[Hub]/) : Traits : Lung FVC : ← →

chr1:153,241,677-155,910,830

Best TWAS P=2.4e-13 · Best GWAS P=1.86e-13 conditioned to 0.106

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	GBAP1	0.10	0.10	lasso	3	0.08	6.1e-07	6.0	6.1	8.2e-10	-0.72	0.37	0.63	FALSE
2	GTEx	Adipose Subcutaneous	GBA	0.08	0.03	lasso	3	0.02	8.9e-03	6.0	5.8	6.5e-09	-0.65	0.24	0.14	FALSE
3	GTEx	Adipose Visceral Omentum	GBAP1	0.07	0.11	enet	5	0.10	5.0e-06	6.3	6.2	5.7e-10	-0.73	0.23	0.69	FALSE
4	GTEx	Artery Aorta	GBAP1	0.31	0.36	enet	22	0.39	1.0e-22	6.3	6.2	7.3e-10	-0.80	0.51	0.49	FALSE
5	GTEx	Artery Tibial	GBAP1	0.21	0.26	lasso	7	0.26	1.3e-20	6.3	5.7	1.0e-08	-0.74	0.80	0.20	FALSE
6	GTEx	Brain Cerebellar Hemisphere	THBS3	0.19	0.26	lasso	2	0.24	8.6e-07	6.0	-6.1	9.8e-10	0.76	0.08	0.85	FALSE
7	GTEx	Breast Mammary Tissue	GBAP1	0.15	0.17	lasso	2	0.15	5.2e-08	6.3	6.3	3.1e-10	-0.76	0.59	0.40	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	GBAP1	0.21	0.05	lasso	3	0.06	4.5e-03	6.0	5.3	1.4e-07	-0.59	0.41	0.19	FALSE
9	GTEx	Cells Transformed fibroblasts	GBAP1	0.18	0.16	lasso	6	0.15	1.6e-11	6.3	6.0	1.5e-09	-0.73	0.75	0.25	FALSE
10	GTEx	Colon Sigmoid	GBAP1	0.16	0.13	enet	8	0.14	8.4e-06	6.3	7.0	2.4e-12	-0.89	0.02	0.98	FALSE
11	GTEx	Colon Transverse	GBAP1	0.13	0.15	lasso	5	0.11	6.4e-06	6.3	6.1	1.4e-09	-0.74	0.51	0.48	FALSE
12	GTEx	Colon Transverse	THBS3	0.11	0.09	lasso	4	0.09	5.9e-05	6.3	-5.7	1.4e-08	0.72	0.40	0.27	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	GBAP1	0.22	0.19	enet	6	0.17	6.8e-07	6.0	6.5	6.6e-11	-0.78	0.07	0.92	FALSE
14	GTEx	Esophagus Mucosa	GBAP1	0.12	0.12	enet	22	0.09	1.7e-06	6.3	5.9	3.2e-09	-0.69	0.70	0.30	FALSE
15	GTEx	Esophagus Mucosa	THBS3	0.15	0.15	lasso	2	0.13	6.8e-09	6.3	-6.2	5.0e-10	0.76	0.80	0.20	FALSE
16	GTEx	Esophagus Mucosa	MUC1	0.17	0.20	lasso	4	0.18	5.6e-12	-7.3	-7.3	2.6e-13	0.99	0.00	1.00	FALSE
17	GTEx	Esophagus Mucosa	RP11-263K19.4	0.14	0.14	lasso	4	0.12	1.5e-08	6.3	-6.2	4.8e-10	0.76	0.72	0.28	FALSE
18	GTEx	Esophagus Muscularis	GBAP1	0.09	0.13	enet	4	0.12	8.9e-08	5.9	6.2	6.1e-10	-0.73	0.54	0.46	FALSE
19	GTEx	Heart Left Ventricle	GBAP1	0.18	0.22	enet	13	0.18	1.1e-09	5.9	5.6	2.2e-08	-0.68	0.85	0.15	FALSE
20	GTEx	Lung	GBAP1	0.16	0.16	lasso	5	0.15	1.6e-11	5.9	6.0	2.5e-09	-0.70	0.91	0.09	FALSE
21	GTEx	Lung	THBS3	0.11	0.07	lasso	4	0.04	1.0e-03	6.3	-6.1	1.1e-09	0.72	0.63	0.26	FALSE
22	GTEx	Nerve Tibial	GBAP1	0.12	0.14	lasso	1	0.14	8.9e-10	6.3	6.3	3.2e-10	-0.75	0.75	0.25	FALSE
23	GTEx	Nerve Tibial	GBA	0.14	0.02	lasso	5	0.01	3.3e-02	6.3	5.8	6.6e-09	-0.66	0.40	0.14	FALSE
24	GTEx	Pancreas	GBAP1	0.12	0.17	enet	10	0.14	2.4e-06	5.9	5.2	1.6e-07	-0.64	0.41	0.50	FALSE
25	GTEx	Pancreas	THBS3	0.36	0.14	lasso	6	0.12	1.0e-05	6.0	-5.5	3.0e-08	0.70	0.32	0.16	FALSE
26	GTEx	Pancreas	GBA	0.12	0.05	enet	10	0.02	4.2e-02	6.3	5.9	4.4e-09	-0.67	0.12	0.65	FALSE
27	GTEx	Prostate	GBAP1	0.47	0.30	lasso	7	0.32	1.1e-08	6.3	5.6	1.8e-08	-0.75	0.24	0.74	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	GBAP1	0.15	0.06	lasso	4	0.06	3.6e-04	-7.2	7.3	2.7e-13	-0.96	0.01	0.99	FALSE
29	GTEx	Skin Sun Exposed Lower leg	RP11-263K19.4	0.04	0.01	enet	9	0.01	3.3e-02	6.3	-5.8	6.1e-09	0.70	0.21	0.40	FALSE
30	GTEx	Small Intestine Terminal Ileum	GBAP1	0.20	0.13	lasso	10	0.11	1.8e-03	-3.2	5.4	8.4e-08	-0.77	0.08	0.52	FALSE
31	GTEx	Spleen	GBAP1	0.33	0.23	enet	20	0.28	7.9e-08	6.0	6.5	9.7e-11	-0.79	0.03	0.96	FALSE
32	GTEx	Spleen	RP11-422P24.10	0.28	-0.01	enet	23	0.01	1.8e-01	3.7	6.0	1.6e-09	-0.03	0.03	0.34	TRUE
33	GTEx	Stomach	GBAP1	0.09	0.12	lasso	3	0.13	1.2e-06	5.9	5.2	2.0e-07	-0.62	0.62	0.31	FALSE
34	GTEx	Testis	THBS3	0.11	0.11	lasso	2	0.09	1.2e-04	5.9	-6.0	1.9e-09	0.71	0.23	0.62	FALSE
35	GTEx	Testis	MUC1	0.20	0.02	lasso	7	0.07	7.5e-04	-7.2	-5.2	1.7e-07	0.71	0.01	0.97	FALSE
36	GTEx	Testis	RP11-263K19.4	0.08	0.12	lasso	2	0.10	2.4e-05	5.9	-5.9	3.0e-09	0.70	0.16	0.64	FALSE
37	GTEx	Thyroid	GBAP1	0.23	0.28	lasso	10	0.27	4.6e-21	6.0	6.1	1.1e-09	-0.75	0.79	0.21	FALSE
38	GTEx	Vagina	GBAP1	0.27	0.08	lasso	7	0.17	1.3e-04	-3.9	5.7	1.2e-08	-0.74	0.03	0.88	FALSE
39	GTEx	Whole Blood	THBS3	0.17	0.20	enet	5	0.21	1.0e-18	6.3	-6.2	5.9e-10	0.75	0.80	0.20	FALSE
40	GTEx	Whole Blood	RP11-263K19.4	0.15	0.17	lasso	4	0.17	9.5e-16	6.3	-6.2	6.3e-10	0.74	0.82	0.18	FALSE
41	METSIM	Adipose	THBS3	0.09	0.10	lasso	7	0.12	4.7e-17	6.3	-6.1	9.2e-10	0.69	0.79	0.21	FALSE
42	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM46	0.03	0.00	blup	33	0.02	3.6e-03	-7.3	-5.7	9.2e-09	0.85	0.01	0.69	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	GBA	0.03	0.00	blup	26	0.02	3.1e-04	-3.0	5.3	1.1e-07	-0.68	0.03	0.69	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	GBAP1	0.02	0.03	lasso	4	0.03	1.3e-07	6.3	5.7	1.4e-08	-0.68	0.28	0.70	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	THBS3	0.02	0.02	blup	26	0.02	4.0e-05	6.0	-5.2	2.1e-07	0.72	0.08	0.80	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIM46	0.03	0.01	blup	32	0.01	4.9e-03	-7.4	-6.1	1.4e-09	0.72	0.00	0.68	FALSE
47	The Cancer Genome Atlas	Esophageal Carcinoma	FAM189B	0.36	0.05	lasso	3	0.02	6.1e-02	6.3	6.2	5.9e-10	-0.75	0.00	0.26	FALSE
48	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MUC1	0.04	0.01	enet	4	0.02	1.3e-03	-7.3	-7.3	2.4e-13	0.88	0.00	0.86	TRUE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	THBS3	0.02	0.03	lasso	4	0.03	2.1e-04	6.3	-6.4	2.0e-10	0.80	0.03	0.92	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	GBAP1	0.03	0.01	blup	26	0.02	1.9e-03	-3.2	5.6	2.0e-08	-0.81	0.04	0.81	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	GBAP1	0.02	0.03	enet	2	0.02	2.3e-03	6.3	6.3	3.1e-10	-0.76	0.02	0.57	FALSE
52	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GBAP1	0.05	0.04	blup	26	0.04	1.6e-03	6.3	6.8	1.0e-11	-0.84	0.01	0.84	FALSE
53	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRIM46	0.08	0.08	lasso	2	0.07	2.1e-05	6.3	-6.3	3.2e-10	0.75	0.08	0.75	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	THBS3	0.10	0.12	enet	11	0.10	4.4e-11	6.0	-6.2	6.6e-10	0.73	0.84	0.16	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	GBAP1	0.02	0.01	blup	24	0.02	3.0e-03	6.3	5.8	5.0e-09	-0.80	0.01	0.63	FALSE