Hub : Genes

MRPS35

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0730 0.0300 9.9e-03 0.005 0.028 0.000 0.032 -0.001 7.6e-02 2.2e-04 3.4e-01 8e-05 4.7e-01
2 GTEx Esophagus Mucosa 0.1790 0.0570 4.4e-04 -0.003 NA 0.010 NA 0.006 6.8e-01 NA 6.6e-02 NA 1.1e-01
3 METSIM Adipose 0.0617 0.0224 6.4e-04 -0.001 0.008 0.002 0.007 -0.002 5.8e-01 2.1e-02 1.3e-01 3e-02 7.7e-01
4 YFS Blood 0.0398 0.0123 4.4e-05 0.018 0.017 0.027 0.020 0.025 9.1e-07 1.8e-06 3.3e-09 2e-07 1.0e-08
5 TCGA Breast Invasive Carcinoma 0.0152 0.0087 6.2e-03 0.009 0.009 0.004 NA 0.006 4.9e-03 4.4e-03 3.9e-02 NA 1.5e-02
6 TCGA Kidney Renal Clear Cell Carcinoma 0.0429 0.0262 8.4e-03 0.031 0.019 0.016 NA 0.025 2.0e-04 2.7e-03 6.2e-03 NA 7.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.8 1.3 2.5 1.6 -1.1 1.4 0.9 0.8 0.6
Bipolar Disorder or Schizophrenia 0.7 1.8 3.3 1.8 -1.8 1.4 -0.5 0.4 -1.4
Depressed Affect (Nagel 2018) 1.6 3.3 9.8 3.1 -2.6 0.7 -0.9 -0.4 -1.3
Depression (Nagel 2018) 0.8 1.1 3.8 1.9 -1.5 -0.2 0.0 0.8 -0.2
Intelligence (Savage-Jansen 2018) 0.6 1.9 4.2 0.8 -1.8 -2.0 -0.9 -1.1 -1.0
Neuroticism (Nagel 2018) 1.0 2.4 5.4 2.2 -2.3 1.6 0.7 1.0 -0.1
Schizophrenia (2018) 0.8 1.7 5.2 1.0 -1.4 0.7 -1.3 -0.1 -2.3
Schizophrenia vs Biploar Disorder 1.5 2.0 7.0 -2.6 1.8 0.5 1.0 0.6 0.5
Worry (Nagel 2018) 0.5 1.0 2.9 1.7 -0.7 0.7 0.9 1.0 0.1
Alzheimer’s Disease (in mother) 0.3 0.3 1.2 0.7 1.1 -0.3 -0.0 0.4 -0.1
Alzheimer’s Disease (in father) 2.1 2.3 4.7 2.2 -0.8 0.0 -1.5 -1.6 -1.9
Alzheimer’s Disease (including proxy) 0.3 0.5 1.4 1.2 0.0 -0.4 -0.5 -0.5 -0.9
Crohns Disease (2017) 0.5 1.2 3.9 -2.0 0.1 0.9 -0.8 -0.2 -1.3
Irritable Bowel Disease (IBD) 0.5 1.1 3.0 -1.2 0.1 1.1 -0.9 -0.4 -1.7
Ulcerative Colitis (UC) 0.3 0.6 1.7 -0.3 0.1 1.1 -0.5 -0.3 -1.3
Major Depression (MDD) 0.1 0.1 0.3 0.4 -0.6 -0.0 0.0 0.4 0.2
Reaction Time 0.5 0.9 2.1 -0.7 0.2 -1.4 -1.3 -0.9 0.5
Verbal and Numeric Reasoning (VNR) 0.7 1.6 6.0 1.4 -1.3 -2.4 0.0 -0.3 -0.2
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.8 1.0 3.7 -0.1 0.7 1.9 -0.5 -1.0 -0.7
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.7 1.1 2.5 -1.6 -0.6 0.7 -0.9 -1.4 -0.5
Bipolar Disorder (2011) 0.4 0.4 1.6 1.3 -0.0 0.9 -0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.4 0.6 1.3 -0.9 -0.4 -0.1 1.0 0.2 1.1
Coronary Artery Disease (CAD) 0.2 0.2 1.0 -0.5 -0.1 1.0 -0.2 0.1 -0.2
Crohns Disease (2012) 0.5 0.7 3.2 -1.8 -0.2 0.2 -0.3 -0.2 -1.0
Mean Putamen Volume 0.6 0.7 2.4 -0.1 -0.4 -1.6 0.7 1.0 0.2
Fasting Glucose 0.9 1.1 2.3 -1.5 1.3 -1.3 0.1 -0.7 -0.0
HbA1C 1.4 1.6 3.3 -0.5 1.1 1.7 1.8 0.8 1.1
HDL Cholesterol 0.8 1.4 3.6 1.8 -0.7 -1.9 -0.7 -0.1 -0.5
LDL Cholesterol 0.6 0.9 4.6 -0.5 -0.1 2.1 0.1 0.3 -0.5
Lupus 0.5 0.7 1.8 -0.5 1.2 0.3 1.3 1.0 0.2
Neuroticism (2016) 0.4 0.5 2.3 1.5 -0.1 -0.1 0.3 0.5 0.6
Primary Biliary Cirrhosis 0.6 0.8 1.8 -0.4 0.8 0.7 -1.0 -1.0 -1.3
Rheumatoid Arthritis 0.6 0.8 2.3 1.1 0.4 1.5 -0.1 -0.2 -1.0
Schizophrenia (2014) 0.5 1.1 1.9 1.4 -1.4 0.6 -0.5 0.2 -1.4
Triglycerides 0.4 0.7 1.4 -1.1 1.0 1.2 -0.3 -0.4 0.3
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.9 -0.9 1.4 0.7 0.5 0.0 -0.3
Ulcerative Colitis 0.9 1.3 2.9 1.2 -0.9 0.3 -1.2 -0.9 -1.7
Blood Eosinophil Count 0.1 0.8 2.0 1.3 0.3 -1.4 0.4 0.2 -0.8
Blood Platelet Count 0.0 0.4 1.1 -0.0 -1.0 -0.6 -0.6 -0.8 -0.3
Blood Red Count 0.1 1.3 2.7 -1.0 -0.4 -1.3 -1.5 -1.6 0.4
Blood White Count 0.2 1.7 6.8 0.1 0.4 -2.6 -1.4 -0.4 -0.9
Heel T-Score 2.9 22.8 42.6 -5.1 6.0 6.5 3.3 2.5 3.8
BMI 0.4 2.4 9.7 -0.4 -3.1 -0.8 1.1 1.2 1.2
Height 1.9 36.0 101.4 -9.6 10.1 4.6 -0.2 -1.3 0.7
Waist Hip Ratio (WHR) 2.7 12.2 35.4 -2.9 6.0 1.0 3.1 2.4 3.6
Systolic Blood Pressure 0.8 4.1 7.5 0.1 1.7 1.6 2.7 2.5 2.2
Smoking Status 0.4 0.9 3.2 -0.4 0.5 1.8 1.2 0.8 0.1
Allergy or Eczema 0.2 0.4 1.3 -0.1 0.9 -0.3 0.1 1.2 -0.6
Cardiovascular Disease 0.6 2.0 4.0 -0.3 0.4 2.0 1.8 1.7 1.2
Hypothyroidism (self reported) 0.3 0.6 2.3 -1.1 0.3 -1.5 -0.2 -0.3 0.2
Respiratory disease 0.3 0.6 1.2 0.7 -0.7 0.5 -1.1 -0.8 -0.7
Type 2 Diabetes (T2D) (2018) 2.2 4.1 13.0 -0.5 1.2 3.6 2.4 1.7 1.1
Lung FEV1/FVC ratio 3.8 19.3 39.9 -2.0 5.6 0.5 6.3 4.8 4.1
Lung FVC 5.3 27.0 121.0 3.2 -11.0 -2.5 -3.4 -1.0 -3.4
Neuroticism 0.7 1.6 6.4 2.5 -1.4 0.7 -0.1 0.2 -1.0
Chronotype (morning person) 0.6 1.3 2.3 1.0 -0.5 1.0 1.5 1.5 1.1
Hair Pigment 0.0 0.8 2.9 -0.5 -0.6 1.7 0.1 0.9 -0.5
Tanning 0.0 0.5 1.5 0.7 0.1 -0.3 0.8 1.2 0.7
Hand grip strength (left) 0.6 1.6 4.1 -2.0 1.4 -0.5 1.0 1.0 1.2
Number of treatments/medications taken 0.3 0.6 2.2 -0.3 1.1 -0.1 0.4 1.5 -0.2
Average weekly spirits intake 0.4 0.5 1.4 0.0 -0.3 -0.4 1.0 1.2 0.7
Sensitivity / hurt feelings 1.7 2.9 6.4 0.3 -2.4 2.5 1.2 1.8 0.6
Frequency of depressed mood in last 2 weeks 1.8 2.5 9.6 3.1 -2.1 -0.1 -0.5 -0.1 -0.7
Hearing difficulty/problems: Yes 1.4 2.1 4.1 -0.9 2.0 1.5 1.6 1.3 1.1
Relative age of first facial hair 1.5 3.1 8.2 0.2 2.9 0.5 2.6 1.1 1.3
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 5.4 2.3 -1.1 0.4 -0.7 -1.0 -1.2
Ever used hormone-replacement therapy (HRT) 0.4 0.5 2.5 0.4 -0.5 -1.6 -0.3 -0.0 0.1
Ever had hysterectomy (womb removed) 0.3 0.3 0.8 -0.8 0.3 -0.0 0.0 -0.9 0.6
Systolic blood pressure, automated reading 0.6 1.8 4.0 -0.2 0.8 1.3 2.0 1.6 1.4
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 2.3 -0.5 -0.1 1.5 -0.2 -0.9 0.0
Angina 0.4 0.5 0.8 0.8 0.5 -0.6 0.9 0.9 0.5
Medication for hormone replacement therapy 0.5 0.5 1.5 0.2 -0.1 -1.2 0.2 0.5 -1.2
Vitamin and mineral supplements 0.4 0.5 1.5 0.6 0.5 -1.2 -0.0 -0.9 0.5
Supplements: Zinc 0.1 0.1 0.6 -0.1 -0.7 0.3 -0.1 0.3 -0.3
Medication: Co-codamol 0.7 0.8 1.7 -0.0 0.2 -1.3 -1.2 -0.3 -1.2
Medication: Metformin 1.0 1.5 5.2 0.2 1.0 2.3 1.4 0.6 0.4
Diabetes (father) 0.8 1.0 2.5 0.7 1.2 1.6 0.2 0.5 -1.1
Diabetes (mother) 2.8 3.6 5.5 -1.1 2.2 2.0 2.3 1.4 2.1
Severe depression (siblings) 3.4 3.7 13.3 1.6 -3.6 -1.7 -1.4 -0.7 -1.1
Pack years adult smoking proportion 0.2 0.3 0.9 0.7 -1.0 0.1 -0.4 0.1 -0.2
Impedance of leg (right) 0.8 4.1 14.2 -0.5 3.8 -0.5 1.6 2.5 0.9
Leg fat-free mass (left) 0.7 3.9 10.1 -3.2 -0.0 0.9 -2.1 -2.7 -1.1
Trunk fat percentage 0.7 2.9 14.0 -3.7 -0.2 1.0 0.5 0.8 1.1
Hand grip strength (right) 0.4 1.0 2.4 -1.0 1.6 -1.6 -0.1 -0.1 -0.4
Townsend deprivation index at recruitment 0.2 0.3 1.0 -0.2 -0.4 0.4 -0.8 0.3 -1.0
Current tobacco smoking 1.5 2.5 5.8 2.4 -2.0 0.5 -1.0 -0.6 -1.9
Average weekly fortified wine intake 0.7 0.8 1.3 1.1 -1.1 1.1 0.6 0.1 0.9
Maternal smoking around birth 0.1 0.2 0.8 -0.3 0.1 -0.9 0.2 0.3 0.4
Fed-up feelings 0.8 1.4 4.4 1.2 -2.1 0.2 -1.0 -0.9 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.5 1.2 -1.2 0.1 0.2 0.5 -0.1
Relative age voice broke 1.0 1.6 3.3 -0.3 1.1 -0.1 1.8 1.8 1.1
Taking other prescription medications 0.6 0.9 3.8 2.0 -0.9 0.7 0.0 0.4 -0.5
Age when periods started (menarche) 0.7 1.7 4.8 -0.6 2.2 -0.6 1.1 1.7 0.5
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 4.2 0.2 1.1 -2.1 0.2 -0.3 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.1 7.0 -2.0 0.9 2.7 1.5 1.0 1.8
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 3.5 1.9 -0.9 -1.0 -1.1 -1.0 -1.4
Qualifications: CSEs or equivalent 1.0 1.3 2.6 -0.1 -0.7 1.2 1.2 1.6 1.3
Serious illness, injury or assault to yourself 0.5 0.6 1.3 1.2 -0.6 0.8 0.4 0.9 -0.5
High blood pressure 1.7 4.8 9.0 -0.4 0.6 2.0 3.0 2.9 2.6
Hayfever, allergic rhinitis or eczema 0.2 0.5 2.5 0.0 0.5 0.3 0.5 1.6 0.2
Multivitamins +/- minerals 0.2 0.3 0.8 0.1 -0.6 0.9 -0.2 0.1 -0.7
Stomach or abdominal pain in last month 0.2 0.2 0.7 0.4 -0.2 -0.3 -0.3 0.2 -0.8
Supplements: Glucosamine 0.4 0.5 2.1 -0.0 -0.0 -1.4 -0.9 -0.1 -0.5
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.3 0.2 -0.6 -0.2 0.1 -0.1 -0.1
Medication: Atenolol 2.3 2.9 4.4 1.5 -1.2 1.6 2.0 1.7 2.1
Medication: Levothyroxine sodium 0.2 0.4 1.1 -0.9 -0.3 -1.0 -0.5 -0.2 -0.3
Sitting height 0.7 4.6 13.2 -0.7 3.6 0.5 -2.0 -2.8 -1.4
Chronic bronchitis/emphysema (father) 0.2 0.2 0.5 0.2 0.7 0.1 -0.5 -0.7 -0.5
High blood pressure (mother) 0.5 0.6 1.5 0.1 -0.9 0.3 1.2 1.2 0.3
Body mass index (BMI) 0.4 1.6 7.2 -1.3 -2.7 -0.5 0.3 0.6 0.5
Impedance of leg (left) 0.8 4.0 14.8 0.0 3.8 0.1 1.6 2.5 0.8
Leg predicted mass (left) 0.7 4.0 10.5 -3.2 0.0 0.9 -2.0 -2.7 -1.0
Trunk fat mass 0.8 3.3 17.6 -4.2 0.3 1.1 0.2 0.4 0.9
Waist circumference 0.8 2.8 13.1 -3.6 0.2 0.9 0.6 0.7 1.4
Number of incorrect matches in round 0.2 0.4 1.6 -0.3 -0.1 -1.3 0.6 0.1 0.6
Past tobacco smoking 1.0 1.8 2.9 1.6 -1.2 -1.7 -1.1 -1.7 -0.1
Alcohol usually taken with meals 0.1 0.2 0.6 0.2 0.2 0.6 -0.8 -0.4 -0.1
Nervous feelings 1.4 2.6 5.3 1.3 0.3 2.2 2.3 1.5 1.1
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.8 6.9 2.6 -2.0 0.1 0.1 0.3 0.0
Hearing difficulty/problems with background noise 2.2 3.6 7.1 -0.4 0.7 2.7 2.4 2.3 1.8
Hair/balding pattern: Pattern 2 0.3 0.4 1.7 -1.3 -0.3 0.5 0.2 0.4 0.5
Had menopause 2.2 2.8 4.6 -1.9 2.1 -0.1 1.9 1.5 1.8
Had other major operations 1.0 1.2 3.8 0.3 -0.8 -0.3 -1.9 -1.3 -0.8
Forced vital capacity (FVC) 2.0 7.6 19.5 -0.2 -4.4 -1.0 -3.4 -2.2 -2.9
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 4.1 -2.0 1.7 1.9 0.6 0.5 1.1
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 3.3 0.6 -0.6 0.3 1.2 1.8 0.9
Qualifications: None of the above 0.7 1.6 3.2 -1.4 -0.3 0.3 1.3 1.6 1.8
Financial difficulties in last 2 years 1.7 2.2 6.8 2.6 -2.3 0.3 -0.6 -0.0 -0.8
Mouth/teeth dental problems 0.8 1.2 2.3 -0.8 1.3 1.4 0.7 0.5 1.5
Heart attack 0.8 1.1 3.0 -0.3 0.6 0.2 1.6 1.7 0.7
Allergy 0.2 0.4 0.9 -0.1 -0.2 -0.9 -0.6 -1.0 -0.4
Pain all over the body in last month 7.0 7.5 12.2 -2.1 -0.4 2.4 3.4 3.5 3.4
Diabetes (self-reported) 1.9 3.0 9.7 0.1 1.2 3.1 2.2 1.2 0.9
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.5 -0.5 -0.3 -0.6 0.1 -0.3 0.7
Medication: Ramipril 1.3 1.7 3.2 1.5 -1.0 0.7 1.5 1.8 0.9
Medication: Simvastatin 1.6 2.4 4.5 -0.9 2.0 0.9 1.9 2.1 0.9
Fluid intelligence score 1.5 3.0 5.5 2.3 -1.3 -1.7 -1.6 -1.8 -1.5
Illnesses of siblings 0.2 0.2 0.5 0.1 -0.7 0.4 -0.4 -0.7 -0.1
Neuroticism score 1.3 2.6 7.8 2.8 -2.2 1.5 0.6 0.8 0.1
Weight 0.5 2.3 12.0 -3.5 0.5 0.9 -0.5 -0.7 0.1
Impedance of arm (right) 0.6 2.7 7.6 -2.3 1.7 2.7 -0.3 -0.4 -0.0
Arm fat percentage (right) 0.6 2.5 8.7 -2.9 -2.1 0.9 0.3 0.8 0.8
Trunk fat-free mass 0.6 3.4 6.6 -2.6 2.5 0.4 -1.5 -2.0 -1.2
Hip circumference 0.9 3.7 15.2 -3.9 -1.8 1.4 -1.0 -1.0 -0.1
Time employed in main current job 2.3 2.7 4.8 -1.8 2.2 2.1 1.0 0.3 1.5
Alcohol intake versus 10 years previously 0.1 0.2 0.4 -0.3 0.6 -0.5 0.2 0.5 0.4
Father’s age at death 0.2 0.3 0.5 -0.7 -0.7 0.3 -0.6 0.0 -0.6
Worrier / anxious feelings 0.6 1.1 4.9 2.2 -0.8 0.0 -0.6 -0.1 -0.8
Frequency of tiredness / lethargy in last 2 weeks 2.1 3.4 9.2 3.0 -2.0 -1.3 -1.5 -0.7 -1.7
Falls in the last year 1.2 1.6 3.5 1.0 -0.4 1.1 1.9 1.4 1.4
Hair/balding pattern: Pattern 3 1.2 1.7 3.1 1.0 0.6 -1.7 -1.2 -1.7 -1.2
Number of live births 1.2 1.6 5.8 1.6 -2.4 0.3 -0.7 -0.4 -0.8
Forced expiratory volume in 1-second (FEV1) 1.5 4.9 14.2 0.0 -3.8 -1.5 -2.3 -1.3 -2.5
Pulse rate 2.0 3.4 6.7 0.0 -2.4 -0.6 -2.6 -1.8 -2.0
Happiness 1.7 2.0 4.2 0.5 -2.1 -0.6 -1.5 -1.9 -1.2
Noisy workplace 2.4 2.9 7.2 -0.7 1.0 1.1 2.2 2.7 1.6
Qualifications: A levels/AS levels or equivalent 0.6 1.2 2.4 0.1 -0.6 -1.2 -0.9 -1.6 -1.5
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 1.0 -0.0 -0.5 0.3 -0.4 0.2 -1.0
Mouth/teeth dental problems: Dentures 0.2 0.3 1.4 0.0 -0.0 0.1 0.3 1.2 -0.3
Asthma 0.1 0.2 0.7 0.9 -0.5 -0.3 -0.3 0.1 -0.4
Medication: Ibuprofen (e.g. Nurofen) 2.7 3.5 5.4 1.8 -2.1 -2.0 -2.3 -0.9 -1.8
Medication: Cholesterol lowering 0.8 1.3 2.9 0.0 1.1 1.4 1.2 1.7 0.3
Depression (self-reported) 2.2 2.6 7.2 1.4 -2.7 -0.1 -1.3 -1.5 -1.7
Medication: Lansoprazole 1.2 1.3 2.6 -0.6 -1.6 1.5 0.9 0.9 1.0
Prospective memory result 0.6 0.7 1.7 1.3 -0.9 0.4 -0.9 -0.5 -0.6
Lung cancer (father) 0.4 0.4 1.3 0.8 -0.6 1.1 -0.3 -0.5 -0.0
Illnesses of mother 0.7 0.9 1.7 0.5 -0.8 -0.7 -1.2 -1.3 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 3.0 12.3 0.2 -3.5 -0.4 -1.5 -1.0 -1.5
Pulse wave Arterial Stiffness index 2.2 2.6 4.9 -0.2 -1.0 -1.8 -2.0 -1.5 -2.2
Impedance of arm (left) 0.4 1.9 7.3 -1.8 0.9 2.7 -0.1 -0.2 0.2
Arm fat mass (right) 0.4 1.8 7.9 -2.8 -1.6 0.6 -0.2 0.1 0.4
Trunk predicted mass 0.6 3.3 6.5 -2.6 2.5 0.4 -1.5 -1.9 -1.1
Standing height 1.5 14.8 41.9 -5.0 6.5 3.0 -1.8 -2.9 -1.0
Length of working week for main job 0.5 0.6 1.3 0.7 -0.7 -0.9 -0.4 -0.3 -1.1
Exposure to tobacco smoke at home 0.3 0.4 0.7 -0.7 0.7 0.9 -0.1 0.3 -0.6
Breastfed as a baby 2.9 3.6 7.9 -2.0 2.8 -0.1 2.2 0.9 1.8
Tense / ‘highly strung’ 0.5 0.9 2.4 1.6 -0.6 0.6 1.1 0.7 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 4.1 1.4 -2.0 1.7 0.4 0.2 -0.5
Hair/balding pattern: Pattern 4 2.2 5.4 14.2 -0.9 3.3 3.8 1.9 0.4 1.5
Birth weight of first child 0.2 0.3 0.7 -0.5 -0.2 0.9 -0.3 -0.3 -0.7
Peak expiratory flow (PEF) 1.8 4.2 9.6 0.3 -2.2 -3.1 -2.0 -0.8 -2.5
Pulse wave reflection index 0.3 0.3 1.0 -0.5 0.1 -1.0 0.3 0.7 -0.4
Ever highly irritable/argumentative for 2 days 3.2 3.8 11.5 2.0 -3.4 -1.0 -1.9 -1.4 -0.9
Loud music exposure frequency 0.2 0.2 0.8 0.4 0.9 0.4 0.0 -0.0 -0.0
Qualifications: O levels/GCSEs or equivalent 1.9 3.0 4.6 2.1 -1.3 -1.6 -1.8 -1.6 -1.8
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 3.3 -0.2 -1.8 -1.3 -1.2 -1.1 -1.3
Blood clot in the leg (DVT) 0.8 1.1 2.8 -1.7 1.6 0.5 0.2 -0.8 0.2
Medication: Paracetamol 2.0 3.3 6.0 1.7 -2.5 -2.0 -1.9 -0.5 -1.6
Headache pain in last month 3.2 5.5 8.1 2.0 -2.5 -2.8 -2.8 -1.4 -2.2
Medication for cholesterol, blood pressure or diabetes 2.0 3.2 8.7 0.5 -0.9 -1.6 -2.3 -2.9 -1.3
Glaucoma (self-reported) 0.6 0.7 2.6 -0.5 -0.5 1.6 0.5 -0.7 0.4
Gout (self-reported) 0.6 0.8 1.4 0.7 1.2 0.9 1.0 0.3 0.9
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.5 -1.2 -0.1 -0.8 -0.1 0.0 0.0
Medication: Amlodipine 0.2 0.3 0.7 -0.1 0.3 0.5 0.8 0.5 0.5
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.7 0.2 0.3 -0.8 0.2 0.2 -0.1
Birth weight 0.4 0.9 3.2 1.0 1.8 -1.0 0.3 0.5 -0.5
Chronic bronchitis/emphysema (mother) 1.1 1.3 2.8 -1.7 0.7 1.5 -0.6 -1.4 0.1
High blood pressure (siblings) 0.4 0.5 1.4 0.2 -0.3 -0.6 0.9 1.2 0.7
Forced vital capacity (FVC), Best measure 1.9 7.1 20.9 0.7 -4.6 -0.2 -3.1 -2.2 -2.5
Body fat percentage 0.7 2.7 11.5 -3.4 -0.7 0.5 0.8 1.4 1.2
Leg fat percentage (right) 0.8 2.9 6.4 -2.4 -0.4 -0.8 1.5 2.5 1.4
Arm fat-free mass (right) 0.3 1.5 3.4 -1.8 1.6 -0.3 -1.0 -1.2 -0.6
Exposure to tobacco smoke outside home 3.2 4.3 7.3 2.5 -1.3 -0.0 -2.6 -1.9 -2.7
Comparative body size at age 10 0.3 0.7 1.6 0.3 -1.3 0.4 1.0 0.7 1.0
Number of full brothers 0.7 0.9 3.0 -0.3 -1.7 -0.9 -0.9 0.3 -0.8
Worry too long after embarrassment 0.2 0.4 0.9 1.0 -0.6 0.8 0.3 0.6 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 2.0 2.6 6.7 2.6 -2.1 1.5 0.6 1.3 -0.4
Wheeze or whistling in the chest in last year 0.2 0.3 0.8 0.5 0.4 0.3 -0.5 0.5 -0.9
Number of children fathered 0.3 0.3 1.0 0.7 -1.0 0.4 0.0 -0.4 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 2.9 3.4 6.0 -1.3 1.6 2.4 1.9 1.4 2.2
Age at first live birth 1.2 2.1 9.9 -3.1 1.4 0.6 -0.0 -0.7 -0.0
Pulse wave peak to peak time 2.4 2.8 5.0 -0.1 1.5 2.1 2.0 1.3 2.2
Health satisfaction 2.3 3.0 6.9 1.6 -2.6 0.4 -1.9 -1.2 -1.9
Shortness of breath walking on level ground 1.0 1.2 3.3 1.1 -0.6 -0.1 -1.8 -1.0 -1.2
Qualifications: College or University degree 0.7 2.1 4.6 -0.8 0.5 -1.4 -2.1 -1.7 -1.6
Eye problems/disorders: None of the above 0.3 0.4 1.2 0.5 -0.2 -1.1 0.1 0.8 0.0
Mouth/teeth dental problems: Loose teeth 0.9 1.1 5.5 0.8 -2.4 -0.4 0.4 0.3 0.3
Emphysema/chronic bronchitis 0.4 0.5 2.2 0.2 0.3 0.1 -0.6 -0.5 -1.5
Medication for pain relief, constipation, heartburn 1.9 3.2 6.9 -2.6 1.5 1.8 1.8 -0.1 1.9
Neck or shoulder pain in last month 0.2 0.3 0.5 0.6 0.5 -0.6 0.0 0.7 -0.5
Medication: Blood pressure 2.6 4.6 10.4 -1.0 0.8 2.4 2.6 3.2 1.7
Angina (self-reported) 0.5 0.7 1.3 0.9 0.6 -0.7 1.1 1.0 0.6
Migraine (self-reported) 0.4 0.5 1.5 -1.2 0.5 -0.9 -0.1 0.3 0.6
Medication: Ibuprofen 3.7 4.5 7.2 1.6 -2.1 -2.5 -2.7 -1.3 -2.2
Medication: Allopurinol 0.8 1.0 1.9 0.9 0.5 0.5 1.3 1.4 1.1
Medication: Omeprazole 0.6 0.7 1.3 -1.1 -1.2 0.5 -0.9 -0.8 -0.3
Medication: Seretide 50 evohaler 0.9 1.0 4.7 0.1 2.2 0.5 0.3 -0.9 0.1
Mean time to correctly identify matches 0.6 1.2 2.6 -1.4 1.2 -1.6 -0.4 -0.2 1.1
Heart disease (mother) 0.8 1.0 2.9 1.2 0.5 -1.7 0.4 1.0 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.5 1.8 -0.9 1.3 0.1 0.3 0.7 -0.3
Whole body fat mass 0.5 2.2 11.8 -3.4 -0.4 0.7 0.1 0.3 0.7
Leg fat mass (right) 0.5 1.9 8.2 -2.9 -0.4 -0.1 0.7 1.3 1.0
Arm predicted mass (right) 0.3 1.6 4.3 -2.1 1.5 -0.3 -1.0 -1.3 -0.5
Pulse rate, automated reading 0.9 2.9 10.6 -3.3 -1.6 -0.6 -1.6 -1.1 0.4
Alcohol intake frequency. 0.4 1.0 4.6 0.4 -2.1 -0.1 -0.5 0.1 1.0
Comparative height size at age 10 1.7 9.6 14.1 -3.8 3.5 3.4 -2.9 -2.8 -1.9
Number of full sisters 0.1 0.2 0.5 0.5 -0.1 0.4 0.2 0.7 0.1
Suffer from ‘nerves’ 0.7 1.2 4.0 0.8 -0.9 2.0 0.9 0.9 0.2
Overall health rating 1.9 4.0 8.3 2.1 -2.9 -0.6 -2.1 -1.2 -2.3
Chest pain or discomfort 0.8 1.2 4.4 1.3 -2.1 -0.6 -0.2 0.7 -0.5
Had major operations 0.1 0.2 0.3 0.4 -0.6 0.1 -0.2 0.3 -0.6
Age at last live birth 1.4 2.1 7.2 -2.7 1.0 1.4 -0.7 -1.1 -0.7
Family relationship satisfaction 0.6 0.7 1.9 0.9 -1.4 0.8 -0.5 -0.8 0.1
Leg pain on walking 1.2 1.4 3.1 0.5 -1.6 -0.9 -1.8 -0.7 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 2.1 0.1 -0.4 0.7 1.2 1.5 0.2
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.1 0.6 1.1 0.4 1.0 0.3 1.4
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.6 -0.4 1.5 -1.6 0.5 -0.2 0.9
Medication: Aspirin 1.6 2.1 4.0 1.4 2.0 0.9 1.6 1.9 0.4
Supplements: Vitamin C 0.7 0.8 1.9 -1.4 -0.7 1.2 -0.0 1.1 -0.2
Knee pain experienced in last month 1.1 1.7 5.2 -1.6 1.2 2.3 -0.5 -0.4 -0.8
Hypertension (Self-reported) 2.1 5.9 10.2 -0.8 1.2 2.5 3.2 3.2 2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.2 -0.1 -1.1 0.1 0.4 0.5 1.1
Illnesses of father: Heart disease 0.4 0.5 1.8 1.3 -0.7 -0.2 0.4 0.6 -0.4
Illnesses of siblings: Diabetes 2.3 2.9 5.2 -0.9 2.3 1.6 2.3 1.3 1.4
Smoking status: Previous 2.0 2.9 5.0 -2.2 2.0 1.3 1.6 1.8 1.0
Forced expiratory volume in 1-second (FEV1), predicted 1.4 3.0 6.0 -1.9 2.4 1.6 -1.3 -1.8 -0.9
Whole body fat-free mass 0.6 3.4 7.7 -2.8 1.6 0.6 -1.8 -2.4 -1.2
Leg fat-free mass (right) 0.8 4.1 8.8 -2.8 -0.1 1.2 -2.2 -3.0 -1.3
Arm fat percentage (left) 0.7 2.7 7.6 -2.8 -2.7 0.7 0.2 0.6 0.7
Average weekly red wine intake 1.2 1.7 5.4 -0.6 1.6 2.3 1.1 0.8 0.4
Handedness (chirality/laterality): Left-handed 2.3 2.8 6.6 -1.3 -0.6 1.7 2.0 1.1 2.6
Mood swings 1.3 2.4 6.4 2.5 -2.1 0.6 -0.9 -0.5 -1.4
Loneliness, isolation 0.4 0.5 2.5 1.6 -0.5 0.7 -0.1 -0.3 -0.1
Long-standing illness, disability or infirmity 0.6 0.9 4.0 2.0 -0.7 0.1 0.5 0.7 -0.2
Ever had bowel cancer screening 1.8 2.1 4.8 -0.3 0.6 0.6 2.2 2.0 1.7
Diabetes diagnosed by doctor 2.0 3.3 7.6 -0.1 1.1 2.8 2.6 1.6 1.3
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 4.7 -0.0 0.1 -0.3 -1.5 -1.5 -2.2
Friendships satisfaction 3.0 3.7 6.8 1.6 -2.4 -0.6 -2.6 -2.3 -1.2
Qualifications: nursing, teaching 0.6 0.9 2.5 0.2 1.0 -0.5 -0.7 -1.6 -1.2
Commuting to job workplace: Walk 0.6 0.6 3.0 -1.7 -0.2 -0.6 -0.2 0.4 -0.4
Eye problems/disorders: Cataract 1.3 1.5 3.7 0.3 -0.3 -0.5 -1.8 -1.9 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.2 0.2 0.9 -0.3 0.2 -0.1 -0.0 -1.0 -0.6
Medication for cholesterol 1.9 2.9 5.4 0.2 -1.4 1.7 -2.1 -2.3 -1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 2.6 0.4 1.6 -0.1 0.6 0.7 0.3
Back pain experienced in last month 0.2 0.3 0.6 0.7 0.1 -0.2 -0.7 -0.8 -0.4
Mineral and other dietary supplements 0.3 0.4 0.8 0.7 -0.2 0.9 0.7 0.2 0.4
Breast cancer (self-reported) 0.9 1.1 5.5 0.6 0.7 2.4 0.0 -0.4 0.2
Asthma (self-reported) 0.1 0.2 0.8 0.9 -0.6 -0.2 -0.3 0.2 -0.4
Osteoporosis (self-reported) 1.8 2.2 7.7 1.0 0.5 1.4 -1.6 0.1 -2.8
Osteoarthritis (self-reported) 0.8 1.0 3.3 1.3 -0.9 -1.8 -0.4 -0.0 0.2
Medication: Aspirin 1.3 1.7 3.6 1.9 1.9 0.7 1.0 1.2 -0.2
Medication: Gliclazide 3.4 3.8 7.8 -0.2 1.4 2.8 2.2 2.4 1.7
Illnesses of father: None of the above (group 1) 0.6 0.7 1.2 -0.9 1.1 -0.3 0.7 0.9 1.0
Smoking status: Current 1.6 2.5 5.6 2.4 -1.9 0.6 -1.1 -0.7 -2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.7 3.5 17.7 0.1 -4.2 -0.8 1.0 0.8 0.9
Whole body water mass 0.6 3.4 7.8 -2.8 1.5 0.6 -1.7 -2.3 -1.1
Leg predicted mass (right) 0.8 4.1 8.9 -2.8 -0.1 1.2 -2.2 -3.0 -1.3
Arm fat mass (left) 0.4 1.8 7.8 -2.8 -1.6 0.6 -0.2 -0.0 0.4
Number of self-reported non-cancer illnesses 0.7 1.2 4.5 -0.4 -0.2 2.1 1.0 0.8 0.7
Average weekly champagne plus white wine intake 0.1 0.2 0.9 -0.9 0.5 0.1 0.0 0.1 -0.2
Miserableness 1.8 3.1 6.2 2.5 -2.3 0.9 -1.5 -1.2 -1.7
Guilty feelings 1.2 1.9 3.0 1.7 -1.4 1.6 1.4 0.7 1.0
Wears glasses or contact lenses 0.3 0.3 0.8 -0.5 -0.4 -0.9 0.4 0.2 0.7
Ever taken oral contraceptive pill 1.0 1.1 2.2 -1.0 1.5 -0.0 -1.1 0.1 -1.4
Hearing aid user 0.2 0.2 0.3 -0.4 0.5 0.4 0.1 0.5 0.6
Mother’s age at death 0.3 0.3 1.0 -0.1 -0.7 -0.4 0.5 1.0 0.2
Financial situation satisfaction 1.4 1.8 5.1 1.6 -2.3 0.3 -1.2 -0.4 -1.1
Tinnitus: Yes, now most or all of the time 1.3 1.6 4.0 0.4 0.4 0.3 2.0 1.8 1.3
Commuting to job workplace: Public transport 1.3 1.5 3.1 -0.1 0.1 -1.3 -1.3 -1.8 -1.6
Eye problems/disorders: Glaucoma 0.4 0.5 1.9 -0.1 0.0 0.9 -0.2 -1.4 -0.1
Medication: Blood pressure 1.6 3.0 6.1 0.7 1.3 -0.8 2.2 2.0 2.5
Pain type(s) experienced in last month: Hip pain 3.7 4.6 11.6 1.7 -3.4 -0.9 -2.5 -2.0 -1.5
Supplements: Fish oil (including cod liver oil) 0.2 0.3 1.0 -0.4 -0.5 0.1 -1.0 -0.3 -0.6
High cholesterol (Self-reported) 0.7 1.2 2.7 -0.2 1.2 0.4 1.6 1.4 0.9
Medication: Bendroflumethiazide 1.8 2.7 3.9 0.7 1.8 -1.7 1.6 2.0 1.7
Medication: Paracetamol 1.2 1.8 3.5 0.7 -1.8 -1.9 -1.5 -0.1 -1.2
Medication: Lisinopril 1.2 1.5 2.5 -0.3 1.6 0.7 1.4 1.4 1.4
Medication: Atorvastatin 0.2 0.3 1.2 1.1 -0.1 -0.4 0.2 0.5 -0.4
Illnesses of father: High blood pressure 0.5 0.6 3.0 0.1 0.1 1.7 0.2 0.2 -0.8
Alcohol drinker status: Never 0.9 1.1 3.1 -0.1 -0.1 0.0 1.2 1.3 1.8
Ever smoked 0.6 1.0 3.6 -0.4 0.4 1.9 -0.2 0.4 -1.4
Basal metabolic rate 0.6 3.1 9.0 -3.0 1.1 0.6 -1.6 -2.1 -1.0
Leg fat percentage (left) 0.6 2.1 5.0 -2.0 -0.5 -0.7 1.2 2.2 1.2
Arm fat-free mass (left) 0.4 2.1 5.3 -2.3 2.0 0.0 -1.0 -1.5 -0.6
Number of operations (self-reported) 0.6 0.9 1.9 0.6 -0.9 -0.2 -1.4 -1.2 -1.0
Average weekly beer plus cider intake 0.3 0.4 0.9 -0.1 0.8 0.3 -0.5 -0.7 -1.0
Irritability 2.0 3.4 8.2 1.0 -1.4 2.9 1.8 2.0 1.3
Risk taking 0.8 1.2 3.8 0.9 -0.9 1.9 0.7 1.0 0.3
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.4 -1.2 0.6 0.3 -0.1 0.0 0.0
Fractured/broken bones in last 5 years 0.6 0.7 1.8 1.4 1.0 -1.2 -0.4 -0.2 -0.2
Age started oral contraceptive pill 1.5 1.9 4.4 -0.9 1.0 -0.0 1.6 2.1 1.6
Diastolic blood pressure, automated reading 0.2 0.7 1.9 -1.2 0.1 -0.2 0.7 0.5 1.4
Ever depressed for a whole week 1.6 1.9 4.2 0.2 -0.3 1.6 2.0 2.1 0.9
Unable to work because of sickness or disability 0.4 0.5 1.3 0.6 0.7 -0.3 0.7 1.1 -0.1
Commuting to job workplace: Cycle 1.4 1.7 3.1 -0.2 -1.4 0.6 1.6 1.8 1.4
Myopia 1.8 2.6 3.3 1.4 -1.3 -1.8 -1.7 -1.6 -1.8
Vascular/heart problems diagnosed by doctor 2.0 5.4 10.8 -0.0 -0.8 -1.9 -3.3 -3.2 -2.6
Cholesterol lowering medication 1.5 2.2 3.7 -1.0 1.6 0.4 1.9 1.8 1.6
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 4.3 -0.4 -2.1 0.5 -1.5 -1.5 -1.0
Pain experienced in last month 0.8 1.4 2.7 -1.1 0.8 0.2 1.6 1.1 1.7
Supplements: Calcium 1.1 1.2 3.0 0.4 -1.4 -0.0 -1.2 -0.6 -1.7
Basal cell carcinoma (self-reported) 1.1 1.3 2.9 1.1 -0.6 -0.2 1.1 1.5 1.7
Heart attack/myocardial infarction (self-reported) 0.7 1.0 2.7 0.0 0.5 0.1 1.5 1.6 0.7
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 3.3 -1.8 1.6 0.4 0.1 -0.9 0.1
Heart disease (siblings) 0.5 0.6 2.2 0.7 -0.5 0.2 0.6 1.5 0.2
Alcohol drinker status: Previous 0.2 0.2 1.2 0.1 0.0 1.1 -0.1 0.3 -0.0
Pack years of smoking 0.1 0.1 0.2 0.4 -0.3 -0.3 -0.0 0.3 0.1
Impedance of whole body 0.3 1.7 5.6 -1.1 2.4 1.5 0.6 0.9 0.5
Leg fat mass (left) 0.4 1.5 6.9 -2.6 -0.5 -0.1 0.5 1.1 0.8
Arm predicted mass (left) 0.4 2.0 5.6 -2.4 1.9 0.2 -0.9 -1.3 -0.4