Hub : Genes

MRPS35

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0730	0.0300	9.9e-03	0.005	0.028	0.000	0.032	-0.001	7.6e-02	2.2e-04	3.4e-01	8e-05	4.7e-01
2	GTEx	Esophagus Mucosa	0.1790	0.0570	4.4e-04	-0.003	NA	0.010	NA	0.006	6.8e-01	NA	6.6e-02	NA	1.1e-01
3	METSIM	Adipose	0.0617	0.0224	6.4e-04	-0.001	0.008	0.002	0.007	-0.002	5.8e-01	2.1e-02	1.3e-01	3e-02	7.7e-01
4	YFS	Blood	0.0398	0.0123	4.4e-05	0.018	0.017	0.027	0.020	0.025	9.1e-07	1.8e-06	3.3e-09	2e-07	1.0e-08
5	TCGA	Breast Invasive Carcinoma	0.0152	0.0087	6.2e-03	0.009	0.009	0.004	NA	0.006	4.9e-03	4.4e-03	3.9e-02	NA	1.5e-02
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0429	0.0262	8.4e-03	0.031	0.019	0.016	NA	0.025	2.0e-04	2.7e-03	6.2e-03	NA	7.1e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.8	1.3	2.5	1.6	-1.1	1.4	0.9	0.8	0.6
Bipolar Disorder or Schizophrenia	0.7	1.8	3.3	1.8	-1.8	1.4	-0.5	0.4	-1.4
Depressed Affect (Nagel 2018)	1.6	3.3	9.8	3.1	-2.6	0.7	-0.9	-0.4	-1.3
Depression (Nagel 2018)	0.8	1.1	3.8	1.9	-1.5	-0.2	0.0	0.8	-0.2
Intelligence (Savage-Jansen 2018)	0.6	1.9	4.2	0.8	-1.8	-2.0	-0.9	-1.1	-1.0
Neuroticism (Nagel 2018)	1.0	2.4	5.4	2.2	-2.3	1.6	0.7	1.0	-0.1
Schizophrenia (2018)	0.8	1.7	5.2	1.0	-1.4	0.7	-1.3	-0.1	-2.3
Schizophrenia vs Biploar Disorder	1.5	2.0	7.0	-2.6	1.8	0.5	1.0	0.6	0.5
Worry (Nagel 2018)	0.5	1.0	2.9	1.7	-0.7	0.7	0.9	1.0	0.1
Alzheimer’s Disease (in mother)	0.3	0.3	1.2	0.7	1.1	-0.3	-0.0	0.4	-0.1
Alzheimer’s Disease (in father)	2.1	2.3	4.7	2.2	-0.8	0.0	-1.5	-1.6	-1.9
Alzheimer’s Disease (including proxy)	0.3	0.5	1.4	1.2	0.0	-0.4	-0.5	-0.5	-0.9
Crohns Disease (2017)	0.5	1.2	3.9	-2.0	0.1	0.9	-0.8	-0.2	-1.3
Irritable Bowel Disease (IBD)	0.5	1.1	3.0	-1.2	0.1	1.1	-0.9	-0.4	-1.7
Ulcerative Colitis (UC)	0.3	0.6	1.7	-0.3	0.1	1.1	-0.5	-0.3	-1.3
Major Depression (MDD)	0.1	0.1	0.3	0.4	-0.6	-0.0	0.0	0.4	0.2
Reaction Time	0.5	0.9	2.1	-0.7	0.2	-1.4	-1.3	-0.9	0.5
Verbal and Numeric Reasoning (VNR)	0.7	1.6	6.0	1.4	-1.3	-2.4	0.0	-0.3	-0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.8	1.0	3.7	-0.1	0.7	1.9	-0.5	-1.0	-0.7
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.7	1.1	2.5	-1.6	-0.6	0.7	-0.9	-1.4	-0.5
Bipolar Disorder (2011)	0.4	0.4	1.6	1.3	-0.0	0.9	-0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.6	1.3	-0.9	-0.4	-0.1	1.0	0.2	1.1
Coronary Artery Disease (CAD)	0.2	0.2	1.0	-0.5	-0.1	1.0	-0.2	0.1	-0.2
Crohns Disease (2012)	0.5	0.7	3.2	-1.8	-0.2	0.2	-0.3	-0.2	-1.0
Mean Putamen Volume	0.6	0.7	2.4	-0.1	-0.4	-1.6	0.7	1.0	0.2
Fasting Glucose	0.9	1.1	2.3	-1.5	1.3	-1.3	0.1	-0.7	-0.0
HbA1C	1.4	1.6	3.3	-0.5	1.1	1.7	1.8	0.8	1.1
HDL Cholesterol	0.8	1.4	3.6	1.8	-0.7	-1.9	-0.7	-0.1	-0.5
LDL Cholesterol	0.6	0.9	4.6	-0.5	-0.1	2.1	0.1	0.3	-0.5
Lupus	0.5	0.7	1.8	-0.5	1.2	0.3	1.3	1.0	0.2
Neuroticism (2016)	0.4	0.5	2.3	1.5	-0.1	-0.1	0.3	0.5	0.6
Primary Biliary Cirrhosis	0.6	0.8	1.8	-0.4	0.8	0.7	-1.0	-1.0	-1.3
Rheumatoid Arthritis	0.6	0.8	2.3	1.1	0.4	1.5	-0.1	-0.2	-1.0
Schizophrenia (2014)	0.5	1.1	1.9	1.4	-1.4	0.6	-0.5	0.2	-1.4
Triglycerides	0.4	0.7	1.4	-1.1	1.0	1.2	-0.3	-0.4	0.3
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.9	-0.9	1.4	0.7	0.5	0.0	-0.3
Ulcerative Colitis	0.9	1.3	2.9	1.2	-0.9	0.3	-1.2	-0.9	-1.7
Blood Eosinophil Count	0.1	0.8	2.0	1.3	0.3	-1.4	0.4	0.2	-0.8
Blood Platelet Count	0.0	0.4	1.1	-0.0	-1.0	-0.6	-0.6	-0.8	-0.3
Blood Red Count	0.1	1.3	2.7	-1.0	-0.4	-1.3	-1.5	-1.6	0.4
Blood White Count	0.2	1.7	6.8	0.1	0.4	-2.6	-1.4	-0.4	-0.9
Heel T-Score	2.9	22.8	42.6	-5.1	6.0	6.5	3.3	2.5	3.8
BMI	0.4	2.4	9.7	-0.4	-3.1	-0.8	1.1	1.2	1.2
Height	1.9	36.0	101.4	-9.6	10.1	4.6	-0.2	-1.3	0.7
Waist Hip Ratio (WHR)	2.7	12.2	35.4	-2.9	6.0	1.0	3.1	2.4	3.6
Systolic Blood Pressure	0.8	4.1	7.5	0.1	1.7	1.6	2.7	2.5	2.2
Smoking Status	0.4	0.9	3.2	-0.4	0.5	1.8	1.2	0.8	0.1
Allergy or Eczema	0.2	0.4	1.3	-0.1	0.9	-0.3	0.1	1.2	-0.6
Cardiovascular Disease	0.6	2.0	4.0	-0.3	0.4	2.0	1.8	1.7	1.2
Hypothyroidism (self reported)	0.3	0.6	2.3	-1.1	0.3	-1.5	-0.2	-0.3	0.2
Respiratory disease	0.3	0.6	1.2	0.7	-0.7	0.5	-1.1	-0.8	-0.7
Type 2 Diabetes (T2D) (2018)	2.2	4.1	13.0	-0.5	1.2	3.6	2.4	1.7	1.1
Lung FEV1/FVC ratio	3.8	19.3	39.9	-2.0	5.6	0.5	6.3	4.8	4.1
Lung FVC	5.3	27.0	121.0	3.2	-11.0	-2.5	-3.4	-1.0	-3.4
Neuroticism	0.7	1.6	6.4	2.5	-1.4	0.7	-0.1	0.2	-1.0
Chronotype (morning person)	0.6	1.3	2.3	1.0	-0.5	1.0	1.5	1.5	1.1
Hair Pigment	0.0	0.8	2.9	-0.5	-0.6	1.7	0.1	0.9	-0.5
Tanning	0.0	0.5	1.5	0.7	0.1	-0.3	0.8	1.2	0.7
Hand grip strength (left)	0.6	1.6	4.1	-2.0	1.4	-0.5	1.0	1.0	1.2
Number of treatments/medications taken	0.3	0.6	2.2	-0.3	1.1	-0.1	0.4	1.5	-0.2
Average weekly spirits intake	0.4	0.5	1.4	0.0	-0.3	-0.4	1.0	1.2	0.7
Sensitivity / hurt feelings	1.7	2.9	6.4	0.3	-2.4	2.5	1.2	1.8	0.6
Frequency of depressed mood in last 2 weeks	1.8	2.5	9.6	3.1	-2.1	-0.1	-0.5	-0.1	-0.7
Hearing difficulty/problems: Yes	1.4	2.1	4.1	-0.9	2.0	1.5	1.6	1.3	1.1
Relative age of first facial hair	1.5	3.1	8.2	0.2	2.9	0.5	2.6	1.1	1.3
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	5.4	2.3	-1.1	0.4	-0.7	-1.0	-1.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.5	0.4	-0.5	-1.6	-0.3	-0.0	0.1
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	-0.8	0.3	-0.0	0.0	-0.9	0.6
Systolic blood pressure, automated reading	0.6	1.8	4.0	-0.2	0.8	1.3	2.0	1.6	1.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.3	-0.5	-0.1	1.5	-0.2	-0.9	0.0
Angina	0.4	0.5	0.8	0.8	0.5	-0.6	0.9	0.9	0.5
Medication for hormone replacement therapy	0.5	0.5	1.5	0.2	-0.1	-1.2	0.2	0.5	-1.2
Vitamin and mineral supplements	0.4	0.5	1.5	0.6	0.5	-1.2	-0.0	-0.9	0.5
Supplements: Zinc	0.1	0.1	0.6	-0.1	-0.7	0.3	-0.1	0.3	-0.3
Medication: Co-codamol	0.7	0.8	1.7	-0.0	0.2	-1.3	-1.2	-0.3	-1.2
Medication: Metformin	1.0	1.5	5.2	0.2	1.0	2.3	1.4	0.6	0.4
Diabetes (father)	0.8	1.0	2.5	0.7	1.2	1.6	0.2	0.5	-1.1
Diabetes (mother)	2.8	3.6	5.5	-1.1	2.2	2.0	2.3	1.4	2.1
Severe depression (siblings)	3.4	3.7	13.3	1.6	-3.6	-1.7	-1.4	-0.7	-1.1
Pack years adult smoking proportion	0.2	0.3	0.9	0.7	-1.0	0.1	-0.4	0.1	-0.2
Impedance of leg (right)	0.8	4.1	14.2	-0.5	3.8	-0.5	1.6	2.5	0.9
Leg fat-free mass (left)	0.7	3.9	10.1	-3.2	-0.0	0.9	-2.1	-2.7	-1.1
Trunk fat percentage	0.7	2.9	14.0	-3.7	-0.2	1.0	0.5	0.8	1.1
Hand grip strength (right)	0.4	1.0	2.4	-1.0	1.6	-1.6	-0.1	-0.1	-0.4
Townsend deprivation index at recruitment	0.2	0.3	1.0	-0.2	-0.4	0.4	-0.8	0.3	-1.0
Current tobacco smoking	1.5	2.5	5.8	2.4	-2.0	0.5	-1.0	-0.6	-1.9
Average weekly fortified wine intake	0.7	0.8	1.3	1.1	-1.1	1.1	0.6	0.1	0.9
Maternal smoking around birth	0.1	0.2	0.8	-0.3	0.1	-0.9	0.2	0.3	0.4
Fed-up feelings	0.8	1.4	4.4	1.2	-2.1	0.2	-1.0	-0.9	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.5	1.2	-1.2	0.1	0.2	0.5	-0.1
Relative age voice broke	1.0	1.6	3.3	-0.3	1.1	-0.1	1.8	1.8	1.1
Taking other prescription medications	0.6	0.9	3.8	2.0	-0.9	0.7	0.0	0.4	-0.5
Age when periods started (menarche)	0.7	1.7	4.8	-0.6	2.2	-0.6	1.1	1.7	0.5
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	4.2	0.2	1.1	-2.1	0.2	-0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	7.0	-2.0	0.9	2.7	1.5	1.0	1.8
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	3.5	1.9	-0.9	-1.0	-1.1	-1.0	-1.4
Qualifications: CSEs or equivalent	1.0	1.3	2.6	-0.1	-0.7	1.2	1.2	1.6	1.3
Serious illness, injury or assault to yourself	0.5	0.6	1.3	1.2	-0.6	0.8	0.4	0.9	-0.5
High blood pressure	1.7	4.8	9.0	-0.4	0.6	2.0	3.0	2.9	2.6
Hayfever, allergic rhinitis or eczema	0.2	0.5	2.5	0.0	0.5	0.3	0.5	1.6	0.2
Multivitamins +/- minerals	0.2	0.3	0.8	0.1	-0.6	0.9	-0.2	0.1	-0.7
Stomach or abdominal pain in last month	0.2	0.2	0.7	0.4	-0.2	-0.3	-0.3	0.2	-0.8
Supplements: Glucosamine	0.4	0.5	2.1	-0.0	-0.0	-1.4	-0.9	-0.1	-0.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.2	-0.6	-0.2	0.1	-0.1	-0.1
Medication: Atenolol	2.3	2.9	4.4	1.5	-1.2	1.6	2.0	1.7	2.1
Medication: Levothyroxine sodium	0.2	0.4	1.1	-0.9	-0.3	-1.0	-0.5	-0.2	-0.3
Sitting height	0.7	4.6	13.2	-0.7	3.6	0.5	-2.0	-2.8	-1.4
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	0.2	0.7	0.1	-0.5	-0.7	-0.5
High blood pressure (mother)	0.5	0.6	1.5	0.1	-0.9	0.3	1.2	1.2	0.3
Body mass index (BMI)	0.4	1.6	7.2	-1.3	-2.7	-0.5	0.3	0.6	0.5
Impedance of leg (left)	0.8	4.0	14.8	0.0	3.8	0.1	1.6	2.5	0.8
Leg predicted mass (left)	0.7	4.0	10.5	-3.2	0.0	0.9	-2.0	-2.7	-1.0
Trunk fat mass	0.8	3.3	17.6	-4.2	0.3	1.1	0.2	0.4	0.9
Waist circumference	0.8	2.8	13.1	-3.6	0.2	0.9	0.6	0.7	1.4
Number of incorrect matches in round	0.2	0.4	1.6	-0.3	-0.1	-1.3	0.6	0.1	0.6
Past tobacco smoking	1.0	1.8	2.9	1.6	-1.2	-1.7	-1.1	-1.7	-0.1
Alcohol usually taken with meals	0.1	0.2	0.6	0.2	0.2	0.6	-0.8	-0.4	-0.1
Nervous feelings	1.4	2.6	5.3	1.3	0.3	2.2	2.3	1.5	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	6.9	2.6	-2.0	0.1	0.1	0.3	0.0
Hearing difficulty/problems with background noise	2.2	3.6	7.1	-0.4	0.7	2.7	2.4	2.3	1.8
Hair/balding pattern: Pattern 2	0.3	0.4	1.7	-1.3	-0.3	0.5	0.2	0.4	0.5
Had menopause	2.2	2.8	4.6	-1.9	2.1	-0.1	1.9	1.5	1.8
Had other major operations	1.0	1.2	3.8	0.3	-0.8	-0.3	-1.9	-1.3	-0.8
Forced vital capacity (FVC)	2.0	7.6	19.5	-0.2	-4.4	-1.0	-3.4	-2.2	-2.9
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	4.1	-2.0	1.7	1.9	0.6	0.5	1.1
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.3	0.6	-0.6	0.3	1.2	1.8	0.9
Qualifications: None of the above	0.7	1.6	3.2	-1.4	-0.3	0.3	1.3	1.6	1.8
Financial difficulties in last 2 years	1.7	2.2	6.8	2.6	-2.3	0.3	-0.6	-0.0	-0.8
Mouth/teeth dental problems	0.8	1.2	2.3	-0.8	1.3	1.4	0.7	0.5	1.5
Heart attack	0.8	1.1	3.0	-0.3	0.6	0.2	1.6	1.7	0.7
Allergy	0.2	0.4	0.9	-0.1	-0.2	-0.9	-0.6	-1.0	-0.4
Pain all over the body in last month	7.0	7.5	12.2	-2.1	-0.4	2.4	3.4	3.5	3.4
Diabetes (self-reported)	1.9	3.0	9.7	0.1	1.2	3.1	2.2	1.2	0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	-0.5	-0.3	-0.6	0.1	-0.3	0.7
Medication: Ramipril	1.3	1.7	3.2	1.5	-1.0	0.7	1.5	1.8	0.9
Medication: Simvastatin	1.6	2.4	4.5	-0.9	2.0	0.9	1.9	2.1	0.9
Fluid intelligence score	1.5	3.0	5.5	2.3	-1.3	-1.7	-1.6	-1.8	-1.5
Illnesses of siblings	0.2	0.2	0.5	0.1	-0.7	0.4	-0.4	-0.7	-0.1
Neuroticism score	1.3	2.6	7.8	2.8	-2.2	1.5	0.6	0.8	0.1
Weight	0.5	2.3	12.0	-3.5	0.5	0.9	-0.5	-0.7	0.1
Impedance of arm (right)	0.6	2.7	7.6	-2.3	1.7	2.7	-0.3	-0.4	-0.0
Arm fat percentage (right)	0.6	2.5	8.7	-2.9	-2.1	0.9	0.3	0.8	0.8
Trunk fat-free mass	0.6	3.4	6.6	-2.6	2.5	0.4	-1.5	-2.0	-1.2
Hip circumference	0.9	3.7	15.2	-3.9	-1.8	1.4	-1.0	-1.0	-0.1
Time employed in main current job	2.3	2.7	4.8	-1.8	2.2	2.1	1.0	0.3	1.5
Alcohol intake versus 10 years previously	0.1	0.2	0.4	-0.3	0.6	-0.5	0.2	0.5	0.4
Father’s age at death	0.2	0.3	0.5	-0.7	-0.7	0.3	-0.6	0.0	-0.6
Worrier / anxious feelings	0.6	1.1	4.9	2.2	-0.8	0.0	-0.6	-0.1	-0.8
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	9.2	3.0	-2.0	-1.3	-1.5	-0.7	-1.7
Falls in the last year	1.2	1.6	3.5	1.0	-0.4	1.1	1.9	1.4	1.4
Hair/balding pattern: Pattern 3	1.2	1.7	3.1	1.0	0.6	-1.7	-1.2	-1.7	-1.2
Number of live births	1.2	1.6	5.8	1.6	-2.4	0.3	-0.7	-0.4	-0.8
Forced expiratory volume in 1-second (FEV1)	1.5	4.9	14.2	0.0	-3.8	-1.5	-2.3	-1.3	-2.5
Pulse rate	2.0	3.4	6.7	0.0	-2.4	-0.6	-2.6	-1.8	-2.0
Happiness	1.7	2.0	4.2	0.5	-2.1	-0.6	-1.5	-1.9	-1.2
Noisy workplace	2.4	2.9	7.2	-0.7	1.0	1.1	2.2	2.7	1.6
Qualifications: A levels/AS levels or equivalent	0.6	1.2	2.4	0.1	-0.6	-1.2	-0.9	-1.6	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.0	-0.0	-0.5	0.3	-0.4	0.2	-1.0
Mouth/teeth dental problems: Dentures	0.2	0.3	1.4	0.0	-0.0	0.1	0.3	1.2	-0.3
Asthma	0.1	0.2	0.7	0.9	-0.5	-0.3	-0.3	0.1	-0.4
Medication: Ibuprofen (e.g. Nurofen)	2.7	3.5	5.4	1.8	-2.1	-2.0	-2.3	-0.9	-1.8
Medication: Cholesterol lowering	0.8	1.3	2.9	0.0	1.1	1.4	1.2	1.7	0.3
Depression (self-reported)	2.2	2.6	7.2	1.4	-2.7	-0.1	-1.3	-1.5	-1.7
Medication: Lansoprazole	1.2	1.3	2.6	-0.6	-1.6	1.5	0.9	0.9	1.0
Prospective memory result	0.6	0.7	1.7	1.3	-0.9	0.4	-0.9	-0.5	-0.6
Lung cancer (father)	0.4	0.4	1.3	0.8	-0.6	1.1	-0.3	-0.5	-0.0
Illnesses of mother	0.7	0.9	1.7	0.5	-0.8	-0.7	-1.2	-1.3	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	12.3	0.2	-3.5	-0.4	-1.5	-1.0	-1.5
Pulse wave Arterial Stiffness index	2.2	2.6	4.9	-0.2	-1.0	-1.8	-2.0	-1.5	-2.2
Impedance of arm (left)	0.4	1.9	7.3	-1.8	0.9	2.7	-0.1	-0.2	0.2
Arm fat mass (right)	0.4	1.8	7.9	-2.8	-1.6	0.6	-0.2	0.1	0.4
Trunk predicted mass	0.6	3.3	6.5	-2.6	2.5	0.4	-1.5	-1.9	-1.1
Standing height	1.5	14.8	41.9	-5.0	6.5	3.0	-1.8	-2.9	-1.0
Length of working week for main job	0.5	0.6	1.3	0.7	-0.7	-0.9	-0.4	-0.3	-1.1
Exposure to tobacco smoke at home	0.3	0.4	0.7	-0.7	0.7	0.9	-0.1	0.3	-0.6
Breastfed as a baby	2.9	3.6	7.9	-2.0	2.8	-0.1	2.2	0.9	1.8
Tense / ‘highly strung’	0.5	0.9	2.4	1.6	-0.6	0.6	1.1	0.7	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	4.1	1.4	-2.0	1.7	0.4	0.2	-0.5
Hair/balding pattern: Pattern 4	2.2	5.4	14.2	-0.9	3.3	3.8	1.9	0.4	1.5
Birth weight of first child	0.2	0.3	0.7	-0.5	-0.2	0.9	-0.3	-0.3	-0.7
Peak expiratory flow (PEF)	1.8	4.2	9.6	0.3	-2.2	-3.1	-2.0	-0.8	-2.5
Pulse wave reflection index	0.3	0.3	1.0	-0.5	0.1	-1.0	0.3	0.7	-0.4
Ever highly irritable/argumentative for 2 days	3.2	3.8	11.5	2.0	-3.4	-1.0	-1.9	-1.4	-0.9
Loud music exposure frequency	0.2	0.2	0.8	0.4	0.9	0.4	0.0	-0.0	-0.0
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	4.6	2.1	-1.3	-1.6	-1.8	-1.6	-1.8
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.3	-0.2	-1.8	-1.3	-1.2	-1.1	-1.3
Blood clot in the leg (DVT)	0.8	1.1	2.8	-1.7	1.6	0.5	0.2	-0.8	0.2
Medication: Paracetamol	2.0	3.3	6.0	1.7	-2.5	-2.0	-1.9	-0.5	-1.6
Headache pain in last month	3.2	5.5	8.1	2.0	-2.5	-2.8	-2.8	-1.4	-2.2
Medication for cholesterol, blood pressure or diabetes	2.0	3.2	8.7	0.5	-0.9	-1.6	-2.3	-2.9	-1.3
Glaucoma (self-reported)	0.6	0.7	2.6	-0.5	-0.5	1.6	0.5	-0.7	0.4
Gout (self-reported)	0.6	0.8	1.4	0.7	1.2	0.9	1.0	0.3	0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.5	-1.2	-0.1	-0.8	-0.1	0.0	0.0
Medication: Amlodipine	0.2	0.3	0.7	-0.1	0.3	0.5	0.8	0.5	0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.7	0.2	0.3	-0.8	0.2	0.2	-0.1
Birth weight	0.4	0.9	3.2	1.0	1.8	-1.0	0.3	0.5	-0.5
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.8	-1.7	0.7	1.5	-0.6	-1.4	0.1
High blood pressure (siblings)	0.4	0.5	1.4	0.2	-0.3	-0.6	0.9	1.2	0.7
Forced vital capacity (FVC), Best measure	1.9	7.1	20.9	0.7	-4.6	-0.2	-3.1	-2.2	-2.5
Body fat percentage	0.7	2.7	11.5	-3.4	-0.7	0.5	0.8	1.4	1.2
Leg fat percentage (right)	0.8	2.9	6.4	-2.4	-0.4	-0.8	1.5	2.5	1.4
Arm fat-free mass (right)	0.3	1.5	3.4	-1.8	1.6	-0.3	-1.0	-1.2	-0.6
Exposure to tobacco smoke outside home	3.2	4.3	7.3	2.5	-1.3	-0.0	-2.6	-1.9	-2.7
Comparative body size at age 10	0.3	0.7	1.6	0.3	-1.3	0.4	1.0	0.7	1.0
Number of full brothers	0.7	0.9	3.0	-0.3	-1.7	-0.9	-0.9	0.3	-0.8
Worry too long after embarrassment	0.2	0.4	0.9	1.0	-0.6	0.8	0.3	0.6	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	6.7	2.6	-2.1	1.5	0.6	1.3	-0.4
Wheeze or whistling in the chest in last year	0.2	0.3	0.8	0.5	0.4	0.3	-0.5	0.5	-0.9
Number of children fathered	0.3	0.3	1.0	0.7	-1.0	0.4	0.0	-0.4	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	2.9	3.4	6.0	-1.3	1.6	2.4	1.9	1.4	2.2
Age at first live birth	1.2	2.1	9.9	-3.1	1.4	0.6	-0.0	-0.7	-0.0
Pulse wave peak to peak time	2.4	2.8	5.0	-0.1	1.5	2.1	2.0	1.3	2.2
Health satisfaction	2.3	3.0	6.9	1.6	-2.6	0.4	-1.9	-1.2	-1.9
Shortness of breath walking on level ground	1.0	1.2	3.3	1.1	-0.6	-0.1	-1.8	-1.0	-1.2
Qualifications: College or University degree	0.7	2.1	4.6	-0.8	0.5	-1.4	-2.1	-1.7	-1.6
Eye problems/disorders: None of the above	0.3	0.4	1.2	0.5	-0.2	-1.1	0.1	0.8	0.0
Mouth/teeth dental problems: Loose teeth	0.9	1.1	5.5	0.8	-2.4	-0.4	0.4	0.3	0.3
Emphysema/chronic bronchitis	0.4	0.5	2.2	0.2	0.3	0.1	-0.6	-0.5	-1.5
Medication for pain relief, constipation, heartburn	1.9	3.2	6.9	-2.6	1.5	1.8	1.8	-0.1	1.9
Neck or shoulder pain in last month	0.2	0.3	0.5	0.6	0.5	-0.6	0.0	0.7	-0.5
Medication: Blood pressure	2.6	4.6	10.4	-1.0	0.8	2.4	2.6	3.2	1.7
Angina (self-reported)	0.5	0.7	1.3	0.9	0.6	-0.7	1.1	1.0	0.6
Migraine (self-reported)	0.4	0.5	1.5	-1.2	0.5	-0.9	-0.1	0.3	0.6
Medication: Ibuprofen	3.7	4.5	7.2	1.6	-2.1	-2.5	-2.7	-1.3	-2.2
Medication: Allopurinol	0.8	1.0	1.9	0.9	0.5	0.5	1.3	1.4	1.1
Medication: Omeprazole	0.6	0.7	1.3	-1.1	-1.2	0.5	-0.9	-0.8	-0.3
Medication: Seretide 50 evohaler	0.9	1.0	4.7	0.1	2.2	0.5	0.3	-0.9	0.1
Mean time to correctly identify matches	0.6	1.2	2.6	-1.4	1.2	-1.6	-0.4	-0.2	1.1
Heart disease (mother)	0.8	1.0	2.9	1.2	0.5	-1.7	0.4	1.0	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.8	-0.9	1.3	0.1	0.3	0.7	-0.3
Whole body fat mass	0.5	2.2	11.8	-3.4	-0.4	0.7	0.1	0.3	0.7
Leg fat mass (right)	0.5	1.9	8.2	-2.9	-0.4	-0.1	0.7	1.3	1.0
Arm predicted mass (right)	0.3	1.6	4.3	-2.1	1.5	-0.3	-1.0	-1.3	-0.5
Pulse rate, automated reading	0.9	2.9	10.6	-3.3	-1.6	-0.6	-1.6	-1.1	0.4
Alcohol intake frequency.	0.4	1.0	4.6	0.4	-2.1	-0.1	-0.5	0.1	1.0
Comparative height size at age 10	1.7	9.6	14.1	-3.8	3.5	3.4	-2.9	-2.8	-1.9
Number of full sisters	0.1	0.2	0.5	0.5	-0.1	0.4	0.2	0.7	0.1
Suffer from ‘nerves’	0.7	1.2	4.0	0.8	-0.9	2.0	0.9	0.9	0.2
Overall health rating	1.9	4.0	8.3	2.1	-2.9	-0.6	-2.1	-1.2	-2.3
Chest pain or discomfort	0.8	1.2	4.4	1.3	-2.1	-0.6	-0.2	0.7	-0.5
Had major operations	0.1	0.2	0.3	0.4	-0.6	0.1	-0.2	0.3	-0.6
Age at last live birth	1.4	2.1	7.2	-2.7	1.0	1.4	-0.7	-1.1	-0.7
Family relationship satisfaction	0.6	0.7	1.9	0.9	-1.4	0.8	-0.5	-0.8	0.1
Leg pain on walking	1.2	1.4	3.1	0.5	-1.6	-0.9	-1.8	-0.7	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.1	0.1	-0.4	0.7	1.2	1.5	0.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.1	0.6	1.1	0.4	1.0	0.3	1.4
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.6	-0.4	1.5	-1.6	0.5	-0.2	0.9
Medication: Aspirin	1.6	2.1	4.0	1.4	2.0	0.9	1.6	1.9	0.4
Supplements: Vitamin C	0.7	0.8	1.9	-1.4	-0.7	1.2	-0.0	1.1	-0.2
Knee pain experienced in last month	1.1	1.7	5.2	-1.6	1.2	2.3	-0.5	-0.4	-0.8
Hypertension (Self-reported)	2.1	5.9	10.2	-0.8	1.2	2.5	3.2	3.2	2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	-0.1	-1.1	0.1	0.4	0.5	1.1
Illnesses of father: Heart disease	0.4	0.5	1.8	1.3	-0.7	-0.2	0.4	0.6	-0.4
Illnesses of siblings: Diabetes	2.3	2.9	5.2	-0.9	2.3	1.6	2.3	1.3	1.4
Smoking status: Previous	2.0	2.9	5.0	-2.2	2.0	1.3	1.6	1.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	6.0	-1.9	2.4	1.6	-1.3	-1.8	-0.9
Whole body fat-free mass	0.6	3.4	7.7	-2.8	1.6	0.6	-1.8	-2.4	-1.2
Leg fat-free mass (right)	0.8	4.1	8.8	-2.8	-0.1	1.2	-2.2	-3.0	-1.3
Arm fat percentage (left)	0.7	2.7	7.6	-2.8	-2.7	0.7	0.2	0.6	0.7
Average weekly red wine intake	1.2	1.7	5.4	-0.6	1.6	2.3	1.1	0.8	0.4
Handedness (chirality/laterality): Left-handed	2.3	2.8	6.6	-1.3	-0.6	1.7	2.0	1.1	2.6
Mood swings	1.3	2.4	6.4	2.5	-2.1	0.6	-0.9	-0.5	-1.4
Loneliness, isolation	0.4	0.5	2.5	1.6	-0.5	0.7	-0.1	-0.3	-0.1
Long-standing illness, disability or infirmity	0.6	0.9	4.0	2.0	-0.7	0.1	0.5	0.7	-0.2
Ever had bowel cancer screening	1.8	2.1	4.8	-0.3	0.6	0.6	2.2	2.0	1.7
Diabetes diagnosed by doctor	2.0	3.3	7.6	-0.1	1.1	2.8	2.6	1.6	1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	4.7	-0.0	0.1	-0.3	-1.5	-1.5	-2.2
Friendships satisfaction	3.0	3.7	6.8	1.6	-2.4	-0.6	-2.6	-2.3	-1.2
Qualifications: nursing, teaching	0.6	0.9	2.5	0.2	1.0	-0.5	-0.7	-1.6	-1.2
Commuting to job workplace: Walk	0.6	0.6	3.0	-1.7	-0.2	-0.6	-0.2	0.4	-0.4
Eye problems/disorders: Cataract	1.3	1.5	3.7	0.3	-0.3	-0.5	-1.8	-1.9	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.9	-0.3	0.2	-0.1	-0.0	-1.0	-0.6
Medication for cholesterol	1.9	2.9	5.4	0.2	-1.4	1.7	-2.1	-2.3	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.6	0.4	1.6	-0.1	0.6	0.7	0.3
Back pain experienced in last month	0.2	0.3	0.6	0.7	0.1	-0.2	-0.7	-0.8	-0.4
Mineral and other dietary supplements	0.3	0.4	0.8	0.7	-0.2	0.9	0.7	0.2	0.4
Breast cancer (self-reported)	0.9	1.1	5.5	0.6	0.7	2.4	0.0	-0.4	0.2
Asthma (self-reported)	0.1	0.2	0.8	0.9	-0.6	-0.2	-0.3	0.2	-0.4
Osteoporosis (self-reported)	1.8	2.2	7.7	1.0	0.5	1.4	-1.6	0.1	-2.8
Osteoarthritis (self-reported)	0.8	1.0	3.3	1.3	-0.9	-1.8	-0.4	-0.0	0.2
Medication: Aspirin	1.3	1.7	3.6	1.9	1.9	0.7	1.0	1.2	-0.2
Medication: Gliclazide	3.4	3.8	7.8	-0.2	1.4	2.8	2.2	2.4	1.7
Illnesses of father: None of the above (group 1)	0.6	0.7	1.2	-0.9	1.1	-0.3	0.7	0.9	1.0
Smoking status: Current	1.6	2.5	5.6	2.4	-1.9	0.6	-1.1	-0.7	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.5	17.7	0.1	-4.2	-0.8	1.0	0.8	0.9
Whole body water mass	0.6	3.4	7.8	-2.8	1.5	0.6	-1.7	-2.3	-1.1
Leg predicted mass (right)	0.8	4.1	8.9	-2.8	-0.1	1.2	-2.2	-3.0	-1.3
Arm fat mass (left)	0.4	1.8	7.8	-2.8	-1.6	0.6	-0.2	-0.0	0.4
Number of self-reported non-cancer illnesses	0.7	1.2	4.5	-0.4	-0.2	2.1	1.0	0.8	0.7
Average weekly champagne plus white wine intake	0.1	0.2	0.9	-0.9	0.5	0.1	0.0	0.1	-0.2
Miserableness	1.8	3.1	6.2	2.5	-2.3	0.9	-1.5	-1.2	-1.7
Guilty feelings	1.2	1.9	3.0	1.7	-1.4	1.6	1.4	0.7	1.0
Wears glasses or contact lenses	0.3	0.3	0.8	-0.5	-0.4	-0.9	0.4	0.2	0.7
Ever taken oral contraceptive pill	1.0	1.1	2.2	-1.0	1.5	-0.0	-1.1	0.1	-1.4
Hearing aid user	0.2	0.2	0.3	-0.4	0.5	0.4	0.1	0.5	0.6
Mother’s age at death	0.3	0.3	1.0	-0.1	-0.7	-0.4	0.5	1.0	0.2
Financial situation satisfaction	1.4	1.8	5.1	1.6	-2.3	0.3	-1.2	-0.4	-1.1
Tinnitus: Yes, now most or all of the time	1.3	1.6	4.0	0.4	0.4	0.3	2.0	1.8	1.3
Commuting to job workplace: Public transport	1.3	1.5	3.1	-0.1	0.1	-1.3	-1.3	-1.8	-1.6
Eye problems/disorders: Glaucoma	0.4	0.5	1.9	-0.1	0.0	0.9	-0.2	-1.4	-0.1
Medication: Blood pressure	1.6	3.0	6.1	0.7	1.3	-0.8	2.2	2.0	2.5
Pain type(s) experienced in last month: Hip pain	3.7	4.6	11.6	1.7	-3.4	-0.9	-2.5	-2.0	-1.5
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.0	-0.4	-0.5	0.1	-1.0	-0.3	-0.6
High cholesterol (Self-reported)	0.7	1.2	2.7	-0.2	1.2	0.4	1.6	1.4	0.9
Medication: Bendroflumethiazide	1.8	2.7	3.9	0.7	1.8	-1.7	1.6	2.0	1.7
Medication: Paracetamol	1.2	1.8	3.5	0.7	-1.8	-1.9	-1.5	-0.1	-1.2
Medication: Lisinopril	1.2	1.5	2.5	-0.3	1.6	0.7	1.4	1.4	1.4
Medication: Atorvastatin	0.2	0.3	1.2	1.1	-0.1	-0.4	0.2	0.5	-0.4
Illnesses of father: High blood pressure	0.5	0.6	3.0	0.1	0.1	1.7	0.2	0.2	-0.8
Alcohol drinker status: Never	0.9	1.1	3.1	-0.1	-0.1	0.0	1.2	1.3	1.8
Ever smoked	0.6	1.0	3.6	-0.4	0.4	1.9	-0.2	0.4	-1.4
Basal metabolic rate	0.6	3.1	9.0	-3.0	1.1	0.6	-1.6	-2.1	-1.0
Leg fat percentage (left)	0.6	2.1	5.0	-2.0	-0.5	-0.7	1.2	2.2	1.2
Arm fat-free mass (left)	0.4	2.1	5.3	-2.3	2.0	0.0	-1.0	-1.5	-0.6
Number of operations (self-reported)	0.6	0.9	1.9	0.6	-0.9	-0.2	-1.4	-1.2	-1.0
Average weekly beer plus cider intake	0.3	0.4	0.9	-0.1	0.8	0.3	-0.5	-0.7	-1.0
Irritability	2.0	3.4	8.2	1.0	-1.4	2.9	1.8	2.0	1.3
Risk taking	0.8	1.2	3.8	0.9	-0.9	1.9	0.7	1.0	0.3
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.4	-1.2	0.6	0.3	-0.1	0.0	0.0
Fractured/broken bones in last 5 years	0.6	0.7	1.8	1.4	1.0	-1.2	-0.4	-0.2	-0.2
Age started oral contraceptive pill	1.5	1.9	4.4	-0.9	1.0	-0.0	1.6	2.1	1.6
Diastolic blood pressure, automated reading	0.2	0.7	1.9	-1.2	0.1	-0.2	0.7	0.5	1.4
Ever depressed for a whole week	1.6	1.9	4.2	0.2	-0.3	1.6	2.0	2.1	0.9
Unable to work because of sickness or disability	0.4	0.5	1.3	0.6	0.7	-0.3	0.7	1.1	-0.1
Commuting to job workplace: Cycle	1.4	1.7	3.1	-0.2	-1.4	0.6	1.6	1.8	1.4
Myopia	1.8	2.6	3.3	1.4	-1.3	-1.8	-1.7	-1.6	-1.8
Vascular/heart problems diagnosed by doctor	2.0	5.4	10.8	-0.0	-0.8	-1.9	-3.3	-3.2	-2.6
Cholesterol lowering medication	1.5	2.2	3.7	-1.0	1.6	0.4	1.9	1.8	1.6
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	4.3	-0.4	-2.1	0.5	-1.5	-1.5	-1.0
Pain experienced in last month	0.8	1.4	2.7	-1.1	0.8	0.2	1.6	1.1	1.7
Supplements: Calcium	1.1	1.2	3.0	0.4	-1.4	-0.0	-1.2	-0.6	-1.7
Basal cell carcinoma (self-reported)	1.1	1.3	2.9	1.1	-0.6	-0.2	1.1	1.5	1.7
Heart attack/myocardial infarction (self-reported)	0.7	1.0	2.7	0.0	0.5	0.1	1.5	1.6	0.7
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	3.3	-1.8	1.6	0.4	0.1	-0.9	0.1
Heart disease (siblings)	0.5	0.6	2.2	0.7	-0.5	0.2	0.6	1.5	0.2
Alcohol drinker status: Previous	0.2	0.2	1.2	0.1	0.0	1.1	-0.1	0.3	-0.0
Pack years of smoking	0.1	0.1	0.2	0.4	-0.3	-0.3	-0.0	0.3	0.1
Impedance of whole body	0.3	1.7	5.6	-1.1	2.4	1.5	0.6	0.9	0.5
Leg fat mass (left)	0.4	1.5	6.9	-2.6	-0.5	-0.1	0.5	1.1	0.8
Arm predicted mass (left)	0.4	2.0	5.6	-2.4	1.9	0.2	-0.9	-1.3	-0.4