Best TWAS P=5.41e-13 · Best GWAS P=4.36e-12 conditioned to 0.192
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | KIF27 | 0.18 | 0.14 | lasso | 4 | 0.13 | 7.1e-16 | 5.1 | -5.1 | 2.9e-07 | -0.45 | 0.99 | 0.01 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RMI1 | 0.11 | 0.03 | lasso | 3 | 0.04 | 3.8e-04 | 6.8 | 7.1 | 1.3e-12 | 0.86 | 0.00 | 0.99 | FALSE |
| 3 | GTEx | Testis | GKAP1 | 0.18 | 0.00 | lasso | 6 | 0.02 | 6.7e-02 | -4.4 | -5.2 | 1.9e-07 | -0.56 | 0.03 | 0.83 | FALSE |
| 4 | GTEx | Testis | RMI1 | 0.12 | 0.11 | enet | 15 | 0.14 | 1.3e-06 | 6.8 | 6.0 | 2.0e-09 | 0.93 | 0.00 | 0.99 | FALSE |
| 5 | METSIM | Adipose | RMI1 | 0.04 | 0.02 | lasso | 7 | 0.01 | 4.9e-03 | 6.6 | 6.3 | 3.1e-10 | 0.88 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RMI1 | 0.05 | 0.04 | lasso | 2 | 0.00 | 1.8e-01 | 6.8 | 6.8 | 1.5e-11 | 0.97 | 0.00 | 0.83 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | RMI1 | 0.40 | 0.03 | lasso | 2 | 0.06 | 1.9e-04 | 6.9 | 7.2 | 5.4e-13 | 0.87 | 0.00 | 0.99 | TRUE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KIF27 | 0.04 | 0.03 | blup | 41 | 0.03 | 8.2e-05 | 5.1 | -5.3 | 1.1e-07 | -0.40 | 0.38 | 0.11 | FALSE |
| 9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RMI1 | 0.05 | 0.06 | enet | 5 | 0.06 | 2.2e-05 | 6.6 | 5.8 | 7.3e-09 | 0.82 | 0.01 | 0.97 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | C9orf64 | 0.04 | 0.00 | blup | 34 | 0.02 | 6.1e-03 | 6.6 | -7.0 | 3.4e-12 | -0.75 | 0.01 | 0.74 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | KIF27 | 0.04 | 0.04 | blup | 41 | 0.03 | 3.6e-04 | 5.1 | -5.4 | 8.3e-08 | -0.43 | 0.22 | 0.12 | FALSE |