TWAS hub - FAM189B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Putamen basal ganglia	0.3410	0.1010	4.9e-04	0.012	NA	-0.003	NA	0.011	1.6e-01	NA	3.8e-01	NA	1.7e-01
2	GTEx	Breast Mammary Tissue (Male)	0.2091	0.1204	3.1e-02	-0.001	NA	-0.012	NA	-0.010	3.4e-01	NA	7.8e-01	NA	6.3e-01
3	GTEx	Breast Mammary Tissue (Female)	0.0510	0.0437	1.1e-01	-0.008	NA	-0.009	NA	-0.005	6.4e-01	NA	7.1e-01	NA	4.8e-01
4	GTEx	Lung	0.0850	0.0405	1.5e-03	0.051	NA	0.048	NA	0.048	8.6e-05	NA	1.4e-04	NA	1.4e-04
5	GTEx	Skin Not Sun Exposed Suprapubic	0.0930	0.0390	2.5e-04	0.004	NA	0.044	NA	0.019	1.9e-01	NA	2.0e-03	NA	3.0e-02
6	GTEx	Thyroid	0.0770	0.0260	5.6e-07	0.098	NA	0.106	NA	0.114	6.3e-08	NA	1.7e-08	NA	5.3e-09
7	GTEx	Whole Blood	0.0470	0.0260	5.0e-03	0.004	NA	0.010	NA	0.001	1.2e-01	NA	3.5e-02	NA	2.6e-01
8	YFS	Blood	0.0205	0.0083	1.2e-05	0.011	0.016	0.015	0.016	0.016	1.3e-04	4.8e-06	6.2e-06	3.3e-06	4.0e-06
9	TCGA	Esophageal Carcinoma	0.3560	0.1610	8.7e-03	0.051	0.018	0.008	NA	0.023	9.8e-03	8.4e-02	1.7e-01	NA	6.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Crohns Disease (2012)	14.6	23.5	33.1	-4.6	-5.2	-3.1	-5.0	-5.8	-5.4	-4.7	5.2	-4.1
Irritable Bowel Disease (IBD)	12.3	29.2	38.4	-4.3	-4.7	-5.5	-5.5	-5.8	-5.6	-4.9	5.9	-6.2
Breast Cancer	11.0	26.5	43.2	4.8	5.0	6.6	5.5	4.0	5.6	4.0	-5.2	5.3
Crohns Disease (2017)	10.8	23.6	34.8	-3.7	-4.7	-4.7	-5.0	-5.9	-5.3	-3.5	5.5	-4.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	10.2	12.1	16.5	-3.3	-4.1	-3.3	-3.8	-3.0	-3.9	-3.3	3.1	-3.4
Mouth/teeth dental problems: Dentures	9.8	16.5	29.7	-2.9	-2.8	-5.2	-3.2	-2.9	-3.1	-4.5	5.1	-5.5
Ulcerative Colitis (UC)	7.4	13.9	23.1	-3.2	-2.8	-3.9	-3.6	-3.4	-3.5	-4.2	3.8	-4.8
Medication: Ramipril	7.1	9.1	15.7	-3.4	-3.6	-1.8	-4.0	-1.7	-3.8	-2.9	2.7	-2.3
Mouth/teeth dental problems	7.0	10.7	24.2	1.9	2.0	4.3	2.4	2.6	2.1	3.5	-4.1	4.9
Medication: Atorvastatin	6.3	7.8	13.0	-2.6	-2.9	-2.6	-2.9	-2.9	-2.8	-1.4	3.0	-3.6
Pain experienced in last month	5.9	9.8	19.2	-3.5	-3.3	-3.0	-3.1	-1.7	-3.3	-3.0	4.4	-2.1
Medication for cholesterol, blood pressure or diabetes	5.7	9.4	11.1	3.2	3.3	2.6	3.3	2.6	3.2	3.3	-3.2	2.7
Qualifications: NVQ or HND or HNC or equivalent	5.4	6.4	11.4	-2.1	-2.5	-2.1	-3.1	-3.4	-2.8	-2.9	1.9	-1.5
Number of full brothers	5.1	6.5	13.2	-3.6	-3.2	-0.7	-3.0	-2.2	-2.9	-2.5	2.2	-0.8
Medication: Blood pressure	4.6	8.1	10.2	-2.9	-3.2	-2.3	-2.9	-2.8	-2.8	-3.1	2.5	-2.8
Miserableness	4.5	7.8	11.6	-2.5	-2.3	-3.4	-2.1	-2.7	-2.2	-3.1	3.2	-3.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.2	4.9	7.3	2.1	2.4	-0.0	2.6	2.7	2.5	2.2	-2.4	1.7
Financial situation satisfaction	4.2	5.2	7.5	-2.1	-2.2	-1.7	-2.5	-2.2	-2.6	-2.2	2.7	-2.0
Smoking status: Previous	4.1	6.1	16.4	-0.9	-1.1	-4.0	-1.6	-1.9	-1.3	-1.8	3.0	-4.0
Severe depression (siblings)	4.0	4.5	10.3	-3.2	-2.1	-2.4	-2.2	-1.5	-1.8	-2.2	1.5	-1.6
Medication: Aspirin	4.0	5.2	13.5	-3.7	-2.3	-1.4	-2.2	-2.2	-1.9	-2.5	1.7	-1.8
Gout (self-reported)	3.9	5.3	18.3	0.9	0.8	4.0	0.7	0.7	0.9	2.3	-2.2	4.3
Ulcerative Colitis	3.7	5.4	10.8	-1.2	-1.6	-2.3	-2.4	-2.1	-2.5	-2.7	2.0	-3.3
Frequency of depressed mood in last 2 weeks	3.7	5.1	11.1	-2.2	-1.9	-2.4	-1.4	-3.3	-1.6	-2.1	2.0	-2.8
High blood pressure (mother)	3.7	5.2	11.7	1.9	2.2	3.4	1.8	1.2	2.2	1.7	-2.6	2.7
Nervous feelings	3.6	6.7	11.4	2.1	3.1	2.4	3.3	1.9	3.4	1.4	-2.9	2.1
Medication: Allopurinol	3.6	4.7	20.2	1.1	0.7	4.5	0.7	0.3	0.7	1.4	-1.6	3.9
Medication: Gliclazide	3.6	4.0	8.3	-1.9	-1.6	-2.9	-1.6	-0.8	-1.6	-1.8	2.3	-2.7
Depressed Affect (Nagel 2018)	3.5	7.3	13.8	-1.8	-1.8	-3.2	-1.5	-2.8	-1.6	-3.0	3.7	-3.7
Impedance of leg (left)	3.5	17.1	73.4	-1.8	-2.4	-8.6	-2.0	-1.3	-2.1	-3.8	4.4	-5.3
Family relationship satisfaction	3.5	4.3	9.5	-3.1	-1.9	-2.3	-1.6	-1.1	-1.6	-2.2	2.3	-1.8
Past tobacco smoking	3.3	6.1	17.4	0.8	1.4	4.2	1.5	2.2	1.4	1.9	-2.8	3.8
Bipolar Disorder or Schizophrenia	3.2	7.9	15.0	-3.0	-3.3	-2.4	-2.7	-1.6	-3.0	-3.9	1.5	-3.0
Tinnitus: Yes, but not now, but have in the past	3.2	3.4	5.8	2.3	2.1	0.4	2.2	1.8	2.4	2.0	-1.6	0.4
Impedance of leg (right)	3.1	14.9	67.7	-1.5	-2.1	-8.2	-1.7	-0.8	-1.9	-3.2	4.2	-5.0
Hair/balding pattern: Pattern 2	3.1	4.0	7.7	-1.5	-2.4	-0.9	-2.8	-2.5	-2.7	-1.1	1.6	-1.4
Birth weight	3.1	6.7	13.9	3.7	3.3	0.7	3.1	1.5	2.9	2.4	-2.5	1.8
Medication: Ibuprofen (e.g. Nurofen)	3.0	3.9	7.9	2.3	2.1	0.6	1.6	2.0	1.9	2.4	-2.8	1.1
Bipolar Disorder (2018)	2.9	4.6	7.0	-2.3	-2.4	-2.2	-2.0	-1.9	-2.4	-2.6	2.3	0.0
High cholesterol (Self-reported)	2.9	5.2	8.6	-1.7	-2.4	-1.9	-2.4	-1.5	-2.5	-2.1	2.8	-2.9
Risk taking	2.9	4.2	11.4	-1.4	-1.8	-1.9	-1.5	-2.3	-1.9	-1.5	2.0	-3.4
Mean Putamen Volume	2.8	3.2	5.8	-1.9	-2.1	-1.1	-2.2	-1.3	-2.4	-2.0	1.8	-0.4
Lung FVC	2.8	14.2	38.4	2.5	3.0	5.1	2.8	3.0	2.9	3.8	-2.9	6.2
Diabetes (self-reported)	2.8	4.3	11.2	-1.7	-1.6	-3.3	-1.9	-1.4	-1.8	-1.3	2.4	-2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	8.9	-1.5	-1.4	-2.1	-1.5	-3.0	-1.5	-1.1	1.7	-2.5
Hayfever, allergic rhinitis or eczema	2.7	5.8	14.0	-1.1	-2.2	-3.7	-1.3	-2.2	-1.9	-2.5	2.4	-3.1
Allergy	2.7	6.2	16.7	0.7	2.1	4.1	1.0	1.9	1.7	2.8	-2.6	3.5
Medication: Ibuprofen	2.7	3.2	6.2	2.4	1.8	0.2	1.4	2.0	1.6	2.3	-2.5	0.4
Number of full sisters	2.7	3.3	7.1	-2.3	-2.2	0.3	-2.7	-1.4	-2.7	-1.6	0.4	0.7
Medication: Aspirin	2.7	3.6	10.1	-3.2	-1.9	-1.7	-1.8	-1.8	-1.5	-1.9	1.3	-1.3
Depression (Nagel 2018)	2.6	3.9	8.4	-1.6	-1.8	-1.4	-1.2	-2.9	-1.3	-2.3	1.9	-2.7
Alzheimer’s Disease (in father)	2.6	2.8	6.7	1.4	1.7	1.0	1.1	2.6	1.1	2.3	-1.5	1.7
Schizophrenia (2014)	2.6	5.8	11.0	-3.3	-3.3	-1.0	-2.6	-1.8	-2.8	-3.3	0.7	0.0
Smoking Status	2.6	6.2	9.0	-1.9	-2.2	-2.8	-2.9	-3.0	-2.7	-2.2	2.4	-1.9
Medication: Cholesterol lowering	2.6	4.0	5.7	-2.3	-2.0	-2.1	-2.2	-1.0	-2.0	-1.9	2.4	-1.8
Loud music exposure frequency	2.6	2.8	4.9	0.6	1.4	1.5	1.8	2.2	1.9	1.1	-1.8	2.1
Chest pain or discomfort	2.6	3.7	6.2	-1.5	-1.8	-1.9	-1.9	-2.5	-2.1	-1.2	1.9	-2.2
Loneliness, isolation	2.6	3.5	6.7	-1.6	-1.3	-2.1	-0.8	-2.1	-1.1	-2.0	2.6	-2.5
Blood Red Count	2.5	24.6	102.0	-1.6	-1.2	-8.6	-1.5	-2.8	-1.4	-4.1	3.7	-10.1
Arm fat percentage (right)	2.5	9.9	19.9	2.9	2.3	1.6	2.0	2.5	2.3	4.3	-4.5	4.4
Pulse wave reflection index	2.5	3.1	6.6	-0.6	-1.2	-2.6	-1.5	-1.7	-1.2	-1.5	2.5	-2.2
Arm fat percentage (left)	2.5	9.8	21.0	2.9	2.2	1.9	2.0	2.2	2.2	4.3	-4.6	4.2
Mouth/teeth dental problems: Bleeding gums	2.4	3.1	8.3	-0.7	-1.2	-2.9	-1.6	-1.7	-1.4	-1.2	2.5	-1.5
Hair/balding pattern: Pattern 4	2.3	5.7	18.1	0.9	1.8	2.3	2.0	2.7	1.8	2.1	-2.2	4.3
Diabetes diagnosed by doctor	2.3	3.7	7.3	-1.7	-1.6	-2.7	-1.9	-1.1	-1.9	-1.0	2.6	-2.3
Worry (Nagel 2018)	2.2	4.7	9.2	2.8	2.8	0.8	3.0	0.8	2.9	1.4	-2.4	-0.1
Fasting Glucose	2.2	2.7	5.2	-1.1	-1.2	-0.6	-1.7	-2.3	-1.7	-1.4	1.7	-2.2
Leg fat-free mass (left)	2.2	11.4	43.7	1.6	1.7	6.6	1.0	1.6	1.3	3.5	-3.8	4.6
Leg predicted mass (left)	2.2	11.6	43.7	1.7	1.8	6.6	1.1	1.6	1.4	3.6	-3.9	4.6
Blood clot in the leg (DVT)	2.2	2.8	6.5	-1.3	-1.5	-2.2	-1.3	-0.7	-1.5	-1.8	2.5	-1.6
Leg predicted mass (right)	2.2	11.5	45.8	1.6	1.7	6.8	1.1	1.4	1.3	3.4	-3.9	4.6
Fed-up feelings	2.1	3.8	8.4	-1.5	-1.5	-2.9	-1.2	-1.8	-1.1	-1.9	2.5	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.7	16.0	0.2	0.4	4.0	0.9	1.1	0.8	1.9	-1.9	4.0
Qualifications: CSEs or equivalent	2.1	2.8	5.6	-1.7	-2.2	-0.9	-2.4	-0.3	-2.2	-1.9	1.3	-0.8
Wheeze or whistling in the chest in last year	2.1	3.8	7.7	-1.2	-1.8	-2.1	-1.2	-2.2	-1.8	-1.8	2.1	-2.8
Emphysema/chronic bronchitis	2.1	2.4	7.1	-0.3	-0.4	-2.2	-0.9	-0.6	-0.8	-1.6	2.3	-2.7
Leg fat-free mass (right)	2.1	11.5	47.1	1.5	1.6	6.9	1.0	1.4	1.2	3.3	-3.9	4.6
Breast cancer (self-reported)	2.1	2.5	5.2	-2.3	-2.2	0.1	-1.6	-2.0	-1.7	-1.1	1.1	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.4	10.5	1.6	1.9	2.5	1.7	1.3	1.5	2.4	-1.9	3.2
Commuting to job workplace: Public transport	2.1	2.5	6.3	1.4	1.4	2.2	0.7	2.1	0.9	0.5	-1.2	2.5
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	6.1	-1.4	-1.5	-2.1	-1.3	-0.5	-1.5	-1.7	2.5	-1.6
Allergy or Eczema	2.0	5.3	13.0	-1.2	-2.3	-3.6	-1.4	-2.3	-1.9	-2.0	2.2	-2.9
Ever had hysterectomy (womb removed)	2.0	2.3	4.7	1.2	1.1	1.6	1.6	2.2	1.3	1.3	-2.1	0.4
Current tobacco smoking	2.0	3.2	6.7	-1.7	-2.2	-0.5	-2.4	-1.9	-2.6	-1.2	1.8	0.6
Maternal smoking around birth	2.0	2.9	5.8	-2.4	-2.3	0.0	-2.1	-1.7	-2.2	-1.6	0.7	0.4
Time employed in main current job	2.0	2.3	4.4	1.1	1.6	1.6	1.7	2.1	1.6	1.2	-1.2	1.2
Worrier / anxious feelings	2.0	3.8	8.0	2.8	2.8	-0.2	2.5	1.1	2.5	1.2	-1.8	0.3
Breastfed as a baby	2.0	2.5	4.5	-2.1	-1.9	-0.2	-1.3	-2.1	-1.7	-1.5	0.6	-1.7
Arm fat mass (left)	2.0	8.2	18.8	1.9	1.5	3.6	1.1	1.7	1.4	3.5	-4.1	4.3
Ever taken oral contraceptive pill	2.0	2.3	5.4	-1.2	-1.6	-2.3	-1.1	-0.9	-1.2	-2.2	0.5	-1.6
Tanning	1.9	23.1	34.5	-5.8	-5.9	-2.3	-5.0	-5.0	-5.2	-4.5	4.5	-4.0
Arm fat mass (right)	1.9	8.0	17.8	2.0	1.7	3.4	1.2	1.8	1.5	3.5	-4.1	4.2
Migraine (self-reported)	1.9	2.4	5.0	0.8	1.9	-0.2	2.2	0.9	2.1	1.8	-2.0	0.1
Asthma (self-reported)	1.9	3.8	6.2	-1.4	-2.4	-1.8	-1.3	-1.6	-1.9	-2.5	2.3	-2.0
Illnesses of father: None of the above (group 1)	1.9	2.4	4.1	-2.0	-1.9	-1.8	-1.6	-0.7	-1.6	-1.2	1.6	-0.8
Basal cell carcinoma (self-reported)	1.9	2.2	3.5	1.7	1.6	0.3	1.9	1.4	1.8	1.5	-1.6	0.9
Impedance of arm (right)	1.8	8.2	24.5	2.8	2.8	-5.0	3.0	2.6	3.0	2.0	-2.0	0.4
Forced expiratory volume in 1-second (FEV1)	1.8	6.1	15.3	1.8	2.0	2.9	1.7	1.4	1.6	3.3	-2.4	3.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.7	14.9	2.2	2.0	2.2	1.7	1.4	1.7	3.2	-2.1	3.9
Eye problems/disorders: None of the above	1.8	2.1	6.4	0.7	1.0	2.1	0.5	0.7	0.7	1.1	-2.5	2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	3.9	-2.0	-1.3	-1.6	-1.2	-0.6	-1.0	-1.4	1.7	-1.2
Ever smoked	1.8	3.2	6.5	-0.6	-1.2	-2.6	-1.5	-2.2	-1.4	-1.1	2.0	-2.5
Diastolic blood pressure, automated reading	1.8	5.6	8.6	2.1	1.6	2.8	1.6	2.8	1.8	2.6	-2.9	2.6
Cardiovascular Disease	1.7	5.7	8.9	-2.4	-3.0	-1.6	-3.0	-2.7	-2.9	-1.7	1.6	-2.1
Townsend deprivation index at recruitment	1.7	2.3	3.2	-1.4	-1.4	-1.1	-1.8	-1.8	-1.7	-1.6	1.7	-1.0
Diverticular disease/diverticulitis (self-reported)	1.7	2.1	4.8	1.4	1.0	-0.1	1.3	2.2	1.0	1.4	-1.4	2.1
Pain all over the body in last month	1.7	1.8	4.9	2.2	1.7	0.3	1.7	-0.0	1.5	1.2	-1.2	0.3
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.7	4.1	-2.0	-1.5	-1.1	-1.7	-1.7	-1.6	-2.0	1.3	-1.7
Asthma	1.7	3.4	5.7	-1.3	-2.2	-1.7	-1.1	-1.4	-1.7	-2.4	2.1	-2.0
Impedance of arm (left)	1.7	8.1	21.9	2.9	2.8	-4.7	3.2	2.3	3.1	2.0	-2.3	0.2
Pulse wave peak to peak time	1.7	2.0	5.8	0.7	1.0	2.4	1.2	1.0	1.3	0.9	-1.6	1.7
Eye problems/disorders: Cataract	1.7	2.0	3.9	-1.1	-1.8	-1.0	-1.3	-0.7	-1.5	-1.6	2.0	-1.2
Average weekly champagne plus white wine intake	1.7	2.3	3.9	1.8	1.3	0.9	1.3	1.6	1.4	1.6	-2.0	1.6
Qualifications: College or University degree	1.6	4.9	11.6	1.8	2.7	0.1	3.4	2.4	3.3	1.7	-1.7	0.1
Knee pain experienced in last month	1.6	2.5	5.9	1.4	1.0	2.4	0.9	0.3	0.8	2.1	-2.3	1.7
Back pain experienced in last month	1.6	2.3	6.2	0.8	1.1	2.1	0.8	0.4	1.2	1.5	-2.5	1.9
Schizophrenia (2018)	1.5	3.1	8.1	-2.0	-2.3	-1.4	-1.8	-0.5	-1.9	-2.9	0.2	-1.2
Type 2 Diabetes (T2D) (2018)	1.5	2.9	9.8	-1.1	-1.3	-3.1	-1.4	-0.1	-1.5	-0.2	2.4	-1.8
Medication: Metformin	1.5	2.1	7.0	-0.8	-0.6	-2.6	-1.1	-1.1	-0.9	-0.6	1.6	-2.2
Forced vital capacity (FVC)	1.5	5.8	16.6	1.9	2.1	4.1	1.6	1.0	1.5	2.7	-1.8	3.4
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	4.5	0.1	-0.9	-2.1	-0.7	-2.0	-1.0	-0.9	1.5	-2.1
Illnesses of mother	1.5	1.9	3.9	-1.6	-1.1	-1.9	-0.9	-0.4	-1.1	-1.4	1.2	-2.0
Illnesses of father: Heart disease	1.5	2.0	8.2	0.3	0.3	2.9	0.1	-0.1	0.1	1.4	-1.8	2.2
Fractured/broken bones in last 5 years	1.5	2.0	3.1	-1.6	-1.6	-0.6	-1.7	-0.8	-1.5	-1.6	1.8	-0.8
Supplements: Calcium	1.5	1.6	4.2	-0.4	-1.1	-1.1	-0.7	-1.1	-0.9	-1.9	2.0	-1.3
Blood Platelet Count	1.4	16.8	44.1	-1.1	-1.9	-6.6	-1.7	-2.8	-2.1	-3.6	5.7	-6.5
Ever used hormone-replacement therapy (HRT)	1.4	1.8	5.4	0.9	0.8	2.2	1.2	0.9	1.0	0.8	-2.3	0.7
Trunk fat percentage	1.4	5.8	12.7	2.4	1.5	0.3	1.3	2.0	1.5	3.4	-3.5	3.6
Trunk fat mass	1.4	6.1	15.3	2.0	1.2	2.0	1.0	1.8	1.2	3.3	-3.6	3.9
Weight	1.4	7.1	25.5	1.0	0.7	5.0	0.3	1.3	0.5	2.8	-3.5	3.9
Pulse wave Arterial Stiffness index	1.4	1.6	5.1	-0.4	-0.8	-2.3	-1.1	-0.8	-1.2	-0.7	1.4	-1.6
Forced vital capacity (FVC), Best measure	1.4	5.0	10.9	2.2	2.0	3.2	1.7	0.8	1.5	2.6	-1.6	3.3
Health satisfaction	1.4	1.8	3.3	0.7	1.7	-0.2	1.6	1.6	1.7	0.7	-1.8	1.0
Shortness of breath walking on level ground	1.4	1.7	4.0	1.4	1.3	0.3	1.6	1.0	1.7	0.9	-2.0	0.1
Mood swings	1.4	2.5	7.6	-0.1	0.2	-2.8	-0.5	-1.8	-0.3	-0.9	2.1	-2.5
Basal metabolic rate	1.4	7.7	41.2	0.6	0.7	6.4	0.1	0.8	0.3	2.3	-2.9	3.6
Heel T-Score	1.3	10.3	45.0	0.5	-0.1	5.6	0.8	1.4	0.3	2.3	-2.8	6.7
Body mass index (BMI)	1.3	5.5	15.8	1.1	0.8	4.0	0.4	1.0	0.6	2.7	-3.2	3.6
Hair/balding pattern: Pattern 3	1.3	1.9	4.4	1.1	1.2	-1.3	1.7	2.1	1.8	-0.4	-0.8	-1.3
Peak expiratory flow (PEF)	1.3	2.9	6.7	1.1	1.1	1.4	1.1	1.5	1.0	2.3	-2.4	2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	4.5	-1.0	-0.9	-0.8	-0.2	-2.1	-0.4	-0.2	1.9	-1.9
Whole body fat-free mass	1.3	7.3	44.4	0.3	0.5	6.7	-0.0	0.6	0.1	1.9	-2.4	3.3
Whole body water mass	1.3	7.3	44.5	0.3	0.5	6.7	-0.1	0.6	0.1	1.9	-2.4	3.4
Impedance of whole body	1.3	6.6	48.4	0.9	0.4	-7.0	0.9	0.8	0.8	-0.8	0.9	-2.5
Type 2 Diabetes (T2D) (2012)	1.2	1.4	4.0	-1.5	-0.9	-0.7	-1.2	-2.0	-1.2	-0.7	1.1	0.0
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	11.0	0.0	-0.1	3.3	0.2	0.8	0.1	1.2	-0.9	3.3
Number of live births	1.2	1.7	4.1	-1.3	-1.0	-0.5	-1.7	-0.4	-1.3	-2.0	1.4	-1.4
Happiness	1.2	1.5	8.8	-0.6	-0.1	-3.0	-0.0	-1.4	0.2	-0.5	1.0	-1.0
Medication: Omeprazole	1.2	1.4	4.4	-0.5	-0.0	-2.1	-0.0	-1.3	0.1	-1.2	0.5	-2.1
Whole body fat mass	1.2	5.0	13.2	1.6	0.9	2.2	0.6	1.5	0.8	3.0	-3.3	3.6
Pulse rate, automated reading	1.2	3.8	10.2	1.7	1.7	-0.2	2.6	3.2	2.2	1.8	-1.7	0.8
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	4.2	1.3	1.3	-0.4	1.0	2.0	1.1	0.7	-1.2	1.0
Long-standing illness, disability or infirmity	1.2	1.8	4.3	-1.5	-1.0	-1.0	-1.0	-2.1	-1.0	-1.9	1.0	-1.4
Waist Hip Ratio (WHR)	1.1	5.0	17.1	-0.4	-1.0	-4.1	-0.9	-2.3	-1.0	-2.1	1.5	-3.6
Hair Pigment	1.1	31.0	69.7	-4.9	-5.1	-3.9	-4.3	-4.8	-5.0	-5.2	8.3	-7.1
Medication for hormone replacement therapy	1.1	1.3	3.8	0.7	0.8	1.2	1.1	0.0	0.6	1.5	-1.9	0.9
Diabetes (mother)	1.1	1.4	2.7	-1.0	-1.3	-0.7	-1.6	-1.2	-1.4	-1.3	1.0	-0.2
Heart attack	1.1	1.4	3.8	-1.9	-1.4	0.1	-1.8	-0.2	-1.3	-1.0	1.0	0.1
Chronic bronchitis/emphysema (mother)	1.1	1.3	4.5	-1.0	-1.4	0.3	-1.0	-0.1	-1.2	-2.1	1.2	-0.7
Body fat percentage	1.1	4.2	9.5	2.0	1.1	0.3	1.0	1.6	1.1	3.1	-3.0	3.0
Heart disease (mother)	1.1	1.3	2.6	1.6	1.6	0.4	0.8	0.5	1.2	1.4	-0.6	1.2
Smoking status: Current	1.1	1.8	3.9	-1.0	-1.7	-0.5	-1.7	-1.5	-2.0	-0.7	1.1	0.8
Guilty feelings	1.1	1.6	4.4	-2.1	-1.7	0.1	-1.2	-1.1	-1.4	-0.9	0.1	-1.5
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.4	-0.0	0.6	0.8	1.2	1.2	1.1	-0.9	-1.6	1.9
Body Mass Index (BMI) (2010)	1.0	1.4	4.0	1.1	1.1	2.0	1.0	0.6	1.3	1.0	-1.6	0.0
HDL Cholesterol	1.0	1.6	3.5	1.5	1.3	0.4	1.7	1.9	1.6	0.2	-1.1	0.0
LDL Cholesterol	1.0	1.5	4.6	-1.0	-1.3	-1.7	-0.9	-0.7	-1.2	-0.9	2.1	0.0
Systolic blood pressure, automated reading	1.0	2.9	9.7	0.8	0.1	3.1	0.1	1.9	0.2	1.5	-1.6	2.6
Serious illness, injury or assault to yourself	1.0	1.2	3.6	-1.5	-1.0	-0.6	-0.6	-0.9	-0.6	-1.0	1.2	-1.9
Trunk fat-free mass	1.0	5.9	42.0	-0.4	-0.0	6.5	-0.5	0.2	-0.4	1.0	-1.8	2.6
Lung cancer (father)	1.0	1.2	4.6	0.1	-0.8	-2.1	-0.4	-1.0	-0.6	-1.2	1.2	-1.1
Trunk predicted mass	1.0	5.7	40.7	-0.4	-0.1	6.4	-0.5	0.2	-0.4	1.0	-1.7	2.5
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	6.9	1.3	1.0	2.6	0.7	1.0	0.9	1.1	-2.1	0.7
Comparative body size at age 10	1.0	2.7	4.5	1.8	2.1	1.9	1.4	1.6	1.8	1.2	-1.6	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	5.6	-0.2	-0.9	-0.7	-0.6	-2.4	-0.9	-0.7	0.6	-1.3
Heart attack/myocardial infarction (self-reported)	1.0	1.2	3.6	-1.9	-1.2	0.4	-1.7	0.1	-1.2	-0.9	0.8	0.2
Respiratory disease	0.9	2.1	3.0	-0.4	-1.5	-1.6	-1.3	-1.4	-1.7	-1.4	1.7	-1.4
Neuroticism	0.9	2.2	9.8	0.4	0.6	-2.1	0.9	-1.0	0.8	-1.5	0.7	-3.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.6	-1.3	-0.7	-1.0	-0.3	-1.6	-0.5	-1.5	0.9	-1.3
Hearing difficulty/problems with background noise	0.9	1.4	6.5	-0.1	0.5	-1.9	0.9	-0.8	1.0	-0.1	-0.4	-2.5
Had other major operations	0.9	1.1	2.5	-1.1	-1.4	0.8	-1.6	-0.1	-1.5	0.1	0.2	1.2
Hip circumference	0.9	3.7	15.3	0.3	0.3	3.9	-0.0	1.2	0.1	2.0	-2.4	2.6
Qualifications: A levels/AS levels or equivalent	0.9	2.0	4.2	1.7	1.8	-0.5	2.0	0.9	2.0	1.6	-0.5	-0.6
Tense / ‘highly strung’	0.9	1.5	6.3	-0.6	-0.3	-1.7	0.1	-1.4	-0.0	-0.8	1.2	-2.5
Worry too long after embarrassment	0.9	1.5	6.3	-0.4	-0.1	-1.8	0.2	-1.4	-0.0	-0.8	1.2	-2.5
Number of children fathered	0.9	1.0	2.3	-0.7	-1.4	1.5	-1.3	-0.1	-1.3	-0.4	-0.2	1.0
Age at first live birth	0.9	1.6	4.3	1.4	2.1	0.3	1.7	0.9	1.7	0.9	-0.3	0.7
Medication: Seretide 50 evohaler	0.9	1.0	2.7	-0.2	-1.2	-0.3	-0.8	-0.8	-1.1	-1.3	1.7	-0.9
Arm predicted mass (right)	0.9	4.5	30.7	-1.0	-1.1	5.5	-1.4	-0.5	-1.4	0.3	-0.5	1.8
Number of self-reported non-cancer illnesses	0.9	1.6	3.6	-0.2	-1.2	-1.9	-1.1	-1.5	-1.3	-0.8	1.1	-1.6
Arm fat-free mass (left)	0.9	4.8	33.2	-0.6	-0.6	5.8	-1.1	-0.0	-0.9	0.8	-1.1	2.3
Irritability	0.9	1.5	4.0	-0.8	-0.7	-1.9	-0.3	-0.2	-0.5	-1.8	2.0	-1.1
Vascular/heart problems diagnosed by doctor	0.9	2.4	5.3	2.0	2.3	0.3	2.0	1.2	1.9	1.2	-1.1	0.9
Alcohol drinker status: Previous	0.9	1.1	2.2	-1.5	-1.3	-0.5	-0.7	-1.5	-1.0	-0.5	0.7	-1.1
Arm predicted mass (left)	0.9	4.6	32.1	-0.8	-0.7	5.7	-1.2	-0.1	-1.1	0.5	-0.9	2.1
HbA1C	0.8	0.8	1.9	-0.7	-1.2	-0.5	-1.1	0.3	-1.4	-0.0	1.1	-1.0
BMI	0.8	4.4	17.7	0.3	0.6	2.6	-0.3	1.1	0.2	2.3	-2.8	4.2
Lung FEV1/FVC ratio	0.8	4.2	15.5	1.0	0.7	-3.9	0.6	2.1	0.8	2.6	-2.5	1.6
Sensitivity / hurt feelings	0.8	1.4	3.2	1.2	1.1	-0.7	1.8	0.1	1.8	0.2	-0.7	-1.4
Relative age voice broke	0.8	1.3	3.1	-0.8	-1.7	0.2	-1.7	-0.4	-1.7	-1.1	0.8	-0.1
Illnesses of siblings	0.8	1.1	2.5	1.6	1.1	-0.6	1.1	0.8	1.0	1.3	-0.0	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.0	-0.6	-0.9	-0.6	-1.2	-1.4	-1.0	-0.6	1.2	-0.8
Birth weight of first child	0.8	1.4	2.5	1.4	1.6	-0.2	1.2	0.7	1.1	1.5	-1.1	1.3
Arm fat-free mass (right)	0.8	4.1	27.6	-1.0	-1.1	5.2	-1.4	-0.6	-1.3	0.3	-0.4	1.6
Mean time to correctly identify matches	0.8	1.6	2.8	-1.7	-1.3	-1.2	-1.2	-0.8	-1.1	-1.6	1.6	0.1
Leg pain on walking	0.8	1.0	1.8	0.6	1.0	0.7	1.0	1.4	0.9	1.1	-1.2	1.1
Hypertension (Self-reported)	0.8	2.3	5.1	-1.6	-2.3	-0.6	-1.9	-1.6	-1.9	-1.0	1.2	-1.0
Age started oral contraceptive pill	0.8	1.0	2.3	1.5	1.4	0.6	1.1	0.5	1.3	0.6	-0.1	-0.6
Neuroticism (Nagel 2018)	0.7	1.6	6.3	0.0	0.2	-1.7	0.7	-1.1	0.5	-1.3	1.1	-2.5
Reaction Time	0.7	1.3	2.5	-1.3	-1.3	-0.9	-1.4	-1.0	-1.4	-0.5	1.6	0.1
Age at First Birth	0.7	1.0	2.8	-0.4	0.3	1.2	0.7	1.3	0.7	0.6	-1.7	1.2
Average weekly spirits intake	0.7	0.8	4.0	-0.8	-0.9	0.6	-0.8	0.5	-0.8	-0.4	-0.0	2.0
Average weekly fortified wine intake	0.7	0.8	2.7	-1.6	-0.7	1.1	-0.4	-0.1	-0.3	-0.1	-0.7	1.5
Age when periods started (menarche)	0.7	1.6	3.3	-1.6	-1.2	-1.2	-1.2	-1.8	-0.9	-1.1	1.4	0.1
Stomach or abdominal pain in last month	0.7	0.9	3.0	1.7	1.1	-0.4	1.2	-0.3	1.2	-0.2	-0.5	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	3.8	-0.7	-0.6	-0.7	-0.6	-1.3	-0.7	-1.2	0.7	-1.9
Neuroticism score	0.7	1.4	6.0	0.3	0.5	-1.9	0.8	-0.9	0.7	-0.8	0.6	-2.5
Commuting to job workplace: Car/motor vehicle	0.7	0.9	1.7	-0.9	-1.0	-1.3	-0.2	-0.9	-0.4	-0.9	0.7	-1.3
Cholesterol lowering medication	0.7	1.0	2.5	-0.4	-1.0	-0.7	-1.1	-0.9	-1.2	-0.5	1.2	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.8	0.0	0.4	-1.7	0.6	-0.6	0.7	-1.0	-0.1	-1.4
Heart disease (siblings)	0.7	0.8	2.1	-1.3	-0.7	0.1	-1.1	-0.6	-0.8	-1.4	0.0	1.1
Rheumatoid Arthritis	0.6	0.8	1.6	0.8	0.9	-1.3	1.1	0.3	1.0	0.4	0.1	-1.2
Blood White Count	0.6	4.3	11.4	-1.6	-2.3	-1.9	-1.9	-0.6	-2.3	-2.3	3.4	-1.1
Hypothyroidism (self reported)	0.6	1.3	4.8	0.8	0.6	2.2	0.5	0.2	0.5	1.0	-1.9	0.6
Vitamin and mineral supplements	0.6	0.8	1.7	-1.0	-0.7	-0.8	-0.8	-1.0	-0.6	-0.8	1.3	-0.7
Supplements: Glucosamine	0.6	0.8	3.1	0.6	0.2	1.7	0.8	-0.2	0.5	0.3	-1.8	0.2
Medication: Lansoprazole	0.6	0.6	2.2	0.0	-0.4	-0.2	-0.2	-1.0	-0.3	-0.6	1.5	-1.3
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.1	0.3	-0.1	-1.4	0.2	0.7	0.2	-1.2	0.9	-1.5
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.2	0.1	-0.6	-0.6	-0.4	-0.3	-0.5	-1.1	1.2	-1.5
Average weekly red wine intake	0.6	0.9	2.4	-0.2	-0.8	-1.1	-0.7	-1.5	-0.7	-1.3	0.5	-1.1
Hearing aid user	0.6	0.7	1.6	0.8	0.9	1.3	1.0	0.2	1.0	0.5	-0.9	0.5
Alcohol drinker status: Never	0.6	0.7	2.1	0.2	0.8	1.4	1.0	0.2	1.0	-0.1	-1.1	0.2
Ever depressed for a whole week	0.6	0.7	2.5	-1.6	-0.9	-0.3	-1.2	-0.3	-1.0	-0.5	0.3	0.6
Myopia	0.6	0.9	1.5	-0.8	-1.1	-1.2	-1.0	-0.7	-1.0	-1.1	0.2	-1.1
Alzheimer’s Disease (in mother)	0.5	0.6	2.8	-0.2	-0.1	-0.9	-0.3	-1.7	-0.3	-0.2	0.1	-1.2
Prostate Cancer	0.5	0.7	4.8	-0.5	-0.3	-2.2	-0.3	0.1	-0.1	-0.5	0.9	-0.2
Primary Biliary Cirrhosis	0.5	0.7	1.6	-0.9	-1.1	0.9	-1.2	-0.1	-1.3	-0.4	0.7	-0.3
Hearing difficulty/problems: Yes	0.5	0.7	2.0	0.0	0.4	-0.5	1.2	0.2	0.9	0.5	-1.3	-1.4
Supplements: Zinc	0.5	0.5	1.7	1.3	0.7	0.3	0.9	0.8	0.7	-0.1	-0.3	-0.6
High blood pressure	0.5	1.4	3.4	-1.2	-1.9	-0.0	-1.4	-1.2	-1.4	-0.8	0.8	-0.9
Medication: Levothyroxine sodium	0.5	0.8	2.2	1.2	0.7	1.2	0.5	0.0	0.6	0.7	-1.5	-0.5
Had menopause	0.5	0.7	3.5	0.2	0.3	0.9	0.5	1.9	0.6	-0.7	-0.0	0.8
Medication: Simvastatin	0.5	0.8	1.5	-1.2	-0.7	-0.0	-0.9	-0.2	-0.9	-1.2	1.2	-0.6
Father’s age at death	0.5	0.7	1.9	1.4	1.0	-0.5	1.1	1.2	0.8	0.3	-0.2	-0.4
Prospective memory result	0.5	0.6	1.6	0.2	0.6	0.9	0.4	1.1	0.2	0.3	-1.3	1.2
High blood pressure (siblings)	0.5	0.7	3.5	0.1	0.3	1.0	0.5	0.6	0.5	0.3	-1.0	1.9
Leg fat mass (right)	0.5	1.9	6.1	0.5	-0.4	1.8	-0.5	0.5	-0.4	1.9	-1.7	2.5
Suffer from ‘nerves’	0.5	0.8	1.4	1.1	1.2	-0.2	1.0	0.5	1.0	0.4	-1.0	-1.0
Had major operations	0.5	0.6	2.0	-1.0	-0.8	-0.8	-0.6	-0.4	-0.5	-0.4	0.5	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.8	0.4	-0.0	1.9	-0.3	-1.7	-0.1	1.5	-0.4	0.6
Eye problems/disorders: Glaucoma	0.5	0.6	1.8	0.8	0.8	0.1	1.2	-0.1	0.8	1.4	0.1	-0.4
Leg fat mass (left)	0.5	2.1	6.6	0.6	-0.3	1.9	-0.5	0.5	-0.3	1.9	-1.9	2.6
Major Depression (MDD)	0.4	0.4	1.6	-0.9	-0.3	-0.5	-0.6	-0.4	-0.6	-0.6	1.3	-0.1
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.7	0.2	1.2	1.1	1.1	0.5	1.3	1.3	-0.6	0.1
Triglycerides	0.4	0.6	1.5	-0.9	-0.6	-0.6	-0.7	-1.2	-0.5	-1.1	0.4	0.0
Hand grip strength (left)	0.4	0.9	2.3	-0.1	-1.5	1.4	-1.4	0.1	-1.4	0.1	0.0	-0.3
Relative age of first facial hair	0.4	0.8	2.2	-0.5	-0.8	0.3	-1.5	-1.0	-1.4	-0.3	0.3	0.6
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.9	0.5	0.8	0.6	0.8	0.2	0.9	0.9	-0.6	0.6
Diabetes (father)	0.4	0.5	0.8	-0.9	-0.8	0.8	-0.8	-0.7	-0.8	-0.8	0.4	-0.3
Pack years adult smoking proportion	0.4	0.6	2.0	0.4	0.3	1.3	-0.0	-0.9	0.2	0.7	-1.4	0.4
Hand grip strength (right)	0.4	1.1	3.8	1.2	-0.5	2.0	-0.4	1.3	-0.4	0.9	-0.9	0.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.7	-0.1	-0.2	1.3	0.0	0.4	-0.0	0.3	-1.2	0.7
Multivitamins +/- minerals	0.4	0.5	1.9	0.0	0.4	0.6	0.7	0.3	0.4	0.0	-1.4	1.0
Medication: Atenolol	0.4	0.5	2.4	-0.4	-0.6	1.5	-0.6	-0.5	-0.5	0.0	-0.2	1.0
Falls in the last year	0.4	0.6	2.3	-1.1	-0.7	0.2	-0.4	-0.4	-0.6	-1.5	0.4	-0.7
Exposure to tobacco smoke at home	0.4	0.4	1.4	1.2	0.7	-0.2	0.0	-0.0	0.4	0.9	-0.6	-0.3
Glaucoma (self-reported)	0.4	0.4	1.6	1.0	0.6	0.1	0.8	-0.1	0.4	1.3	0.3	-0.1
Exposure to tobacco smoke outside home	0.4	0.5	1.3	1.1	0.3	-0.7	0.3	0.7	0.3	1.1	-0.6	-0.6
Supplements: Vitamin C	0.4	0.5	1.2	0.9	0.7	-0.2	0.8	0.8	0.8	0.4	0.2	-1.1
Commuting to job workplace: Walk	0.4	0.4	1.0	0.9	0.4	0.6	-0.2	0.8	-0.0	-0.1	-1.0	0.9
Wears glasses or contact lenses	0.4	0.5	1.7	-0.3	0.0	-1.3	0.3	1.3	0.4	-0.7	-0.3	-0.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.4	0.4	0.7	0.2	1.2	-0.5	0.9	0.8	-0.7	-0.3
Schizophrenia vs Biploar Disorder	0.3	0.4	2.0	-0.4	-0.4	1.2	-0.3	-0.0	-0.1	-0.4	0.0	1.4
Alzheimer’s Disease (including proxy)	0.3	0.4	1.3	0.5	0.9	0.1	0.3	0.5	0.4	1.1	-1.1	0.2
Blood Eosinophil Count	0.3	2.3	4.6	0.9	1.9	-1.5	1.7	2.1	1.9	0.8	-1.3	-0.8
Height	0.3	6.1	42.4	0.1	0.2	6.5	0.2	0.7	0.1	1.2	-2.2	2.4
Angina	0.3	0.4	0.9	-1.0	-0.2	-0.5	-0.8	-0.3	-0.7	-0.9	0.6	0.2
Chronic bronchitis/emphysema (father)	0.3	0.3	1.3	0.9	0.6	1.1	-0.2	0.4	-0.2	-0.5	0.2	-0.2
Waist circumference	0.3	1.0	2.9	0.2	-0.3	1.7	-0.5	0.0	-0.5	1.3	-1.7	0.9
Length of working week for main job	0.3	0.3	1.2	0.5	-0.2	-0.1	-0.6	-0.5	-0.5	-0.2	1.1	0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.0	0.7	1.0	-0.2	0.9	0.2	1.0	0.9	-0.7	0.6
Headache pain in last month	0.3	0.5	0.8	0.6	0.5	-0.6	0.9	0.0	0.8	0.8	-0.9	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.4	-0.2	-0.6	1.2	-0.1	-0.5	-0.5	-0.5	-0.6	0.0
Neck or shoulder pain in last month	0.3	0.4	1.0	1.0	0.5	0.2	-0.1	0.8	0.3	0.6	-0.8	-0.3
Angina (self-reported)	0.3	0.4	0.9	-0.9	-0.2	-0.5	-0.7	-0.3	-0.6	-0.9	0.5	0.2
Comparative height size at age 10	0.3	1.7	6.1	0.6	0.7	2.5	1.0	1.2	0.9	0.7	-2.0	0.9
Friendships satisfaction	0.3	0.4	1.0	-1.0	-0.1	-0.7	0.5	0.9	0.3	-0.3	0.1	-0.8
Qualifications: nursing, teaching	0.3	0.5	1.0	0.4	0.5	0.9	0.8	1.0	0.8	1.0	-0.3	-0.4
Mineral and other dietary supplements	0.3	0.3	1.0	0.2	0.7	-0.8	0.5	0.0	0.6	1.0	0.4	0.2
Mother’s age at death	0.3	0.3	0.7	-0.3	0.1	0.6	0.6	0.1	0.7	-0.8	-0.5	-0.7
Medication: Blood pressure	0.3	0.6	3.5	0.5	-0.0	1.9	0.3	-0.0	0.3	0.6	-0.6	0.5
Medication: Paracetamol	0.3	0.4	1.2	0.5	0.9	-0.6	0.4	1.1	0.7	0.1	-0.6	0.2
Number of operations (self-reported)	0.3	0.5	1.0	-1.0	-0.9	-0.5	-0.8	-0.3	-1.0	-0.0	0.4	-0.5
Average weekly beer plus cider intake	0.3	0.5	1.8	0.9	0.8	-0.0	0.1	0.1	0.3	1.4	-0.8	-0.8
Commuting to job workplace: Cycle	0.3	0.4	1.2	0.5	0.3	-0.1	0.5	-1.1	0.5	0.2	0.1	-1.1
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.7	-0.0	0.8	1.3	0.9	0.9	1.1	1.0	0.1	0.3
Ovarian Cancer	0.2	0.2	0.8	-0.3	-0.2	0.3	0.1	0.8	-0.0	-0.5	0.9	-0.2
Coronary Artery Disease (CAD)	0.2	0.3	0.8	0.2	0.6	0.0	0.8	0.5	0.9	0.0	-0.6	0.0
Lupus	0.2	0.2	1.1	0.2	0.4	1.1	0.4	-0.2	0.5	0.1	-0.1	0.5
Chronotype (morning person)	0.2	0.5	2.1	0.2	0.1	-1.5	-0.1	-0.4	-0.1	-0.6	0.9	-1.0
Number of treatments/medications taken	0.2	0.4	1.0	-0.7	-1.0	-0.9	-0.6	-0.1	-0.7	-0.5	-0.1	-0.4
Medication: Co-codamol	0.2	0.2	0.6	0.2	0.6	0.3	0.3	-0.2	0.4	0.8	-0.6	0.6
Alcohol usually taken with meals	0.2	0.3	1.3	0.2	0.4	-0.6	0.1	0.2	0.2	-1.2	0.0	-0.8
Pulse rate	0.2	0.3	1.7	-0.4	0.1	-0.1	0.6	1.3	0.2	0.4	-0.3	0.0
Noisy workplace	0.2	0.3	1.2	0.0	-1.1	-0.7	-0.2	-0.3	-0.4	-0.2	0.4	-0.5
Depression (self-reported)	0.2	0.3	1.0	-0.5	-0.2	-0.5	-0.2	0.2	-0.4	-1.0	0.5	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.5	0.2	-0.3	1.2	0.2	-0.4	0.1	0.9	-0.5	-0.4
Ever highly irritable/argumentative for 2 days	0.2	0.2	1.0	0.3	-0.1	-0.4	0.3	0.3	-0.0	0.8	-1.0	0.1
Medication: Paracetamol	0.2	0.3	0.9	0.3	0.9	-0.4	0.2	0.7	0.6	-0.2	-0.7	0.6
Leg fat percentage (right)	0.2	0.7	1.6	0.3	-0.7	0.1	-0.8	0.6	-0.8	1.3	-1.1	1.2
Medication for pain relief, constipation, heartburn	0.2	0.4	1.4	0.8	-0.0	1.2	0.0	0.2	-0.3	0.4	1.1	0.2
Alcohol intake frequency.	0.2	0.5	1.2	0.6	1.1	0.5	1.1	-0.1	1.1	0.4	-0.4	0.6
Overall health rating	0.2	0.3	0.9	0.5	0.5	-0.9	0.4	-0.3	0.6	0.5	-0.8	0.3
Age at last live birth	0.2	0.3	1.0	0.6	1.0	-0.3	0.6	0.2	0.8	-0.3	0.5	0.1
Illnesses of siblings: Diabetes	0.2	0.3	0.6	-0.6	-0.4	0.7	-0.4	-0.8	-0.2	-0.6	-0.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.1	0.4	0.3	1.1	0.1	0.3	0.2	0.5	-0.6	-0.4
Osteoporosis (self-reported)	0.2	0.3	1.0	-0.1	-0.5	-0.4	-0.3	0.1	-0.4	-0.5	1.0	-0.9
Osteoarthritis (self-reported)	0.2	0.3	0.7	0.8	0.8	0.6	0.5	0.3	0.3	0.5	-0.7	0.3
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.3	0.1	0.2	0.3	-0.4	-1.1	-0.3	0.1	-0.1	-0.8
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.1	-0.0	-0.2	1.0	-0.0	0.4	0.0	-0.8	-0.5	0.1
Medication: Lisinopril	0.2	0.3	1.1	-0.5	-0.3	0.5	-0.2	-0.1	-0.3	-1.0	-0.1	-0.9
Illnesses of father: High blood pressure	0.2	0.3	0.7	0.7	0.4	-0.4	0.5	0.5	0.6	-0.1	-0.3	-0.8
Leg fat percentage (left)	0.2	0.7	1.5	0.3	-0.7	0.1	-0.8	0.3	-0.7	1.1	-1.1	1.2
Pack years of smoking	0.2	0.3	1.2	0.3	0.2	0.8	0.0	-0.7	0.1	0.4	-1.1	0.0
Neuroticism (2016)	0.1	0.2	0.5	-0.2	0.7	-0.2	0.3	0.1	0.6	-0.6	0.2	0.0
Taking other prescription medications	0.1	0.1	0.3	-0.0	-0.4	0.1	0.1	-0.3	-0.2	-0.4	-0.2	-0.5
Number of incorrect matches in round	0.1	0.1	0.5	-0.1	0.1	0.7	-0.4	-0.1	-0.3	-0.4	-0.5	0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	-0.2	0.1	-0.1	-0.2	0.6	-0.1	-0.4	0.1	0.6
Qualifications: None of the above	0.1	0.2	0.7	-0.5	0.3	0.6	-0.5	0.5	-0.3	-0.1	-0.8	0.1
Financial difficulties in last 2 years	0.1	0.1	0.4	0.3	0.3	-0.2	-0.3	-0.7	-0.2	0.2	0.2	-0.5
Fluid intelligence score	0.1	0.3	1.0	-0.3	0.2	0.6	0.4	-0.5	0.5	1.0	-0.1	-0.5
Standing height	0.1	1.4	8.3	-0.0	0.1	2.9	-0.0	0.8	-0.1	0.6	-1.1	1.4
Medication: Amlodipine	0.1	0.2	0.5	-0.2	0.2	-0.7	0.6	0.1	0.5	-0.1	0.5	-0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.7	-0.2	-0.4	0.8	-0.2	-0.2	0.1	-0.0	-0.3	0.3
Ever had bowel cancer screening	0.1	0.1	0.4	0.4	0.3	0.6	0.2	0.1	0.3	-0.2	0.1	0.6
Medication for cholesterol	0.1	0.2	0.9	-0.2	0.1	-1.0	-0.0	0.4	0.2	-0.6	0.5	-0.3
Medication: Bendroflumethiazide	0.1	0.2	0.7	-0.2	-0.3	-0.0	-0.4	-0.7	-0.4	0.2	0.1	-0.8
Unable to work because of sickness or disability	0.1	0.1	0.4	-0.7	-0.5	0.2	-0.2	-0.4	-0.4	-0.2	0.2	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Systolic Blood Pressure	0.0	0.1	0.4	-0.1	-0.6	0.2	-0.4	0.5	-0.5	0.2	0.1	0.4
Sitting height	0.0	0.2	0.9	-0.1	-0.0	0.7	0.5	0.5	0.1	1.0	-0.1	0.1
Alcohol intake versus 10 years previously	0.0	0.1	0.2	-0.3	-0.4	0.4	-0.1	-0.1	-0.2	-0.2	0.3	-0.0

Hub : Genes

FAM189B

Models

Trait associations