[Hub]/) : Traits : Lung FVC : ← →

chr12:26,986,748-29,432,481

Best TWAS P=1.49e-71 · Best GWAS P=3.7e-66 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CCDC91	0.08	0.06	lasso	6	0.07	9.4e-09	14.1	-15.1	1.1e-51	0.64	0.95	0.05	FALSE
2	GTEx	Adipose Subcutaneous	RP11-967K21.1	0.08	0.02	lasso	8	0.01	2.1e-02	-17.0	-15.5	3.1e-54	0.90	0.03	0.94	TRUE
3	GTEx	Adrenal Gland	CCDC91	0.16	0.01	lasso	16	0.03	3.5e-02	-2.7	6.3	2.9e-10	-0.11	0.15	0.08	TRUE
4	GTEx	Adrenal Gland	RP11-967K21.1	0.22	0.02	lasso	4	0.02	6.5e-02	-16.9	-15.6	3.9e-55	0.90	0.02	0.79	FALSE
5	GTEx	Artery Aorta	CCDC91	0.16	0.00	enet	37	0.02	4.1e-02	13.8	15.3	4.9e-53	-0.49	0.28	0.27	FALSE
6	GTEx	Artery Aorta	RP11-967K21.1	0.07	0.02	lasso	7	0.01	7.9e-02	-16.0	-17.9	1.5e-71	0.79	0.18	0.48	TRUE
7	GTEx	Artery Coronary	RP11-967K21.1	0.18	0.12	lasso	7	0.07	1.8e-03	-17.1	-17.1	8.1e-66	0.96	0.02	0.96	TRUE
8	GTEx	Artery Tibial	RP11-967K21.1	0.09	0.10	lasso	11	0.07	2.4e-06	-15.8	-16.8	1.6e-63	0.90	0.16	0.84	FALSE
9	GTEx	Cells Transformed fibroblasts	CCDC91	0.10	0.10	lasso	5	0.09	5.5e-07	12.8	13.0	8.2e-39	-0.48	0.97	0.01	FALSE
10	GTEx	Cells Transformed fibroblasts	RP11-967K21.1	0.07	0.07	lasso	2	0.07	3.7e-06	13.0	-13.7	5.2e-43	0.54	0.93	0.05	FALSE
11	GTEx	Colon Transverse	CCDC91	0.11	0.01	lasso	6	0.00	4.6e-01	13.3	16.9	3.4e-64	-0.72	0.24	0.33	FALSE
12	GTEx	Colon Transverse	RP11-967K21.1	0.12	0.07	lasso	8	0.05	1.6e-03	-15.8	-16.7	7.4e-63	0.89	0.06	0.91	FALSE
13	GTEx	Esophagus Mucosa	MRPS35	0.18	0.00	enet	20	0.01	6.6e-02	2.9	-11.0	2.4e-28	0.15	0.09	0.18	TRUE
14	GTEx	Esophagus Mucosa	CCDC91	0.18	0.04	enet	36	0.03	3.1e-03	-16.0	12.3	7.4e-35	-0.39	0.18	0.59	FALSE
15	GTEx	Esophagus Muscularis	RP11-967K21.1	0.07	0.06	lasso	5	0.04	2.2e-03	-16.0	-16.0	6.5e-58	0.87	0.08	0.76	FALSE
16	GTEx	Esophagus Muscularis	RP11-860B13.1	0.19	0.07	enet	24	0.06	2.1e-04	3.4	10.1	3.3e-24	-0.38	0.41	0.47	TRUE
17	GTEx	Heart Atrial Appendage	CCDC91	0.10	0.06	lasso	8	0.04	4.4e-03	12.8	12.5	5.1e-36	-0.50	0.44	0.07	FALSE
18	GTEx	Heart Atrial Appendage	RP11-967K21.1	0.08	0.09	lasso	1	0.08	2.3e-04	13.0	-13.0	1.4e-38	0.51	0.47	0.05	TRUE
19	GTEx	Lung	CCDC91	0.14	0.00	enet	33	0.06	1.5e-05	3.3	8.4	4.5e-17	-0.31	0.18	0.41	FALSE
20	GTEx	Muscle Skeletal	RP11-967K21.1	0.04	0.01	lasso	9	0.00	2.9e-01	13.3	-13.6	2.1e-42	0.51	0.29	0.09	FALSE
21	GTEx	Pituitary	RP11-967K21.1	0.20	0.04	lasso	7	0.04	4.4e-02	-13.7	-13.0	8.3e-39	0.64	0.11	0.16	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	CCDC91	0.26	0.05	lasso	15	0.04	4.1e-03	13.3	12.8	2.3e-37	-0.51	0.78	0.16	FALSE
23	GTEx	Skin Sun Exposed Lower leg	CCDC91	0.09	0.01	enet	8	0.01	2.6e-02	13.0	13.3	1.2e-40	-0.53	0.18	0.69	FALSE
24	GTEx	Testis	PPFIBP1	0.23	0.00	enet	48	0.01	7.9e-02	5.7	6.3	2.4e-10	-0.24	0.08	0.05	FALSE
25	GTEx	Thyroid	CCDC91	0.15	0.12	enet	42	0.12	2.9e-09	13.8	14.1	3.1e-45	-0.57	1.00	0.00	FALSE
26	GTEx	Thyroid	RP11-967K21.1	0.05	0.00	enet	7	0.00	2.8e-01	-13.9	-15.0	5.5e-51	0.67	0.05	0.62	TRUE
27	NTR	Blood	CCDC91	0.01	0.01	blup	648	0.00	9.0e-03	-15.5	15.7	1.8e-55	-0.75	0.08	0.80	TRUE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCDC91	0.04	0.04	lasso	3	0.03	1.8e-06	14.1	14.1	4.8e-45	-0.55	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCDC91	0.06	0.02	blup	174	0.04	2.9e-05	-15.8	17.6	4.8e-69	-0.85	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	CCDC91	0.09	0.01	blup	170	0.02	1.0e-03	13.8	15.8	4.8e-56	-0.64	0.19	0.66	FALSE
31	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCDC91	0.09	0.11	lasso	2	0.12	2.3e-05	13.8	13.8	2.8e-43	-0.56	0.75	0.03	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC91	0.22	0.00	enet	16	0.04	2.5e-05	4.2	8.6	1.0e-17	-0.24	0.02	0.06	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC91	0.40	0.12	blup	175	0.14	4.9e-13	13.6	11.4	2.6e-30	-0.36	1.00	0.00	FALSE