Best TWAS P=5.83e-11 · Best GWAS P=6.67e-11 conditioned to 0.069
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Nerve Tibial | NRBF2 | 0.08 | 0.09 | enet | 11 | 0.06 | 5.0e-05 | -4.7 | 5.5 | 4.4e-08 | 0.55 | 0.95 | 0.02 | FALSE |
2 | GTEx | Thyroid | NRBF2 | 0.11 | 0.05 | lasso | 3 | 0.07 | 2.5e-06 | 3.6 | 5.8 | 7.3e-09 | 0.73 | 0.04 | 0.95 | FALSE |
3 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NRBF2 | 0.07 | 0.04 | blup | 42 | 0.02 | 7.3e-03 | -4.9 | 5.7 | 9.1e-09 | 0.62 | 0.07 | 0.42 | FALSE |
4 | The Cancer Genome Atlas | Colon Adenocarcinoma | NRBF2 | 0.13 | 0.10 | enet | 11 | 0.09 | 4.9e-06 | -4.9 | 5.8 | 7.4e-09 | 0.63 | 0.08 | 0.80 | FALSE |
5 | The Cancer Genome Atlas | Glioblastoma Multiforme | JMJD1C | 0.11 | 0.02 | blup | 87 | 0.05 | 1.4e-02 | -4.9 | 6.5 | 5.8e-11 | 0.85 | 0.03 | 0.44 | TRUE |
6 | The Cancer Genome Atlas | Glioblastoma Multiforme | NRBF2 | 0.17 | 0.09 | enet | 10 | 0.13 | 1.1e-04 | -4.9 | 6.2 | 5.3e-10 | 0.83 | 0.01 | 0.90 | FALSE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | NRBF2 | 0.09 | 0.06 | enet | 8 | 0.07 | 2.7e-08 | -4.9 | 5.3 | 1.5e-07 | 0.43 | 0.92 | 0.04 | FALSE |