height	0.1	2.8	5.1	2.3	-1.5	1.0
Waist Hip Ratio (WHR)	0.7	2.9	8.4	2.9	0.1	-0.7
Systolic Blood Pressure	0.1	0.6	1.5	-0.5	1.2	-0.1
Smoking Status	0.3	0.8	2.0	-0.3	1.4	0.5
Allergy or Eczema	0.6	1.6	2.7	0.1	1.7	1.4
Cardiovascular Disease	0.3	0.9	2.5	-0.1	-0.2	-1.6
Hypothyroidism (self reported)	0.1	0.2	0.6	-0.2	-0.2	0.8
Respiratory disease	0.3	0.6	1.4	0.2	-1.2	-0.5
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.1	1.4	-0.9	-1.0
Lung FEV1/FVC ratio	0.0	0.2	0.6	0.7	0.4	0.1
Lung FVC	3.8	19.2	29.1	-5.4	5.0	2.0
Neuroticism	0.6	1.3	3.4	0.1	0.8	1.8
Chronotype (morning person)	1.5	3.5	7.6	-0.8	2.8	1.5
Hair Pigment	0.0	0.5	1.0	0.6	-1.0	-0.0
Tanning	0.0	0.5	1.0	0.5	1.0	0.6
Hand grip strength (left)	2.3	6.0	8.3	-1.9	2.9	2.4
Number of treatments/medications taken	0.3	0.5	0.8	0.3	0.7	0.9
Average weekly spirits intake	0.3	0.4	0.9	0.9	-0.5	-0.4
Sensitivity / hurt feelings	0.8	1.4	2.4	-1.6	1.1	0.8
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.2	-0.4	-0.4	-0.5
Hearing difficulty/problems: Yes	0.4	0.7	1.8	-1.4	0.3	-0.3
Relative age of first facial hair	1.1	2.4	2.9	-1.2	1.6	1.7
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.9	-0.4	-0.4	-1.4
Ever used hormone-replacement therapy (HRT)	1.5	1.8	3.3	-0.9	1.8	1.2
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	-0.8	-0.2	-0.6
Systolic blood pressure, automated reading	0.5	1.5	2.5	-1.0	1.6	0.9
Eye problems/disorders: Diabetes related eye disease	3.4	3.8	4.9	2.2	-1.8	-1.8
Angina	1.2	1.6	3.8	-1.9	1.0	0.3
Medication for hormone replacement therapy	0.6	0.7	1.4	-1.2	0.8	0.2
Vitamin and mineral supplements	0.9	1.3	2.3	-1.5	1.1	0.5
Supplements: Zinc	0.9	0.9	2.7	1.7	0.0	0.3
Medication: Co-codamol	1.0	1.2	1.5	-1.2	0.7	1.2
Medication: Metformin	0.2	0.3	0.6	0.8	0.3	-0.3
Diabetes (father)	0.9	1.1	1.7	1.3	-0.9	0.8
Diabetes (mother)	1.0	1.2	3.6	0.1	-0.2	1.9
Severe depression (siblings)	1.5	1.7	4.0	1.0	0.1	2.0
Pack years adult smoking proportion	0.2	0.3	0.6	-0.7	0.0	0.8
Impedance of leg (right)	0.1	0.5	1.0	1.0	-0.3	-0.6
Leg fat-free mass (left)	0.2	1.2	2.5	-1.1	0.2	1.6
Trunk fat percentage	0.8	3.4	7.6	-2.8	0.9	1.3
Hand grip strength (right)	4.7	12.7	16.8	-3.4	4.1	3.2
Townsend deprivation index at recruitment	0.4	0.6	1.6	-0.5	-0.0	-1.3
Current tobacco smoking	0.2	0.2	0.6	-0.7	-0.3	0.3
Average weekly fortified wine intake	4.5	5.3	7.3	1.4	-2.6	-2.7
Maternal smoking around birth	0.3	0.5	1.1	0.4	-1.0	-0.5
Fed-up feelings	0.5	1.0	2.4	-1.5	0.5	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	3.6	0.1	-1.9	-1.2
Relative age voice broke	0.8	1.3	2.5	-0.0	1.2	1.6
Taking other prescription medications	0.8	1.3	2.0	-0.3	1.4	1.3
Age when periods started (menarche)	0.5	1.1	2.4	-0.3	-0.9	-1.6
Bilateral oophorectomy (both ovaries removed)	4.7	5.4	7.5	-2.7	2.6	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.0	-0.9	0.5	1.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.0	0.0	-0.2	1.0
Qualifications: CSEs or equivalent	0.4	0.5	1.2	0.3	-1.1	0.4
Serious illness, injury or assault to yourself	0.2	0.2	0.4	-0.5	-0.6	0.1
High blood pressure	0.2	0.5	0.6	-0.7	-0.5	-0.8
Hayfever, allergic rhinitis or eczema	0.9	2.0	3.4	-0.7	1.8	1.5
Multivitamins +/- minerals	0.3	0.3	0.5	0.6	-0.7	0.1
Stomach or abdominal pain in last month	0.2	0.3	0.5	0.3	-0.7	-0.4
Supplements: Glucosamine	0.2	0.3	0.5	0.7	0.6	-0.1
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	4.9	1.4	-0.7	-2.2
Medication: Atenolol	1.1	1.3	3.2	0.4	-0.8	-1.8
Medication: Levothyroxine sodium	0.4	0.6	1.0	-1.0	-0.2	0.9
Sitting height	0.1	0.6	0.7	0.5	-0.9	0.8
Chronic bronchitis/emphysema (father)	0.3	0.4	1.1	-0.2	-0.0	1.0
High blood pressure (mother)	0.6	0.8	1.5	0.4	0.8	1.2
Body mass index (BMI)	1.4	6.1	11.4	-3.4	1.9	1.8
Impedance of leg (left)	0.1	0.3	0.6	0.8	-0.1	-0.4
Leg predicted mass (left)	0.2	1.1	2.4	-1.0	0.2	1.5
Trunk fat mass	0.9	3.9	7.4	-2.7	1.0	1.8
Waist circumference	0.5	1.7	2.0	-1.4	1.0	1.4
Number of incorrect matches in round	1.1	1.9	2.8	-0.0	1.7	1.6
Past tobacco smoking	2.0	3.7	8.6	-0.0	-2.9	-1.6
Alcohol usually taken with meals	1.1	1.8	2.1	1.4	-1.4	-1.1
Nervous feelings	0.9	1.7	3.4	1.2	-1.8	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	-0.2	-0.3	-0.3
Hearing difficulty/problems with background noise	0.9	1.5	2.1	-1.2	1.0	1.5
Hair/balding pattern: Pattern 2	5.1	6.5	9.0	-1.5	3.0	2.9
Had menopause	0.3	0.4	0.9	-1.0	0.3	0.2
Had other major operations	0.4	0.4	1.0	-1.0	0.2	-0.5
Forced vital capacity (FVC)	0.9	3.6	4.8	-2.2	1.7	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.4	0.0	-1.2	0.9
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.2	-0.5	-1.5	-0.9
Qualifications: None of the above	0.6	1.4	2.8	-1.1	1.7	0.3
Financial difficulties in last 2 years	1.0	1.4	3.1	-0.4	-1.8	-1.0
Mouth/teeth dental problems	0.2	0.3	0.8	-0.3	0.9	0.3
Heart attack	0.4	0.6	1.6	0.1	-0.2	-1.3
Allergy	0.2	0.6	1.4	-0.2	-0.5	-1.2
Pain all over the body in last month	2.0	2.1	3.7	0.9	-1.9	-1.3
Diabetes (self-reported)	0.2	0.4	0.6	0.7	0.8	-0.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.8	0.5	0.8	0.9
Medication: Ramipril	1.1	1.5	4.0	-0.1	-0.6	-2.0
Medication: Simvastatin	2.1	3.1	3.8	1.8	-1.4	-1.9
Fluid intelligence score	0.2	0.3	0.7	0.8	-0.6	-0.1
Illnesses of siblings	0.8	1.1	2.1	-1.0	1.5	0.2
Neuroticism score	0.3	0.7	1.9	-0.1	0.5	1.4
Weight	0.8	3.8	5.7	-2.4	1.2	2.1
Impedance of arm (right)	1.5	7.0	8.5	2.9	-2.9	-2.1
Arm fat percentage (right)	0.9	3.4	7.6	-2.8	0.9	1.4
Trunk fat-free mass	0.4	2.2	3.9	-1.2	1.1	2.0
Hip circumference	0.5	2.4	4.4	-2.1	0.3	1.6
Time employed in main current job	2.5	2.9	3.7	1.7	-1.4	-1.9
Alcohol intake versus 10 years previously	1.4	2.1	2.6	1.6	-1.4	-1.4
Father’s age at death	0.4	0.5	1.4	0.0	0.1	1.2
Worrier / anxious feelings	0.1	0.2	0.4	0.6	0.4	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.2	-0.7	0.1
Falls in the last year	0.0	0.0	0.1	0.1	0.3	0.1
Hair/balding pattern: Pattern 3	1.2	1.8	3.0	0.9	-1.7	-1.2
Number of live births	0.3	0.4	0.6	-0.5	0.6	0.8
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	4.2	-2.1	1.9	1.8
Pulse rate	0.2	0.4	0.5	0.7	-0.7	-0.3
Happiness	0.4	0.5	1.1	0.1	0.6	1.0
Noisy workplace	0.4	0.5	0.7	-0.7	-0.6	-0.8
Qualifications: A levels/AS levels or equivalent	0.9	1.9	2.5	1.4	-1.1	-1.6
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.4	1.1	-1.0	-1.6
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	-0.1	-0.5	-0.3
Asthma	0.4	0.7	1.4	0.8	-1.2	0.3
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	1.7	-1.0	1.3	1.1
Medication: Cholesterol lowering	0.2	0.3	0.7	0.3	0.8	0.2
Depression (self-reported)	0.3	0.4	0.8	-0.6	0.1	0.9
Medication: Lansoprazole	0.5	0.6	1.2	-1.1	0.4	0.7
Prospective memory result	2.2	2.8	5.6	-1.4	2.4	0.9
Lung cancer (father)	0.5	0.6	1.3	-1.1	0.3	0.7
Illnesses of mother	0.5	0.6	1.1	-0.8	-0.2	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.6	5.1	-2.3	2.2	2.0
Pulse wave Arterial Stiffness index	0.7	0.9	1.9	-0.5	-1.4	-0.7
Impedance of arm (left)	1.2	5.8	6.9	2.4	-2.6	-2.1
Arm fat mass (right)	1.1	4.7	9.3	-3.1	1.1	1.9
Trunk predicted mass	0.3	1.9	3.6	-1.0	1.0	1.9
Standing height	0.2	1.9	2.9	1.7	-1.3	1.0
Length of working week for main job	0.4	0.4	0.6	-0.8	0.4	-0.7
Exposure to tobacco smoke at home	0.6	0.7	1.1	-1.0	1.0	-0.2
Breastfed as a baby	1.1	1.4	3.1	-0.8	1.8	0.6
Tense / ‘highly strung’	0.2	0.4	0.5	0.7	-0.7	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	0.9	0.6	-0.9	0.9
Hair/balding pattern: Pattern 4	0.7	1.8	3.2	-0.5	-1.4	-1.8
Birth weight of first child	0.2	0.3	0.4	-0.6	0.4	0.6
Peak expiratory flow (PEF)	0.2	0.4	0.6	-0.8	0.4	0.6
Pulse wave reflection index	1.7	2.1	5.2	-0.4	-1.0	-2.3
Ever highly irritable/argumentative for 2 days	1.6	1.9	4.0	-1.3	-0.3	2.0
Loud music exposure frequency	0.9	1.0	2.1	0.9	-1.5	0.3
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	3.5	1.4	-1.9	-1.0
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.0	-0.2	-0.2	0.2
Blood clot in the leg (DVT)	1.8	2.3	3.1	1.5	-1.8	-1.3
Medication: Paracetamol	1.0	1.7	3.5	-0.5	1.1	1.9
Headache pain in last month	0.9	1.6	2.0	-1.4	1.2	1.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.9	-0.9	-0.6	-0.5
Glaucoma (self-reported)	1.1	1.3	3.6	0.1	-0.6	-1.9
Gout (self-reported)	0.4	0.6	1.4	-0.6	1.2	0.0
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.8	-1.1	0.3	1.3
Medication: Amlodipine	0.2	0.3	0.5	0.4	0.7	-0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	-0.0	-0.5	-0.3
Birth weight	0.9	1.9	3.2	0.3	-1.8	-1.6
Chronic bronchitis/emphysema (mother)	3.6	4.2	7.9	-2.8	2.1	-0.1
High blood pressure (siblings)	0.7	1.0	2.5	0.6	-1.6	0.0
Forced vital capacity (FVC), Best measure	1.0	3.5	4.4	-2.1	1.8	1.7
Body fat percentage	1.2	4.9	10.3	-3.2	1.2	1.7
Leg fat percentage (right)	1.8	6.6	12.6	-3.5	1.9	1.9
Arm fat-free mass (right)	0.7	3.4	4.8	-1.9	1.4	2.2
Exposure to tobacco smoke outside home	0.6	0.8	1.3	1.2	0.6	0.9
Comparative body size at age 10	0.5	1.4	2.3	-1.2	0.7	1.5
Number of full brothers	1.1	1.4	2.7	1.1	-1.7	0.4
Worry too long after embarrassment	1.9	3.2	4.8	-1.7	1.4	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.5	-0.2	-1.6	-0.4
Wheeze or whistling in the chest in last year	1.1	1.9	4.9	0.8	-0.2	2.2
Number of children fathered	2.2	2.5	6.1	-0.3	1.1	2.5
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.1	-1.1	0.6	0.6
Age at first live birth	0.8	1.4	2.2	1.5	-1.0	-1.0
Pulse wave peak to peak time	1.0	1.2	1.9	0.6	1.4	1.1
Health satisfaction	0.5	0.6	1.2	-0.1	-1.1	-0.8
Shortness of breath walking on level ground	0.2	0.3	0.4	-0.4	-0.6	0.6
Qualifications: College or University degree	0.7	2.1	5.5	2.3	-0.5	-0.8
Eye problems/disorders: None of the above	2.4	2.8	7.0	0.5	1.1	2.6
Mouth/teeth dental problems: Loose teeth	2.3	2.7	4.5	0.7	-1.8	-2.1
Emphysema/chronic bronchitis	1.0	1.1	2.2	-0.4	0.9	1.5
Medication for pain relief, constipation, heartburn	2.2	3.8	6.6	0.9	-2.0	-2.6
Neck or shoulder pain in last month	3.4	4.9	10.2	-1.4	3.2	1.5
Medication: Blood pressure	0.2	0.3	0.7	0.8	0.3	-0.2
Angina (self-reported)	1.1	1.5	3.7	-1.9	0.9	0.1
Migraine (self-reported)	2.5	3.1	4.7	0.9	2.2	1.9
Medication: Ibuprofen	1.7	2.1	2.5	-1.4	1.6	1.3
Medication: Allopurinol	3.0	4.0	6.3	-2.3	2.5	0.7
Medication: Omeprazole	0.4	0.5	0.8	0.9	-0.5	-0.6
Medication: Seretide 50 evohaler	0.8	0.9	2.7	0.0	-0.3	1.6
Mean time to correctly identify matches	1.2	2.3	4.6	-1.6	2.1	0.1
Heart disease (mother)	0.7	0.9	1.7	0.8	0.5	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	-0.5	0.1	0.6
Whole body fat mass	1.0	4.2	8.2	-2.9	1.1	1.8
Leg fat mass (right)	1.6	6.3	9.8	-3.1	1.7	2.5
Arm predicted mass (right)	0.6	3.3	4.1	-1.9	1.4	2.0
Pulse rate, automated reading	0.1	0.3	0.5	0.7	0.5	-0.1
Alcohol intake frequency.	0.3	0.8	1.3	-0.7	-1.1	-0.7
Comparative height size at age 10	0.1	0.5	0.8	0.5	-0.7	0.9
Number of full sisters	2.4	2.9	4.5	-2.0	2.1	0.7
Suffer from ‘nerves’	1.7	2.6	4.8	2.2	-1.6	0.8
Overall health rating	0.1	0.2	0.6	-0.8	-0.1	-0.2
Chest pain or discomfort	0.6	0.8	0.9	0.9	-1.0	0.8
Had major operations	0.5	0.6	1.0	0.6	-1.0	-0.6
Age at last live birth	0.6	0.8	1.0	1.0	-0.9	-0.8
Family relationship satisfaction	1.5	1.9	5.2	0.7	-0.0	2.3
Leg pain on walking	0.2	0.3	0.4	-0.6	-0.3	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.3	-1.2	0.3	0.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.0	-0.8	-0.3	-1.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.0	-0.4	1.0	0.1
Medication: Aspirin	1.3	1.8	2.9	0.5	1.5	1.7
Supplements: Vitamin C	0.6	0.7	1.6	0.6	-0.3	1.3
Knee pain experienced in last month	4.0	6.2	9.3	-3.0	2.5	1.7
Hypertension (Self-reported)	0.1	0.4	0.5	-0.7	-0.5	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.4	0.1	0.7	-0.0
Illnesses of father: Heart disease	0.3	0.4	0.8	0.9	-0.5	-0.2
Illnesses of siblings: Diabetes	0.0	0.0	0.0	-0.2	0.1	-0.0
Smoking status: Previous	2.4	3.6	8.4	0.3	2.9	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.3	1.2	-1.5	0.5
Whole body fat-free mass	0.4	2.1	3.8	-1.2	0.9	1.9
Leg fat-free mass (right)	0.2	1.1	2.4	-1.0	0.2	1.5
Arm fat percentage (left)	0.9	3.5	8.1	-2.8	0.8	1.3
Average weekly red wine intake	0.7	1.1	2.0	1.4	-0.8	-0.8
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.6	0.1	1.2	1.6
Mood swings	0.6	1.1	2.5	-0.6	0.6	1.6
Loneliness, isolation	0.2	0.3	0.5	-0.5	0.4	0.7
Long-standing illness, disability or infirmity	0.4	0.6	1.7	-1.3	0.3	0.0
Ever had bowel cancer screening	0.6	0.7	1.2	0.3	0.9	1.1
Diabetes diagnosed by doctor	0.7	1.1	2.9	1.7	-0.6	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	1.6	0.6	1.3	1.2
Friendships satisfaction	0.6	0.7	1.0	-1.0	0.9	0.5
Qualifications: nursing, teaching	0.7	1.2	2.3	0.5	-1.5	-0.9
Commuting to job workplace: Walk	1.2	1.2	3.2	1.8	-0.7	-0.3
Eye problems/disorders: Cataract	0.9	1.0	1.9	0.4	-0.9	-1.4
Mouth/teeth dental problems: Mouth ulcers	3.1	4.9	8.0	2.8	-2.3	-1.2
Medication for cholesterol	1.0	1.5	2.9	1.7	-1.1	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.3	3.9	7.8	-1.4	1.4	2.8
Back pain experienced in last month	2.5	3.7	6.2	-1.4	1.7	2.5
Mineral and other dietary supplements	0.3	0.4	1.2	-1.1	-0.1	-0.0
Breast cancer (self-reported)	0.3	0.4	0.7	-0.8	-0.2	-0.6
Asthma (self-reported)	0.3	0.6	1.0	0.8	-1.0	0.6
Osteoporosis (self-reported)	0.1	0.1	0.3	0.1	-0.5	-0.3
Osteoarthritis (self-reported)	1.8	2.3	3.9	-2.0	1.4	1.2
Medication: Aspirin	1.2	1.6	2.5	0.4	1.4	1.6
Medication: Gliclazide	1.7	1.9	4.0	2.0	-0.3	-1.3
Illnesses of father: None of the above (group 1)	0.5	0.6	1.3	-0.6	1.1	-0.4
Smoking status: Current	0.2	0.3	0.5	-0.7	-0.6	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	2.9	-1.7	1.4	0.3
Whole body water mass	0.4	2.3	4.1	-1.3	0.9	2.0
Leg predicted mass (right)	0.2	1.1	2.3	-1.0	0.2	1.5
Arm fat mass (left)	1.1	4.4	8.8	-3.0	1.1	1.8
Number of self-reported non-cancer illnesses	0.1	0.1	0.4	0.6	0.1	-0.0
Average weekly champagne plus white wine intake	0.3	0.4	0.6	0.3	0.7	-0.8
Miserableness	0.2	0.3	0.7	0.1	-0.6	-0.8
Guilty feelings	0.3	0.4	1.0	1.0	-0.5	0.1
Wears glasses or contact lenses	0.2	0.2	0.6	-0.8	0.1	-0.1
Ever taken oral contraceptive pill	0.8	0.9	2.2	0.8	-0.1	-1.5
Hearing aid user	1.3	1.5	3.2	0.9	-1.8	-0.6
Mother’s age at death	0.3	0.4	0.8	-0.3	-0.9	-0.4
Financial situation satisfaction	0.2	0.3	0.7	-0.5	0.2	0.8
Tinnitus: Yes, now most or all of the time	1.0	1.1	3.3	0.3	0.0	-1.8
Commuting to job workplace: Public transport	1.1	1.3	2.0	1.3	0.7	1.4
Eye problems/disorders: Glaucoma	1.4	1.6	3.6	-1.1	0.2	-1.9
Medication: Blood pressure	0.8	1.5	3.4	-1.8	0.3	-1.0
Pain type(s) experienced in last month: Hip pain	1.9	2.3	3.3	-1.1	1.8	1.6
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	0.3	0.4	-0.3
High cholesterol (Self-reported)	0.2	0.4	1.3	-0.1	1.1	-0.1
Medication: Bendroflumethiazide	1.3	2.0	3.7	-1.9	-1.2	-0.8
Medication: Paracetamol	1.7	2.6	5.0	-0.4	1.7	2.2
Medication: Lisinopril	1.0	1.3	1.9	0.9	1.4	1.2
Medication: Atorvastatin	0.8	1.0	1.8	-0.9	0.7	1.3
Illnesses of father: High blood pressure	0.0	0.0	0.1	-0.2	0.1	0.3
Alcohol drinker status: Never	1.1	1.3	2.3	-1.1	-1.5	-0.6
Ever smoked	1.4	2.4	4.6	-0.4	2.1	1.6
Basal metabolic rate	0.5	2.7	4.5	-1.6	1.0	2.1
Leg fat percentage (left)	1.7	6.0	11.9	-3.5	1.7	1.8
Arm fat-free mass (left)	0.7	3.7	5.5	-1.8	1.5	2.4
Number of operations (self-reported)	0.1	0.2	0.3	-0.5	-0.2	-0.6
Average weekly beer plus cider intake	0.1	0.2	0.5	0.3	-0.7	-0.3
Irritability	1.0	1.6	4.4	0.2	0.7	2.1
Risk taking	0.6	0.9	2.2	0.6	-1.5	-0.1
Ever had prostate specific antigen (PSA) test	3.5	4.0	9.2	-1.4	3.0	0.9
Fractured/broken bones in last 5 years	3.5	4.5	7.5	1.2	-2.7	-2.1
Age started oral contraceptive pill	1.1	1.3	3.3	0.0	-0.9	-1.8
Diastolic blood pressure, automated reading	0.6	1.9	3.0	-0.5	1.7	1.6
Ever depressed for a whole week	1.7	2.1	2.2	1.5	-1.5	-1.4
Unable to work because of sickness or disability	1.0	1.3	3.4	-0.2	-0.6	-1.9
Commuting to job workplace: Cycle	0.2	0.2	0.3	0.4	0.5	0.5
Myopia	0.2	0.2	0.4	-0.5	0.7	0.1
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.7	0.9	0.2	0.8
Cholesterol lowering medication	0.2	0.3	0.9	0.2	0.1	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	0.7	0.3	0.1
Pain experienced in last month	4.0	6.7	8.4	1.9	-2.8	-2.9
Supplements: Calcium	0.0	0.0	0.1	-0.1	-0.3	-0.0
Basal cell carcinoma (self-reported)	0.6	0.7	1.0	0.4	1.0	1.0
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.9	0.5	-0.6	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	2.1	1.4	-1.4	-1.0
Heart disease (siblings)	0.3	0.4	0.8	0.4	-0.3	-0.9
Alcohol drinker status: Previous	1.9	2.1	4.5	2.1	-0.3	-1.3
Pack years of smoking	0.5	0.7	1.6	-0.6	0.4	1.3
Impedance of whole body	0.8	3.9	4.5	2.1	-2.0	-1.8
Leg fat mass (left)	1.5	5.8	9.7	-3.1	1.5	2.3
Arm predicted mass (left)	0.7	3.4	4.6	-1.9	1.4	2.1