TWAS hub - TRIM46

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.0290	0.0190	0.00610	-0.001	0.024	0.010	NA	0.003	4.4e-01	3.6e-03	0.04700	NA	1.8e-01
2	TCGA	Breast Invasive Carcinoma	0.0268	0.0156	0.00350	0.011	0.009	0.000	NA	0.004	2.1e-03	4.9e-03	0.27000	NA	3.7e-02
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.0810	0.0440	0.00024	0.077	0.063	0.045	NA	0.069	7.1e-06	4.7e-05	0.00051	NA	2.1e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Mouth/teeth dental problems: Dentures	15.0	25.3	34.6	5.9	3.3	5.5
Blood Red Count	14.2	137.5	187.7	10.9	13.7	10.3
Irritable Bowel Disease (IBD)	13.9	33.0	38.7	6.2	4.7	6.2
Medication: Allopurinol	13.7	18.2	20.0	-4.5	-4.4	-3.9
Breast Cancer	13.1	31.5	38.9	-6.2	-5.2	-5.3
Mouth/teeth dental problems	13.0	20.0	26.9	-5.2	-3.0	-4.9
Gout (self-reported)	12.7	17.5	20.4	-4.5	-3.7	-4.3
Impedance of leg (left)	11.1	53.9	82.6	9.1	7.2	5.2
Crohns Disease (2017)	10.4	22.8	25.8	5.1	4.3	4.9
Impedance of leg (right)	10.1	48.8	78.0	8.8	6.6	4.9
Ulcerative Colitis (UC)	9.6	18.1	22.9	4.7	3.1	4.8
Smoking status: Previous	9.0	13.4	20.0	4.5	1.9	4.0
High blood pressure (mother)	8.9	12.5	15.1	-3.9	-3.8	-2.8
Risk taking	8.8	12.8	16.5	3.2	4.1	3.4
Crohns Disease (2012)	8.7	14.0	16.6	3.8	3.3	4.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	8.7	10.3	12.0	3.2	3.0	3.5
Medication: Atorvastatin	7.6	9.4	12.9	3.3	2.1	3.6
Past tobacco smoking	7.3	13.4	19.4	-4.4	-2.4	-3.9
Lung FVC	7.2	36.4	39.5	-5.7	-6.1	-6.3
Leg fat-free mass (right)	6.4	34.0	54.5	-7.4	-5.2	-4.5
Miserableness	6.4	11.1	12.9	3.6	3.0	3.4
Leg fat-free mass (left)	6.3	33.3	51.1	-7.2	-5.3	-4.5
Leg predicted mass (right)	6.3	33.5	53.4	-7.3	-5.1	-4.5
Leg predicted mass (left)	6.2	33.1	50.7	-7.1	-5.3	-4.5
Allergy	6.2	14.2	20.2	-4.5	-3.2	-3.5
Impedance of whole body	6.2	31.8	44.6	6.7	6.7	2.5
Medication: Gliclazide	6.0	6.8	9.7	3.1	1.7	2.8
Commuting to job workplace: Public transport	5.9	7.0	7.4	-2.7	-2.7	-2.5
Hayfever, allergic rhinitis or eczema	5.8	12.6	16.2	4.0	3.4	3.1
Heel bone mineral density (BMD) T-score, automated (left)	5.6	12.7	15.9	-3.9	-2.7	-4.0
Ulcerative Colitis	5.5	8.0	10.4	3.1	1.9	3.2
Ever taken oral contraceptive pill	5.3	5.9	12.5	1.5	3.5	1.7
Depressed Affect (Nagel 2018)	5.0	10.6	14.8	3.9	1.8	3.7
Bipolar Disorder (2018)	4.9	7.8	10.3	2.9	2.2	3.2
Illnesses of mother	4.9	6.1	10.2	2.0	3.2	2.0
Basal metabolic rate	4.9	26.9	42.2	-6.5	-5.1	-3.6
Hair/balding pattern: Pattern 4	4.8	11.7	18.1	-3.3	-2.4	-4.2
Whole body fat-free mass	4.8	27.4	42.5	-6.5	-5.4	-3.3
Whole body water mass	4.8	27.4	42.6	-6.5	-5.4	-3.3
Illnesses of father: Heart disease	4.7	6.5	8.5	-2.9	-2.4	-2.3
Emphysema/chronic bronchitis	4.6	5.2	6.9	2.5	1.5	2.6
Heel T-Score	4.5	35.5	45.7	-6.3	-4.6	-6.8
Diabetes (self-reported)	4.5	6.9	9.0	3.0	2.3	2.5
Hayfever/allergic rhinitis (self-reported)	4.5	6.0	6.9	2.6	2.6	2.1
Frequency of depressed mood in last 2 weeks	4.3	6.0	7.5	2.7	1.8	2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	4.2	5.6	5.9	2.4	2.3	2.4
Body mass index (BMI)	4.2	17.9	24.4	-4.9	-4.0	-3.6
Weight	4.2	20.8	32.0	-5.7	-4.0	-3.8
Arm fat mass (left)	4.2	17.2	23.2	-4.8	-3.2	-4.3
Waist Hip Ratio (WHR)	4.1	18.6	23.3	4.8	4.4	3.7
Loneliness, isolation	4.1	5.7	8.0	2.8	1.6	2.5
Fasting Glucose	4.0	4.8	5.9	1.7	2.4	2.3
Trunk fat-free mass	4.0	23.1	35.6	-6.0	-5.2	-2.5
Arm fat mass (right)	4.0	16.4	21.8	-4.7	-3.2	-4.2
Medication: Blood pressure	4.0	7.0	8.4	2.5	2.5	2.9
Trunk predicted mass	3.9	22.4	34.3	-5.9	-5.2	-2.5
Allergy or Eczema	3.8	10.1	14.7	3.8	2.8	2.8
Forced vital capacity (FVC)	3.8	14.6	17.1	-3.8	-4.1	-3.5
Tense / ‘highly strung’	3.8	6.3	6.6	2.6	2.6	2.4
Pulse wave reflection index	3.8	4.7	6.7	2.6	1.6	2.2
Eye problems/disorders: None of the above	3.8	4.4	6.8	-2.6	-1.5	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.8	8.1	10.8	-2.8	-2.4	-3.3
Arm fat-free mass (left)	3.8	19.0	27.8	-5.3	-4.9	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	3.7	8.4	10.8	-3.2	-2.1	-3.3
Medication for cholesterol, blood pressure or diabetes	3.7	6.2	7.7	-2.8	-1.9	-2.7
Medication: Omeprazole	3.7	4.5	5.7	2.4	1.8	2.1
Blood Platelet Count	3.6	41.3	65.4	8.1	4.1	6.5
Arm predicted mass (left)	3.6	18.2	25.9	-5.1	-4.9	-2.1
Medication: Ramipril	3.5	4.5	5.6	1.7	2.2	2.4
Forced expiratory volume in 1-second (FEV1)	3.5	11.8	15.7	-3.5	-2.8	-4.0
Severe depression (siblings)	3.3	3.7	5.0	1.9	2.2	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	3.3	10.4	15.3	-3.0	-2.6	-3.9
Mood swings	3.3	5.9	9.5	3.1	1.3	2.5
Neuroticism	3.2	7.8	10.0	3.2	2.0	3.1
Medication: Metformin	3.2	4.5	5.4	2.3	1.7	2.3
Nervous feelings	3.2	6.0	7.2	-2.5	-2.7	-2.2
Hearing difficulty/problems with background noise	3.2	5.2	6.8	1.9	2.2	2.6
Diabetes diagnosed by doctor	3.2	5.3	7.2	2.7	1.8	2.3
Forced vital capacity (FVC), Best measure	3.1	11.4	12.5	-3.2	-3.5	-3.4
Wheeze or whistling in the chest in last year	3.1	5.6	7.9	2.8	1.2	2.7
Ever smoked	3.1	5.4	7.1	2.7	1.6	2.5
Bipolar Disorder or Schizophrenia	3.0	7.3	9.0	2.5	2.6	3.0
Arm fat percentage (right)	3.0	11.7	18.5	-3.5	-2.1	-4.3
High blood pressure (siblings)	3.0	4.3	6.1	-1.7	-2.5	-1.9
Arm predicted mass (right)	3.0	15.4	24.0	-4.9	-4.4	-1.7
Family relationship satisfaction	3.0	3.7	3.8	1.9	1.9	1.9
Systolic blood pressure, automated reading	2.9	8.5	11.1	-3.3	-2.7	-2.6
Fed-up feelings	2.9	5.2	9.0	3.0	1.2	2.3
Loud music exposure frequency	2.9	3.1	4.4	-1.8	-1.4	-2.1
Mouth/teeth dental problems: Bleeding gums	2.9	3.7	5.6	2.4	1.8	1.6
Arm fat-free mass (right)	2.9	15.0	21.6	-4.7	-4.6	-1.6
High cholesterol (Self-reported)	2.9	5.1	8.5	2.3	1.2	2.9
Pain experienced in last month	2.9	4.8	7.2	2.7	1.6	2.2
Depression (Nagel 2018)	2.8	4.2	6.6	2.2	1.0	2.6
BMI	2.8	16.1	19.8	-4.5	-3.4	-4.1
Lung cancer (father)	2.8	3.3	4.9	2.0	2.2	1.1
Chest pain or discomfort	2.8	4.0	6.0	2.4	1.2	2.2
Arm fat percentage (left)	2.8	11.2	17.2	-3.6	-1.8	-4.2
Illnesses of father: None of the above (group 1)	2.8	3.5	6.2	1.9	2.5	0.8
Serious illness, injury or assault to yourself	2.7	3.2	3.6	1.6	1.9	1.9
Hip circumference	2.7	11.6	19.4	-4.4	-3.0	-2.5
Impedance of arm (left)	2.7	12.6	25.6	3.5	5.1	-0.2
Alzheimer’s Disease (in father)	2.6	2.8	4.3	-2.1	-1.2	-1.6
Impedance of arm (right)	2.6	12.1	22.8	3.7	4.8	-0.4
Worry too long after embarrassment	2.5	4.1	6.3	2.0	1.4	2.5
Pulse wave peak to peak time	2.5	2.9	3.7	-1.9	-1.4	-1.7
Neuroticism score	2.4	5.0	6.0	2.4	1.8	2.5
Whole body fat mass	2.4	10.0	12.8	-3.5	-2.1	-3.6
Back pain experienced in last month	2.4	3.4	5.7	-2.4	-1.1	-1.9
Trunk fat mass	2.3	9.8	14.8	-3.4	-1.8	-3.8
Asthma	2.3	4.5	5.5	2.4	2.0	2.0
Pulse wave Arterial Stiffness index	2.3	2.7	3.4	1.8	1.4	1.6
Asthma (self-reported)	2.3	4.6	5.4	2.3	2.1	2.0
Alzheimer’s Disease (in mother)	2.2	2.5	4.1	1.3	2.0	1.3
Average weekly fortified wine intake	2.2	2.6	3.0	-1.4	-1.7	-1.7
Knee pain experienced in last month	2.2	3.5	6.0	-2.5	-1.1	-1.8
Irritability	2.2	3.8	5.1	2.2	2.3	1.2
Medication: Omeprazole (e.g. Zanprol)	2.2	2.6	3.2	1.8	1.7	1.4
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	4.4	-1.1	-1.4	-2.1
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.6	3.3	1.4	1.8	1.6
Financial situation satisfaction	2.1	2.7	4.0	1.7	1.1	2.0
Diastolic blood pressure, automated reading	2.1	6.6	9.9	-3.1	-1.9	-2.5
Smoking Status	2.0	4.8	6.3	2.5	2.1	2.0
Number of self-reported non-cancer illnesses	2.0	3.5	4.5	1.9	2.1	1.6
Neuroticism (Nagel 2018)	1.9	4.4	6.1	2.3	1.3	2.5
Had menopause	1.9	2.4	5.6	-1.0	-2.4	-0.8
Happiness	1.9	2.3	3.7	1.9	1.5	1.0
Medication: Cholesterol lowering	1.9	3.0	5.0	2.2	0.9	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	3.4	1.2	1.8	1.3
Medication: Aspirin	1.9	2.4	3.4	1.7	1.0	1.8
Type 2 Diabetes (T2D) (2018)	1.8	3.4	6.3	2.5	0.9	1.8
Chronic bronchitis/emphysema (father)	1.8	2.2	6.1	-0.6	-2.5	0.1
Blood clot in the leg (DVT)	1.8	2.3	4.5	2.1	0.1	1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.8	2.0	2.7	1.6	1.3	1.2
Deep venous thrombosis (DVT) (self-reported)	1.8	2.4	4.5	2.1	0.3	1.6
Average weekly spirits intake	1.6	2.0	3.8	-1.5	0.3	-1.9
Medication: Atenolol	1.6	2.0	2.6	-1.5	-1.6	-1.0
Alcohol usually taken with meals	1.6	2.6	6.4	0.9	2.5	0.8
Time employed in main current job	1.6	1.8	2.1	-1.4	-1.4	-1.2
Peak expiratory flow (PEF)	1.6	3.6	6.6	-2.1	0.2	-2.6
Heart disease (mother)	1.6	1.9	3.6	-0.9	-1.9	-1.2
Leg fat mass (left)	1.6	6.1	7.5	-2.7	-2.1	-2.5
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.4	1.8	0.5	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	3.3	1.6	-0.5	1.8
Average weekly red wine intake	1.5	2.1	4.2	1.0	2.0	1.1
Ever had prostate specific antigen (PSA) test	1.5	1.7	3.2	-1.3	-0.4	-1.8
Trunk fat percentage	1.4	5.6	12.4	-2.0	-0.6	-3.5
Breastfed as a baby	1.4	1.7	3.2	0.9	1.1	1.8
Leg fat mass (right)	1.4	5.6	6.5	-2.5	-2.1	-2.4
Cardiovascular Disease	1.3	4.2	6.0	1.4	2.5	2.2
Respiratory disease	1.3	2.8	4.1	2.0	1.5	1.4
Had other major operations	1.3	1.6	1.7	-1.3	-1.2	-1.3
Comparative body size at age 10	1.3	3.6	6.4	-1.9	-2.5	-1.1
Mouth/teeth dental problems: Loose teeth	1.3	1.5	2.1	1.5	0.7	1.4
Commuting to job workplace: Car/motor vehicle	1.3	1.5	1.9	1.4	0.9	1.3
Schizophrenia vs Biploar Disorder	1.2	1.6	1.9	-1.3	-1.0	-1.4
Lung FEV1/FVC ratio	1.2	6.1	13.5	1.6	3.7	-1.6
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	1.8	1.3	1.1	1.3
Hair/balding pattern: Pattern 3	1.2	1.8	2.2	1.5	1.3	1.2
Had major operations	1.2	1.4	2.1	1.4	0.4	1.4
Leg pain on walking	1.2	1.5	2.5	-0.9	-1.6	-1.1
Medication: Aspirin	1.2	1.6	2.1	1.5	0.9	1.3
Hearing aid user	1.2	1.3	2.8	-0.9	-1.7	-0.6
Myopia	1.2	1.8	3.1	0.9	1.8	1.1
Cholesterol lowering medication	1.2	1.8	2.6	1.0	1.4	1.6
Supplements: Calcium	1.2	1.3	1.9	1.1	0.8	1.4
Age at First Birth	1.1	1.6	3.1	-1.8	-0.5	-1.2
Neuroticism (2016)	1.1	1.6	3.3	0.4	1.2	1.8
Hair Pigment	1.1	32.1	47.7	6.7	2.0	6.9
Sensitivity / hurt feelings	1.1	1.9	2.2	1.4	1.3	1.5
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.3	-1.8	-0.7	-0.7
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.5	1.3	0.1	1.9
Birth weight	1.1	2.4	3.0	-1.1	-1.7	-1.7
Body fat percentage	1.1	4.2	8.9	-1.8	-0.8	-3.0
Number of children fathered	1.1	1.3	2.2	-1.5	-0.8	-1.0
Chronotype (morning person)	1.0	2.3	3.6	1.5	1.9	1.0
Hearing difficulty/problems: Yes	1.0	1.5	2.0	0.9	1.3	1.4
Townsend deprivation index at recruitment	1.0	1.4	1.6	1.2	1.3	1.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.1	-1.5	-0.8	-0.7
Illnesses of siblings	1.0	1.4	1.6	1.2	1.3	1.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.8	1.2	0.9	1.7
Medication: Lansoprazole	1.0	1.1	1.7	1.2	0.4	1.3
Long-standing illness, disability or infirmity	1.0	1.5	2.2	1.5	0.7	1.4
Eye problems/disorders: Cataract	1.0	1.1	1.9	1.4	0.4	1.1
Average weekly champagne plus white wine intake	1.0	1.4	2.3	-1.4	-0.3	-1.5
HbA1C	0.9	1.0	1.9	1.4	0.4	1.0
Schizophrenia (2014)	0.9	2.1	2.9	0.9	1.7	1.6
Hand grip strength (right)	0.9	2.4	3.3	-1.7	-1.8	-0.8
Hair/balding pattern: Pattern 2	0.9	1.2	1.9	1.2	0.5	1.4
Number of live births	0.9	1.3	1.9	1.3	0.4	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	2.7	-1.5	-1.6	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.7	-0.8	-0.2	-1.6
Wears glasses or contact lenses	0.9	1.0	2.6	0.7	1.6	0.2
Medication: Blood pressure	0.9	1.6	2.6	-1.4	-1.6	-0.5
Schizophrenia (2018)	0.8	1.7	2.7	0.9	1.6	1.2
Height	0.8	14.8	30.0	-5.5	-3.0	-2.3
Tanning	0.8	10.0	16.4	3.0	2.2	4.0
Medication for hormone replacement therapy	0.8	0.9	1.6	-1.3	-0.2	-1.0
Financial difficulties in last 2 years	0.8	1.1	2.9	-0.5	-1.7	0.5
Prospective memory result	0.8	1.0	1.4	-1.0	0.9	-1.2
Ovarian Cancer	0.7	0.9	2.6	-0.1	-1.6	0.1
Prostate Cancer	0.7	1.0	2.4	1.5	0.8	0.2
Rheumatoid Arthritis	0.7	0.9	1.4	1.2	0.4	1.1
Relative age of first facial hair	0.7	1.4	2.8	-1.0	-1.7	-0.6
Ever had hysterectomy (womb removed)	0.7	0.8	1.4	-1.2	-0.9	-0.4
Medication: Co-codamol	0.7	0.8	1.6	-0.6	-1.2	-0.6
Qualifications: CSEs or equivalent	0.7	1.0	1.9	0.6	1.4	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.6	-1.3	-0.2	-1.1
Length of working week for main job	0.7	0.8	2.1	-0.0	-1.4	-0.5
Headache pain in last month	0.7	1.3	2.8	0.8	1.7	0.6
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.1	-1.8	-0.6	-0.8
Commuting to job workplace: Walk	0.7	0.8	1.1	-1.1	-0.7	-0.9
Lupus	0.6	0.9	1.9	-0.6	-1.4	-0.6
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	0.9	-0.8	-1.0	-0.6
Multivitamins +/- minerals	0.6	0.8	1.4	-1.2	-0.0	-1.0
Stomach or abdominal pain in last month	0.6	0.8	1.1	1.1	1.0	0.5
Supplements: Glucosamine	0.6	0.8	2.1	-1.5	0.3	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.2	0.6	1.1	0.8
Number of full brothers	0.6	0.8	0.9	0.8	1.0	0.8
Medication: Seretide 50 evohaler	0.6	0.6	0.9	0.8	-0.6	0.9
Guilty feelings	0.6	0.9	2.3	0.0	0.7	1.5
Commuting to job workplace: Cycle	0.6	0.7	1.2	0.8	0.7	1.1
Basal cell carcinoma (self-reported)	0.6	0.7	0.8	-0.7	-0.9	-0.9
Alcohol drinker status: Previous	0.6	0.7	1.1	0.7	0.8	1.0
Major Depression (MDD)	0.5	0.7	1.9	0.3	-1.4	-0.0
Mean Putamen Volume	0.5	0.6	1.4	1.2	-0.3	0.4
Vitamin and mineral supplements	0.5	0.7	1.1	1.1	0.6	0.7
Waist circumference	0.5	1.7	3.6	-1.9	-0.9	-0.8
Qualifications: A levels/AS levels or equivalent	0.5	1.0	1.9	0.8	1.4	0.7
Exposure to tobacco smoke at home	0.5	0.6	1.6	-0.2	-1.3	0.3
Birth weight of first child	0.5	1.0	1.6	-0.6	-1.0	-1.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.3	0.2	-1.1	0.6
Exposure to tobacco smoke outside home	0.5	0.6	1.2	0.4	1.1	0.7
Supplements: Vitamin C	0.5	0.6	1.3	0.8	-0.1	1.1
Friendships satisfaction	0.5	0.6	0.8	0.5	0.9	0.8
Osteoporosis (self-reported)	0.5	0.6	0.9	0.9	0.4	0.9
Heart disease (siblings)	0.5	0.6	0.9	-1.0	-0.3	-1.0
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.1	-1.1	-1.4	-0.3
Alzheimer’s Disease (including proxy)	0.4	0.5	1.3	-0.4	1.1	-0.1
Hypothyroidism (self reported)	0.4	1.0	2.4	-1.6	-0.3	-0.6
Suffer from ‘nerves’	0.4	0.6	1.0	0.3	0.8	1.0
Eye problems/disorders: Glaucoma	0.4	0.5	1.2	0.4	1.1	0.4
Medication: Lisinopril	0.4	0.5	0.9	0.4	0.7	0.9
Average weekly beer plus cider intake	0.4	0.6	1.0	0.5	1.0	0.7
Ever depressed for a whole week	0.4	0.4	0.9	-0.4	-0.9	-0.6
Blood Eosinophil Count	0.3	2.6	3.6	1.9	1.9	0.8
Blood White Count	0.3	2.1	3.7	1.9	1.1	1.2
Number of treatments/medications taken	0.3	0.5	0.7	0.8	0.8	0.4
Diabetes (father)	0.3	0.3	0.5	-0.7	-0.6	0.3
Pack years adult smoking proportion	0.3	0.4	0.7	-0.8	-0.5	-0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	-0.1	-0.9	-0.4
Number of incorrect matches in round	0.3	0.5	0.9	-0.9	0.7	-0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.5	-0.3	-0.7	-0.6
Depression (self-reported)	0.3	0.4	0.6	0.8	0.1	0.8
Standing height	0.3	2.7	5.5	-2.3	-0.8	-1.4
Glaucoma (self-reported)	0.3	0.4	1.1	0.2	1.0	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.7	-0.8	0.5	-0.0
Health satisfaction	0.3	0.4	1.1	-0.4	-0.3	-1.0
Medication: Ibuprofen	0.3	0.3	0.5	-0.5	0.7	-0.4
Number of full sisters	0.3	0.4	0.7	-0.8	-0.3	-0.7
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.1	-0.2	-0.3	-1.1
Ever had bowel cancer screening	0.3	0.4	0.5	-0.5	-0.7	-0.6
Mineral and other dietary supplements	0.3	0.4	0.8	0.6	-0.9	-0.3
Fractured/broken bones in last 5 years	0.3	0.3	0.6	0.7	0.1	0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.1	-0.8	-1.0	-0.1
Hand grip strength (left)	0.2	0.7	1.2	-0.8	-1.1	0.3
Relative age voice broke	0.2	0.3	0.6	-0.4	-0.8	0.0
Qualifications: None of the above	0.2	0.3	0.8	-0.5	-0.9	-0.1
Father’s age at death	0.2	0.3	0.4	0.7	-0.4	0.5
Pulse rate	0.2	0.4	1.1	0.2	1.1	-0.0
Noisy workplace	0.2	0.2	0.4	0.7	-0.1	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.6	-0.7	0.3
Medication: Amlodipine	0.2	0.3	0.6	0.8	0.3	0.4
Leg fat percentage (right)	0.2	0.7	1.4	-0.7	-0.6	-1.2
Medication for pain relief, constipation, heartburn	0.2	0.4	0.8	-0.5	-0.9	-0.2
Neck or shoulder pain in last month	0.2	0.3	0.7	-0.2	-0.9	0.2
Mean time to correctly identify matches	0.2	0.3	0.8	0.4	-0.9	-0.1
Alcohol intake frequency.	0.2	0.6	1.1	-0.5	-1.0	-0.6
Comparative height size at age 10	0.2	1.3	3.1	-1.8	-0.0	-0.8
Hypertension (Self-reported)	0.2	0.6	1.1	0.5	0.7	1.0
Illnesses of siblings: Diabetes	0.2	0.2	0.4	-0.1	0.6	0.5
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	-0.6	-0.3	-0.4
Qualifications: nursing, teaching	0.2	0.3	0.6	-0.3	0.8	0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.6	-0.8	-0.6	0.4
Osteoarthritis (self-reported)	0.2	0.2	0.3	-0.6	-0.5	-0.3
Smoking status: Current	0.2	0.2	0.7	-0.2	0.2	-0.8
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	0.4	-0.0	0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.7	-0.8	-0.2	-0.1
Medication: Bendroflumethiazide	0.2	0.3	0.8	0.1	-0.4	0.9
Illnesses of father: High blood pressure	0.2	0.2	0.6	0.1	0.0	0.8
Alcohol drinker status: Never	0.2	0.3	0.6	-0.8	0.3	-0.2
Leg fat percentage (left)	0.2	0.7	1.4	-0.7	-0.4	-1.2
Number of operations (self-reported)	0.2	0.3	0.5	0.4	-0.7	0.5
Age started oral contraceptive pill	0.2	0.2	0.4	0.0	-0.5	0.6
Unable to work because of sickness or disability	0.2	0.2	0.6	-0.1	-0.8	0.1
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.5	-0.3	-0.7	-0.3
Worry (Nagel 2018)	0.1	0.2	0.4	-0.2	0.7	0.1
Primary Biliary Cirrhosis	0.1	0.2	0.3	-0.2	0.6	0.3
Angina	0.1	0.1	0.2	0.4	0.3	-0.2
Supplements: Zinc	0.1	0.1	0.3	0.3	0.1	0.6
Diabetes (mother)	0.1	0.1	0.2	0.4	-0.4	0.2
Current tobacco smoking	0.1	0.1	0.4	-0.2	-0.0	-0.6
Maternal smoking around birth	0.1	0.1	0.1	-0.4	0.1	-0.4
Taking other prescription medications	0.1	0.1	0.3	0.2	0.3	0.5
Age when periods started (menarche)	0.1	0.2	0.5	0.7	-0.4	0.0
High blood pressure	0.1	0.3	0.8	0.1	0.5	0.9
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.3	-0.1	0.5
Heart attack	0.1	0.1	0.3	-0.0	-0.5	-0.1
Pain all over the body in last month	0.1	0.1	0.2	0.2	-0.4	-0.3
Medication: Simvastatin	0.1	0.2	0.4	0.2	-0.3	0.6
Fluid intelligence score	0.1	0.2	0.5	-0.7	0.0	0.5
Falls in the last year	0.1	0.2	0.5	0.1	-0.1	0.7
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	-0.2	0.6	-0.6
Medication: Paracetamol	0.1	0.1	0.4	0.1	-0.2	-0.6
Age at first live birth	0.1	0.2	0.4	-0.3	-0.2	-0.6
Qualifications: College or University degree	0.1	0.3	0.9	-0.3	0.9	-0.0
Angina (self-reported)	0.1	0.1	0.1	0.4	0.3	-0.2
Migraine (self-reported)	0.1	0.1	0.2	0.2	0.4	-0.2
Pulse rate, automated reading	0.1	0.3	0.7	-0.3	-0.3	-0.8
Overall health rating	0.1	0.2	0.4	0.1	-0.6	-0.3
Medication for cholesterol	0.1	0.2	0.6	0.8	-0.1	0.2
Mother’s age at death	0.1	0.2	0.5	0.1	0.1	0.7
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	-0.3	0.4	0.3
Medication: Paracetamol	0.1	0.1	0.3	0.5	0.3	-0.2
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.8	-0.1	-0.5	-0.9
Pack years of smoking	0.1	0.2	0.4	-0.4	-0.6	-0.1
Reaction Time	0.0	0.1	0.2	0.2	-0.4	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Systolic Blood Pressure	0.0	0.1	0.1	-0.4	0.2	-0.3
Sitting height	0.0	0.3	0.9	-0.0	-1.0	-0.1
Alcohol intake versus 10 years previously	0.0	0.0	0.1	0.0	0.3	0.0
Worrier / anxious feelings	0.0	0.1	0.1	0.1	-0.2	-0.4
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.1	0.4	-0.1
Shortness of breath walking on level ground	0.0	0.0	0.0	-0.1	0.0	-0.1
Age at last live birth	0.0	0.1	0.1	0.3	-0.3	-0.1
Breast cancer (self-reported)	0.0	0.0	0.0	0.1	-0.0	0.0

Hub : Genes

TRIM46

Models

Trait associations